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Extract from the Register of European Patents

EP About this file: EP3668997

EP3668997 - MiRNA DETARGETING SYSTEM FOR TISSUE SPECIFIC INTERFERENCE [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  03.11.2023
Database last updated on 03.09.2024
FormerRequest for examination was made
Status updated on  22.05.2020
FormerThe international publication has been made
Status updated on  13.04.2019
Most recent event   Tooltip06.05.2024New entry: Reply to examination report 
Applicant(s)For all designated states
Research Institute at Nationwide Children's Hospital
700 Children's Drive, Room W172
Columbus, Ohio 43205 / US
[2020/26]
Inventor(s)01 / HARPER, Scott, Quenton
384 Briarbend Boulevard
Powell, OH 43065 / US
 [2020/26]
Representative(s)Forresters IP LLP
Skygarden
Erika-Mann-Straße 11
80636 München / DE
[N/P]
Former [2020/26]Walker, Ross Thomson
Forresters IP LLP
Skygarden
Erika-Mann-Strasse 11
80636 München / DE
Application number, filing date18863924.902.10.2018
[2020/26]
WO2018US54005
Priority number, dateUS201762566966P02.10.2017         Original published format: US 201762566966 P
[2020/26]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019070741
Date:11.04.2019
Language:EN
[2019/15]
Type: A1 Application with search report 
No.:EP3668997
Date:24.06.2020
Language:EN
The application published by WIPO in one of the EPO official languages on 11.04.2019 takes the place of the publication of the European patent application.
[2020/26]
Search report(s)International search report - published on:US11.04.2019
(Supplementary) European search report - dispatched on:EP15.04.2021
ClassificationIPC:C12N15/11, C12N15/113, A61K31/7088, A61P21/00
[2021/20]
CPC:
C12N15/63 (EP); C12N15/113 (EP,US); A61K35/76 (US);
C12N15/111 (EP); C12N15/86 (US); C12N7/00 (US);
A61K48/00 (US); C12N2310/141 (EP); C12N2330/51 (EP);
C12N2750/14143 (US); Y02A50/30 (EP) (-)
Former IPC [2020/26]C12Q1/68, C07H21/02
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/26]
Extension statesBA20.03.2020
ME20.03.2020
Validation statesKH20.03.2020
MA20.03.2020
MD20.03.2020
TN20.03.2020
TitleGerman:SYSTEM ZUM MIRNA-DETARGETING FÜR GEWEBESPEZIFISCHE INTERFERENZ[2020/26]
English:MiRNA DETARGETING SYSTEM FOR TISSUE SPECIFIC INTERFERENCE[2020/26]
French:SYSTÈME DE DÉCIBLAGE DE MIARN POUR INTERFÉRENCE SPÉCIFIQUE D'UN TISSU[2020/26]
Entry into regional phase20.03.2020National basic fee paid 
20.03.2020Search fee paid 
20.03.2020Designation fee(s) paid 
20.03.2020Examination fee paid 
Examination procedure20.03.2020Examination requested  [2020/26]
15.11.2021Amendment by applicant (claims and/or description)
03.11.2023Despatch of a communication from the examining division (Time limit: M06)
03.05.2024Reply to a communication from the examining division
Fees paidRenewal fee
14.10.2020Renewal fee patent year 03
29.09.2021Renewal fee patent year 04
15.09.2022Renewal fee patent year 05
13.09.2023Renewal fee patent year 06
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Documents cited:Search[X]US2010186103  (GAO GUANGPING [US], et al) [X] 1,3,7-11,14,15 * claims 1-6,18 *;
 [XYI]WO2010138263  (UNIV MASSACHUSETTS [US], et al) [X] 1-3,7-11,14,15 * page 24; claims 29-39 * [Y] 4,12,13 [I] 5,6;
 [XYI]WO2011133890  (UNIV MASSACHUSETTS [US], et al) [X] 1,3,7-11,14,15 * page 7; examples 1,3,8; claims 1,11,12,30; sequence 21 * [Y] 4,12,13 [I] 2,5,6;
 [A]WO2013016352  (NATIONWIDE CHILDREN S HOSPITAL INC [US], et al) [A] 1-15* claims 1-10 *;
 [XP]WO2017173411  (RES INST AT NATION WIDE CHILDREN'S HOSPITAL [US]) [XP] 1-15 * claims 1-16,21,22; sequence 3 *;
 [Y]  - A GEISLER ET AL, "microRNA122-regulated transgene expression increases specificity of cardiac gene transfer upon intravenous delivery of AAV9 vectors", GENE THERAPY, (20101104), vol. 18, no. 2, doi:10.1038/gt.2010.141, ISSN 0969-7128, pages 199 - 209, XP055078590 [Y] 1-15 * figures 2,6 *

DOI:   http://dx.doi.org/10.1038/gt.2010.141
 [Y]  - ZHOU H ET AL, "A tightly regulated Pol III promoter for synthesis of miRNA genes in tandem", BIOCHIMICA ET BIOPHYSICA ACTA. GENE REGULATORY MECHANISMS, ELSEVIER, AMSTERDAM, NL, vol. 1779, no. 11, doi:10.1016/J.BBAGRM.2008.03.011, ISSN 1874-9399, (20080407), pages 773 - 779, (20080407), XP025678681 [Y] 1-15 * figures 2,3 *

DOI:   http://dx.doi.org/10.1016/j.bbagrm.2008.03.011
 [A]  - RAVIKANTH DANDA ET AL, "Targeted Expression of Suicide Gene by Tissue-Specific Promoter and MicroRNA Regulation for Cancer Gene Therapy", PLOS ONE, (20131231), vol. 8, no. 12, doi:10.1371/journal.pone.0083398, page e83398, XP055320669 [A] 1-15 * figure 4 *

DOI:   http://dx.doi.org/10.1371/journal.pone.0083398
 [A]  - WOLFF LISA J ET AL, "Effect of tissue-specific promoters and microRNA recognition elements on stability of transgene expression after hydrodynamic naked plasmid DNA delivery", HUMAN GENE THERAPY, GB, vol. 20, no. 4, doi:10.1089/hum.2008.088, ISSN 1043-0342, (20090312), pages 374 - 388, URL: https://www.liebertpub.com/doi/pdfplus/10.1089/hum.2008.088, XP055792052 [A] 1-15 * figure 1 *

DOI:   http://dx.doi.org/10.1089/hum.2008.088
International search[Y]US2013195801  (GAO GUANGPING [US], et al) [Y] 1-3 * Abstract; para [0007]; para [0012] *;
 [Y]US2017166925  (GAO GUANGPING [US], et al) [Y] 1-3 * Claim 1; para [0029]; para [0030]; para [0040]; para [0099] *;
 [Y]  - MCMANUS et al., "Gene silencing using micro-RNA designed hairpins", RNA, (20020600), vol. 8, no. 6, doi:doi:10.1017/S1355838202024032, pages 842 - 850, XP008021481 [Y] 1-3 * . Especially Abstract, page 847, col 2, last para *

DOI:   http://dx.doi.org/10.1017/S1355838202024032
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