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Extract from the Register of European Patents

EP About this file: EP3898595

EP3898595 - PYRIMIDONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS [Right-click to bookmark this link]
StatusThe patent has been granted
Status updated on  29.03.2024
Database last updated on 07.10.2024
FormerGrant of patent is intended
Status updated on  29.11.2023
FormerExamination is in progress
Status updated on  16.06.2022
FormerRequest for examination was made
Status updated on  24.09.2021
FormerThe international publication has been made
Status updated on  02.07.2020
Formerunknown
Status updated on  14.02.2020
Most recent event   Tooltip29.03.2024(Expected) grantpublished on 01.05.2024  [2024/18]
Applicant(s)For all designated states
Merck Sharp & Dohme LLC
126 East Lincoln Avenue
Rahway, New Jersey 07065 / US
[2022/42]
Former [2021/43]For all designated states
Merck Sharp & Dohme Corp.
126 East Lincoln Road
Rahway, New Jersey 07065-0907 / US
Inventor(s)01 / CONVERSO, Antonella
770 Sumneytown Pike
West Point, Pennsylvania 19486 / US
02 / EL MARROUNI, Abdellatif
770 Sumneytown Pike
West Point, Pennsylvania 19486 / US
03 / FORSTER, Ashley
770 Sumneytown Pike
West Point, Pennsylvania 19486 / US
04 / FRIE, Jessica, L.
770 Sumneytown Pike
West Point, Pennsylvania 19486 / US
05 / HUNTER, David, N.
770 Sumneytown Pike
West Point, Pennsylvania 19486 / US
06 / KUDUK, Scott, D.
219 Summerwind Lane
Harleysville, Pennsylvania 19438 / US
07 / MITCHELL, Helen, J.
770 Sumneytown Pike
West Point, Pennsylvania 19486 / US
08 / NANTERMET, Philippe
770 Sumneytown Pike
West Point, Pennsylvania 19486 / US
09 / SHA, Deyou
770 Sumneytown Pike
West Point, Pennsylvania 19486 / US
10 / SHIPE, William Daniel
770 Sumneytown Pike
West Point, Pennsylvania 18486 / US
11 / WANG, Cheng
770 Sumneytown Pike
West Point, Pennsylvania 19486 / US
12 / WANG, Deping
770 Sumneytown Pike
West Point, Pennsylvania 19486 / US
 [2021/43]
Representative(s)Merck Sharp & Dohme LLC
120 Moorgate
London EC2M 6UR / GB
[2024/18]
Former [2021/43]Jaap, David Robert
Merck Sharp & Dohme Corp.
120 Moorgate
London, EC2M 6UR / GB
Application number, filing date19845846.513.12.2019
[2021/43]
WO2019US66125
Priority number, dateUS201862781356P18.12.2018         Original published format: US 201862781356 P
[2021/43]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2020131597
Date:25.06.2020
Language:EN
[2020/26]
Type: A1 Application with search report 
No.:EP3898595
Date:27.10.2021
Language:EN
The application published by WIPO in one of the EPO official languages on 25.06.2020 takes the place of the publication of the European patent application.
[2021/43]
Type: B1 Patent specification 
No.:EP3898595
Date:01.05.2024
Language:EN
[2024/18]
Search report(s)International search report - published on:EP25.06.2020
ClassificationIPC:C07D239/52, A61K31/505, A61P31/18
[2021/43]
CPC:
C07D239/52 (EP,IL,KR); C07D403/06 (KR,US); A61K31/513 (KR);
A61K45/06 (US); A61P31/18 (EP,IL,KR); C07D403/14 (KR)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/43]
Extension statesBA19.07.2021
ME19.07.2021
Validation statesMA19.07.2021
MD19.07.2021
TN19.07.2021
TitleGerman:PYRIMIDONDERIVATE ALS SELEKTIVE CYTOTOXISCHE MITTEL GEGEN HIV-INFIZIERTE ZELLEN[2021/43]
English:PYRIMIDONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS[2021/43]
French:DÉRIVÉS DE PYRIMIDONE EN TANT QU'AGENTS CYTOTOXIQUES SÉLECTIFS CONTRE DES CELLULES INFECTÉES PAR LE VIH[2021/43]
Entry into regional phase19.07.2021National basic fee paid 
19.07.2021Designation fee(s) paid 
19.07.2021Examination fee paid 
Examination procedure18.06.2021Observations by third parties
14.07.2021Amendment by applicant (claims and/or description)
19.07.2021Examination requested  [2021/43]
19.07.2021Date on which the examining division has become responsible
15.06.2022Despatch of a communication from the examining division (Time limit: M06)
24.01.2023Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
13.03.2023Reply to a communication from the examining division
17.05.2023Despatch of a communication from the examining division (Time limit: M04)
04.09.2023Reply to a communication from the examining division
30.11.2023Communication of intention to grant the patent
21.03.2024Fee for grant paid
21.03.2024Fee for publishing/printing paid
21.03.2024Receipt of the translation of the claim(s)
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
13.03.2023Request for further processing filed
13.03.2023Full payment received (date of receipt of payment)
Request granted
23.03.2023Decision despatched
Fees paidRenewal fee
16.12.2021Renewal fee patent year 03
09.12.2022Renewal fee patent year 04
12.12.2023Renewal fee patent year 05
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Cited inInternational search[XI]WO2014058747  (MERCK SHARP & DOHME [US], et al) [X] 1-4,14-19,22-31 * Compounds IX-3 in Scheme IX on page 59;; examples 136-137,141,143-145; claims 1,17,21 * [I] 1-31;
 [A]WO2015153304  (MERCK SHARP & DOHME [US], et al) [A] 1-31* claims 1,13 *
Examination   - Chelur Dattananda S. ET AL, "Targeted cell killing by reconstituted caspases", Proceedings of the National Academy of Sciences, (20070213), vol. 104, no. 7, doi:10.1073/pnas.0610877104, ISSN 0027-8424, pages 2283 - 2288, XP093046410

DOI:   http://dx.doi.org/10.1073/pnas.0610877104
by applicant   - J. B. DINOSO et al., Proc. Natl. Acad. Sci. U.S.A., (20090000), vol. 106, no. 23, pages 9403 - 9408
    - TACHEDJIAN et al., Proc. Natl. Acad. Sci. U.S.A., (20010000), vol. 98, no. 13, page 7188
    - TACHEDJIAN et al., FEBS Lett., (20050000), vol. 579, page 379
    - FIGUEIREDO et al., PLOS Path., (20060000), vol. 2, no. 11, page 1051
    - SUDO et al., J. Virol., (20130000), vol. 87, no. 6, page 3348
    - JOCHMANS et al., Retrovirology, (20100000), vol. 7, page 89
    - ZERBATO et al., Antimicrob. Agents Chemother, (20170000), vol. 61, no. 3
    - TRINITE et al., Retrovirology, (20190000), vol. 16, no. 17
    - S. AITIPAMULA et al., Crystal Growth and Design, (20120000), vol. 12, no. 5, pages 2147 - 2152
    - A.T.M. SERAJUDDIN, J Pharm Sci, (19990000), vol. 88, no. 10, pages 1058 - 1066
    - F. KESISOGLOUS. PANMAIY. WU, Advanced Drug Delivery Reviews, (20070000), vol. 59, no. 7, pages 631 - 644
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.