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Extract from the Register of European Patents

EP About this file: EP3760642

EP3760642 - HUMAN ANTIGEN BINDING PROTEINS THAT BIND BETA-KLOTHO, FGF RECEPTORS AND COMPLEXES THEREOF [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  02.07.2021
Database last updated on 22.08.2024
FormerThe application has been published
Status updated on  04.12.2020
Most recent event   Tooltip19.12.2023New entry: Renewal fee paid 
Applicant(s)For all designated states
Amgen Inc.
One Amgen Center Drive
Thousand Oaks, California 91320-1799 / US
[2021/01]
Inventor(s)01 / Hu, Shaw-Fen Sylvia
986 Lynnmere Drive
Thousand Oaks, CA 91360 / US
02 / Foltz, Ian
2108 Knightswood Place
Burnaby, British Columbia V5A 4B9 / CA
03 / King, Chadwick T.
1325 Moody Avenue
North Vancouver, British Columbia V7L 3T5 / CA
04 / Li, Yang
1142 Cuesta Drive
Mountain View, CA 94040 / US
05 / Arora, Taruna
291 Whiteclem Way
Palo Alto, CA 94306 / US
 [2021/01]
Representative(s)Murgitroyd & Company
165-169 Scotland Street
Glasgow G5 8PL / GB
[N/P]
Former [2021/01]Altmann Stößel Dick Patentanwälte PartG mbB
Dudenstrasse 46
68167 Mannheim / DE
Application number, filing date20178046.703.12.2010
[2021/01]
Priority number, dateUS200926732109P07.12.2009         Original published format: US 26732109 P
US201038184610P10.09.2010         Original published format: US 38184610 P
[2021/01]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3760642
Date:06.01.2021
Language:EN
[2021/01]
Search report(s)(Supplementary) European search report - dispatched on:EP24.11.2020
ClassificationIPC:C07K16/18, C07K16/28, A61K39/395, A61P3/04, C07K19/00, C07K14/71
[2021/01]
CPC:
C07K16/2863 (EP,IL,US); C07K16/28 (KR,US); A61K38/17 (KR);
A61K38/18 (KR); A61K39/395 (KR); A61K47/42 (KR);
A61K48/00 (KR); A61K49/16 (KR); A61P1/16 (EP);
A61P29/00 (EP); A61P3/00 (EP); A61P3/04 (EP);
A61P3/06 (EP); A61P3/08 (EP); A61P3/10 (EP);
A61P43/00 (EP); A61P9/00 (EP); C07K14/435 (KR);
C07K14/475 (KR); C07K14/71 (EP,IL,US); C07K16/18 (EP,IL,KR,US);
C07K16/22 (KR); C07K16/40 (US); A61K2039/505 (EP,IL,US);
C07K2317/21 (EP,IL,US); C07K2317/24 (US); C07K2317/32 (EP,IL,US);
C07K2317/34 (US); C07K2317/53 (US); C07K2317/54 (US);
C07K2317/55 (US); C07K2317/56 (EP,IL,US); C07K2317/565 (EP,IL,US);
C07K2317/622 (US); C07K2317/626 (US); C07K2317/75 (EP,IL,US);
C07K2317/92 (EP,IL,US); C07K2319/30 (EP,IL,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/31]
Former [2021/01]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:MENSCHLICHES ANTIGEN BINDENDE PROTEINE ZUR BINDUNG VON BETA-KLOTHO, FGF-REZEPTOREN UND KOMPLEXE DARAUS[2021/01]
English:HUMAN ANTIGEN BINDING PROTEINS THAT BIND BETA-KLOTHO, FGF RECEPTORS AND COMPLEXES THEREOF[2021/01]
French:PROTÉINES DE LIAISON À ANTIGÈNE HUMAIN QUI SE LIENT À BÊTA-KLOTHO, AUX RÉCEPTEURS DE FGF ET AUX COMPLEXES DE CEUX-CI[2021/01]
Examination procedure30.06.2021Amendment by applicant (claims and/or description)
30.06.2021Examination requested  [2021/31]
30.06.2021Date on which the examining division has become responsible
