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Extract from the Register of European Patents

EP About this file: EP3740761

EP3740761 - COMPANION DIAGNOSTIC FOR NSAIDS AND DONEPEZIL FOR TREATING SPECIFIC SUBPOPULATIONS OF PATIENTS SUFFERING FROM ALZHEIMER'S DISEASE [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  15.12.2023
Database last updated on 15.06.2024
FormerRequest for examination was made
Status updated on  23.10.2020
FormerThe international publication has been made
Status updated on  27.07.2019
Most recent event   Tooltip19.04.2024Change: Despatch of examination report + time limit 
19.04.2024New entry: Reply to examination report 
Applicant(s)For all designated states
University of North Texas Health Science Center at Fort Worth
3500 Camp Bowie Boulevard
Fort Worth, TX 76107 / US
[2020/48]
Inventor(s)01 / O'BRYANT, Sid, E.
1517 Greenleaf Drive
Aledo, TX 76008 / US
 [2020/48]
Representative(s)Barker Brettell LLP
100 Hagley Road
Edgbaston
Birmingham B16 8QQ / GB
[2020/48]
Application number, filing date19741031.914.01.2019
[2020/48]
WO2019US13498
Priority number, dateUS201862618857P18.01.2018         Original published format: US 201862618857 P
[2020/48]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019143562
Date:25.07.2019
Language:EN
[2019/30]
Type: A1 Application with search report 
No.:EP3740761
Date:25.11.2020
Language:EN
The application published by WIPO in one of the EPO official languages on 25.07.2019 takes the place of the publication of the European patent application.
[2020/48]
Search report(s)International search report - published on:KR25.07.2019
(Supplementary) European search report - dispatched on:EP22.09.2021
ClassificationIPC:G01N33/68
[2020/48]
CPC:
G01N33/9486 (EP); G01N33/5008 (US); G01N33/6869 (US);
G01N33/6896 (EP); G01N33/944 (EP); G01N2800/2821 (EP);
G01N2800/52 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/48]
TitleGerman:BEGLEITDIAGNOSTIK FÜR NSAIDS UND DONEPEZIL ZUR BEHANDLUNG SPEZIFISCHER SUBPOPULATIONEN VON PATIENTEN, DIE AN MORBUS ALZHEIMER LEIDEN[2020/48]
English:COMPANION DIAGNOSTIC FOR NSAIDS AND DONEPEZIL FOR TREATING SPECIFIC SUBPOPULATIONS OF PATIENTS SUFFERING FROM ALZHEIMER'S DISEASE[2020/48]
French:DIAGNOSTIC COMPAGNON POUR AINS ET DONÉPÉZIL POUR LE TRAITEMENT DE SOUS-POPULATIONS SPÉCIFIQUES DE PATIENTS SOUFFRANT DE LA MALADIE D'ALZHEIMER[2020/48]
Entry into regional phase31.07.2020National basic fee paid 
31.07.2020Search fee paid 
31.07.2020Designation fee(s) paid 
31.07.2020Examination fee paid 
Examination procedure31.07.2020Examination requested  [2020/48]
07.04.2022Amendment by applicant (claims and/or description)
18.12.2023Despatch of a communication from the examining division (Time limit: M06)
18.04.2024Reply to a communication from the examining division
Fees paidRenewal fee
13.01.2021Renewal fee patent year 03
31.12.2021Renewal fee patent year 04
12.01.2023Renewal fee patent year 05
11.01.2024Renewal fee patent year 06
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[A]WO9840061  (UNIV LOMA LINDA MED [US]);
 [A]US2014018446  (ROYALL DONALD R [US], et al);
 [Y]WO2014066318  (GEN HOSPITAL CORP [US], et al);
 [XYI]US2016291036  (O'BRYANT SID E [US])
International search[A]US2010280562  (PI BO [US], et al) [A] 27-31, 53, 55-58* See the whole document. *;
 [A]US2014147863  (O'BRYANT SIDNEY E [US], et al) [A] 27-31, 53, 55-58 * See the whole document. *;
 [X]US2016291036  (O'BRYANT SID E [US]) [X] 27-31, 53, 55-58 * See paragraphs [0010], [0109]; claims 110-117, 123-124, 129-134. *;
 [X]  - O'BRYANT, SID et al., "A proinflammatory endophenotype predicts treatment response in a multicenter trial of NSAIDs in AD", Alzheimer's & dementia: the journal of the Alzheimer's Association, (20140000), vol. 10, no. 4, pages P273 - P274, XP055629766 [X] 27-28, 31, 53, 55, 58 * See P273-P274. *

