EP3724205 - CYCLIC DINUCLEOTIDES AS STING AGONISTS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 28.04.2023 Database last updated on 22.08.2024 | |
Former | The patent has been granted Status updated on 20.05.2022 | ||
Former | Grant of patent is intended Status updated on 06.02.2022 | ||
Former | Examination is in progress Status updated on 23.04.2021 | ||
Former | Request for examination was made Status updated on 18.09.2020 | ||
Former | The international publication has been made Status updated on 21.06.2019 | ||
Former | unknown Status updated on 18.01.2019 | Most recent event Tooltip | 14.06.2024 | Lapse of the patent in a contracting state New state(s): MC | published on 17.07.2024 [2024/29] | Applicant(s) | For all designated states Janssen Biotech, Inc. 800/850 Ridgeview Drive Horsham, PA 19044 / US | [2020/43] | Inventor(s) | 01 /
BEIGELMAN, Leonid 260 E. Grand Avenue South San Francisco, California 94080 / US | 02 /
BIGNAN, Gilles 1400 Welsh and McKean Roads Spring House, Pennsylvania 19477 / US | 03 /
CONNOLLY, Peter J. c/o Janssen Research & Development, LLC Geraldine Cooney-21-2024 1400 McKean Rd. Spring House, PA 19477 / US | 04 /
EDWARDS, James Patrick 1400 Welsh and McKean Roads Spring House, Pennsylvania 19477 / US | 05 /
EMANUEL, Stuart 1400 Welsh and McKean Roads Spring House, Pennsylvania 19477 / US | 06 /
LAQUERRE, Sylvia 1400 Welsh and McKean Roads Spring House, Pennsylvania 19477 / US | 07 /
RICHTER, Mark 1400 Welsh and McKean Roads Spring House, Pennsylvania 19477 / US | 08 /
SCHEPENS, Wim Gert Griet Turnhoutseweg 30 2340 Beerse / BE | 09 /
THATIKONDA, Santhosh Kumar 260 E. Grand Avenue South San Francisco, California 94080 / US | 10 /
THURING, Johannes Wilhelmus John Fitzgerald Turnhoutseweg 30 2340 Beerse / BE | 11 /
VIELLEVOYE, Marcel Turnhoutseweg 30 2340 Beerse / BE | 12 /
WANG, Guangyi 260 E. Grand Avenue South San Francisco, California 94080 / US | 13 /
ZHONG, Minghong 260 E. Grand Avenue South San Francisco, California 94080 / US | [2022/25] |
Former [2020/43] | 01 /
BEIGELMAN, Leonid 260 E. Grand Avenue South San Francisco, California 94080 / US | ||
02 /
BIGNAN, Gilles 1400 Welsh and McKean Roads Spring House, Pennsylvania 19477 / US | |||
03 /
CONNOLLY, Peter J. 1400 Welsh and McKean Roads Spring House, Pennsylvania 19477 / US | |||
04 /
EDWARDS, James Patrick 1400 Welsh and McKean Roads Spring House, Pennsylvania 19477 / US | |||
05 /
EMANUEL, Stuart 1400 Welsh and McKean Roads Spring House, Pennsylvania 19477 / US | |||
06 /
LAQUERRE, Sylvia 1400 Welsh and McKean Roads Spring House, Pennsylvania 19477 / US | |||
07 /
RICHTER, Mark 1400 Welsh and McKean Roads Spring House, Pennsylvania 19477 / US | |||
08 /
SCHEPENS, Wim Gert Griet Turnhoutseweg 30 2340 Beerse / BE | |||
09 /
THATIKONDA, Santhosh Kumar 260 E. Grand Avenue South San Francisco, California 94080 / US | |||
10 /
