EP3764098 - INFLUENZA POTENCY ASSAYS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 22.09.2023 Database last updated on 04.06.2024 | |
Former | The patent has been granted Status updated on 14.10.2022 | ||
Former | Grant of patent is intended Status updated on 10.07.2022 | ||
Former | Examination is in progress Status updated on 27.06.2022 | ||
Former | Grant of patent is intended Status updated on 15.02.2022 | ||
Former | Examination is in progress Status updated on 06.08.2021 | ||
Former | Request for examination was made Status updated on 16.07.2021 | ||
Former | The application has been published Status updated on 11.12.2020 | Most recent event Tooltip | 24.05.2024 | Lapse of the patent in a contracting state New state(s): CH, IT | published on 26.06.2024 [2024/26] | Applicant(s) | For all designated states Seqirus UK Limited Point Level 3, 29 Market Street Maidenhead, Berkshire SL6 8AA / GB | [2021/02] | Inventor(s) | 01 /
WEN, Yingxia Waltham, MA 02451 / US | 02 /
SETTEMBRE, Ethan C. Waltham, MA 02451 / US | 03 /
WANG, Zihao Waltham, MA 02451 / US | [2022/45] |
Former [2021/02] | 01 /
WEN, Yingxia c/o Seqirus 45 Sidney Street Cambridge, MA 02139 / US | ||
02 /
SETTEMBRE, Ethan C. c/o Seqirus 45 Sidney Street Cambridge, MA 02139 / US | |||
03 /
WANG, Zihao c/o Seqirus 45 Sidney Street Cambridge, MA 02139 / US | Representative(s) | Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB | [2022/46] |
Former [2021/02] | Wise, Daniel Joseph Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB | Application number, filing date | 20193293.6 | 07.07.2016 | [2021/02] | Priority number, date | EP20150175765 | 07.07.2015 Original published format: EP 15175765 | EP20160152829 | 26.01.2016 Original published format: EP 16152829 | [2021/02] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP3764098 | Date: | 13.01.2021 | Language: | EN | [2021/02] | Type: | B1 Patent specification | No.: | EP3764098 | Date: | 16.11.2022 | Language: | EN | [2022/46] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 07.10.2020 | Classification | IPC: | G01N33/569, G01N33/68 | [2021/02] | CPC: |
G01N33/6848 (EP,CN,KR,US);
A61K39/12 (CN);
A61K39/145 (KR,US);
A61P31/16 (EP,CN);
C12N7/00 (US);
G01N27/447 (CN);
G01N27/62 (CN);
G01N30/02 (CN);
G01N30/7266 (KR);
G01N33/56983 (EP,CN,US);
C12N2760/16034 (US);
C12N2760/16051 (US);
C12N2760/16134 (CN);
G01N2030/8831 (KR);
G01N2333/11 (EP,CN,KR,US);
G01N2458/15 (KR)
(-)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2021/33] |
Former [2021/02] | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR | Title | German: | INFLUENZA-STÄRKE-ASSAYS | [2021/02] | English: | INFLUENZA POTENCY ASSAYS | [2021/02] | French: | DOSAGE DE LA PUISSANCE DE LA GRIPPE | [2022/31] |
