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Extract from the Register of European Patents

EP About this file: EP3719501

EP3719501 - METHOD FOR MEASURING QUALITY OF THERAPEUTIC CELL THROUGH REAL-TIME GLUTATHIONE MEASUREMENT [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.11.2023
Database last updated on 26.07.2024
FormerThe patent has been granted
Status updated on  02.12.2022
FormerGrant of patent is intended
Status updated on  02.08.2022
FormerExamination is in progress
Status updated on  21.01.2022
FormerRequest for examination was made
Status updated on  04.09.2020
FormerThe international publication has been made
Status updated on  08.06.2019
Most recent event   Tooltip05.07.2024Lapse of the patent in a contracting state
New state(s): MC		published on 07.08.2024 [2024/32]
Applicant(s)For all designated states
Cell2in, Inc.
6F 103 Daehak-ro
Jongno-gu
Seoul 03080 / KR
[2020/41]
Inventor(s)01 / KANG, Heun Soo
102-701 8
Dogok-ro 28-gil
Gangnam-gu
Seoul 06272 / KR
02 / KIM, Hye Mi
201-ho
36
Dobong-ro 95-gil
Gangbuk-gu
Seoul 01054 / KR
03 / SONG, Ji Eun
(Bangbae-dong
Bangbae Dongyang Paragon) 402-ho
67
Nambusunhwan-ro 309-gil, Seocho-gu
Seoul 06706 / KR
04 / YANG, Gwang Mo
702-ho
14
Gunja-ro 4-gil
Gwangjin-gu
Seoul 05010 / KR
05 / SHIN, Ji Woong
102-404
15
Gajwa-ro 12-gil
Eunpyeong-gu
Seoul 03438 / KR
06 / KANG, Hye Won
60
Gurojungang-ro 18-gil
Guro-gu
Seoul 08303 / KR
07 / KIM, Yong Hwan
101-801
55
Simin-daero 327beon-gil
Dongan-gu
Anyang-si Gyeonggi-do 14055 / KR
08 / KIM, Myung Jin
106-1802
25
Yeouidaebang-ro 43na-gil
Yeongdeungpo-gu
Seoul 07360 / KR
 [2020/41]
Representative(s)Schnappauf, Georg
ZSP Patentanwälte PartG mbB
Hansastraße 32
80686 München / DE
[2020/41]
Application number, filing date18884812.128.11.2018
[2020/41]
WO2018KR14825
Priority number, dateKR2017016056328.11.2017         Original published format: KR 20170160563
KR2018009487814.08.2018         Original published format: KR 20180094878
[2020/41]
Filing languageKO
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019107917
Date:06.06.2019
Language:KO
[2019/23]
Type: A1 Application with search report 
No.:EP3719501
Date:07.10.2020
Language:EN
[2020/41]
Type: B1 Patent specification 
No.:EP3719501
Date:04.01.2023
Language:EN
[2023/01]
Search report(s)International search report - published on:KR06.06.2019
(Supplementary) European search report - dispatched on:EP09.06.2021
ClassificationIPC:G01N33/68, G01N33/50
[2020/41]
CPC:
G01N33/5073 (EP); G01N33/6815 (EP,KR,US); G01N33/68 (US);
A61K38/063 (US); G01N21/6428 (US); G01N33/5005 (US);
G01N33/5008 (KR); G01N33/5044 (KR,US); G01N33/5076 (US);
G01N33/6812 (KR); G01N33/6893 (KR,US); G01N2021/6439 (US);
G01N2800/7009 (EP,KR,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/41]
Extension statesBANot yet paid
MENot yet paid
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:VERFAHREN ZUR MESSUNG DER QUALITÄT EINER THERAPEUTISCHEN ZELLE DURCH ECHTZEIT-GLUTATHIONMESSUNG[2020/41]
English:METHOD FOR MEASURING QUALITY OF THERAPEUTIC CELL THROUGH REAL-TIME GLUTATHIONE MEASUREMENT[2020/41]
French:PROCÉDÉ DE MESURE DE LA QUALITÉ D'UNE CELLULE THÉRAPEUTIQUE PAR MESURE EN TEMPS RÉEL DU GLUTATHION[2020/41]
Entry into regional phase27.05.2020Translation filed 
27.05.2020National basic fee paid 
27.05.2020Search fee paid 
27.05.2020Designation fee(s) paid 
27.05.2020Examination fee paid 
Examination procedure27.05.2020Examination requested  [2020/41]
29.12.2021Amendment by applicant (claims and/or description)
21.01.2022Despatch of a communication from the examining division (Time limit: M04)
06.04.2022Reply to a communication from the examining division
03.08.2022Communication of intention to grant the patent
28.11.2022Fee for grant paid
