EP3527662 - NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED TUMOUR ANTIGEN [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 02.12.2022 Database last updated on 14.06.2024 | |
Former | The patent has been granted Status updated on 24.12.2021 | ||
Former | Grant of patent is intended Status updated on 12.09.2021 | ||
Former | Examination is in progress Status updated on 23.07.2021 | ||
Former | Grant of patent is intended Status updated on 06.07.2021 | ||
Former | Examination is in progress Status updated on 21.05.2021 | ||
Former | Grant of patent is intended Status updated on 13.04.2021 | ||
Former | Examination is in progress Status updated on 02.07.2020 | ||
Former | Request for examination was made Status updated on 19.07.2019 | Most recent event Tooltip | 14.06.2024 | Lapse of the patent in a contracting state New state(s): TR | published on 17.07.2024 [2024/29] | Applicant(s) | For all designated states CureVac AG Friedrich-Miescher-Straße 15 72076 Tübingen / DE | [2021/10] |
Former [2019/34] | For all designated states CureVac AG Paul-Ehrlich-Str. 15 72076 Tübingen / DE | Inventor(s) | 01 /
THEß, Andreas c/o IP Department CureVac AG Friedrich-Miescher-Str. 15 72706 Tübingen / DE | 02 /
SCHLAKE, Thomas c/o IP Department CureVac AG Friedrich-Miescher-Str. 15 72706 Tübingen / DE | 03 /
PROBST, Jochen c/o IP Department CureVac AG Friedrich-Miescher-Str. 15 72706 Tübingen / DE | [2020/41] |
Former [2019/34] | 01 /
THEß, Andreas c/o IP DEPARTMENT CureVac AG Paul Ehrlich Str. 15 72076 Tübingen / DE | ||
02 /
SCHLAKE, Thomas c/o IP DEPARTMENT CureVac AG Paul Ehrlich Str. 15 72076 Tübingen / DE | |||
03 /
PROBST, Jochen c/o IP DEPARTMENT CureVac AG Paul Ehrlich Str. 15 72076 Tübingen / DE | Representative(s) | Graf von Stosch Patentanwaltsgesellschaft mbH Prinzregentenstraße 22 80538 München / DE | [2019/34] | Application number, filing date | 19154524.3 | 15.02.2013 | [2019/34] | Priority number, date | WO2012EP00674 | 15.02.2012 Original published format: PCT/EP2012/000674 | [2019/34] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP3527662 | Date: | 21.08.2019 | Language: | EN | [2019/34] | Type: | B1 Patent specification | No.: | EP3527662 | Date: | 26.01.2022 | Language: | EN | [2022/04] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 22.05.2019 | Classification | IPC: | C12N15/67, A61K39/00, C12N15/63 | [2019/34] | CPC: |
A61K39/0011 (EP,US);
A61K39/001102 (EP,US);
A61K39/001104 (EP,US);
A61K39/001106 (EP,US);
A61K39/001109 (EP,US);
A61K39/001111 (EP,US);
A61K39/001112 (EP,US);
A61K39/001113 (EP,US);
A61K39/001119 (EP,US);
A61K39/001124 (EP,US);
A61K39/001129 (EP,US);
A61K39/001132 (EP,US);
A61K39/001134 (EP,US);
A61K39/001139 (EP,US);
A61K39/00114 (EP,US);
A61K39/001149 (EP,US);
A61K39/00115 (EP,US);
A61K39/001151 (EP,US);
A61K39/001153 (EP,US);
A61K39/001156 (EP,US);
A61K39/001157 (EP,US);
A61K39/001158 (EP,US);
A61K39/001162 (EP,US);
A61K39/001164 (EP,US);
A61K39/001166 (EP,US);
A61K39/001168 (EP,US);
A61K39/00117 (EP,US);
A61K39/001176 (EP,US);
A61K39/001182 (EP,US);
A61K39/001184 (EP,US);
A61K39/001186 (EP,US);
A61K39/001188 (EP,US);
A61K39/001189 (EP,US);
A61K39/00119 (EP,US);
A61K39/001192 (EP,US);
A61K39/001193 (EP,US);
A61K39/001194 (EP,US);
A61K39/001195 (EP,US);
A61K39/001197 (EP,US);
C12N15/63 (EP);
C12N15/67 (EP);