Parent application(s)   TooltipEP10788204.5  / EP2510009
EP16207166.6  / EP3202787
Fees paidRenewal fee
03.06.2020Renewal fee patent year 03
03.06.2020Renewal fee patent year 04
03.06.2020Renewal fee patent year 05
03.06.2020Renewal fee patent year 06
03.06.2020Renewal fee patent year 07
03.06.2020Renewal fee patent year 08
03.06.2020Renewal fee patent year 09
03.06.2020Renewal fee patent year 10
14.12.2020Renewal fee patent year 11
30.11.2021Renewal fee patent year 12
20.12.2022Renewal fee patent year 13
19.12.2023Renewal fee patent year 14
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[A]WO2005037235  (IMCLONE SYSTEMS INC [US], et al) [A] 1-11 * Examples 6 and 7 *;
 [A]US2007293430  (FRYE CHRISTOPHER C [US], et al) [A] 1-11* whole document, especially Examples 2-3 and Tables 1-2 *;
 [A]WO2008123625  (NAT INST OF ADVANCED IND SCIEN [JP], et al) [A] 1-11 * paragraphs [0002-0004]; page 5, last paragraph; page 6, (5), (7), (8); pages 27-28; Figure 14(4) *;
 [AP]US2010184665  (SUZUKI MASASHI [JP], et al) [AP] 1-11 * paragraphs [0002-0007], [0022-0024], [0030]; paragraph [0031], (5), (7), (8); paragraphs [0110], [0113], [0115]; Figure 14(4) *;
 [A]  - ANONYMOUS, "Monoclonal Anti-human/mouse Klotho beta Antibody", INTERNET CITATION, (20070206), page 1, URL: http://www.rndsystems.com/pdf/MAB3738.pdf, (20110221), XP002624719 [A] 1-11 * the whole document *
 [A]  - MASASHI SUZUKI ET AL, "betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c", MOLECULAR ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US, vol. 22, no. 4, doi:10.1210/ME.2007-0313, ISSN 0888-8809, (20080401), pages 1006 - 1014, (20080110), XP002624718 [A] 1-11 * whole document, especially the Abstract; Figure 3; Figure 2B *

DOI:   http://dx.doi.org/10.1210/ME.2007-0313
 [A]  - XU JING ET AL, "Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice", DIAB, AMERICAN DIABETES ASSOCIATION, US, (20090101), vol. 58, no. 1, doi:10.2337/DB08-0392, ISSN 0012-1797, pages 250 - 259, XP009144078 [A] 1-11 * whole document, especially the Abstract *

DOI:   http://dx.doi.org/10.2337/db08-0392
 [A]  - KHARITONENKOV ALEXEI ET AL, "THE METABOLIC STATE OF DIABETIC MONKEYS IS REGULATED BY FIBROBLAST GROWTH FACTOR-21", ENDOCRINO, THE ENDOCRINE SOCIETY, US, (20070201), vol. 148, no. 2, doi:10.1210/EN.2006-1168, ISSN 0013-7227, pages 774 - 781, XP009078947 [A] 1-11 * whole document, especially the Abstract *

DOI:   http://dx.doi.org/10.1210/en.2006-1168
by applicantUS3773919
 EP0036676
 EP0058481
 US4399216
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 WO8705330
 US4740461
 US4751180
 US4816567
 US4912040
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 US4935233
 US4946778
 US4959455
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 US4968607
 US5011912
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 WO9203918
 WO9215673
 WO9222646
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    - ITOH et al., Trend Genet., (20040000), vol. 20, pages 563 - 69
    - KHARITONENKOV et al., BioDrugs, (20080000), vol. 22, pages 37 - 44
