blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3728613

EP3728613 - CRISPR EFFECTOR SYSTEM BASED MULTIPLEX DIAGNOSTICS [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  25.09.2020
Database last updated on 19.10.2024
FormerThe international publication has been made
Status updated on  29.06.2019
Most recent event   Tooltip27.12.2023New entry: Renewal fee paid 
Applicant(s)For all designated states
The Broad Institute, Inc.
415 Main Street
Cambridge, MA 02142 / US
For all designated states
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
77 Massachusetts Avenue
Cambridge, MA 02139 / US
For all designated states
President And Fellows Of Harvard College
17 Quincy Street
Cambridge, Massachusetts 02138 / US
[2020/44]
Inventor(s)01 / ZHANG, Feng
c/o 415 Main Street
Cambridge, Massachusetts 02142 / US
02 / ZETSCHE, Bernd
c/o 415 Main Street
Cambridge, Massachusetts 02142 / US
03 / GOOTENBERG, Jonathan
c/o 17 Quincy Street
Cambridge, Massachusetts 02138 / US
04 / ABUDAYYEH, Omar
c/o 77 Massachusetts Ave.
Cambridge, Massachusetts 02139 / US
 [2020/44]
Representative(s)De Clercq & Partners
Edgard Gevaertdreef 10a
9830 Sint-Martens-Latem / BE
[2020/44]
Application number, filing date18890190.420.12.2018
[2020/44]
WO2018US66940
Priority number, dateUS201762610066P22.12.2017         Original published format: US 201762610066 P
US201862623546P29.01.2018         Original published format: US 201862623546 P
US201862630814P14.02.2018         Original published format: US 201862630814 P
US201862741501P04.10.2018         Original published format: US 201862741501 P
[2020/44]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2019126577
Date:27.06.2019
Language:EN
[2019/26]
Type: A2 Application without search report 
No.:EP3728613
Date:28.10.2020
Language:EN
The application published by WIPO in one of the EPO official languages on 27.06.2019 takes the place of the publication of the European patent application.
[2020/44]
Search report(s)International search report - published on:US08.08.2019
(Supplementary) European search report - dispatched on:EP14.12.2021
ClassificationIPC:C12N15/90, C12N9/22, C12N15/11, C12N15/10, C12Q1/68, C12Q1/6804, C12Q1/6823
[2021/41]
CPC:
C12Q1/6823 (EP,IL,KR); C12Q1/6876 (US); C12N15/11 (US);
C12N15/115 (US); C12N9/22 (EP,IL,KR,US); C12Q1/6804 (EP,IL,KR,US);
C12N2310/16 (US); C12N2310/20 (KR,US); C12N2800/80 (US);
C12Q2521/301 (IL); C12Q2525/205 (IL); Y02A50/30 (EP) (-)
C-Set:
C12Q1/6804, C12Q2521/301, C12Q2525/205 (EP);
C12Q1/6823, C12Q2521/301 (EP)
Former IPC [2020/44]C12N15/90, C12N9/22, C12N15/11, C12N15/10, C12Q1/68
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/44]
TitleGerman:AUF CRISPR-EFFEKTOR-SYSTEM BASIERENDE MULTIPLEX-DIAGNOSE[2020/44]
English:CRISPR EFFECTOR SYSTEM BASED MULTIPLEX DIAGNOSTICS[2020/44]
French:DIAGNOSTIC MULTIPLEX FONDÉ SUR LES SYSTÈMES EFFECTEURS CRISPR[2020/44]
Entry into regional phase14.07.2020National basic fee paid 
14.07.2020Search fee paid 
14.07.2020Designation fee(s) paid 
14.07.2020Examination fee paid 
Examination procedure14.07.2020Examination requested  [2020/44]
12.07.2022Amendment by applicant (claims and/or description)
Fees paidRenewal fee
28.12.2020Renewal fee patent year 03
27.12.2021Renewal fee patent year 04
27.12.2022Renewal fee patent year 05
27.12.2023Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[YA]WO2017046191  (BIOTYPE DIAGNOSTIC GMBH [DE]) [Y] 14 * abstract *[A] 1,3-11,13;
 [XAY]WO2017219027  (BROAD INST INC [US], et al) [X] 1,3-6,9-11,13 * abstract * * paragraphs [0071] , [0072] , [0103] - [0106] - [0621] , [0756] , [0792] * [A] 14 [Y] 7,8;
 [XY]  - GOOTENBERG JONATHAN S. ET AL, "Nucleic acid detection with CRISPR-Cas13a/C2c2", SCIENCE, US, (20170428), vol. 356, no. 6336, doi:10.1126/science.aam9321, ISSN 0036-8075, pages 438 - 442, XP055816752 [X] 1,3,4,7-11,13 * abstract * * page 438, column 3 - page 439, column 1 * [Y] 1,3-11,13,14

