EP3814499 - COMPOSITIONS AND METHODS FOR GENOMIC EDITING BY INSERTION OF DONOR POLYNUCLEOTIDES [Right-click to bookmark this link] | Status | Request for examination was made Status updated on 03.04.2021 Database last updated on 14.08.2024 | |
Former | The international publication has been made Status updated on 03.01.2020 | ||
Former | unknown Status updated on 25.10.2019 | Most recent event Tooltip | 28.06.2024 | New entry: Renewal fee paid | Applicant(s) | For all designated states CRISPR Therapeutics AG Baarerstrasse 14 6300 Zug / CH | [2021/18] | Inventor(s) | 01 /
CARLO, Troy, Dean Baarerstrasse 14 6300 Zug / CH | 02 /
BOGORAD, Roman, Lvovitch Baarerstrasse 14 6300 Zug / CH | [2021/18] | Representative(s) | Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE | [2021/18] | Application number, filing date | 19787407.6 | 28.06.2019 | [2021/18] | WO2019IB00833 | Priority number, date | US201862691573P | 28.06.2018 Original published format: US 201862691573 P | [2021/18] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2020003006 | Date: | 02.01.2020 | Language: | EN | [2020/01] | Type: | A2 Application without search report | No.: | EP3814499 | Date: | 05.05.2021 | Language: | EN | The application published by WIPO in one of the EPO official languages on 02.01.2020 takes the place of the publication of the European patent application. | [2021/18] | Search report(s) | International search report - published on: | EP | 05.03.2020 | Classification | IPC: | C12N15/11, C12N15/90, A61K31/7088, A61K48/00 | [2021/18] | CPC: |
C12N15/111 (EP,IL);
C12N15/113 (KR);
C12N15/907 (EP,IL,KR,US);
A61K48/00 (EP,IL,KR);
A61K48/0025 (EP,IL);
C12N15/102 (KR);
C12N15/11 (IL,US);
C12N9/22 (IL,KR,US);
C12N2310/18 (IL,US);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2021/18] | Extension states | BA | 27.01.2021 | ME | 27.01.2021 | Title | German: | ZUSAMMENSETZUNGEN UND VERFAHREN ZUR GENOMEDITIERUNG DURCH INSERTION VON DONORPOLYNUKLEOTIDEN | [2021/18] | English: | COMPOSITIONS AND METHODS FOR GENOMIC EDITING BY INSERTION OF DONOR POLYNUCLEOTIDES | [2021/18] | French: | COMPOSITIONS ET PROCÉDÉS D'ÉDITION GÉNOMIQUE PAR INSERTION DE POLYNUCLÉOTIDES DONNEURS | [2021/18] | Entry into regional phase | 27.01.2021 | National basic fee paid | 27.01.2021 | Designation fee(s) paid | 27.01.2021 | Examination fee paid | Examination procedure | 27.01.2021 | Examination requested [2021/18] | 27.01.2021 | Date on which the examining division has become responsible | 11.08.2021 | Amendment by applicant (claims and/or description) | Fees paid | Renewal fee | 27.01.2021 | Renewal fee patent year 03 | 27.06.2022 | Renewal fee patent year 04 | 27.06.2023 | Renewal fee patent year 05 | 27.06.2024 | Renewal fee patent year 06 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [XA]WO2010029303 (ISIS INNOVATION [GB], et al) [X] 1-13,15,17-28,81-85,87-90,95,134 * figure 3; claims 1, 2; table 3 * * the whole document * [A] 14,16,29-80,86,91-94,98-133,135-147; | [A]WO2017072590 (CRISPR THERAPEUTICS AG [CH]) [A] 1-147 * the whole document *; | [A]WO2017077386 (CRISPR THERAPEUTICS AG [CH]) [A] 1-147 * the whole document *; | [XAI]WO2018096356 (HORIZON DISCOVERY