    - KUROSU et al., J. Biol. Chem., (20070000), vol. 282, pages 26687 - 26695
    - OGAWA et al., Proc. Natl. Acad. Sci. USA, (20070000), vol. 104, pages 7432 - 7437
    - KHARITONENKOV et al., J. Cell Physiol., (20080000), vol. 215, pages 1 - 7
    - HONEGGERPLUCKTHUN, J. Mol. Biol., (20010000), vol. 309, pages 657 - 670
    - KOSTELNY et al., J. Immunol., (19920000), vol. 148, pages 1547 - 1553
    - SONGSIVILAILACHMANN, Clin. Exp. Immunol., (19900000), vol. 79, pages 315 - 321
    - KORNDORFER et al., Proteins: Structure, Function, and Bioinformatics, (20030000), vol. 53, no. 1, pages 121 - 129
    - ROQUE et al., Biotechnol. Prog., (20040000), vol. 20, pages 639 - 654
    - CHOTHIA et al., Nature, (19890000), vol. 334, pages 544 - 883
    - HOOGENBOOM et al., J. Mol. Biol., (19910000), vol. 227, page 381
    - CHOTHIALESK, J. Mol. Biol., (19870000), vol. 196, pages 901 - 917
    - LANDSCHULZ et al., Science, (19880000), vol. 242, pages 1759 - 1536
    - HUSTON et al., Proc. Natl. Acad. Sci. USA, (19880000), vol. 85, pages 5879 - 83
    - JAKOBOVITS et al., Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 2551 - 2555
    - POLJAK et al., Structure, (19940000), vol. 2, pages 1121 - 23
    - GRAHAM et al., Virology, (19730000), vol. 52, page 456
    - KRIANGKUM et al., Biomol. Eng., (20010000), vol. 18, pages 31 - 108
    - KIRKLAND et al., J. Immunol., (19860000), vol. 137, pages 3614 - 3619
    - CHU et al., Gene, (19810000), vol. 13, page 197
    - STAHLI et al., Methods in Enzymology, (19830000), vol. 9, pages 242 - 253
    - MOREL et al., Molec. Immunol., (19880000), vol. 25, pages 7 - 15
    - CHEUNG et al., Virology, (19900000), vol. 176, pages 546 - 552
    - MOLDENHAUER et al., Scand. J. Immunol., (19900000), vol. 32, pages 77 - 82
    - CARILLO et al., SIAM J. Applied Math., (19880000), vol. 48, page 1073
    - JAKOBOVITS et al., Nature, (19930000), vol. 362, pages 255 - 258
    - LONBERG et al., Nature, (19940000), vol. 368, pages 856 - 859
    - CHOTHIALESK, J. l lol. Biol., (19870000), vol. 196, pages 901 - 917
    - THOMSEN et al., Proc. Natl. Acad. U.S.A., (19840000), vol. 81, pages 659 - 663
    - CHOU et al., Adv. Enzymol. Relat. Areas Mol. Biol., (19780000), vol. 47, pages 345 - 148
    - HENIKOFF et al., Proc. Natl. Acad. Sci. U.S.A., (19920000), vol. 89, pages 10915 - 10919
    - NEEDLEMAN et al., J. Mol. Biol., (19700000), vol. 48, pages 443 - 453
    - GRIBSKOV et al., Proc. Nat. Acad. Sci., (19870000), vol. 196, pages 4355 - 4358
    - MORRISON et al., Proc. Natl. Acad. Sci. USA, (19850000), vol. 81, pages 6851 - 6855
    - JONES et al., Nature, (19860000), vol. 321, pages 522 - 525
    - RIECHMANN et al., Nature, (19880000), vol. 332, pages 323 - 27
    - BRUGGERMANN et al., Year in Immunol., (19930000), vol. 7, page 33
    - LONBERGHUSZAR, Intern. Rev. Immunol., (19950000), vol. 13, pages 65 - 93
    - HARDINGLONBERG, Ann. N.Y Acad. Sci., (19950000), vol. 764, pages 536 - 546
    - TAYLOR et al., Nucleic Acids Research, (19920000), vol. 20, pages 6287 - 6295
