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Extract from the Register of European Patents

EP About this file: EP3757229

EP3757229 - METHOD OF PREPARING CELL FREE NUCLEIC ACID MOLECULES BY IN SITU AMPLIFICATION [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 14.06.2024 Database last updated on 12.08.2024
Former	Grant of patent is intended Status updated on 05.04.2023
Former	Examination is in progress Status updated on 25.03.2022
Former	Request for examination was made Status updated on 01.10.2021
Former	The application has been published Status updated on 27.11.2020
Most recent event Tooltip	14.06.2024	Application deemed to be withdrawn	published on 17.07.2024 [2024/29]
Applicant(s)	For all designated states Circulogene Theranostics, Inc. 3125 Independence Drive, Suite 301 Birmingham, AL 35209 / US
	[2023/39]
Former [2021/01]	For all designated states Circulogene Theranostics, LLC 3125 Independence Drive Suite 301 Birmingham, Alabama 35209 / US
Inventor(s)	01 / YEH, Chen-Hsiung 2008E Longleaf Drive Birmingham, AL 35216 / US
	[2021/01]
Representative(s)	Bryers Intellectual Property Ltd Bristol & Bath Science Park Dirac Crescent, Emerson's Green Bristol, BS16 7FR / GB
	[N/P]
Former [2021/01]	Bryers LLP 7 Gay Street Bath, Bath and North East Somerset BA1 2PH / GB
Application number, filing date	20174110.5	12.08.2016
	[2021/01]
Priority number, date	US201562204268P	12.08.2015 Original published format: US 201562204268 P
	[2021/01]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	EP3757229
	Date:	30.12.2020
	Language:	EN
	[2020/53]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	02.10.2020
Classification	IPC:	C12Q1/6855	[2021/01]
	CPC:	C12P19/34 (EP,IL,KR,US); C12Q1/6844 (EP,KR,US); C12Q1/68 (IL); C12Q1/6806 (EP,US); C12Q1/6855 (EP); C40B40/06 (EP,IL,US); (+) C40B50/06 (EP,IL,KR,US); C12Q2521/101 (KR,US); C12Q2521/131 (KR,US); C12Q2521/307 (KR,US); C12Q2521/319 (KR,US); C12Q2521/501 (KR,US); C12Q2521/531 (KR,US); C12Q2525/155 (KR,US); C12Q2543/101 (KR,US); C12Y207/01078 (EP,US); C12Y207/07007 (EP,US); C12Y207/07049 (EP,US); C12Y302/02027 (EP,US); C12Y605/01001 (EP,US) (-)
	C-Set:	C12Q1/6806, C12Q2521/531, C12Q2525/131, C12Q2525/191, C12Q2525/301, C12Q2561/113 (EP); C12Q1/6806, C12Q2525/155, C12Q2525/179, C12Q2525/191, C12Q2525/207, C12Q2527/101 (US,EP); C12Q1/6844, C12Q2521/101, C12Q2521/131, C12Q2521/307, C12Q2521/319, C12Q2521/501, C12Q2521/531, C12Q2525/155, C12Q2543/101 (EP,US); C12Q1/6855, C12Q2521/531, C12Q2525/131, C12Q2525/191, C12Q2525/301, C12Q2561/113 (EP)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2021/44]
Former [2021/01]	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Title	German:	VERFAHREN ZUR HERSTELLUNG ZELLFREIER NUKLEINSÄUREMOLEKÜLE DURCH IN-SITU-AMPLIFIZIERUNG	[2021/01]
	English:	METHOD OF PREPARING CELL FREE NUCLEIC ACID MOLECULES BY IN SITU AMPLIFICATION	[2021/01]
	French:	PROCÉDÉ DE PRÉPARATION DE MOLÉCULES D'ACIDE NUCLÉIQUE SANS CELLULES PAR AMPLIFICATION IN SITU	[2021/01]
Examination procedure	28.09.2021	Examination requested [2021/44]
	28.09.2021	Date on which the examining division has become responsible
	29.09.2021	Amendment by applicant (claims and/or description)
	25.03.2022	Despatch of a communication from the examining division (Time limit: M06)
	04.10.2022	Reply to a communication from the examining division
	06.04.2023	Communication of intention to grant the patent
	16.08.2023	Fee for grant paid
	16.08.2023	Fee for publishing/printing paid
	16.08.2023	Receipt of the translation of the claim(s)
	01.03.2024	Application deemed to be withdrawn, date of legal effect [2024/29]
	22.03.2024	Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time [2024/29]
Parent application(s) Tooltip	EP16835999.0 / EP3334834
Request for further processing for:	The application is deemed to be withdrawn due to non-payment of the examination fee
	28.09.2021	Request for further processing filed
	28.09.2021	Full payment received (date of receipt of payment) Request granted
	06.10.2021	Decision despatched
	The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
	28.09.2021	Request for further processing filed
	28.09.2021	Full payment received (date of receipt of payment) Request granted
	06.10.2021	Decision despatched
	The application is deemed to be withdrawn due to non-payment of designation fees TR, SM, SK, SI, SE, RS, RO, PT, PL, NO, NL, MT, MK, MC, LV, LU, LT, IT, IS, IE, HU, HR, GR, GB, FR, FI, ES, EE, DK, DE, CZ, CY, CH, BG, BE, AT, AL
	28.09.2021	Request for further processing filed
	28.09.2021	Full payment received (date of receipt of payment) Request granted
	06.10.2021	Decision despatched
Fees paid	Renewal fee
	03.06.2020	Renewal fee patent year 03
	03.06.2020	Renewal fee patent year 04
	03.06.2020	Renewal fee patent year 05
	23.02.2022	Renewal fee patent year 06
	26.02.2023	Renewal fee patent year 07
	Penalty fee
	Additional fee for renewal fee
	31.08.2021	06 M06 Fee paid on 23.02.2022
	31.08.2022	07 M06 Fee paid on 26.02.2023
	31.08.2023	08 M06 Not yet paid
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	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[A]WO2005090607 (RUBICON GENOMICS INC [US], et al) [A] 1-15* paragraphs [0063] , [0369]; figure 45A; example 26 *;
		[X]WO2011044541 (BAYLOR RES INST [US], et al) [X] 1 * page 19; claim 15 *;
		[A]WO2015100427 (GUARDANT HEALTH INC [US]) [A] 1-15 * paragraph [0317]; example 1 * * paragraph [0286] - paragraph [0289] *;
		[I] - SARAH BREITBACH ET AL, "Direct Quantification of Cell-Free, Circulating DNA from Unpurified Plasma", PLOS ONE, (20140303), vol. 9, no. 3, doi:10.1371/journal.pone.0087838, pages 1 - 11, XP055448112 [I] 1-15 * abstract * DOI: http://dx.doi.org/10.1371/journal.pone.0087838
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		- DAWSON SJ et al., N Engl J Med, (20130000), vol. 368, pages 1199 - 1209
		- DIAZ LA JR et al., Nature, (20120000), vol. 486, no. 7404, pages 537 - 540
		- SEQUIST LV et al., Sci. Transl. Med., (20110000), vol. 23, no. 75, page 75ra26
		- GORMALLY E et al., Mutat. Res., (20070000), vol. 635, no. 2-3, pages 105 - 117
		- TONG YK et al., Clin. Chim. Acta, (20060000), vol. 363, no. 1-2, pages 187 - 196
		- GAUTSCHI O et al., J. Clin. Oncol., (20040000), vol. 22, no. 20, pages 4157 - 4164
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