blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3809838

EP3809838 - GENETICALLY MODIFIED MOUSE MODELS OF ALZHEIMER'S DISEASE [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  09.02.2023
Database last updated on 15.06.2024
FormerRequest for examination was made
Status updated on  26.03.2021
FormerThe international publication has been made
Status updated on  27.12.2019
Most recent event   Tooltip03.05.2024New entry: Reply to examination report 
Applicant(s)For all designated states
The Jackson Laboratory
600 Main Street
Bar Harbor, ME 04609 / US
For all designated states
Indiana University Research & Technology Corporation
518 Indiana Avenue
Indianapolis, IN 46202 / US
For all designated states
Sage Bionetworks
2901 Third Avenue Suite 330
Seattle WA 98121 / US
[2021/17]
Inventor(s)01 / HOWELL, Gareth
600 Main Street
Bar Harbor, ME 04609 / US
02 / CARTER, Gregory
600 Main Street
Bar Harbor, ME 04609 / US
03 / SASNER, Michael
600 Main Street
Bar Harbor, ME 04609 / US
04 / RIZZO, Stacey
600 Main Street
Bar Harbor, ME 04609 / US
05 / WILLIAMS, Harriet
600 Main Street
Bar Harbor, ME 04609 / US
06 / LAMB, Bruce
10487 Windermere
Carmel, IN 46032 / US
07 / TERRITO, Paul
12011 Castlestone Dr.
Fishers, IN 46037 / US
08 / OBLAK, Adrian
11847 Floral Hall Pl.
Fishers, IN 46037 / US
09 / LOGSDON, Ben
2901 Third Avenue, Suite 330
Seattle, WA 98121 / US
10 / MANGRAVITE, Lara
2901 Third Avenue, Suite 330
Seattle, WA 98121 / US
11 / GRAHAM, Leah
600 Main Street
Bar Harbor, Maine 04609 / US
 [2021/17]
Representative(s)Potter Clarkson
Chapel Quarter
Mount Street
Nottingham NG1 6HQ / GB
[N/P]
Former [2021/17]Potter Clarkson
The Belgrave Centre
Talbot Street
Nottingham NG1 5GG / GB
Application number, filing date19821744.021.06.2019
[2021/17]
WO2019US38401
Priority number, dateUS201862687952P21.06.2018         Original published format: US 201862687952 P
US201862700004P18.07.2018         Original published format: US 201862700004 P
[2021/17]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2019246483
Date:26.12.2019
Language:EN
[2019/52]
Type: A1 Application with search report 
No.:EP3809838
Date:28.04.2021
Language:EN
The application published by WIPO in one of the EPO official languages on 26.12.2019 takes the place of the publication of the European patent application.
[2021/17]
Search report(s)International search report - published on:US26.12.2019
(Supplementary) European search report - dispatched on:EP22.02.2022
ClassificationIPC:A01K67/027, C12N9/16, C12N9/06, C07K14/705, C07K14/47, C07K14/775, C12N15/09
[2022/12]
CPC:
C07K14/775 (EP,US); A01K67/0278 (US); A01K67/0275 (EP);
A61K49/0008 (US); C07K14/4711 (EP); C07K14/705 (EP);
C07K14/70503 (EP,US); C12N9/0028 (EP,US); C12N9/16 (EP,US);
C12Y105/0102 (EP,US); C12Y301/04011 (EP,US); A01K2217/072 (EP,US);
A01K2217/15 (EP,US); A01K2227/105 (EP,US); A01K2267/0312 (EP,US) (-)
Former IPC [2021/17]A01K67/027, C07K14/775, C12N15/09
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/17]
TitleGerman:GENETISCH MODIFIZIERTE MAUSMODELLE DER ALZHEIMER-KRANKHEIT[2021/17]
English:GENETICALLY MODIFIED MOUSE MODELS OF ALZHEIMER'S DISEASE[2021/17]
French:MODÈLES DE SOURIS GÉNÉTIQUEMENT MODIFIÉE DE LA MALADIE D'ALZHEIMER[2021/17]
Entry into regional phase20.01.2021National basic fee paid 
20.01.2021Search fee paid 
20.01.2021Designation fee(s) paid 
20.01.2021Examination fee paid 
Examination procedure20.01.2021Examination requested  [2021/17]
26.09.2022Amendment by applicant (claims and/or description)
08.02.2023Despatch of a communication from the examining division (Time limit: M06)
08.09.2023Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
02.11.2023Reply to a communication from the examining division
27.03.2024Despatch of a communication from the examining division (Time limit: M04)
01.05.2024Reply to a communication from the examining division
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
02.11.2023Request for further processing filed
02.11.2023Full payment received (date of receipt of payment)
Request granted
10.11.2023Decision despatched
Fees paidRenewal fee
28.06.2021Renewal fee patent year 03
27.10.2022Renewal fee patent year 04
27.07.2023Renewal fee patent year 05
Penalty fee
Additional fee for renewal fee
30.06.202204   M06   Fee paid on   27.10.2022
30.06.202305   M06   Fee paid on   27.07.2023
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]US2006272038  (DE VIVO MICHAEL [US], et al) [Y] 1,5,16 * example 1 *;
 [Y]  - PAUL J. CHENG-HATHAWAY ET AL, "The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease", MOLECULAR NEURODEGENERATION, (20180601), vol. 13, no. 29, doi:10.1186/s13024-018-0262-8, pages 1 - 12, XP055664658 [Y] 1-16 * Cited in the ISR; page 8 - page 10 *