DOI:   http://dx.doi.org/10.1016/j.jalz.2014.04.447
 [A]  - O'BRYANT, SID E. et al., A serum protein-based algorithm for the detection of Alzheimer disease, (20100000), vol. 67, no. 9, pages 1077 - 1081, XP008181985 [A] 27-31, 53, 55-58 * See the whole document. *

DOI:   http://dx.doi.org/10.1001/archneurol.2010.215
by applicantUS2016291036
    - "Association As. 2013 Alzheimer's Disease facts and figures", Alzheimers Dement, (20130000), vol. 9, pages 1 - 72
    - HURD MDMARTORELL PDELAVANDE AMULLEN KJLANGA KM, "Monetary costs of dementia in the United States", N Engl J Med, (20130000), vol. 368, pages 1326 - 1334
    - LYKETSOS CGSZEKELY CAMIELKE MMROSENBERG PBZANDI PP, "Developing new treatments for Alzheimer's disease: The who, what, when, and how of biomarker-guided therapies", Int Psychogeriatr, (20080000), vol. 20, pages 871 - 889
    - HENCHCLIFFE CDODEL RBEAL MF, "Biomarkers of Parkinson's disease and Dementia with Lewy bodies", Prog Neurobiol, (20110000), vol. 95, pages 601 - 613
    - HU WTCHEN-PLOTKIN AARNOLD SEGROSSMAN MCLARK CMSHAW LMMCCLUSKEY LELMAN LKARLAWISH JHURTIG HI, "Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease", Acta Neuropathol, (20100000), vol. 120, pages 385 - 399, XP019847038
    - HENEKA MTKUMMER MPLATZ E, "Innate immune activation in neurodegenerative disease", Nat Rev Immunol, (20140000), vol. 14, doi:10.1038/nri3705, pages 463 - 477, XP055473907

DOI:   http://dx.doi.org/10.1038/nri3705
    - O'BRYANT SEXIAO GZHANG FEDWARDS MGERMAN DYIN XCOMO TREISCH JHUEBINGER HMGRAFF-RADFORD N, "Validation of a serum screen for Alzheimer's disease across assay platforms, species and tissues", J Alzheimers Dis, (20140000), vol. 42, doi:10.3233/JAD-141041, pages 1325 - 35, XP008181986

DOI:   http://dx.doi.org/10.3233/JAD-141041
    - O'BRYANT SEJOHNSON LEDWARDS MSOARES HDEVOUS MDROSS SROHLFING GHALL J, "Texas Research and Care Consortium. The link between c-reactive protein and Alzheimer's disease among Mexican Americans", J Alzheimers Dis, (20130000), vol. 34, pages 701 - 706
    - O'BRYANT SEXIAO GBARBER RREISCH JDOODY RFAIRCHILD TADAMS PWARING SDIAZ- ARRASTIA R, "Texas Alzheimer's Research Consortium. A serum protein-based algorithm for the detection of Alzheimer disease", Arch Neurol, (20100000), vol. 67, pages 1077 - 1081
    - O'BRYANT SEXIAO GBARBER RHUEBINGER RWILHELMSEN KEDWARDS MGRAFF-RADFORD NDOODY RDI, "A blood-based screening tool for Alzheimer's disease that spans serum and plasma: Findings from TARC and ADNI", PLoS ONE, (20110000), vol. 6, page e28092
    - O'BRYANT SXIAO GBARBER RREISCH JHALL JCULLUM CMDOODY RFAIRCHILD TADAMS PWILHELMSEN K, "A blood based algorithm for the detection of Alzheimer's disease", Dement Geriatr Cogn Disord, (20110000), vol. 32, doi:10.1159/000330750, pages 55 - 62, XP055209773

