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Extract from the Register of European Patents

EP About this file: EP3584237

EP3584237 - ALPHA ADRENERGIC RECEPTOR MODULATORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  21.10.2021
Database last updated on 15.06.2024
FormerThe patent has been granted
Status updated on  06.11.2020
FormerGrant of patent is intended
Status updated on  17.06.2020
FormerRequest for examination was made
Status updated on  17.01.2020
FormerThe application has been published
Status updated on  22.11.2019
Most recent event   Tooltip14.06.2024Lapse of the patent in a contracting state
New state(s): TR		published on 17.07.2024 [2024/29]
Applicant(s)For all designated states
ALLERGAN, INC.
2525 Dupont Drive
Irvine, CA 92612 / US
[2019/52]
Inventor(s)01 / Chow, Ken
20 Tidal Surf
Newport Coast, CA 92657 / US
02 / Gil, Daniel W.
2541 Point Del Mar
Corona Del Mar, CA 92625 / US
03 / Donello, John E.
34041 Pequito Drive
Dana Point, CA 92629 / US
04 / Wang, Liming
16 Trinity
Irvine, CA 92612 / US
05 / Corpuz, Evelyn G.
1 Pollena
Irvine, CA 92602 / US
06 / Fang, Wenkui K.
73 Peppermint Tree
Irvine, CA 92618 / US
07 / Sinha, Santosh C.
199 Sklar Street
Ladera Ranch, CA 92694 / US
08 / Dibas, Mohammed I.
28871 Niguel Vis
Laguna Niguel, CA 92677 / US
 [2019/52]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2019/52]
Application number, filing date19189773.506.10.2010
[2019/52]
Priority number, dateUS200924910109P06.10.2009         Original published format: US 24910109 P
[2019/52]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3584237
Date:25.12.2019
Language:EN
[2019/52]
Type: B1 Patent specification 
No.:EP3584237
Date:09.12.2020
Language:EN
[2020/50]
Search report(s)(Supplementary) European search report - dispatched on:EP20.11.2019
ClassificationIPC:C07D207/22, C07D403/12, C07D409/12, C07D413/12, C07D417/12, C07D471/04, A61K31/4025, // A61P9/00, A61P29/00, A61P27/06, A61P17/00
[2019/52]
CPC:
A61K31/498 (EP,US); A61K31/40 (EP,US); A61K31/4025 (EP,US);
A61K31/404 (EP,US); A61K31/4184 (EP,US); A61K31/435 (EP,US);
A61K31/437 (EP,US); A61K31/4375 (EP,US); A61K31/4709 (EP,US);
A61P17/00 (EP); A61P17/06 (EP); A61P17/10 (EP);
A61P25/00 (EP); A61P27/02 (EP); A61P27/06 (EP);
A61P29/00 (EP); A61P9/00 (EP); C07D207/22 (EP,US);
C07D403/12 (EP,US); C07D409/12 (EP,US); C07D413/12 (EP,US);
C07D417/12 (EP,US); C07D471/04 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/08]
Former [2019/52]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:ALPHA-ADRENERGISCHE REZEPTORMODULATOREN[2019/52]
English:ALPHA ADRENERGIC RECEPTOR MODULATORS[2019/52]
French:MODULATEURS DU RÉCEPTEUR ALPHA-ADRÉNERGIQUE[2019/52]
Examination procedure13.01.2020Examination requested  [2020/08]
13.01.2020Date on which the examining division has become responsible
24.01.2020Amendment by applicant (claims and/or description)
18.06.2020Communication of intention to grant the patent
28.10.2020Fee for grant paid
28.10.2020Fee for publishing/printing paid
28.10.2020Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP10765719.9  / EP2486009
Opposition(s)10.09.2021No opposition filed within time limit [2021/46]
Fees paidRenewal fee
02.08.2019Renewal fee patent year 03
02.08.2019Renewal fee patent year 04
02.08.2019Renewal fee patent year 05
02.08.2019Renewal fee patent year 06
02.08.2019Renewal fee patent year 07
02.08.2019Renewal fee patent year 08
02.08.2019Renewal fee patent year 09
28.10.2019Renewal fee patent year 10
27.10.2020Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU06.10.2010
AL09.12.2020
AT09.12.2020
CY09.12.2020
CZ09.12.2020
DK09.12.2020
EE09.12.2020
ES09.12.2020
FI09.12.2020
HR09.12.2020
IT09.12.2020
LT09.12.2020
LV09.12.2020
MC09.12.2020
MK09.12.2020
NL09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
TR09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
[2024/29]
Former [2024/23]HU06.10.2010
AL09.12.2020
AT09.12.2020
CY09.12.2020
CZ09.12.2020
DK09.12.2020
EE09.12.2020
ES09.12.2020
FI09.12.2020
HR09.12.2020
IT09.12.2020
LT09.12.2020
LV09.12.2020
MC09.12.2020
MK09.12.2020
NL09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2023/33]HU06.10.2010
AL09.12.2020
AT09.12.2020
CY09.12.2020
CZ09.12.2020
DK09.12.2020
EE09.12.2020
ES09.12.2020
FI09.12.2020
HR09.12.2020
IT09.12.2020
LT09.12.2020
LV09.12.2020
MC09.12.2020
NL09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2023/24]AL09.12.2020
AT09.12.2020
CY09.12.2020
CZ09.12.2020
DK09.12.2020
EE09.12.2020
ES09.12.2020
FI09.12.2020
HR09.12.2020
IT09.12.2020
LT09.12.2020
LV09.12.2020
MC09.12.2020
NL09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2022/33]AL09.12.2020
AT09.12.2020
CZ09.12.2020
DK09.12.2020
EE09.12.2020
ES09.12.2020
FI09.12.2020
HR09.12.2020
IT09.12.2020
LT09.12.2020
LV09.12.2020
MC09.12.2020
NL09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2022/23]AL09.12.2020
AT09.12.2020
CZ09.12.2020
DK09.12.2020
EE09.12.2020
ES09.12.2020
FI09.12.2020
HR09.12.2020
IT09.12.2020
LT09.12.2020
LV09.12.2020
NL09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2022/10]AL09.12.2020
AT09.12.2020
CZ09.12.2020
DK09.12.2020
EE09.12.2020
ES09.12.2020
FI09.12.2020
HR09.12.2020
IT09.12.2020
LT09.12.2020
LV09.12.2020
NL09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
PT09.04.2021
Former [2022/08]AL09.12.2020
AT09.12.2020
CZ09.12.2020
DK09.12.2020
EE09.12.2020
ES09.12.2020
FI09.12.2020
HR09.12.2020
IT09.12.2020
LT09.12.2020
LV09.12.2020
NL09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2021/49]AL09.12.2020
AT09.12.2020
CZ09.12.2020
DK09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
IT09.12.2020
LT09.12.2020
LV09.12.2020
NL09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SI09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2021/48]AL09.12.2020
AT09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
IT09.12.2020
LT09.12.2020
LV09.12.2020
NL09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2021/45]AL09.12.2020
AT09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
NL09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2021/42]AT09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
NL09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
IS09.04.2021
PT09.04.2021
Former [2021/39]AT09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
NL09.12.2020
PL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
PT09.04.2021
Former [2021/37]AT09.12.2020
CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
NL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
PT09.04.2021
Former [2021/36]CZ09.12.2020
EE09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
NL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
PT09.04.2021
Former [2021/35]CZ09.12.2020
FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
NL09.12.2020
RO09.12.2020
RS09.12.2020
SE09.12.2020
SK09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
PT09.04.2021
Former [2021/33]FI09.12.2020
HR09.12.2020
LT09.12.2020
LV09.12.2020
NL09.12.2020
RS09.12.2020
SE09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
PT09.04.2021
Former [2021/32]FI09.12.2020
HR09.12.2020
LV09.12.2020
NL09.12.2020
RS09.12.2020
SE09.12.2020
SM09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
Former [2021/30]FI09.12.2020
HR09.12.2020
LV09.12.2020
NL09.12.2020
RS09.12.2020
SE09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
Former [2021/28]FI09.12.2020
HR09.12.2020
LV09.12.2020
RS09.12.2020
SE09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
Former [2021/23]FI09.12.2020
LV09.12.2020
RS09.12.2020
SE09.12.2020
BG09.03.2021
NO09.03.2021
GR10.03.2021
Former [2021/22]FI09.12.2020
RS09.12.2020
NO09.03.2021
Former [2021/20]FI09.12.2020
Documents cited:Search[A]  - DE JONG A P ET AL, "Relationships between structure and alpha-adrenergic receptor affinity of clonidine and some related cyclic amidines", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER BV, NL, vol. 69, no. 2, doi:10.1016/0014-2999(81)90412-X, ISSN 0014-2999, (19810116), pages 175 - 188, (19810116), XP023840198 [A] 1-13 * page 175 - page 177; tables 2,3,4 *