DOI:   http://dx.doi.org/10.1186/s13024-018-0262-8
 [Y]  - MURRAY C. E. ET AL, "APOE [epsilon] 4 is also required in TREM2 R47H variant carriers for Alzheimer's disease to develop", NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY., GB, vol. 45, no. 2, doi:10.1111/nan.12474, ISSN 0305-1846, (20180207), pages 183 - 186, URL: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fnan.12474, XP055890399 [Y] 1-16 * page 185 *

DOI:   http://dx.doi.org/10.1111/nan.12474
 [Y]  - CHAN ELIZABETH S. ET AL, "ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing A[beta] impairment of insulin signaling in an Alzheimer's disease mouse model", SCIENTIFIC REPORTS, vol. 6, no. 1, doi:10.1038/srep26119, (201609), URL: https://www.nature.com/articles/srep26119.pdf, XP055890337 [Y] 1-16 * page 10 *

DOI:   http://dx.doi.org/10.1038/srep26119
 [Y]  - ONOS KRISTEN D ET AL, "Toward more predictive genetic mouse models of Alzheimer's disease", BRAIN RESEARCH BULLETIN, ELSEVIER SCIENCE LTD, OXFORD, GB, (20151217), vol. 122, doi:10.1016/J.BRAINRESBULL.2015.12.003, ISSN 0361-9230, pages 1 - 11, XP029483616 [Y] 1-16 * figure 7; table 1 *

DOI:   http://dx.doi.org/10.1016/j.brainresbull.2015.12.003
 [Y]  - SHAO WEN ET AL, "Genetics of Alzheimer's disease: From pathogenesis to clinical usage", JOURNAL OF CLINICAL NEUROSCIENCE, (2017), vol. 45, doi:10.1016/J.JOCN.2017.06.074, ISSN 0967-5868, pages 1 - 8, XP085232882 [Y] 1-16 * table 2 *

DOI:   http://dx.doi.org/10.1016/j.jocn.2017.06.074
International search[Y]US2006160079  (LANE ROGER M [US]) [Y] 2-3, 4/(2-3)* para [0020], [00129], SEQ ID NO: 6 *;
 [Y]  - HOLTZMAN et al., "Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease", PNAS, (20000314), vol. 97, no. 6, doi:10.1073/pnas.050004797, pages 2892 - 2897, XP055664650 [Y] 1-4, 36-37 * , abstract, pg 2892, col 2, para 2, pg 2895 col 2, para 2 *

DOI:   http://dx.doi.org/10.1073/pnas.050004797
 [Y]  - CASTILLO et al., "Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation", Scientific Reports, (20171219), vol. 7, no. 17762, doi:10.1038/s41598-017-17999-3, pages 1 - 16, XP055664654 [Y] 1-4, 36-37 * , Abstract, pg 8, para 3, pg 14, para 2 *

