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Extract from the Register of European Patents

EP About this file: EP3768820

EP3768820 - A METHOD FOR LYOPHILIZING LIVE VACCINE STRAINS OF FRANCISELLA TULARENSIS [Right-click to bookmark this link]
Former [2021/04]<SMALLCAPS/> FRANCISELLA TULARENSIS A METHOD FOR LYOPHILIZING LIVE VACCINE STRAINS OF
[2022/19]
StatusNo opposition filed within time limit
Status updated on  03.11.2023
Database last updated on 14.09.2024
FormerThe patent has been granted
Status updated on  25.11.2022
FormerGrant of patent is intended
Status updated on  19.07.2022
FormerRequest for examination was made
Status updated on  25.12.2020
FormerThe international publication has been made
Status updated on  28.09.2019
Most recent event   Tooltip16.02.2024Lapse of the patent in a contracting state
New state(s): BE, SI		published on 20.03.2024  [2024/12]
Applicant(s)For all designated states
National Research Council of Canada
1200 Montreal Road
Ottawa, Ontario K1A 0R6 / CA
[2021/04]
Inventor(s)01 / CONLAN, Wayne
1152 Bordeau Grove
Ottawa, Ontario K1C 2M7 / CA
02 / MCRAE, Kevan
200 Pretoria Avenue, Apt. A7
Ottawa, Ontario K1S 1X2 / CA
 [2021/04]
Representative(s)Høiberg P/S
Adelgade 12
1304 Copenhagen K / DK
[2021/04]
Application number, filing date19772499.020.03.2019
[2021/04]
WO2019CA50340
Priority number, dateUS201862645409P20.03.2018         Original published format: US 201862645409 P
[2021/04]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019178687
Date:26.09.2019
Language:EN
[2019/39]
Type: A1 Application with search report 
No.:EP3768820
Date:27.01.2021
Language:EN
The application published by WIPO in one of the EPO official languages on 26.09.2019 takes the place of the publication of the European patent application.
[2021/04]
Type: B1 Patent specification 
No.:EP3768820
Date:28.12.2022
Language:EN
[2022/52]
Search report(s)International search report - published on:CA26.09.2019
(Supplementary) European search report - dispatched on:EP25.11.2021
ClassificationIPC:C12N1/04, A61K39/02, A61K47/10, A61K47/26, A61K47/42, A61K9/19, A61P31/04, A61P37/04, C12N1/20, A61K39/00
[2021/52]
CPC:
A61K9/19 (EP,US); A61K39/0208 (EP,US); A61K47/10 (EP);
A61K9/0019 (US); A61P31/04 (EP); A61P37/04 (EP);
C12N1/04 (EP); C12N1/20 (EP,US); C12N15/102 (US);
A61K2039/522 (EP,US); A61K2039/54 (US); C12N2500/34 (US);
C12N2500/42 (US); Y02A50/30 (EP) (-)
Former IPC [2021/04]C12N1/04, A61K39/02, A61K47/10, A61K47/26, A61K47/42, A61K9/19, A61P31/04, A61P37/04, C12N1/20
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/04]
Extension statesBANot yet paid
MENot yet paid
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:VERFAHREN ZUR LYOPHILISIERUNG VON LEBENDVAKZIN-STÄMMEN VON FRANCISELLA TULARENSIS[2021/04]
English:A METHOD FOR LYOPHILIZING LIVE VACCINE STRAINS OF FRANCISELLA TULARENSIS[2022/32]
French:FRANCISELLA TULARENSIS LYOPHILISATION DE SOUCHES VACCINALES VIVANTE CONTRE[2022/19]
Former [2021/04]<SMALLCAPS/> FRANCISELLA TULARENSIS A METHOD FOR LYOPHILIZING LIVE VACCINE STRAINS OF
Former [2021/04]<SMALLCAPS/> FRANCISELLA TULARENSIS PROC& XC9;D& XC9; DE LYOPHILISATION DE SOUCHES VACCINALES VIVANTE CONTRE
Entry into regional phase20.10.2020National basic fee paid 
20.10.2020Search fee paid 