LTD [GB]) [X] 1-3,5-7,13,15,17-28,81,87-90,95,128-134,136 * figures 5C, 6; claims 1, 7 * * the whole document * [A] 14,16,29-79,98-127,135,137-147 [I] 91,92,96,97; | [E]WO2019239361 (NOVARTIS AG [CH]) [E] 1-13,15,17-28,80-90,93-95,128-134,136 * example 1; claims 1-14, 19; table 1; sequences 16, 24 ** the whole document *; | [XAI] - S. J. ORLANDO ET AL, "Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology", NUCLEIC ACIDS RESEARCH ADVANCE ACCESS, GB, (20100608), vol. 38, no. 15, doi:10.1093/nar/gkq512, ISSN 0305-1048, pages e152 - 1, XP055076783 [X] 1-13,15,17-28,80-90,93-95,128-130,134,136 * figure 4 * * the whole document * [A] 14,16,29-79,98-127,135,137-147 [I] 91,92,96,97,131-133 DOI: http://dx.doi.org/10.1093/nar/gkq512 | [XAI] - SHENGDAR Q TSAI ET AL, "GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases", NATURE BIOTECHNOLOGY, New York, (20141216), vol. 33, no. 2, doi:10.1038/nbt.3117, ISSN 1087-0156, pages 187 - 197, XP055555627 [X] 1-13,15,17-20,22,80-82,87-90,93-95,128-130,134,136 * the whole document * [A] 14,16,29-79,98-127,135,137-147 [I] 91,92,96,97,131-133 DOI: http://dx.doi.org/10.1038/nbt.3117 | [A] - ERIK VAN DER WAL ET AL, "Large-Scale Expansion of Human iPSC-Derived Skeletal Muscle Cells for Disease Modeling and Cell-Based Therapeutic Strategies", STEM CELL REPORTS, United States, (20180503), vol. 10, no. 6, doi:10.1016/j.stemcr.2018.04.002, ISSN 2213-6711, pages 1975 - 1990, XP055657928 [A] 1-147 * the whole document * DOI: http://dx.doi.org/10.1016/j.stemcr.2018.04.002 | [A] - CHENGZU LONG ET AL, "Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing", SCIENCE ADVANCES, (20180131), vol. 4, no. 1, doi:10.1126/sciadv.aap9004, page eaap9004, XP055523128 [A] 1-147 * the whole document * DOI: http://dx.doi.org/10.1126/sciadv.aap9004 | [A] - JEAN-BAPTISTE RENAUD ET AL, "Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases", CELL REPORTS, US, (20160225), vol. 14, no. 9, doi:10.1016/j.celrep.2016.02.018, ISSN 2211-1247, pages 2263 - 2272, XP055566276 [A] 1-147 * the whole document * DOI: http://dx.doi.org/10.1016/j.celrep.2016.02.018 | by applicant | US3687808 | US4469863 | US4476301 | US5013556 | US5023243 | US5031272 | US5034506 | US5166315 | US5177196 | US5185444 | US5188897 | US5214134 | US5216141 | US5235033 | US5264423 | US5264562 | US5264564 | US5276019 | US5278302 | US5286717 | US5321131 | US5399676 | US5405939 | US5405938 | US5434257 | US5453496 | US5455233 | US5466677 | US5470967 | US5476925 | US5489677 | US5519126 | US5536821 | US5541306 | US5541307 | US5550111 | US5561225 | US5563253 | US5571799 | US5587361 | US5596086 | US5602240 | US5608046 | US5610289 | US5618704 | US5623070 | US5625050 | US5633360 | US5663312 | US5677437 | US5677439 | US5817491 | US6027726 | WO2005001248 | US2005222064 | US7404969 | WO2011125054 | WO2011130749 | WO2012099755 | WO2013086354 | WO2013103659 | WO2013116126 | US8691750 | WO2014135998 | WO2015009952 | - LIN et al., Mol Ther Nucleic Acids, (20140000), vol. 3, page e186 | - YIN et al., Nat Biotechnol, (20160000), vol. 34, no. 3, pages 328 - 333 | - LONG et al., Science, (20140000), vol. 345, pages 1184 - 1188 | - TABEBORDBAR et al., Science, (20160000), vol. 