Former [2021/02] | DOSAGE DE LA PUISSANCE DE LA GRIPPE | Examination procedure | 13.07.2021 | Amendment by applicant (claims and/or description) | 13.07.2021 | Examination requested [2021/33] | 13.07.2021 | Date on which the examining division has become responsible | 10.08.2021 | Despatch of a communication from the examining division (Time limit: M04) | 20.12.2021 | Reply to a communication from the examining division | 16.02.2022 | Communication of intention to grant the patent | 24.06.2022 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 11.07.2022 | Communication of intention to grant the patent | 23.09.2022 | Fee for grant paid | 23.09.2022 | Fee for publishing/printing paid | 23.09.2022 | Receipt of the translation of the claim(s) | Parent application(s) Tooltip | EP16738395.9 / EP3320343 | Opposition(s) | 17.08.2023 | No opposition filed within time limit [2023/43] | Fees paid | Renewal fee | 28.08.2020 | Renewal fee patent year 03 | 28.08.2020 | Renewal fee patent year 04 | 28.08.2020 | Renewal fee patent year 05 | 27.07.2021 | Renewal fee patent year 06 | 27.07.2022 | Renewal fee patent year 07 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | AL | 16.11.2022 | AT | 16.11.2022 | CZ | 16.11.2022 | DK | 16.11.2022 | EE | 16.11.2022 | ES | 16.11.2022 | FI | 16.11.2022 | HR | 16.11.2022 | IT | 16.11.2022 | LT | 16.11.2022 | LV | 16.11.2022 | MC | 16.11.2022 | PL | 16.11.2022 | RO | 16.11.2022 | RS | 16.11.2022 | SE | 16.11.2022 | SI | 16.11.2022 | SK | 16.11.2022 | SM | 16.11.2022 | NO | 16.02.2023 | GR | 17.02.2023 | IS | 16.03.2023 | PT | 16.03.2023 | LU | 07.07.2023 | CH | 31.07.2023 | [2024/26] |
Former [2024/18] | AL | 16.11.2022 | |
AT | 16.11.2022 | ||
CZ | 16.11.2022 | ||
DK | 16.11.2022 | ||
EE | 16.11.2022 | ||
ES | 16.11.2022 | ||
FI | 16.11.2022 | ||
HR | 16.11.2022 | ||
LT | 16.11.2022 | ||
LV | 16.11.2022 | ||
MC | 16.11.2022 | ||
PL | 16.11.2022 | ||
RO | 16.11.2022 | ||
RS | 16.11.2022 | ||
SE | 16.11.2022 | ||
SI | 16.11.2022 | ||
SK | 16.11.2022 | ||
SM | 16.11.2022 | ||
NO | 16.02.2023 | ||
GR | 17.02.2023 | ||
IS | 16.03.2023 | ||
PT | 16.03.2023 | ||
LU | 07.07.2023 | ||
Former [2024/14] | AL | 16.11.2022 | |
AT | 16.11.2022 | ||
CZ | 16.11.2022 | ||
DK | 16.11.2022 | ||
EE | 16.11.2022 | ||
ES | 16.11.2022 | ||
FI | 16.11.2022 | ||
HR | 16.11.2022 | ||
LT | 16.11.2022 | ||
LV | 16.11.2022 | ||
MC | 16.11.2022 | ||
PL | 16.11.2022 | ||
RO | 16.11.2022 | ||
RS | 16.11.2022 | ||
SE | 16.11.2022 | ||
SI | 16.11.2022 | ||
SK | 16.11.2022 | ||
SM | 16.11.2022 | ||
NO | 16.02.2023 | ||
GR | 17.02.2023 | ||
IS | 16.03.2023 | ||
PT | 16.03.2023 | ||
Former [2023/51] | AL | 16.11.2022 | |
AT | 16.11.2022 | ||
CZ | 16.11.2022 | ||
DK | 16.11.2022 | ||
EE | 16.11.2022 | ||
ES | 16.11.2022 | ||
FI | 16.11.2022 | ||
HR | 16.11.2022 | ||
LT | 16.11.2022 | ||
LV | 16.11.2022 | ||
PL | 16.11.2022 | ||
RO | 16.11.2022 | ||
RS | 16.11.2022 | ||
SE | 16.11.2022 | ||
SI | 16.11.2022 | ||
SK | 16.11.2022 | ||
SM | 16.11.2022 | ||
NO | 16.02.2023 | ||
GR | 17.02.2023 | ||
IS | 16.03.2023 | ||
PT | 16.03.2023 | ||
Former [2023/38] | AL | 16.11.2022 | |
AT | 16.11.2022 | ||
CZ | 16.11.2022 | ||
DK | 16.11.2022 | ||
EE | 16.11.2022 | ||
ES | 16.11.2022 | ||
FI | 16.11.2022 | ||
HR | 16.11.2022 | ||
LT | 16.11.2022 | ||