20.10.2020Designation fee(s) paid 
20.10.2020Examination fee paid 
Examination procedure20.10.2020Examination requested  [2021/04]
20.06.2022Amendment by applicant (claims and/or description)
20.07.2022Communication of intention to grant the patent
23.11.2022Fee for grant paid
23.11.2022Fee for publishing/printing paid
23.11.2022Receipt of the translation of the claim(s)
Opposition(s)29.09.2023No opposition filed within time limit [2023/49]
Fees paidRenewal fee
22.03.2021Renewal fee patent year 03
21.03.2022Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL28.12.2022
AT28.12.2022
CZ28.12.2022
DK28.12.2022
EE28.12.2022
FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
MC28.12.2022
NL28.12.2022
PL28.12.2022
RO28.12.2022
RS28.12.2022
SI28.12.2022
SK28.12.2022
SM28.12.2022
IE20.03.2023
LU20.03.2023
NO28.03.2023
GR29.03.2023
BE31.03.2023
CH31.03.2023
LI31.03.2023
IS28.04.2023
PT28.04.2023
[2024/11]
Former [2024/09]AL28.12.2022
AT28.12.2022
CZ28.12.2022
DK28.12.2022
EE28.12.2022
FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
MC28.12.2022
NL28.12.2022
PL28.12.2022
RO28.12.2022
RS28.12.2022
SK28.12.2022
SM28.12.2022
IE20.03.2023
LU20.03.2023
NO28.03.2023
GR29.03.2023
CH31.03.2023
LI31.03.2023
IS28.04.2023
PT28.04.2023
Former [2024/08]AL28.12.2022
AT28.12.2022
CZ28.12.2022
DK28.12.2022
EE28.12.2022
FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
MC28.12.2022
NL28.12.2022
PL28.12.2022
RO28.12.2022
RS28.12.2022
SK28.12.2022
SM28.12.2022
IE20.03.2023
LU20.03.2023
NO28.03.2023
GR29.03.2023
IS28.04.2023
PT28.04.2023
Former [2024/02]AL28.12.2022
AT28.12.2022
CZ28.12.2022
DK28.12.2022
EE28.12.2022
FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
MC28.12.2022
NL28.12.2022
PL28.12.2022
RO28.12.2022
RS28.12.2022
SK28.12.2022
SM28.12.2022
LU20.03.2023
NO28.03.2023
GR29.03.2023
IS28.04.2023
PT28.04.2023
Former [2023/48]AL28.12.2022
AT28.12.2022
CZ28.12.2022
DK28.12.2022
EE28.12.2022
FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
MC28.12.2022
NL28.12.2022
PL28.12.2022
RO28.12.2022
RS28.12.2022
SK28.12.2022
SM28.12.2022
NO28.03.2023
GR29.03.2023
IS28.04.2023
PT28.04.2023
Former [2023/46]AL28.12.2022
AT28.12.2022
CZ28.12.2022
DK28.12.2022
EE28.12.2022
FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
NL28.12.2022
PL28.12.2022
RO28.12.2022
RS28.12.2022
SK28.12.2022
SM28.12.2022
NO28.03.2023
GR29.03.2023
IS28.04.2023
PT28.04.2023
Former [2023/39]AL28.12.2022
AT28.12.2022
CZ28.12.2022
EE28.12.2022
FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
NL28.12.2022
PL28.12.2022
RO28.12.2022
RS28.12.2022
SK28.12.2022
SM28.12.2022
NO28.03.2023
GR29.03.2023
IS28.04.2023
PT28.04.2023
Former [2023/38]AL28.12.2022
AT28.12.2022
CZ28.12.2022
EE28.12.2022
FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
NL28.12.2022
PL28.12.2022
RO28.12.2022
RS28.12.2022
SK28.12.2022
SM28.12.2022
NO28.03.2023
GR29.03.2023
PT28.04.2023
Former [2023/37]AL28.12.2022
AT28.12.2022
CZ28.12.2022
EE28.12.2022
FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
NL28.12.2022
RO28.12.2022
RS28.12.2022
SM28.12.2022
NO28.03.2023
GR29.03.2023
PT28.04.2023
Former [2023/35]AT28.12.2022
CZ28.12.2022
EE28.12.2022
FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
NL28.12.2022
RO28.12.2022
RS28.12.2022
SM28.12.2022
