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Extract from the Register of European Patents

EP About this file: EP3876871

EP3876871 - SMALL MOLECULE DRUGS AND METHODS TO ACCELERATE OSSEOINTEGRATION [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  26.01.2024
Database last updated on 14.06.2024
FormerRequest for examination was made
Status updated on  13.08.2021
FormerThe international publication has been made
Status updated on  16.05.2020
Most recent event   Tooltip26.01.2024New entry: Despatch of examination report + time limit 
26.01.2024First examination report 
Applicant(s)For all designated states
The Regents of the University of California
1111 Franklin Street, 12th Floor
Oakland, CA 94607-5200 / US
[2021/37]
Inventor(s)01 / NISHIMURA, Ichiro
c/o UCLA Technology Development Group
10889 Wilshire Blvd., Suite 920
Los Angeles, California 90095-7191 / US
02 / HOKUGO, Akishige
c/o UCLA Technology Development Group
10889 Wilshire Blvd., Suite 920
Los Angeles, California 90095-7191 / US
03 / MORINAGA, Kenzo
c/o UCLA Technology Development Group
10889 Wilshire Blvd., Suite 920
Los Angeles, California 90095-7191 / US
04 / SASAKI, Hodaka
c/o UCLA Technology Development Group
10889 Wilshire Blvd., Suite 920
Los Angeles, California 90095-7191 / US
 [2021/37]
Representative(s)Pearl Cohen Zedek Latzer Baratz UK LLP
The Gridiron Building
One Pancras Square
London N1C 4AG / GB
[2021/37]
Application number, filing date19882121.704.11.2019
[2021/37]
WO2019US59693
Priority number, dateUS201862755698P05.11.2018         Original published format: US 201862755698 P
[2021/37]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2020096975
Date:14.05.2020
Language:EN
[2020/20]
Type: A1 Application with search report 
No.:EP3876871
Date:15.09.2021
Language:EN
The application published by WIPO in one of the EPO official languages on 14.05.2020 takes the place of the publication of the European patent application.
[2021/37]
Search report(s)International search report - published on:US14.05.2020
(Supplementary) European search report - dispatched on:EP06.10.2022
ClassificationIPC:A61K31/198, A61F2/28, A61K31/00, A61K31/37, A61K31/437, A61K31/4709, A61K31/48, A61K31/522, A61P41/00, C12N15/861, C07K14/47
[2022/31]
CPC:
A61F2/28 (EP); A61L27/54 (US); A61K31/00 (EP);
A61K31/197 (US); A61K31/198 (EP); A61K31/366 (US);
A61K31/37 (EP); A61K31/437 (EP,US); A61K31/4709 (EP,US);
A61K31/4745 (US); A61K31/48 (EP); A61K31/522 (EP,US);
A61K6/84 (US); A61L27/06 (US); A61P41/00 (EP);
C07K14/4705 (EP); C12N15/86 (EP); A61F2002/2817 (EP);
A61F2310/00017 (EP); A61F2310/00023 (EP); A61F2310/00029 (EP);
A61F2310/00365 (EP); A61F2310/00796 (EP); A61F2310/00976 (EP);
A61L2300/216 (US); A61L2430/02 (US); A61L2430/12 (US);
C12N2710/10343 (EP) (-)
Former IPC [2021/37]A61F2/28
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/37]
TitleGerman:NIEDERMOLEKULARE ARZNEIMITTEL UND VERFAHREN ZUR BESCHLEUNIGUNG DER KNOCHENINTEGRATION[2021/37]
English:SMALL MOLECULE DRUGS AND METHODS TO ACCELERATE OSSEOINTEGRATION[2021/37]
French:MÉDICAMENTS À PETITES MOLÉCULES ET MÉTHODES POUR ACCÉLÉRER L'OSSÉOINTÉGRATION[2021/37]
Entry into regional phase19.04.2021National basic fee paid 
19.04.2021Search fee paid 
19.04.2021Designation fee(s) paid 
19.04.2021Examination fee paid 
Examination procedure19.04.2021Examination requested  [2021/37]
31.05.2023Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
08.08.2023Amendment by applicant (claims and/or description)
25.01.2024Despatch of a communication from the examining division (Time limit: M04)
Request for further processing for:The application is deemed to be withdrawn due to failure to indicate the wish to proceed further with the application
08.08.2023Request for further processing filed
08.08.2023Full payment received (date of receipt of payment)
Request granted
18.08.2023Decision despatched
The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
08.08.2023Request for further processing filed
08.08.2023Full payment received (date of receipt of payment)
Request granted
18.08.2023Decision despatched
Fees paidRenewal fee
29.11.2021Renewal fee patent year 03
28.11.2022Renewal fee patent year 04
27.11.2023Renewal fee patent year 05
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Documents cited:Search[XYI]WO2007095161  (UNIV NEW YORK [US], et al) [X] 1-7 * pages 6-7, paragraph [0015] * * page 8, paragraphs [0020], [0024] * * pages 21-22, paragraph [0088] * * page 33, paragraph [0120] * * page 39, paragraph [0139] * * page 46, paragraphs [0165]-[0166] * * claims 1, 3, 6, 8, 14, 22, 24, 25, 28, 30, 45, 48 * [Y] 7 [I] 13,14;
 [E]WO2021046438  (UNIV CALIFORNIA [US]) [E] 1,6,13,14 * page 8, paragraph [0035] * * figure 23 ** page 82, paragraph [0267]; example 19 *;
 [XYI]  - KENZO MORINAGA ET AL, "Neuronal PAS domain 2 (Npas2) facilitated osseointegration of titanium implant with rough surface through a neuroskeletal mechanism", BIOMATERIALS, AMSTERDAM, NL, (20181103), vol. 192, doi:10.1016/j.biomaterials.2018.11.003, ISSN 0142-9612, pages 62 - 74, XP055705063 [X] 1-3,6,13,14 * abstract * * page 63, column 1, paragraph 3 * * page 65, column 1, paragraphs 3-4 * * page 68, column 1, paragraphs 2-3 * * page 72, column 2, paragraph 1 * * page 72; figure 6 * * page 73; table 1 * [Y] 7 [I] 4,5,7