LV | 16.11.2022 | ||
PL | 16.11.2022 | ||
RO | 16.11.2022 | ||
RS | 16.11.2022 | ||
SE | 16.11.2022 | ||
SK | 16.11.2022 | ||
SM | 16.11.2022 | ||
NO | 16.02.2023 | ||
GR | 17.02.2023 | ||
IS | 16.03.2023 | ||
PT | 16.03.2023 | ||
Former [2023/37] | AL | 16.11.2022 | |
AT | 16.11.2022 | ||
CZ | 16.11.2022 | ||
DK | 16.11.2022 | ||
EE | 16.11.2022 | ||
ES | 16.11.2022 | ||
FI | 16.11.2022 | ||
HR | 16.11.2022 | ||
LT | 16.11.2022 | ||
LV | 16.11.2022 | ||
PL | 16.11.2022 | ||
RO | 16.11.2022 | ||
RS | 16.11.2022 | ||
SE | 16.11.2022 | ||
SM | 16.11.2022 | ||
NO | 16.02.2023 | ||
GR | 17.02.2023 | ||
IS | 16.03.2023 | ||
PT | 16.03.2023 | ||
Former [2023/35] | AT | 16.11.2022 | |
CZ | 16.11.2022 | ||
DK | 16.11.2022 | ||
EE | 16.11.2022 | ||
ES | 16.11.2022 | ||
FI | 16.11.2022 | ||
HR | 16.11.2022 | ||
LT | 16.11.2022 | ||
LV | 16.11.2022 | ||
PL | 16.11.2022 | ||
RO | 16.11.2022 | ||
RS | 16.11.2022 | ||
SE | 16.11.2022 | ||
SM | 16.11.2022 | ||
NO | 16.02.2023 | ||
GR | 17.02.2023 | ||
IS | 16.03.2023 | ||
PT | 16.03.2023 | ||
Former [2023/34] | AT | 16.11.2022 | |
DK | 16.11.2022 | ||
EE | 16.11.2022 | ||
ES | 16.11.2022 | ||
FI | 16.11.2022 | ||
HR | 16.11.2022 | ||
LT | 16.11.2022 | ||
LV | 16.11.2022 | ||
PL | 16.11.2022 | ||
RS | 16.11.2022 | ||
SE | 16.11.2022 | ||
SM | 16.11.2022 | ||
NO | 16.02.2023 | ||
GR | 17.02.2023 | ||
IS | 16.03.2023 | ||
PT | 16.03.2023 | ||
Former [2023/33] | AT | 16.11.2022 | |
DK | 16.11.2022 | ||
ES | 16.11.2022 | ||
FI | 16.11.2022 | ||
HR | 16.11.2022 | ||
LT | 16.11.2022 | ||
LV | 16.11.2022 | ||
PL | 16.11.2022 | ||
RS | 16.11.2022 | ||
SE | 16.11.2022 | ||
SM | 16.11.2022 | ||
NO | 16.02.2023 | ||
GR | 17.02.2023 | ||
IS | 16.03.2023 | ||
PT | 16.03.2023 | ||
Former [2023/25] | AT | 16.11.2022 | |
ES | 16.11.2022 | ||
FI | 16.11.2022 | ||
HR | 16.11.2022 | ||
LT | 16.11.2022 | ||
LV | 16.11.2022 | ||
PL | 16.11.2022 | ||
RS | 16.11.2022 | ||
SE | 16.11.2022 | ||
NO | 16.02.2023 | ||
GR | 17.02.2023 | ||
IS | 16.03.2023 | ||
PT | 16.03.2023 | ||
Former [2023/23] | AT | 16.11.2022 | |
ES | 16.11.2022 | ||
FI | 16.11.2022 | ||
LT | 16.11.2022 | ||
LV | 16.11.2022 | ||
SE | 16.11.2022 | ||
NO | 16.02.2023 | ||
GR | 17.02.2023 | ||
PT | 16.03.2023 | ||
Former [2023/22] | AT | 16.11.2022 | |
ES | 16.11.2022 | ||
FI | 16.11.2022 | ||
LT | 16.11.2022 | ||
SE | 16.11.2022 | ||
NO | 16.02.2023 | ||
PT | 16.03.2023 | ||
Former [2023/20] | LT | 16.11.2022 | |
NO | 16.02.2023 | Documents cited: | Search | [I]US5858368 (SMITH GALE E [US], et al) [I] 1-15 * the whole document * * examples 6, 7 *; | [XA] - H KANG, "Development of LC-MS method for quantification of haemagglutinin in influenza vaccine", FEBS JOURNAL, (20140901), vol. 281, no. Suppl. 