DOI:   http://dx.doi.org/10.1016/0014-2999(81)90412-X
 [A]  - STEPHAN SCHANN ET AL., "Synthesis and piological evaluation of pyrrolinic isosteres of Rilmenidine", JOURNAL OF MEDICINAL CHEMISTRY., USAMERICAN CHEMICAL SOCIETY. WASHINGTON., (20010324), vol. 44, no. 10, ISSN 0022-2623, pages 1588 - 1593, XP002619044 [A] 1-13 * the whole document *

DOI:   http://dx.doi.org/10.1021/JM001111B
 [A]  - UROSEVIC DRAGAN ET AL., "LNP 906, the first high-affinity photoaffinity ligand selective for I1 imidazoline receptors", BRITISH JOURNAL OF PHARMACOLOGY, NATURE PUBLISHING GROUP, (20040601), vol. 142, no. 3, ISSN 0007-1188, XP002619045 [A] 1-13 * the whole document *

DOI:   http://dx.doi.org/10.1038/sj.bjp.0705784
 [AD]  - MUNK S A ET AL, "Analogs of UK 14,304: structural features responsible for alpha2 adrenoceptor activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, (19950803), vol. 5, no. 15, doi:10.1016/0960-894X(95)00295-5, ISSN 0960-894X, pages 1745 - 1750, XP004135419 [AD] 1-13 * the whole document *

DOI:   http://dx.doi.org/10.1016/0960-894X(95)00295-5
 [AD]  - CHAPLEO C B ET AL, "HETEROAROMATIC ANALOGUES OF THE ALPHA2-ADRENORECEPTOR PARTIAL AGONIST CLONIDINE", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, (19890701), vol. 32, no. 7, doi:10.1021/JM00127A037, ISSN 0022-2623, pages 1627 - 1630, XP000601554 [AD] 1-13 * the whole document *

DOI:   http://dx.doi.org/10.1021/jm00127a037
by applicantUS3636219
 US3890319
 US4515800
 US4587257
 WO9200073
 US5091528
    - "Heteroaromatic Analogues of the alpha.sub.2 -Adrenoreceptor Partial Agonist Clonidine", J. Med. Chem., (19890000), vol. 32, pages 1627 - 1630
    - "Analogs of UK 14,304: Structural Features Responsible for a2 Andrenoceptor Activity", Bioorg. & Med. Chem. Letters, vol. 5, no. 15, pages 1745 - 1750
    - CHEMICAL ABSTRACTS, Database accession no. 1227270-73-6
    - PRINCEN et al., Cytometry, (20030000), vol. 51, pages 35 - 45
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.