DOI:   http://dx.doi.org/10.1016/j.biomaterials.2018.11.003
 [A]  - HASSAN NATHANIEL ET AL, "Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells", PLOS ONE, (20170817), vol. 12, no. 8, doi:10.1371/journal.pone.0183359, page e0183359, XP055935014 [A] 1-7,13,14 * abstract * * page 2, paragraph 3 * * page 8, paragraph l * * page 18, paragraph 2 *

DOI:   http://dx.doi.org/10.1371/journal.pone.0183359
 [A]  - WENJIE HE ET AL, "Rolofylline, an adenosine A1 receptor antagonist, inhibits osteoclast differentiation as an inverse agonist", BRITISH JOURNAL OF PHARMACOLOGY, WILEY-BLACKWELL, UK, (20131028), vol. 170, no. 6, doi:10.1111/BPH.12342, ISSN 0007-1188, pages 1167 - 1176, XP071171667 [A] 1-7,13,14 * abstract * * page 1174, column 1, paragraph 3 *

DOI:   http://dx.doi.org/10.1111/bph.12342
International search[Y]US2004248909  (SUN MIAO-KUN [US], et al) [Y] 14-15, 47-48 * para [0004], [0008] *;
 [XY]  - MORINAGA et al., "Neuronal PAS domain 2 (Npas2) facilitated osseointegration of titanium implant with rough surface through a neuroskeletal mechanism", Biomaterials, vol. 192, pages 62 - 74, XP055705063 [X] 1-13, 31-37, 43-46 * ; Available online 03 November 2018; abstract, pg 62, col 1, para 1, pg 63, col 1, para 5, pg 63, col 2, para 2, pg 65, col 2, para 1, pg 68, col 1, para 1, pg 68, col 1, para 2, pg 68, col 1, para 3, pg 68, col 1, para 4 to col 2, para 1, pg 73, Table 1 * [Y] 14-16, 47-49

DOI:   http://dx.doi.org/10.1016/j.biomaterials.2018.11.003
 [YD]  - SCHEIFF et al., "2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists", Bioorganic & Medicinal Chemistry, (20100000), vol. 18, doi:10.1016/j.bmc.2010.01.072, pages 2195 - 2203, XP026941351 [YD] 16, 49 * ; abstract *

DOI:   http://dx.doi.org/10.1016/j.bmc.2010.01.072
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