A61K2039/53 (EP);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2019/34] | Extension states | BA | 30.01.2019 | ME | 30.01.2019 | Title | German: | NUKLEINSÄURE MIT ODER ZUR CODIERUNG EINER HISTON-HAARNADELSTRUKTUR UND POLY(A)-SEQUENZ ODER EIN POLYADENYLATIONSSIGNAL ZUR ERHÖHUNG DER EXPRESSION EINES CODIERTEN TUMORANTIGENS | [2019/34] | English: | NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED TUMOUR ANTIGEN | [2019/34] | French: | ACIDE NUCLÉIQUE COMPRENANT OU CODANT POUR UNE TIGE-BOUCLE D'HISTONE ET SÉQUENCE POLY(A) OU SIGNAL DE POLYADÉNYLATION POUR AUGMENTER L'EXPRESSION D'UNE PROTÉINE CODÉE | [2019/34] | Examination procedure | 30.01.2019 | Examination requested [2019/34] | 18.02.2020 | Amendment by applicant (claims and/or description) | 06.07.2020 | Despatch of a communication from the examining division (Time limit: M04) | 16.11.2020 | Reply to a communication from the examining division | 14.04.2021 | Communication of intention to grant the patent | 21.05.2021 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 07.07.2021 | Communication of intention to grant the patent | 21.07.2021 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 13.09.2021 | Communication of intention to grant the patent | 20.12.2021 | Fee for grant paid | 20.12.2021 | Fee for publishing/printing paid | 20.12.2021 | Receipt of the translation of the claim(s) | Parent application(s) Tooltip | EP13704551.4 / EP2814961 | EP16001897.4 / EP3178488 | Opposition(s) | 27.10.2022 | No opposition filed within time limit [2023/01] | Fees paid | Renewal fee | 30.01.2019 | Renewal fee patent year 03 | 30.01.2019 | Renewal fee patent year 04 | 30.01.2019 | Renewal fee patent year 05 | 30.01.2019 | Renewal fee patent year 06 | 30.01.2019 | Renewal fee patent year 07 | 30.12.2019 | Renewal fee patent year 08 | 17.02.2021 | Renewal fee patent year 09 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 15.02.2013 | AL | 26.01.2022 | AT | 26.01.2022 | CY | 26.01.2022 | CZ | 26.01.2022 | DK | 26.01.2022 | EE | 26.01.2022 | FI | 26.01.2022 | HR | 26.01.2022 | LT | 26.01.2022 | LV | 26.01.2022 | MC | 26.01.2022 | MK | 26.01.2022 | NL | 26.01.2022 | PL | 26.01.2022 | RO | 26.01.2022 | RS | 26.01.2022 | SE | 26.01.2022 | SI | 26.01.2022 | SK | 26.01.2022 | SM | 26.01.2022 | TR | 26.01.2022 | IE | 15.02.2022 | LU | 15.02.2022 | BE | 28.02.2022 | BG | 26.04.2022 | NO | 26.04.2022 | GR | 27.04.2022 | IS | 26.05.2022 | PT | 26.05.2022 | [2024/29] |
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Former [2022/30] | NL | 26.01.2022 | Documents cited: | Search | [A]WO9842856 (ENZO THERAPEUTICS INC A FULLY [US]) [A] 3,4,15,17-21,23,24 * example 2 *; | [A]WO2006008154 (CUREVAC GMBH [DE], et al) [A] 18 * example 1; claims 1-20 *; | [A]WO2010132867 (IRX THERAPEUTICS INC [US], et al) [A] 3,4,16-21,23,24 * paragraph [0101] - paragraph [0104] *; | [A]WO2011069529 (CUREVAC GMBH [DE], et al) [A] 18 * page 30 - page 54 *; | [XP]WO2012019630 (CUREVAC GMBH [DE], et al) [XP] 1,2,4-14,16,18-24 * page 28 - page 34; claims 1-7,11-15 *; | [XI] - COLLART D ET AL, "A human histone H2B.1 variant gene, located on chromosome 1, ultilizes alternative 3' end processing", JOURNAL OF CELLULAR BIOCHEMISTRY, WILEY-LISS INC, US, (199212), vol. 50, doi:10.1002/JCB.240500406, ISSN 0730-2312, pages 374 - 385, XP002956108 [X] 1,2,5,6,8,9,11,14,15,17 * page 378; figure 1 * [I] 7,10,12,13,22 DOI: http://dx.doi.org/10.1002/jcb.240500406 | [A] - KATO M ET AL, "Histone H2B as an antigen recognized by lung cancer-specific human monoclonal antibody HB4C5.", HUMAN ANTIBODIES AND HYBRIDOMAS APR 1991, (199104), vol. 2, no. 2, ISSN 0956-960X, pages 94 - 101, XP009168615 [A] 1 * abstract * | [A] - J E RUSSEL ET AL, "The stability of human beta-globin mRNA is dependent on structural determinants positioned within its 3' untranslated