NO28.03.2023
GR29.03.2023
PT28.04.2023
Former [2023/34]EE28.12.2022
FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
NL28.12.2022
RS28.12.2022
SM28.12.2022
NO28.03.2023
GR29.03.2023
PT28.04.2023
Former [2023/33]FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
NL28.12.2022
RS28.12.2022
SM28.12.2022
NO28.03.2023
GR29.03.2023
Former [2023/29]FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
NL28.12.2022
RS28.12.2022
NO28.03.2023
GR29.03.2023
Former [2023/25]FI28.12.2022
HR28.12.2022
LT28.12.2022
LV28.12.2022
RS28.12.2022
NO28.03.2023
GR29.03.2023
Former [2023/23]FI28.12.2022
LT28.12.2022
LV28.12.2022
NO28.03.2023
GR29.03.2023
Former [2023/22]FI28.12.2022
LT28.12.2022
NO28.03.2023
Former [2023/20]LT28.12.2022
NO28.03.2023
Documents cited:Search[A]WO0029018  (CHANGCHUN INST OF BIOLOG PRODU [CN], et al) [A] 1-15* claims 4, 9 *;
 [A]EP1123710  (CHANGCHUN INST OF BIOLOG PRODU [CN]) [A] 1-15 * paragraph [0012]; example 2; claim 4 *;
 [A]WO2010124428  (CHANGCHUN BCHT BIOTECHNOLOGY C [CN], et al) [A] 1-15 * the whole document *;
 [A]WO2018027075  (TAKEDA VACCINES INC [US]) [A] 1-15 * example 1 *
International search[A]US2004044393  (YARDEN ORIT [IL], et al) [A] 1-15 * , Page 1, paragraph [0015] - page 11, paragraph [0211]; figures 1-11. *;
 [A]US2007100414  (LICATA DAVID [US], et al) [A] 1-15 * , Page 1, paragraph [0012] - page 18, paragraph [0212]; figures 1 - 26. *;
 [A]WO2014115306  (TERUMO CORP [JP]) [A] 1-15* , Abstract, Figures. *;
 [A]ES2535814T  (GORE ENTERPRISE HOLDINGS INC [US]) [A] 1-15 * , Page 3, line 34 - page 10, line 3; figures 1 - 7. *;
 [A]US2016175125  (BRADY PETER [IE], et al) [A] 1-15 * , Page 1, paragraph [0009] - page 8, paragraph [0082]; figures 1 - 25. *
 [Y]WO2010124377  (CA NAT RESEARCH COUNCIL [CA], et al) [Y] 46-54 and 56 *whole document*;
 [A]  - (20080000), pages 117 - 137, URL: WWW.MEDIGRAPHIC.COM/PDFS/NEUMO/NT-008/NT083C.PDF [A] 1-15 * . *
 [A]  - (20120000), pages 27 - 43, URL: WWW.ZAGUAN.UNIZAR.ES/RECORD/7078/FILES/TESIS-2012-050.PDF [A] 1-15 * . *
 [A]  - (20170201), pages 1 - 105, URL: WWW.OA.UPM.ES/46457/1/IFGSONIACALVOSANCHEZ.PDF [A] 1-15 * . *
 [Y]  - EIGELSBACH, H.T. et al., "Prophylactic effectiveness of live and killed tularemia vaccines", J. Immunol., (19610000), vol. 87, no. 4, ISSN 0022-7767, pages 415 - 425, XP009078420 [Y] 46-54 and 56 *pages 415-416 and 419-420; Table III*
 [A]  - OHTAKE, S. et al., "Formulation and stabilization of Francisella tularensis live vaccine strain", J. Pharm. Sci., (20110800), vol. 100, no. 8, ISSN 0022-3549, pages 3076 - 3087, XP055639487 [A] 1-62 *Table 6; Fig. 4a*

DOI:   http://dx.doi.org/10.1002/jps.22563
 [A]  - MAROHN, M.E. et al., "Live attenuated tularemia vaccines: recent developments and future goals", Vaccine, (20130802), vol. 31, no. 35, ISSN 0264-410X, pages 3485 - 3491, XP028683957 [A] 1-62 *whole document*

DOI:   http://dx.doi.org/10.1016/j.vaccine.2013.05.096
 [A]  - CONLAN, J.W. et al., "Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: effects of host background and route of immunization", Vaccine, (20100217), vol. 28, no. 7, ISSN 0264-410X, pages 1824 - 1831, XP026884519 [A] 1-62 *whole document*

DOI:   http://dx.doi.org/10.1016/j.vaccine.2009.12.001
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