DOI:   http://dx.doi.org/10.1038/s41598-017-17999-3
 [Y]  - CHENG-HATHAWAY et al., "The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease", Mol Neurodegener, (20180601), vol. 13, no. 29, doi:10.1186/s13024-018-0262-8, pages 1 - 12, XP055664658 [Y] 1-4, 37 * , abstract *

DOI:   http://dx.doi.org/10.1186/s13024-018-0262-8
 [Y]  - ATAGI et al., "Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)", J Biol Chem., (20151023), vol. 290, no. 43, doi:10.1074/jbc.M115.679043, ISSN 0021-9258, pages 26043 - 26050, XP055664659 [Y] 1-4, 37 * , abstract, Pg 26048, col 2, last para - pg 26049, col 1, first para *

DOI:   http://dx.doi.org/10.1074/jbc.M115.679043
by applicantUS5356802
 US5436150
 US5487994
 US6453242
 US6534261
 US6534643
 US6607882
 US6830910
 US6858716
 US2005064474
 US2006188987
 WO2007014275
 US7294754
 US7576259
 US7659442
 US8420782
 US8440432
 US8440431
 US8450471
 US8450107
 US2013137161
 US2013137174
    - DIBATTISTA et al., Exp. Neurol., (20160000), vol. 280, pages 97 - 105
    - BU et al., Nature Reviews Neuroscience, (20090000), vol. 10, pages 333 - 344
    - HUANG et al., Cell, (20170000), vol. 168, pages 1 - 15
    - TAMBINI et al., EMBO Reports, (20160000), vol. 17, pages 27 - 36
    - LI, L. et al., DNA Seq, (19990000), vol. 10, no. 4-5, pages 219 - 28
    - PODLISNY, M.B. et al., Am J Pathol, (19910000), vol. 138, no. 6, pages 1423 - 35
    - ROSEN, R.F. et al., Neurobiol Aging, (20160000), vol. 44, pages 185 - 196
    - ROYCHAUDHURI, R. et al., ACS Chem Neurosci, (20150000), vol. 6, no. 12, pages 1941 - 55
    - PABO et al., Ann. Rev. Biochem., (20010000), vol. 70, pages 313 - 340
    - "Embryonic stem cells: methods and protocols", Embryonic stem cells: methods and protocols in Methods Mol Biol, Humana Press, (20020000), page 185
    - ALTSCHUL et al., J. Mol. Biol., (19900000), vol. 215, page 403
    - ALTSCHUL et al., Nucleic Acids Res., (19970000), vol. 25, pages 3379 - 3388
    - SCHORNACK et al., J. Plant Physiol., (20060000), vol. 163, no. 3, pages 256 - 272
    - CHOO et al., Curr Opin. Struct. Biol., (20000000), vol. 10, pages 411 - 416
    - A. NAGYM. GERTSENSTEINK. VINTERSTENR. BEHRINGER, Embryonic stem cells: methods and protocols in Methods in Molecular Biology, Cold Spring Harbor Laboratory Press, (20020000), vol. 185
    - MEYER et al., PNAS USA, (20100000), vol. 107, no. 34, pages 15022 - 15026
    - MEYER et al., PNAS USA, vol. 107, no. 34, pages 15022 - 15026
    - HORVATH, Science, (20100000), vol. 327, pages 167 - 170
    - BARRANGOU et al., Science, (20070000), vol. 318, pages 1709 - 1712
    - MAKAROVA et al., Nature Reviews Microbiology, vol. 9, pages 467 - 477
    - HAFT et al., PLoS Comput Biol., (20050000), vol. 1, no. 6, page e60
    - GASIUNAS et al., PNAS, (20120000), vol. 109, pages 17484 - 17489
    - JINEK et al., Science, (20120000), vol. 337, pages 816 - 821
    - DELTCHEVA et al., Nature, vol. 471, pages 602 - 607
    - MARRAFFINISONTHEIMER, Nature Reviews Genetics, (20100000), vol. 11, pages 181 - 190
    - CARROLL, Molecular Therapy, (20120000), vol. 20, pages 1658 - 1660
    - CHANG et al., Cell Research, (20130000), vol. 23, pages 720 - 723
    - JIANG et al., Nature Biotechnol, (20130000), vol. 31, pages 233 - 239