region", BLOOD, (1996), vol. 87, ISSN 0006-4971, pages 5314 - 5323, XP055043656 [A] 1-9 * page 5322 * | [AD] - DAVILA LOPEZ, M.; SAMUELSSON, T., RNA, (2008), vol. 14, no. 1, pages 1 - 10, XP002686760 [AD] 1-9 * page 4 - page 5; figures 3,4; table 1 * DOI: http://dx.doi.org/10.1261/rna.782308 | [A] - DANIEL J. BATTLE ET AL, "The stem-loop binding protein forms a highly stable and specific complex with the 3' stem-loop of histone mRNAs", RNA, (200101), vol. 7, no. 1, doi:10.1017/S1355838201001820, ISSN 1355-8382, pages 123 - 132, XP055043659 [A] 1-9 * page 129 - page 130; figure 5 * DOI: http://dx.doi.org/10.1017/S1355838201001820 | [A] - TAKASHI NARITA ET AL, "NELF Interacts with CBC and Participates in 3' End Processing of Replication-Dependent Histone mRNAs", MOLECULAR CELL, (200705), vol. 26, no. 3, doi:10.1016/j.molcel.2007.04.011, ISSN 1097-2765, pages 349 - 365, XP055059018 [A] 4 * figure 4 * DOI: http://dx.doi.org/10.1016/j.molcel.2007.04.011 | by applicant | WO0112824 | WO02098443 | WO2007036366 | - MEYER, S.; C. TEMME, Crit Rev Biochem Mol Biol, (20040000), vol. 39, no. 4, pages 197 - 216 | - MICHEL, Y. M.; D. PONCET et al., J Biol Chem, (20000000), vol. 275, no. 41, pages 32268 - 76 | - DOMINSKI, Z; W. F. MARZLUFF, Gene, (20070000), vol. 396, no. 2, pages 373 - 90 | - DAVILA LOPEZ, M.; SAMUELSSON, T., RNA, (20080000), vol. 14, no. 1, pages 1 - 10 | - CHODCHOY, N.; N. B. PANDEY et al., Mol Cell Biol, (19910000), vol. 11, no. 1, pages 497 - 509 | - PANDEY, N. B. et al., Molecular and Cellular Biology, (19940000), vol. 14, no. 3, pages 1709 - 1720 | - WILLIAMS, A. S.; MARZLUFF, W. F., Nucleic Acids Research, (19950000), vol. 23, no. 4, pages 654 - 662 | - SANCHEZ, R; W. F. MARZLUFF, Mol Cell Biol, (20040000), vol. 24, no. 6, pages 2513 - 25 | - WHITELAW, E. et al., Nucleic Acids Research, (19860000), vol. 14, no. 17, pages 7059 - 7070 | - PANDEY, N. B.; MARZLUFF, W. F., Molecular and Cellular Biology, (19870000), vol. 7, no. 12, pages 4557 - 4559 | - PANDEY, N. B. et al., Nucleic Acids Research, (19900000), vol. 18, no. 11, pages 3161 - 3170 | - LUSCHER, B., Proc. Natl. Acad. Sci. USA, (19850000), vol. 82, no. 13, pages 4389 - 4393 | - STAUBER, C et al., EMBO J, (19860000), vol. 5, no. 12, pages 3297 - 3303 | - WAGNER, E. J et al., Mol Cell, (20070000), vol. 28, no. 4, pages 692 - 9 | - GALLIE, D. R.; LEWIS, N. J.; MARZLUFF, W. F, Nucleic Acids Research, (19960000), vol. 24, no. 10, pages 1954 - 1962 | - AKASHI, Curr. Opin. Genet. Dev., (20010000), vol. 11, no. 6, pages 660 - 666 | - HOLCIK et al., Proc. Natl. Acad. Sci. USA, (19970000), vol. 94, pages 2410 - 2414 | - "GenBank", Database accession no. U26404 | - LAI et al., Development, (19950000), vol. 121, pages 2349 - 2360 | - "GenBank", Database accession no. X65300 | - "GenBank", Database accession no. X65327 | - KARLIN et al., PNAS USA, (19930000), vol. 90, pages 5873 - 5877 | - ALTSCHUL et al., Nucleic Acids Res, (19970000), vol. 25, pages 3389 - 3402 | - DAVILA LOPEZ, M.; SAMUELSSON, T, RNA (New York, N.Y., (20080000), vol. 14, no. 1, pages 1 - 10 | - DAVILA LOPEZ, M.; SAMUELSSON, T, RNA, (20080000), vol. 14, no. 1, pages 1 - 10 | - CAKMAKCI et al., Molecular and Cellular Biology, (20080000), vol. 28, no. 3, pages 1182 - 1194 | - THISTED et al., The Journal of Biological Chemistry, (20010000), vol. 276, no. 20, pages 17484 - 17496 | - MAKEYEV, Genomics, (20000000), vol. 67, no. 3, pages 301 - 316 | - CHKHEIDZE et al., Molecular and Cellular Biology, (19990000), vol. 19, no. 7, pages 4572 - 4581 | - BABENDURE, RNA, (20060000), vol. 12, no. 5, pages 851 - 861 |