351, pages 407 - 411 | - MATEOS-GOMEZ et al., Nature, (20150000), vol. 528, no. 7582, pages 258 - 485 | - IYAMAWILSON, DNA Repair, (20130000), vol. 12, no. 8, pages 620 - 636 | - BERGET, J Biol Chem, (19950000), vol. 270, pages 2411 - 2414 | - COX et al., Nature Medicine, (20150000), vol. 21, no. 2, pages 121 - 131 | - REED, Genes Dev, (19890000), vol. 3, no. 12B, pages 2113 - 2123 | - COOLIDGE et al., Nucleic Acids Res, (19970000), vol. 25, no. 4, pages 888 - 896 | - BLENCOWE, Trends Biochem Sci, (20000000), vol. 25, no. 3, pages 106 - 110 | - WANG et al., Mol Cell, (20060000), vol. 23, no. 1, pages 61 - 70 | - WANG et al., Nat Struct Mol Biol, (20120000), vol. 19, no. 10, pages 1044 - 1052 | - CARSTENS et al., Mol Cell Biol, (20000000), vol. 20, no. 19, pages 7388 - 7400 | - REESE, Organic & Biomolecular Chemistry, (20050000), vol. 3, no. 21, page 3851 | - CANNANPEDERSON, J Cell Physiol, (20150000), vol. 231, pages 3 - 14 | - CHIRUVELLA et al., Cold Spring Harb Perspect Biol, (20130000), vol. 5, page a012757 | - KARANAM et al., Mol Cell, (20120000), vol. 47, pages 320 - 329 | - LIXU, Acta Biochim Biophys Sin, (20160000), vol. 48, no. 7, pages 641 - 646 | - HEYER et al., Annu Rev Genet, (20100000), vol. 44, pages 113 - 139 | - KOONIN et al., Curr Opin Microbiol, (20170000), vol. 37, pages 67 - 78 | - MAKAROVA et al., Nat Rev Microbiol, (20150000), vol. 13, no. 11, pages 722 - 36 | - SHMAKOV et al., Mol Cell, (20150000), vol. 60, pages 385 - 397 | - ZETSCHE et al., Cell, (20150000), vol. 163, pages 1 - 13 | - VERMAECKSTEIN, Annual Review of Biochemistry, (19980000), vol. 76, pages 99 - 134 | - GOODCHILD, Bioconjugate Chemistry, (19900000), vol. 1, no. 3, pages 165 - 187 | - CONG et al., Science, (20130000), vol. 339, pages 819 - 823 | - KLEINSTIVER et al., Nat Biotechnol, (20150000), vol. 33, pages 1293 - 1298 | - KLEINSTIVER et al., Nature, (20160000), vol. 529, pages 490 - 495 | - TSAI et al., Nat Biotechnol, (20140000), vol. 32, pages 569 - 576 | - ANDERS et al., Mol Cell, (20160000), vol. 61, pages 895 - 902 | - KIM et al., Nat Comm, (20170000), vol. 8, page 14500 | - FONFARA et al., Nucleic Acids Res, (20130000), vol. 42, pages 2577 - 2590 | - GARNEAU et al., Nature, (20100000), vol. 468, pages 67 - 71 | - MAGADAN et al., PLoS ONE, (20120000), vol. 7, page e40913 | - ESVELT et al., Nat Methods, (20130000), vol. 10, no. 11, pages 1116 - 1121 | - DE MESMAEKER et al., Ace. Chem. Res., (19950000), vol. 28, pages 366 - 374 | - NIELSEN et al., Science, (19910000), vol. 254, page 1497 | - DWAINE A. BRAASCHDAVID R. COREY, Biochemistry, (20020000), vol. 41, no. 14, pages 4503 - 4510 | - Genesis, (20010000), vol. 30, no. 3 | - HEASMAN, J., Dev. Biol., (20020000), vol. 243, pages 209 - 214 | - NASEVICIUS et al., Nat. Genet., (20000000), vol. 26, pages 216 - 220 | - LACERRA et al., Proc. Natl. Acad. Sci., (20000000), vol. 97, pages 9591 - 9596 | - IVERSON, Curr. Opin. Mol. Ther., (20010000), vol. 3, pages 235 - 238 | - WANG et al., J. Gene Med., (20100000), vol. 12, pages 354 - 364 | - WANG et al., J. Am. Chem. Soc, (20000000), vol. 122, pages 8595 - 8602 | - PANYAMLABHASETWAR, Adv Drug Deliv Rev, (20030000), vol. 