28.11.2022Fee for publishing/printing paid
28.11.2022Receipt of the translation of the claim(s)
Opposition(s)05.10.2023No opposition filed within time limit [2023/50]
Fees paidRenewal fee
23.11.2020Renewal fee patent year 03
24.11.2021Renewal fee patent year 04
24.11.2022Renewal fee patent year 05
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT04.01.2023
CZ04.01.2023
DK04.01.2023
EE04.01.2023
ES04.01.2023
FI04.01.2023
HR04.01.2023
IT04.01.2023
LT04.01.2023
LV04.01.2023
MC04.01.2023
NL04.01.2023
PL04.01.2023
RO04.01.2023
RS04.01.2023
SE04.01.2023
SI04.01.2023
SK04.01.2023
SM04.01.2023
NO04.04.2023
GR05.04.2023
IS04.05.2023
PT04.05.2023
[2024/32]
Former [2024/26]AT04.01.2023
CZ04.01.2023
DK04.01.2023
EE04.01.2023
ES04.01.2023
FI04.01.2023
HR04.01.2023
IT04.01.2023
LT04.01.2023
LV04.01.2023
NL04.01.2023
PL04.01.2023
RO04.01.2023
RS04.01.2023
SE04.01.2023
SI04.01.2023
SK04.01.2023
SM04.01.2023
NO04.04.2023
GR05.04.2023
IS04.05.2023
PT04.05.2023
Former [2024/11]AT04.01.2023
CZ04.01.2023
DK04.01.2023
EE04.01.2023
ES04.01.2023
FI04.01.2023
HR04.01.2023
LT04.01.2023
LV04.01.2023
NL04.01.2023
PL04.01.2023
RO04.01.2023
RS04.01.2023
SE04.01.2023
SI04.01.2023
SK04.01.2023
SM04.01.2023
NO04.04.2023
GR05.04.2023
IS04.05.2023
PT04.05.2023
Former [2023/50]AT04.01.2023
CZ04.01.2023
DK04.01.2023
EE04.01.2023
ES04.01.2023
FI04.01.2023
HR04.01.2023
LT04.01.2023
LV04.01.2023
NL04.01.2023
PL04.01.2023
RO04.01.2023
RS04.01.2023
SE04.01.2023
SK04.01.2023
SM04.01.2023
NO04.04.2023
GR05.04.2023
IS04.05.2023
PT04.05.2023
Former [2023/49]AT04.01.2023
CZ04.01.2023
DK04.01.2023
EE04.01.2023
ES04.01.2023
FI04.01.2023
HR04.01.2023
LT04.01.2023
LV04.01.2023
NL04.01.2023
PL04.01.2023
RO04.01.2023
RS04.01.2023
SE04.01.2023
SM04.01.2023
NO04.04.2023
GR05.04.2023
IS04.05.2023
PT04.05.2023
Former [2023/48]AT04.01.2023
DK04.01.2023
EE04.01.2023
ES04.01.2023
FI04.01.2023
HR04.01.2023
LT04.01.2023
LV04.01.2023
NL04.01.2023
PL04.01.2023
RS04.01.2023
SE04.01.2023
SM04.01.2023
NO04.04.2023
GR05.04.2023
IS04.05.2023
PT04.05.2023
Former [2023/46]AT04.01.2023
DK04.01.2023
ES04.01.2023
FI04.01.2023
HR04.01.2023
LT04.01.2023
LV04.01.2023
NL04.01.2023
PL04.01.2023
RS04.01.2023
SE04.01.2023
SM04.01.2023
NO04.04.2023
GR05.04.2023
IS04.05.2023
PT04.05.2023
Former [2023/39]AT04.01.2023
ES04.01.2023
FI04.01.2023
HR04.01.2023
LT04.01.2023
LV04.01.2023
NL04.01.2023
PL04.01.2023
RS04.01.2023
SE04.01.2023
NO04.04.2023
GR05.04.2023
IS04.05.2023
PT04.05.2023
Former [2023/38]AT04.01.2023
ES04.01.2023
FI04.01.2023
HR04.01.2023
LT04.01.2023
LV04.01.2023
NL04.01.2023
PL04.01.2023
RS04.01.2023
SE04.01.2023
NO04.04.2023
GR05.04.2023
PT04.05.2023
Former [2023/37]AT04.01.2023
ES04.01.2023
FI04.01.2023
HR04.01.2023
LT04.01.2023
LV04.01.2023
NL04.01.2023
RS04.01.2023
SE04.01.2023
NO04.04.2023
GR05.04.2023
PT04.05.2023
Former [2023/36]AT04.01.2023
ES04.01.2023
FI04.01.2023
HR04.01.2023
LT04.01.2023
LV04.01.2023
NL04.01.2023
RS04.01.2023
SE04.01.2023
NO04.04.2023
PT04.05.2023
Former [2023/35]AT04.01.2023
ES04.01.2023
HR04.01.2023
LT04.01.2023
NL04.01.2023
RS04.01.2023
NO04.04.2023
PT04.05.2023
Former [2023/34]ES04.01.2023
LT04.01.2023
NL04.01.2023
RS04.01.2023
PT04.05.2023
Former [2023/33]ES04.01.2023
LT04.01.2023
NL04.01.2023
Former [2023/31]NL04.01.2023
Documents cited:Search[X]WO2017032811  (VITROLIFE SWEDEN AB [SE]) [X] 1-12 * the whole document * * page 14, line 34 - page 15, line 9 *;
 [I]  - ZENG WEN ET AL, "Antioxidant treatment enhances human mesenchymal stem cell anti-stress ability and therapeutic efficacy in an acute liver failure model", SCIENTIFIC REPORTS, vol. 5, no. 1, doi:10.1038/srep11100, (20150901), URL: https://www.nature.com/articles/srep11100.pdf, XP055808980 [I] 1-12 * the whole document * * abstract * * page 3, paragraph 4 * * figure 3 *