    - CHEN et al., International Immunology, (19930000), vol. 5, pages 647 - 656
    - TUAILLON et al., J. Immunol., (19940000), vol. 152, pages 2912 - 2920
    - TAYLOR et al., International Immunology, (19940000), vol. 113, pages 579 - 591
    - LONBERGHUSZAR, Intern. Rev. Immunol, (19950000), vol. 13, pages 65 - 93
    - FISHWILD et al., Nature Biotechnology, (19960000), vol. 14, pages 845 - 851
    - MENDEZ et al., Nature Genetics, (19970000), vol. 15, pages 146 - 156
    - MARKS et al., J. 1ol. Biol., (19910000), vol. 222, page 581
    - KYTE et al., J. Mol. Biol., (19820000), vol. 157, pages 105 - 131
    - MOULT, Curr. Op. in Biotech., (19960000), vol. 7, pages 422 - 427
    - CHOU et al., Biochem., (19740000), vol. 13, pages 222 - 245
    - CHOU et al., Biochemistry, (19740000), vol. 113, pages 211 - 222
    - CHOU et al., Ann. Rev. Biochem., (19790000), vol. 47, pages 251 - 276
    - CHOU et al., Biophys. J., (19790000), vol. 26, pages 367 - 384
    - HOLM et al., Nucl. Acid. Res., (19990000), vol. 27, pages 244 - 247
    - BRENNER et al., Curr. Op. Struct. Biol., (19970000), vol. 7, pages 369 - 376
    - JONES, Curr. Opin. Struct. Biol., (19970000), vol. 7, pages 377 - 387
    - SIPPL et al., Structure, (19960000), vol. 4, pages 15 - 19
    - BOWIE et al., Science, (19910000), vol. 253, pages 164 - 170
    - GRIBSKOV et al., Meth. Enzym., (19900000), vol. 183, pages 146 - 159
    - THORNTON et al., Nature, (19910000), vol. 354, page 105
    - FAUCHERE, Adv. Drug Res., (19860000), vol. 15, page 29
    - VEBERFREIDINGER, TINS, (19850000), page 392
    - EVANS et al., J. l\led. Chem., (19870000), vol. 30, page 1229
    - RIZOGIERASCH, Ann. Rev. Biochem., (19920000), vol. 61, page 387
    - HOPP et al., Bio/Technology, (19880000), vol. 6, page 1204
    - ASHKENAZI et al., Proc. Natl. Acad. Sci. USA, (19910000), vol. 88, page 10535
    - BYRN et al., Nature, (19900000), vol. 344, page 677
    - HOLLENBAUGH et al., "Construction of Immunoglobulin Fusion Proteins", Current Protocols in Immunology, (19920000), pages 10.19.1 - 10.19.11
    - BAUM et al., EMBO J., (19940000), vol. 13, pages 3992 - 4001
    - HOPPE et al., FEBS Letters, (19940000), vol. 344, page 191
    - FANSLOW et al., Semin. Immunol., (19940000), vol. 6, pages 267 - 278
    - APLINWRISTON, CRC Crit. Rev. Biochem., (19810000), pages 259 - 306
    - HAKIMUDDIN et al., Arch. Biochem. Biophys., (19870000), vol. 259, page 52
    - EDGE et al., Anal. Biochem., (19810000), vol. 118, page 131
    - THOTAKURA et al., Meth. Enzymol., (19870000), vol. 138, page 350
    - DUSKIN et al., J. Biol. Chem., (19820000), vol. 257, page 3105
    - CHALFIE et al., Science, (19940000), vol. 263, pages 802 - 805
    - STAUBER, Biotechniques, (19980000), vol. 24, pages 462 - 471
    - HEIM et al., Curr. Biol., (19960000), vol. 6, pages 178 - 182
    - ICHIKI et al., J. Immunol., (19930000), vol. 150, pages 5408 - 5417
    - HUSTON et al., Proc. Natl. Acad. Sci. U.S.A., (19880000), vol. 85, pages 5879 - 2607
    - KOHLERMILSTEIN, Nature, (19750000), vol. 256, page 495