DOI:   http://dx.doi.org/10.1159/000330750
    - O'BRYANT SEWARING SCHOBSON VHALL JRMOORE CBBOTTIGLIERI TMASSMAN PDIAZ- ARRASTIA R, "Decreased C-reactive protein levels in alzheimer disease", J Geriatr Psychiatry Neurol, (20100000), vol. 23, doi:10.1177/0891988709351832, pages 49 - 53, XP055360633

DOI:   http://dx.doi.org/10.1177/0891988709351832
    - SCHMIDT RSCHMIDT HCURB JDMASAKI KWHITE LRLAUNER LJ, "Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study", Ann Neurol, (20020000), vol. 52, pages 168 - 174
    - IN'T VELD BARUITENBERG, AHOFMAN, ALAUNER, LJVAN DUIJNCM, STIJNENT, BRETELER MMSTRICKER BH, "Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease", N Engl J Med, (20010000), vol. 345, doi:10.1056/NEJMoa010178, pages 1515 - 1521, XP055017404

DOI:   http://dx.doi.org/10.1056/NEJMoa010178
    - ANTHONY JCBREITNER JCZANDI PPMEYER MRJURASOVA INORTON MCSTONE SV, "Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study", Neurology, (20000000), vol. 54, pages 2066 - 2071
    - ETMINAN MGILL SSAMII A, "Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: Systematic review and meta-analysis of observational studies", BMJ, (20030000), vol. 327, page 128
    - AISEN PSSCHAFER KAGRUNDMAN MPFEIFFER ESANO MDAVIS KLFARLOW MRJIN STHOMAS RGTHAL LJ, "Alzheimer's Disease Cooperative Study. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial", JAMA, (20030000), vol. 289, pages 2819 - 2826
    - GASPARINI LONGINI EWENK G, "Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: Old and new mechanisms of action", J Neurochem., (20040000), vol. 91, doi:10.1111/J.1471-4159.2004.02743.X, pages 521 - 536, XP002671653

DOI:   http://dx.doi.org/10.1111/J.1471-4159.2004.02743.X
    - HIROHATA MONO KNAIKI HYAMADA M, "Non-steroidal anti-inflammatory drugs have anti- amyloidogenic effects for Alzheimer's B-amyloid fibrils in vitro", Neuropharmacology, (20050000), vol. 49, doi:10.1016/j.neuropharm.2005.07.004, pages 1088 - 1099, XP026192891

DOI:   http://dx.doi.org/10.1016/j.neuropharm.2005.07.004
    - KLEGERIS AMCGEER PL, "Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti- inflammatory agents in the treatment of neurodegenerative disease", Curr Alzheimer Res, (20050000), vol. 2, doi:10.2174/1567205054367883, pages 355 - 365, XP009128606

DOI:   http://dx.doi.org/10.2174/1567205054367883
    - THAL LJFERRIS SHKIRBY LBLOCK GALINES CRYUEN EASSAID CNESSLY MLNORMAN BABARANAK CC, "Rofecoxib Protocol 078 study group. A randomized, double- blind, study of rofecoxib in patients with mild cognitive impairment", Neuropsychopharmacology, (20050000), vol. 30, pages 1204 - 1215
    - AISEN PSSCHAFER KAGRUNDMAN MKNOPMAN DTABET N, "Neither rofecoxib nor naproxen slows cognitive decline in people with mild-to-moderate Alzheimer's disease", Evidence- Based Healthcare, (20030000), vol. 7, pages 200 - 201
    - ADAPT RESEARCH GROUPLYKETSOS CGBREITNER JCGREEN RCMARTIN BKMEINERT CPIANTADOSI SSABBAGH M, "Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial", Neurology, (20070000), vol. 68, pages 1800 - 1808
    - GRUNDMAN MTHAL JL, "Treatment of Alzheimer's disease: rationale and strategies", Neurologic Clinics, (20000000), vol. 18, pages 807 - 827
    - O'BRYANT SEXIAO GEDWARDS MDEVOUS MGUPTA VBMARTINS RZHANG FBARBER R, "Texas Alzheimer's Research and Care Consortium (TARCC). Biomarkers of Alzheimer's disease among Mexican Americans", J Alzheimers Dis, (20130000), vol. 34, pages 841 - 849
    - DUONG TNIKOLAEVA MACTON PJ, "C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease", Brain Res, (19970000), vol. 749, doi:10.1016/S0006-8993(96)01359-5, pages 152 - 156, XP001019691

