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EP3823976
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EP About this file: EP3823976
| EP3823976 - CYCLIC DINUCLEOTIDES AS STING AGONISTS [Right-click to bookmark this link] | Status | Request for examination was made Status updated on 23.04.2021 Database last updated on 20.07.2024 | |
| Former | The international publication has been made Status updated on 25.01.2020 | ||
| Former | unknown Status updated on 01.10.2019 | Most recent event Tooltip | 14.06.2023 | New entry: Renewal fee paid | Applicant(s) | For all designated states Janssen Biotech, Inc. 800/850 Ridgeview Drive Horsham, PA 19044 / US | [2021/21] | Inventor(s) | 01 /
EMANUEL, Stuart 1400 Welsh and McKean Roads Spring House, PA 19477 / US | 02 /
RICHTER, Mark 1400 Welsh and McKean Roads Spring House, PA 19477 / US | 03 /
CONNOLLY, Peter J. Welsh & McKean Roads Spring House, PA 19477 / US | 04 /
EDWARDS, James P. Welsh & McKean Roads Spring House, PA 19477 / US | 05 /
WANG, Guangyi 118 Mistletoe Irvine, CA 92620 / US | 06 /
THATIKONDA, Santhosh Kumar 991 East Grant Place San Mateo, CA 94402 / US | 07 /
BEIGELMAN, Leonid 991 East Grant Place San Mateo, CA 94402 / US | 08 /
BIGNAN, Gilles 1400 Welsh and McKean Roads Spring House, PA 19477 / US | 09 /
SCHEPENS, Wim Bert Griet Turnhoutseweg 30 2340 Beerse / BE | 10 /
VIELLEVOYE, Marcel Turnhoutseweg 30 2340 Beerse / BE | 11 /
THURING, Johannes Wilhelmus J.F. Turnhoutseweg 30 2340 Beerse / BE | [2021/21] | Representative(s) | Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB | [N/P] |
| Former [2021/21] | Warner, James Alexander Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB | Application number, filing date | 19773171.4 | 16.07.2019 | [2021/21] | WO2019IB56075 | Priority number, date | US201862699001P | 17.07.2018 Original published format: US 201862699001 P | [2021/21] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2020016782 | Date: | 23.01.2020 | Language: | EN | [2020/04] | Type: | A1 Application with search report | No.: | EP3823976 | Date: | 26.05.2021 | Language: | EN | The application published by WIPO in one of the EPO official languages on 23.01.2020 takes the place of the publication of the European patent application. | [2021/21] | Search report(s) | International search report - published on: | EP | 23.01.2020 | Classification | IPC: | C07H21/02, C07H21/04, A61P35/00, A61P37/02 | [2021/21] | CPC: |
C07H21/02 (EP,IL);
C07H21/00 (KR);
C07H19/207 (US);
A61K31/7084 (KR);
A61P31/12 (KR);
A61P35/00 (EP,IL,KR,US);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2021/21] | Extension states | BA | 11.02.2021 | ME | 11.02.2021 | Validation states | KH | 11.02.2021 | MA | 11.02.2021 | MD | 11.02.2021 | TN | 11.02.2021 | Title | German: | CYCLISCHE DINUKLEOTIDE ALS STING-AGONISTEN | [2021/21] | English: | CYCLIC DINUCLEOTIDES AS STING AGONISTS | [2021/21] | French: | DINUCLÉOTIDES CYCLIQUES EN TANT QU'AGONISTES STING | [2021/21] | Entry into regional phase | 11.02.2021 | National basic fee paid | 11.02.2021 | Designation fee(s) paid | 11.02.2021 | Examination fee paid | Examination procedure | 11.02.2021 | Examination requested [2021/21] | 11.02.2021 | Date on which the examining division has become responsible | 14.09.2021 | Amendment by applicant (claims and/or description) | Fees paid | Renewal fee | 15.07.2021 | Renewal fee patent year 03 | 16.06.2022 | Renewal fee patent year 04 | 14.06.2023 | Renewal fee patent year 05 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [I]WO2017161349 (IMMUNE SENSOR LLC [US], et al) [I] 1-59 * the whole document *; | [I]WO2018045204 (IFM THERAPEUTICS INC [US]) [I] 1-59* the whole document * | by applicant | - ZHONG B et al., "The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation", Immunity, (20080000), vol. 29, doi:doi:10.1016/j.immuni.2008.09.003, pages 538 - 550, XP055021580 DOI: http://dx.doi.org/10.1016/j.immuni.2008.09.003 | - LIU S et al., "Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation", Science, (20150000), pages 2630 - 2637 | - CHEN H et al., "Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity", Cell, (20110000), vol. 14, pages 433 - 446 | - CORRALES, L. et al., "Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity", Cell Reports, (20150000), vol. 11, pages 1 - 13 | - KONNO, H. et al., "Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling", Cell, (20130000), vol. 155, doi:doi:10.1016/j.cell.2013.09.049, pages 688 - 698, XP028758016 DOI: http://dx.doi.org/10.1016/j.cell.2013.09.049 | - SUN, L. et al., "Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway", Science, (20130000), vol. 339, doi:doi:10.1126/science.1232458, pages 786 - 791, XP055294100 DOI: http://dx.doi.org/10.1126/science.1232458 | - BHAT NFITZGERALD KA, "Recognition of Cytosolic DNA by cGAS and other STING-dependent sensors", Eur J Immunol., (20140300), vol. 44, no. 3, pages 634 - 40 | - ZHANG X et al., "Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING", Molecular Cell, (20130000), vol. 51, doi:doi:10.1016/j.molcel.2013.05.022, pages 226 - 235, XP055300246 DOI: http://dx.doi.org/10.1016/j.molcel.2013.05.022 | - DANILCHANKA, OMEKALANOS, JJ, "Cyclic Dinucleotides and the Innate Immune Response", Cell, (20130000), vol. 154, doi:doi:10.1016/j.cell.2013.08.014, pages 962 - 970, XP028706417 DOI: http://dx.doi.org/10.1016/j.cell.2013.08.014 | - LIU S-Y et al., "Systematic identification of type I and type II interferon-induced antiviral factors", Proc. Natl. Acad. Sci., (20120000), vol. 109, pages 4239 - 4244 | - BECKETT et al., "A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation", Protein Science, (19990000), vol. 8, pages 921 - 929, XP002971557 | - HOLFORDSCHEINER, Clin. Pharmacokinet., vol. 6, pages 429 - 453 | - LOEWEMUISCHNEK, Arch. Exp. Pathol Pharmacol., (19260000), vol. 114, pages 313 - 326 | - CHOUTALALAY, Adv. Enzyme Regul., (19840000), vol. 22, page 2755 | - CHEMICAL ABSTRACTS, Database accession no. 1786418-21-0 | - YI, "Single 20 Nucleotide Polymorphisms of Human STING can affect innate immune response to cyclic dinucleotides", PLOS ONE, (20130000), vol. 8, no. 10, doi:doi:10.1371/journal.pone.0077846, page e77846, XP055315013 DOI: http://dx.doi.org/10.1371/journal.pone.0077846 | - ZHANG et al., "Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING", Molecular Cell, (20130000), vol. 51, no. 2, doi:doi:10.1016/j.molcel.2013.05.022, XP055375940 DOI: http://dx.doi.org/10.1016/j.molcel.2013.05.022 |