DOI:   http://dx.doi.org/10.1126/science.aam9321
 [Y]  - EAST-SELETSKY ALEXANDRA ET AL, "RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes", MOLECULAR CELL, ELSEVIER, AMSTERDAM , NL, (20170504), vol. 66, no. 3, doi:10.1016/J.MOLCEL.2017.04.008, ISSN 1097-2765, page 373, XP029999996 [Y] 1,3-11,13,14 * abstract *

DOI:   http://dx.doi.org/10.1016/j.molcel.2017.04.008
International search[A]WO2017184768  (BROAD INST INC [US], et al) [A] 21-24 * para [0011], [0074], [00268], [00533], [00634], [00635], [001282] *;
 [A]WO2017184786  (BROAD INST INC [US], et al) [A] 21-24 * para [0069], [00600]-[00606] *;
 [X]WO2017219027  (BROAD INST INC [US], et al) [X] 1, 3, 5(1,3), (6-9)/5(1,3), 28, 88 * para [0013], [0014], [0029], [00103]-[00106], [00112], [00130], [00140], [00146], [00255], [00753], [00792], [00848]-[00850], [00758] *;
 [XY]  - EAST-SELETSKY et al., "RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes", Mol Cell ., (20170504), vol. 66, no. 3, doi:doi:10.1016/j.molcel.2017.04.008, pages 373 - 383, XP029999996 [X] 1, 3, 5/(1,3), (6-9)/5(1,3), 28, 88 * ; Grapgic Abstract; pg 375, col 1; pg 376, Fig its legend; pg 379, Fig 5 and its legend; pg 380, col 2; pg 382, col 1; Supplementary Materials, pg e2, pg 3 * [Y] 2, 4, 5/(2,4), (6-9)/5/(2,4), 89

DOI:   http://dx.doi.org/10.1016/j.molcel.2017.04.008
 [A]  - Anonymous, "RecName: Full=CRISPR-associated endoribonuclease Cas13a; AltName: Full=CRISPR-associated endoribonuclease C2c2; Short=EndoRNase; AltName: Full=LseC2c2", PROTEIN, (20171122), Database accession no. CS 13A_LISSS, URL: NCBI, XP055628115 [A] 7-9 * ; in entirety, especially amino acids 1016-1021 *
 [Y]  - IYER et al., "Thrombin-Mediated Transcriptional Regulation Using DNA Aptamers inDNA-Based Cell -Free Protein Synthesis", ACS SYNTHETIC BIOLOGY, (20130920), vol. 3, no. 6, pages 340 - 346, XP055628164 [Y] 2, 4, 5, (6-9)/5/(2,4), 89 * ; Abstract, pg 341, Fig 1 and its legend *

DOI:   http://dx.doi.org/10.1021/sb4000756
 [Y]  - GOOTENBERG et al., "Nucleic acid detection with CRISPR-Cas13a/C2c2", Science, (20170428), vol. 356, no. 6336, doi:doi:10.1126/science.aam9321, pages 438 - 442, XP055481345 [Y] 2, 4, 5, (6-9)/5/(2,4), 89 * ; Abstract, pg 1 [according to the posted document], Fig 1 and its legend; pg 1, col 2 to pg 2, col 1 *

DOI:   http://dx.doi.org/10.1126/science.aam9321
 [XP]  - LI et al., "CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA", Cell Res., (20180312), vol. 28, no. 4, pages 491 - 493, XP036483066 [XP] 21-24 * ; in entirety *

DOI:   http://dx.doi.org/10.1038/s41422-018-0022-x
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.