THURING, Johannes Wilhelmus John Fitzgerald Turnhoutseweg 30 2340 Beerse / BE | |||
11 /
VIELLEVOYE, Marcel Turnhoutseweg 30 2340 Beerse / BE | |||
12 /
WANG, Guangyi 260 E. Grand Avenue South San Francisco, California 94080 / US | |||
13 /
ZHONG, Minghong 260 E. Grand Avenue South San Francisco, California 94080 / US | Representative(s) | Murgitroyd & Company 165-169 Scotland Street Glasgow G5 8PL / GB | [N/P] |
Former [2022/25] | Mitchell, Simon James Murgitroyd & Company London Euston House 24 Eversholt Street London NW1 1AD / GB | ||
Former [2020/43] | Mitchell, Simon James Urquhart-Dykes & Lord LLP Euston House 24 Eversholt Street London NW1 1AD / GB | Application number, filing date | 18830620.3 | 14.12.2018 | [2020/43] | WO2018US65677 | Priority number, date | US201762599111P | 15.12.2017 Original published format: US 201762599111 P | [2020/43] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2019118839 | Date: | 20.06.2019 | Language: | EN | [2019/25] | Type: | A1 Application with search report | No.: | EP3724205 | Date: | 21.10.2020 | Language: | EN | The application published by WIPO in one of the EPO official languages on 20.06.2019 takes the place of the publication of the European patent application. | [2020/43] | Type: | B1 Patent specification | No.: | EP3724205 | Date: | 22.06.2022 | Language: | EN | [2022/25] | Search report(s) | International search report - published on: | EP | 20.06.2019 | Classification | IPC: | C07H21/02, A61K31/7084, C07H21/04, A61P31/00, A61P31/12, A61P35/00 | [2020/43] | CPC: |
C07H21/02 (EP);
C07H21/00 (KR);
C07H21/04 (EP,US);
A61K31/7084 (EP,KR,US);
A61K9/0053 (US);
A61P31/12 (KR);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2020/43] | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | KH | Not yet paid | MA | Not yet paid | MD | Not yet paid | TN | Not yet paid | Title | German: | CYCLISCHE DINUKLEOTIDE ALS STING-AGONISTEN | [2020/43] | English: | CYCLIC DINUCLEOTIDES AS STING AGONISTS | [2020/43] | French: | DINUCLÉOTIDES CYCLIQUES UTILISÉS EN TANT QU'AGONISTES DE STING | [2020/43] | Entry into regional phase | 11.06.2020 | National basic fee paid | 11.06.2020 | Designation fee(s) paid | 11.06.2020 | Examination fee paid | Examination procedure | 11.06.2020 | Examination requested [2020/43] | 11.06.2020 | Date on which the examining division has become responsible | 26.01.2021 | Amendment by applicant (claims and/or description) | 22.04.2021 | Despatch of a communication from the examining division (Time limit: M06) | 02.11.2021 | Reply to a communication from the examining division | 07.02.2022 | Communication of intention to grant the patent | 11.05.2022 | Fee for grant paid | 11.05.2022 | Fee for publishing/printing paid | 11.05.2022 | Receipt of the translation of the claim(s) | Opposition(s) | 23.03.2023 | No opposition filed within time limit [2023/22] | Fees paid | Renewal