DOI:   http://dx.doi.org/10.1016/S0006-8993(96)01359-5
    - IWAMOTO NNISHIYAMA EOHWADA JARAI H, "Demonstration of CRP immunoreactivity in brains of Alzheimer's disease: immunohistochemical study using formic acid pretreatment of tissue sections", Neurosci Lett, (19940000), vol. 177, doi:10.1016/0304-3940(94)90035-3, pages 23 - 26, XP025829984

DOI:   http://dx.doi.org/10.1016/0304-3940(94)90035-3
    - BREITNER JCBAKER LDMONTINE TJMEINERT CLLYKETSOS CGASHE KHBRANDT JCRAFT SEVANS DEGREEN RC, "ADAPT Research Group. Extended results of the Alzheimer's disease anti-inflammatory prevention trial", Alzheimers Dement, (20110000), vol. 7, pages 402 - 411
    - MCGEER EGMCGEER PL, "The importance of inflammatory mechanisms in Alzheimer disease", Exp Gerontol, (19980000), vol. 33, pages 371 - 378
    - GOTTSCHALL PE, "Beta-amyloid induction of gelatinase B secretion in cultured microglia: inhibition by dexamethasone and indomethacin", Neuroreport, (19960000), vol. 7, pages 3077 - 3080, XP002070236
    - NETLAND EENEWTON JLMAJOCHA RETATE BA, "Indomethacin reverses the microglial response to amyloid beta", Neurobiol Aging, (19980000), vol. 19, pages 201 - 204
    - MACKENZIE IRMUNOZ DG, "Nonsteroidal anti-inflammatory drugs use and Alzheimer-type pathology in aging", Neurology, (19980000), vol. 50, pages 986 - 990
    - ROGERS JKIRBY LCHEMPELMAN SRBERRY DLMCGEER PLKASZNIAK AWZALINSKI JCOFIELD MMANSUKHANI LWILLSON P et al., "Clinical trial of indomethacin in Alzheimer's disease", Neurology, (19930000), vol. 43, pages 1609 - 1611, XP002070235
    - TOCCO GFREIRE-MOAR JSCHREIBER SSSAKHI SHAISEN PSPASINETTI GM, "Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease", Exp Neurol, (19970000), vol. 144, pages 339 - 349
    - PASINETTI GMAISEN PS, "Clycooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain", Neuroscience, (19980000), vol. 87, pages 319 - 324
    - HALL JRWIECHMANN ARJOHNSON LAEDWARDS MBARBER RCCUNNINGHAM RSINGH MO'BRYANT SE, "The impact of APOE status on relationship of biomarkers of vascular risk and systemic inflammation to neuropsychiatric symptoms in Alzheimer's disease", J Alzheimers Dis, (20140000), vol. 40, pages 887 - 896
    - O'BRYANT SEJOHNSON LREISCH JEDWARDS MHALL JBARBER RDEVOUS DM SRROYALL DSINGH M, "Risk factors for mild cognitive impairment among Mexican Americans", Alzheimers Dement, (20130000), vol. 9, pages 622 - 631
    - CUNNINGHAM RLSINGH MO'BRYANT SEHALL JRBARBER RC, "Oxidative stress, testosterone, and cognition among caucasian and mexican-american men with and without Alzheimer's disease", J Alzheimers Dis, (20140000), vol. 40, pages 563 - 573
    - JOHNSON LAHALL JRO'BRYANT SE, "A Depressive Endophenotype of Mild Cognitive Impairment and Alzheimer's Disease", PLoS ONE, (20130000), vol. 8, page e68848
    - JOHNSON LASOHRABI HRHALL JRTADDEI KEDWARDS MMARTINS RN, "A depressive endophenotype of poorer cognition among cognitively healthy community- dwelling adults: Results from the Western Australia Memory Study", Int J Geriatr Psychiatry, (20150800), vol. 30, no. 8, pages 881 - 6
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