    - KORTT et al., Proto Eng., (19970000), vol. 10, page 423
    - DE GRAAF et al., Methods Mol Biol., (20020000), vol. 178, pages 379 - 387
    - LANTTO et al., Methods tlo . Biol., (20020000), vol. 178, pages 303 - 316
    - BLOOM et al., Protein Science, (19970000), vol. 6, page 407
    - MARKS et al., BioTechnology, (19920000), vol. 10, page 779
    - YAMAMOTO et al., Cell, (19800000), vol. 22, pages 787 - 797
    - BIANCHIMCGREW, Biotech. Biotechnol. Bioeng., (20030000), vol. 84, pages 439 - 44
    - Remington's Pharmaceutical Sciences, Mack Publishing Company, (19900000), vol. 185
    - BENOISTCHAMBON, Nature, (19810000), vol. 290, pages 304 - 310
    - WAGNER et al., Proc. Natl. Acad. Sci. U.S.A., (19810000), vol. 78, pages 1444 - 1445
    - PRINSTER et al., Nature, (19820000), vol. 296, pages 39 - 42
    - VILLA-KAMAROFF et al., Proc. Natl. Acad. Sci. U.S.A., (19780000), vol. 75, pages 3727 - 3731
    - DEBOER et al., Proc. Natl. Acad. Sci. U.S.A., (19830000), vol. 80, pages 21 - 25
    - GROSSCHEDL et al., Cell, (19840000), vol. 38, pages 647 - 658
    - ORNITZ et al., Cold Spring Harbor Symp. Quant. Biol., (19860000), vol. 50, pages 399 - 409
    - MACDONALD, Hepatology, (19870000), vol. 7, pages 425 - 515
    - MOGRAM et al., Nature, (19850000), vol. 314, pages 283 - 286
    - ALEXANDER et al., Mol. Cell. Biol., (19870000), vol. 7, pages 1436 - 1444
    - KOLLIAS et al., Cell, (19860000), vol. 46, pages 485 - 495
    - PINKERT et al., Genes and Devel., (19870000), vol. 1, pages 161 - 171
    - KRUMLAUF et al., Mol. Cell. Biol., (19850000), vol. 5, pages 1639 - 1648
    - HAMMER et al., Science, (19870000), vol. 253, pages 53 - 58
    - READHEAD et al., Cell, (19870000), vol. 48, pages 703 - 712
    - MASON et al., Science, (19860000), vol. 234, pages 1372 - 1378
    - COSMAN et al., Nature, (19840000), vol. 312, page 768
    - TIJSSEN, Practice and Theoiy of Enzyme Immunoassays, John Wiley & Sons, (19930000), vol. 15
    - JALKANEN et al., J. Cell Biol., (19870000), vol. 105, pages 3087 - 3096
    - JALKANEN et al., J. Cell. Biol., (19850000), vol. 101, pages 976 - 985
    - SIDMAN et al., Biopolymers, (19830000), vol. 2, pages 547 - 556
    - LANGER et al., J. Biomed. Mater. Res., (19810000), vol. 15, pages 167 - 277
    - LANGER, Chem. Tech., (19820000), vol. 12, pages 98 - 105
    - EPPSTEIN et al., Proc. Natl. Acad. Sci. U.S.A., (19850000), vol. 82, pages 3688 - 3692
    - Invest. Ophthalmol Vis Sci, (20020000), vol. 43, pages 3292 - 3298
    - Proc. Natl. Acad. Sciences USA, (20060000), vol. 103, pages 3896 - 3901
    - KEARNEY et al., J. Immunol., (19790000), vol. 123, pages 1548 - 1550
    - KUROSU et al., 7. Biol. Chem., (20070000), vol. 282, pages 26687 - 26695
    - NANEVICZ et al., J. Biol. Chem., (19950000), vol. 270, no. 37, pages 21619 - 21625
    - ZUPNICK et al., J. Biol. Chem., (20060000), vol. 281, no. 29, pages 20464 - 20473
 US20210612673
 US19460613818
 WO1993US00829
 WO1994US01875
 US19960759620
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.