fee | 14.12.2020 | Renewal fee patent year 03 | 10.11.2021 | Renewal fee patent year 04 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 14.12.2018 | AL | 22.06.2022 | AT | 22.06.2022 | CY | 22.06.2022 | CZ | 22.06.2022 | DK | 22.06.2022 | EE | 22.06.2022 | FI | 22.06.2022 | HR | 22.06.2022 | LT | 22.06.2022 | LV | 22.06.2022 | MC | 22.06.2022 | MK | 22.06.2022 | PL | 22.06.2022 | RO | 22.06.2022 | RS | 22.06.2022 | SE | 22.06.2022 | SI | 22.06.2022 | SK | 22.06.2022 | SM | 22.06.2022 | BG | 22.09.2022 | NO | 22.09.2022 | GR | 23.09.2022 | IS | 22.10.2022 | PT | 24.10.2022 | LU | 14.12.2022 | [2024/29] |
Former [2024/27] | HU | 14.12.2018 | |
AL | 22.06.2022 | ||
AT | 22.06.2022 | ||
CY | 22.06.2022 | ||
CZ | 22.06.2022 | ||
DK | 22.06.2022 | ||
EE | 22.06.2022 | ||
FI | 22.06.2022 | ||
HR | 22.06.2022 | ||
LT | 22.06.2022 | ||
LV | 22.06.2022 | ||
MK | 22.06.2022 | ||
PL | 22.06.2022 | ||
RO | 22.06.2022 | ||
RS | 22.06.2022 | ||
SE | 22.06.2022 | ||
SI | 22.06.2022 | ||
SK | 22.06.2022 | ||
SM | 22.06.2022 | ||
BG | 22.09.2022 | ||
NO | 22.09.2022 | ||
GR | 23.09.2022 | ||
IS | 22.10.2022 | ||
PT | 24.10.2022 | ||
LU | 14.12.2022 | ||
Former [2024/24] | HU | 14.12.2018 | |
AL | 22.06.2022 | ||
AT | 22.06.2022 | ||
CY | 22.06.2022 | ||
CZ | 22.06.2022 | ||
DK | 22.06.2022 | ||
EE | 22.06.2022 | ||
FI | 22.06.2022 | ||
HR | 22.06.2022 | ||
LT | 22.06.2022 | ||
LV | 22.06.2022 | ||
PL | 22.06.2022 | ||
RO | 22.06.2022 | ||
RS | 22.06.2022 | ||
SE | 22.06.2022 | ||
SI | 22.06.2022 | ||
SK | 22.06.2022 | ||
SM | 22.06.2022 | ||
BG | 22.09.2022 | ||
NO | 22.09.2022 | ||
GR | 23.09.2022 | ||
IS | 22.10.2022 | ||
PT | 24.10.2022 | ||
LU | 14.12.2022 | ||
Former [2024/21] | AL | 22.06.2022 | |
AT | 22.06.2022 | ||
CY | 22.06.2022 | ||
CZ | 22.06.2022 | ||
DK | 22.06.2022 | ||
EE | 22.06.2022 | ||
FI | 22.06.2022 | ||
HR | 22.06.2022 | ||
LT | 22.06.2022 | ||
LV | 22.06.2022 | ||
PL | 22.06.2022 | ||
RO | 22.06.2022 | ||
RS | 22.06.2022 | ||
SE | 22.06.2022 | ||
SI | 22.06.2022 | ||
SK | 22.06.2022 | ||
SM | 22.06.2022 | ||
BG | 22.09.2022 | ||
NO | 22.09.2022 | ||
GR | 23.09.2022 | ||
IS | 22.10.2022 | ||
PT | 24.10.2022 | ||
LU | 14.12.2022 | ||
Former [2023/38] | AL | 22.06.2022 | |
AT | 22.06.2022 | ||
CZ | 22.06.2022 | ||
DK | 22.06.2022 | ||
EE | 22.06.2022 | ||
FI | 22.06.2022 | ||
HR | 22.06.2022 | ||
LT | 22.06.2022 | ||
LV | 22.06.2022 | ||
PL | 22.06.2022 | ||
RO | 22.06.2022 | ||
RS | 22.06.2022 | ||
SE | 22.06.2022 | ||
SI | 22.06.2022 | ||
SK | 22.06.2022 | ||
SM | 22.06.2022 | ||
BG | 22.09.2022 | ||
NO | 22.09.2022 | ||
GR | 23.09.2022 | ||
IS | 22.10.2022 | ||
PT | 24.10.2022 | ||
LU | 14.12.2022 | ||
Former [2023/37] | AL | 22.06.2022 | |
AT | 22.06.2022 | ||
CZ | 22.06.2022 | ||
DK | 22.06.2022 | ||
EE | 22.06.2022 | ||
FI | 22.06.2022 | ||
HR | 22.06.2022 | ||
LT | 22.06.2022 | ||
LV | 22.06.2022 | ||