55, pages 329 - 347 | - PEER et al., Nature Nanotech., (20070000), vol. 2, pages 751 - 760 | - SAPRA et al., Prog. Lipid Res., (20030000), vol. 42, no. 5, pages 439 - 62 | - ABRA et al., J. Liposome Res., (20020000), vol. 12, pages 1 - 3 | - ALLEN et al., Biochimica et Biophysica Acta, (19950000), vol. 1237, pages 99 - 108 | - DEFREES et al., Journal of the American Chemistry Society, (19960000), vol. 118, pages 6101 - 6104 | - BLUME et al., Biochimica et Biophysica Acta, (19930000), vol. 1149, pages 180 - 184 | - KLIBANOV et al., Journal of Liposome Research, (19920000), vol. 2, pages 321 - 334 | - ZALIPSKY, Bioconjugate Chemistry, (19930000), vol. 4, pages 296 - 299 | - ZALIPSKY, FEBS Letters, (19940000), vol. 353, pages 71 - 74 | - KIRPOTIN et al., FEBS Letters, (19960000), vol. 388, pages 115 - 118 | - RENNEISEN et al., J. Bio. Chem., (19900000), vol. 265, pages 16337 - 16342 | - LEONETTI et al., Proc. Natl. Acad. Sci. (USA, (19900000), vol. 87, pages 2448 - 2451 | - "Covalent Attachment of Proteins to Liposomes", HEATH, Methods in Enzymology, Academic Press, Inc., (19870000), vol. 149, pages 111 - 119 | - MAHON et al., Bioconjug Chem., (20100000), vol. 21, pages 1448 - 1454 | - SCHROEDER et al., J Intern Med., (20100000), vol. 267, pages 9 - 21 | - AKINC et al., Nat. Biotechnol., (20080000), vol. 26, pages 561 - 569 | - LOVE et al., Proc Natl Acad Sci USA., (20100000), vol. 107, pages 1864 - 1869 | - SIEGWART et al., Proc Natl Acad Sci USA., (20110000), vol. 108, pages 12996 - 3001 | - AKINC et al., Mol Ther., (20090000), vol. 17, pages 872 - 879 | - MURUGAIAH et al., Analytical Biochemistry, (20100000), vol. 401, page 61 | - LIUHUANG, Molecular Therapy, (20100000), pages 669 - 670 | - ODA et al., Nucleic Acids Res, (19910000), vol. 19, pages 5263 - 5267 | - HAFEZHAUSNER, Genome, (20120000), vol. 55, pages 553 - 69 | - CARROLL, Ann. Rev. Biochem., (20140000), vol. 83, pages 409 - 39 | - GUPTAMUSUNURU, J. Clin. Invest., (20140000), vol. 124, pages 4154 - 61 | - SMITHWATERMAN, Adv. Appl. Math., (19810000), vol. 2, page 482 | - NEEDLEMANWUNSCH, J. Mol. Biol., (19700000), vol. 48, pages 444 - 453 | - PEARSONLIPMAN, Proc. Nat'l. Acad. Sci. USA, (19880000), vol. 85, page 2444 | - ALTSCHUL et al., J. Mol. Biol., (19900000), vol. 215, pages 403 - 410 | - E. MEYERSW. MILLER, CABIOS, (19890000), vol. 4, pages 11 - 17 | - ALTSCHUL et al., Nucleic Acids Res., (19970000), vol. 25, no. 17, pages 3389 - 3402 | - BERGE et al., J Pharm Sci, (19770000), vol. 66, pages 1 - 19 | - RYEBAELL, Curr Med Chem, (20050000), vol. 12, no. 26, pages 3127 - 3141 | - ELLIOT et al., MedChemCom, (20120000), vol. 3, no. 7, pages 735 - 751 | - GAO et al., Nucleic Acids Res, (20080000), vol. 36, no. 7, pages 2257 - 2267 | - MERSCH et al., BMC Bioinformatics, (20080000), vol. 9, page 369 | - WANG et al., Cell, (20040000), vol. 119, pages 831 - 845 | - HAVENS et al., RNA, (20130000), vol. 4, pages 247 - 266 | - STERNER et al., Proc Natl Acad Sci USA, (19960000), vol. 93, no. 26, pages 15081 - 15085 | - MASELLA et al., BMC Bioinformatics, (20120000), vol. 13, page 31 | - KREUTZ et al., Front Physiol., (20170000), vol. 8, page 862 | WO2012US58519 | WO2013US30062 |