DOI:   http://dx.doi.org/10.1038/srep11100
 [I]  - YAHATA TAKASHI ET AL, "Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 118, no. 11, doi:10.1182/BLOOD-2011-01-330050, ISSN 0006-4971, (20110915), pages 2941 - 2950, (20201120), XP086509172 [I] 1-12 * the whole document * * abstract *

DOI:   http://dx.doi.org/10.1182/blood-2011-01-330050
International search[X]KR20160059978  (METABOLIC ENGINEERING LAB CO LTD [KR], et al) [X] 1-12;
 [A]WO2017016631  (MERCK PATENT GMBH [DE]) [A] 1-12;
 [X]  - KIM, Yeong Hwan et al., "Converging Translational Research Center for the Development of Pulmonary Fibrosis Therapeutics", Final Report, Seoul National University R&DB Foundation, (201404), pages 1 - 241, XP009520719 [X] 1-12
 [A]  - CHO, A YOUNG, "A coumarin-based fluorescence sensor for the reversible detection of thiols", Chemistry Letters, (20120000), doi:10.1246/cl.2012.1611, pages 1611 - 1612, XP055309332 [A] 1-12

DOI:   http://dx.doi.org/10.1246/cl.2012.1611
 [A]  - DANNENMANN, BENJAMIN, "High glutathione and glutathione peroxidase-2 levels mediate cell -type-specific DNA damage protection in human induced pluripotent stem cells", Stem Cell Reports, (20150512), doi:10.1016/j.stemcr.2015.04.004, pages 886 - 898, XP055455633 [A] 1-12

DOI:   http://dx.doi.org/10.1016/j.stemcr.2015.04.004
 [PX]  - JEONG, EUI MAN, "Real-time monitoring of glutathione in living cells reveals that high glutathione levels are required to maintain stem cell function", Stem Cell Reports, (20180104), pages 600 - 614, XP055616173 [PX] 1-12 * Supplemental Information (1-16 *

DOI:   http://dx.doi.org/10.1016/j.stemcr.2017.12.007
by applicantJP5185443B
 KR20170107429
    - E. ROBBINS et al., J Exp Med., (19700601), vol. 131, no. 6, pages 1211 - 22
    - GEORGAKOPOULOU EA et al., Aging, (20130100), vol. 5, no. 1, pages 37 - 50
    - THOMAS KUILMAN et al., Genes Dev., (20101115), vol. 24, no. 22, pages 2463 - 79
    - JEAN-PHILIPPE COPP et al., Annu Rev Pathol., (20100000), vol. 5, pages 99 - 118
 KR20150161745
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