PL | 22.06.2022 | ||
RO | 22.06.2022 | ||
RS | 22.06.2022 | ||
SE | 22.06.2022 | ||
SI | 22.06.2022 | ||
SK | 22.06.2022 | ||
SM | 22.06.2022 | ||
BG | 22.09.2022 | ||
NO | 22.09.2022 | ||
GR | 23.09.2022 | ||
IS | 22.10.2022 | ||
PT | 24.10.2022 | ||
Former [2023/21] | AL | 22.06.2022 | |
AT | 22.06.2022 | ||
CZ | 22.06.2022 | ||
DK | 22.06.2022 | ||
EE | 22.06.2022 | ||
FI | 22.06.2022 | ||
HR | 22.06.2022 | ||
LT | 22.06.2022 | ||
LV | 22.06.2022 | ||
PL | 22.06.2022 | ||
RO | 22.06.2022 | ||
RS | 22.06.2022 | ||
SE | 22.06.2022 | ||
SK | 22.06.2022 | ||
SM | 22.06.2022 | ||
BG | 22.09.2022 | ||
NO | 22.09.2022 | ||
GR | 23.09.2022 | ||
IS | 22.10.2022 | ||
PT | 24.10.2022 | ||
Former [2023/17] | AL | 22.06.2022 | |
AT | 22.06.2022 | ||
CZ | 22.06.2022 | ||
EE | 22.06.2022 | ||
FI | 22.06.2022 | ||
HR | 22.06.2022 | ||
LT | 22.06.2022 | ||
LV | 22.06.2022 | ||
PL | 22.06.2022 | ||
RO | 22.06.2022 | ||
RS | 22.06.2022 | ||
SE | 22.06.2022 | ||
SK | 22.06.2022 | ||
SM | 22.06.2022 | ||
BG | 22.09.2022 | ||
NO | 22.09.2022 | ||
GR | 23.09.2022 | ||
IS | 22.10.2022 | ||
PT | 24.10.2022 | ||
Former [2023/12] | AT | 22.06.2022 | |
CZ | 22.06.2022 | ||
EE | 22.06.2022 | ||
FI | 22.06.2022 | ||
HR | 22.06.2022 | ||
LT | 22.06.2022 | ||
LV | 22.06.2022 | ||
PL | 22.06.2022 | ||
RO | 22.06.2022 | ||
RS | 22.06.2022 | ||
SE | 22.06.2022 | ||
SK | 22.06.2022 | ||
SM | 22.06.2022 | ||
BG | 22.09.2022 | ||
NO | 22.09.2022 | ||
GR | 23.09.2022 | ||
IS | 22.10.2022 | ||
PT | 24.10.2022 | ||
Former [2023/11] | AT | 22.06.2022 | |
CZ | 22.06.2022 | ||
EE | 22.06.2022 | ||
FI | 22.06.2022 | ||
HR | 22.06.2022 | ||
LT | 22.06.2022 | ||
LV | 22.06.2022 | ||
PL | 22.06.2022 | ||
RO | 22.06.2022 | ||
RS | 22.06.2022 | ||
SE | 22.06.2022 | ||
SK | 22.06.2022 | ||
SM | 22.06.2022 | ||
BG | 22.09.2022 | ||
NO | 22.09.2022 | ||
GR | 23.09.2022 | ||
PT | 24.10.2022 | ||
Former [2023/09] | AT | 22.06.2022 | |
CZ | 22.06.2022 | ||
EE | 22.06.2022 | ||
FI | 22.06.2022 | ||
HR | 22.06.2022 | ||
LT | 22.06.2022 | ||
LV | 22.06.2022 | ||
RO | 22.06.2022 | ||
RS | 22.06.2022 | ||
SE | 22.06.2022 | ||
SK | 22.06.2022 | ||
SM | 22.06.2022 | ||
BG | 22.09.2022 | ||
NO | 22.09.2022 | ||
GR | 23.09.2022 | ||
PT | 24.10.2022 | ||
Former [2023/07] | AT | 22.06.2022 | |
FI | 22.06.2022 | ||
HR | 22.06.2022 | ||
LT | 22.06.2022 | ||
LV | 22.06.2022 | ||
RS | 22.06.2022 | ||
SE | 22.06.2022 | ||
BG | 22.09.2022 | ||
NO | 22.09.2022 | ||
GR | 23.09.2022 | ||
Former [2022/50] | FI | 22.06.2022 | |
HR | 22.06.2022 | ||
LT | 22.06.2022 | ||
LV | 22.06.2022 | ||
RS | 22.06.2022 | ||
SE | 22.06.2022 | ||
BG | 22.09.2022 | ||
NO | 22.09.2022 | ||
GR | 23.09.2022 | ||
Former [2022/49] | FI | 22.06.2022 | |
HR | 22.06.2022 | ||
LT | 22.06.2022 | ||
LV | 22.06.2022 | ||
SE | 22.06.2022 | ||
BG | 22.09.2022 | ||
NO | 22.09.2022 | ||
GR | 23.09.2022 | ||
Former [2022/47] | FI | 22.06.2022 | |