    - MALI et al., Science, (20130000), vol. 339, pages 823 - 826
    - WANG et al., Cell, (20130000), vol. 153, pages 1173 - 1183
    - SCHOLZEBOCH, Curr Opin Microbiol, (20110000), vol. 14, pages 47 - 53
    - BONAS et al., Mol Gen Genet, (19890000), vol. 218, pages 127 - 136
    - MOSCOUBOGDANOVE, Science, (20090000), vol. 326, pages 1509 - 1512
    - GAJ et al., Trends in Biotechnol, (20130000), vol. 31, no. 7, pages 397 - 405
    - KIM et al., PNAS, (19960000), vol. 93, pages 1156 - 1160
    - CHRISTIAN et al., Genetics, (20100000), vol. 186, pages 451 - 459
    - LI et al., Nucleic Acids Res, (20110000), vol. 39, pages 6315 - 6325
    - MILLER et al., Nat Biotechnol, (20110000), vol. 29, pages 143 - 148
    - ANSAI et al., Genetics, (20130000), vol. 193, pages 739 - 749
    - HOCKEMEYER et al., Nature Biotechnol., (20110000), vol. 29, pages 731 - 734
    - MOORE et al., PLoS ONE, (20120000), vol. 7, page e37877
    - STROUD et al., J. Biol. Chem., (20130000), vol. 288, pages 1685 - 1690
    - WEFERS et al., PNAS, (20130000), vol. 110, pages 3782 - 3787
    - MAKKERH et al., Curr Biol., (19960000), vol. 6, pages 1025 - 1027
    - KALDERON, Cell, (19840000), vol. 39, pages 499 - 509
    - DINGWALLET et al., J Cell Biol., (19880000), vol. 107, pages 841 - 9
    - MCLANECORBETT, IUBMB Life, (20090000), vol. 61, pages 697 - 70
    - LI et al., PNAS, (19930000), vol. 90, pages 2764 - 2768
    - HAUSCHILD et al., PNAS, (20110000), vol. 108, pages 12013 - 12017
    - ORLANDO et al., Nucleic Acids Res., (20100000), vol. 38, pages e152 - e152
    - PORTEUSCARROLL, Nature Biotechnology, (20050000), vol. 23, pages 967 - 973
    - BEERLI, Nature Biotechnol., (20020000), vol. 20, pages 135 - 141
    - ISALAN et al., Nature Biotechnol., (20010000), vol. 19, pages 656 - 660
    - SEGAL et al., Curr Opin. Biotechnol., (20010000), vol. 12, pages 632 - 637
    - SERA et al., Biochemistry, (20020000), vol. 41, pages 7074 - 7081
    - MAKKERH et al., Current Biology, (19960000), vol. 6, pages 1025 - 1027
    - LI et al., PNAS, (19920000), vol. 89, pages 4275 - 4279
    - KIM et al., PNAS, (19940000), vol. 91, pages 883 - 887
    - KIM et al., J. Biol. Chem., (19940000), vol. 269, pages 31978 - 31982
    - ROBERTS et al., Nucleic Acids Res., (20030000), vol. 31, pages 418 - 420
    - BITINAITE et al., PNAS, (19980000), vol. 95, pages 10,570 - 10,575
    - ABBOUD, S. L. et al., J. Histochem & Cytochem., (20030000), vol. 51, no. 7, pages 941 - 949
    - SCHORPP et al., Nucl. Acids Res., (19960000), vol. 24, no. 9, pages 1787 - 1788
    - MCBURNEY, M. W. et al., Devel. Dynamics, (19940000), vol. 200, pages 278 - 293
    - MAJUMDER, M. et al., Blood, (19960000), vol. 87, no. 8, pages 3203 - 3211
    - BUEHR, M. et al., "Genesis of embryonic stem cells. Philosophical Transactions of the Royal Society B", Biological Sciences, (20030000), vol. 358, pages 1397 - 1402
    - NAGY et al., Development, (19900000), vol. 110, pages 815 - 821
    - KRAUS et al., Genesis, (20100000), vol. 48, pages 394 - 399
    - RADU et al., "An in vivo Assay to Test Blood Vessel Permeability.", J. Vis. Exp., (20130000), no. 73, page 50062
    - Oligonucleotide Synthesis: Methods and Applications, Humana Press
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.