LT | 22.06.2022 | ||
SE | 22.06.2022 | ||
NO | 22.09.2022 | Cited in | International search | [I]WO2017161349 (IMMUNE SENSOR LLC [US], et al) [I] 1-25* the whole document in particular claim 1, pages 298 and 325; pages 298,325 * | Examination | WO2020016782 | by applicant | WOO1002369 | WO0210192 | WO02068470 | WO2010027827 | WO2010077634 | WO2011066342 | WO2013019906 | US8383796 | - ZHONG B et al., "The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation", Immunity, (20080000), vol. 29, doi:doi:10.1016/j.immuni.2008.09.003, pages 538 - 550, XP055021580 DOI: http://dx.doi.org/10.1016/j.immuni.2008.09.003 | - LIU S et al., "Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation", Science, (20150000), pages 2630 - 2637 | - CHEN H et al., "Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity", Cell, (20110000), vol. 14, pages 433 - 446 | - CORRALES, L. et al., "Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity", Cell Reports, (20150000), vol. 1, no. 1, pages 1 - 13 | - KONNO, H. et al., "Cyclic dinucleotides trigger ULK1 (ATGl) phosphorylation of STING to prevent sustained innate immune signaling", Cell, (20130000), vol. 155, doi:doi:10.1016/j.cell.2013.09.049, pages 688 - 698, XP028758016 DOI: http://dx.doi.org/10.1016/j.cell.2013.09.049 | - SUN, L. et al., "Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway", Science, (20130000), vol. 339, doi:doi:10.1126/science.1232458, pages 786 - 791, XP055294100 DOI: http://dx.doi.org/10.1126/science.1232458 | - BHAT N; FITZGERALD KA, "Recognition of Cytosolic DNA by cGAS and other STING-dependent sensors", Eur J Immunol., (20140300), vol. 44, no. 3, pages 634 - 40 | - ZHANG X et al., "Cyclic GMP-A]\;UJ Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING", Molecular Cell, (20130000), vol. 51, doi:doi:10.1016/j.molcel.2013.05.022, pages 226 - 235, XP055300246 DOI: http://dx.doi.org/10.1016/j.molcel.2013.05.022 | - DANILCHANKA, O; MEKALANOS, JJ, "Cyclic Dinucleotides and the Innate Immune Response", Cell, (20130000), vol. 154, doi:doi:10.1016/j.cell.2013.08.014, pages 962 - 970, XP028706417 DOI: http://dx.doi.org/10.1016/j.cell.2013.08.014 | - LIU S-Y et al., "Systematic identification of type I and type II interferon-induced antiviral factors", Proc. Natl. Acad. Sci., (20120000), vol. 109, pages 4239 - 4244 | - VAN DER JEUGHT et al., Oncotarget, (20150000), vol. 6, no. 3, pages 1359 - 1381 | - MARABELLE, A. et al., Clinical Cancer Research, (20140000), vol. 20, no. 7, pages 1747 - 1756 | - HOLFORD; SCHEINER, Clin. Pharmacokinet., (19980000), vol. 6, pages 429 - 453 | - LOEWE; MUISCHNEK, Arch. Exp. Pathol Pharmacol., (19260000), vol. 114, pages 313 - 326 | - CHOU; TALALAY, Adv. Enzyme Regul., (19840000), vol. 22, pages 27 - 55 | - J. Chem. Soc., Perkin Trans., (20020000), vol. 1, pages 485 - 495 | - CHEMICAL ABSTRACTS, Database accession no. 170871-87-1 |