1, page 113, XP055233341 [X] 1-6,9-15 * abstract * [A] 7,8 | [IA] - WEI CHIH-JEN ET AL, "Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, (20080701), vol. 82, no. 13, doi:10.1128/JVI.00187-08, ISSN 0022-538X, pages 6200 - 6208, XP009138042 [I] 1-6,9-15 * the whole document * * abstract * [A] 7,8 DOI: http://dx.doi.org/10.1128/JVI.00187-08 | [X] - A. CERIOTTI ET AL, "Trimer formation determines the rate of influenza virus haemagglutinin transport in the early stages of secretion in Xenopus oocytes", THE JOURNAL OF CELL BIOLOGY : JCB, US, (19900801), vol. 111, no. 2, doi:10.1083/jcb.111.2.409, ISSN 0021-9525, pages 409 - 420, XP055233340 [X] 1-15 * the whole document * * page 414; table 1 * DOI: http://dx.doi.org/10.1083/jcb.111.2.409 | [XP] - WEN YINGXIA ET AL, "Conformationally selective biophysical assay for influenza vaccine potency determination", VACCINE, (20150906), vol. 33, no. 41, doi:10.1016/J.VACCINE.2015.08.077, ISSN 0264-410X, pages 5342 - 5349, XP029277477 [XP] 1-15 * the whole document * DOI: http://dx.doi.org/10.1016/j.vaccine.2015.08.077 | [IP] - WEN YINGXIA ET AL, "Trypsin pre-treatment corrects SRID over-estimation of immunologically active, pre-fusion HA caused by mixed immunoprecipitin rings", VACCINE, ELSEVIER, AMSTERDAM, NL, (20160504), vol. 34, no. 29, doi:10.1016/J.VACCINE.2016.04.091, ISSN 0264-410X, pages 3388 - 3395, XP029596068 [IP] 1-15 * the whole document * * abstract * DOI: http://dx.doi.org/10.1016/j.vaccine.2016.04.091 | by applicant | WO9014837 | WO9511700 | WO9637624 | WO9737000 | WO9737001 | WO9846262 | US5948410 | US6080725 | WO0060050 | EP0870508 | WO0104333 | WO0121151 | WO0122992 | WO0164846 | WO0183794 | WO0185938 | WO0228422 | WO02067983 | WO02074336 | EP1260581 | WO02097072 | WO03023021 | WO03023025 | WO03043415 | WO03076601 | US6630161 | US6635452 | US6649354 | US6649372 | WO2005042728 | WO2005097181 | WO2005113756 | WO2005113758 | WO2006027698 | WO2006067211 | WO2006071563 | WO2006108846 | WO2006113373 | US7132519 | US2007014805 | WO2007052163 | US2007191314 | WO2008043774 | WO2009000891 | WO2009110873 | WO2010052214 | WO2010136896 | WO2013087945 | WO2014141125 | - WILLIAMS, M. S., "Single-radial-immunodiffusion as an in vitro potency assay for human inactivated viral vaccines", Vet Microbiol, (19930000), vol. 37, no. 3-4, doi:10.1016/0378-1135(93)90027-5, pages 253 - 262, XP023914316 DOI: http://dx.doi.org/10.1016/0378-1135(93)90027-5 | - FITZGERALDNEEDY, Dev Biol Stand, (19860000), vol. 64, pages 73 - 79 | - KAPTEYN et al., Vaccine, (20090000), vol. 27, pages 1468 - 77 | - LORBETSKIE et al., Vaccine, (20110000), vol. 29, pages 3377 - 89 | - WILLIAMSA et al., Vaccine, (20080000), vol. 26, pages 2510 - 20 | - SANTANA et al., Anal Chem, (20140000), vol. 86, pages 4088 - 95 | - BODLE et al., Influenza Other Respir Viruses, (20130000), vol. 7, pages 191 - 200 | - SKEHEL et al., Proc Natl Acad Sci USA, (19820000), vol. 79, pages 968 - 72 | - BOTTCHER et al., J Virol, (20061000), vol. 80, no. 19, pages 9896 - 9898 | - KAPTEYN et al., Vaccine, (20060000), vol. 24, pages 3137 - 44 | - PICOTTIAEBERSOLD, Nat Methods, (20120000), vol. 9, pages 555 - 66 | - HUCKRIEDE et al., Methods Enzymol, (20030000), vol. 373, pages 74 - 91 | - HERLOCHER et al., J Infect Dis, (20040000), vol. 190, no. 9, pages 1627 - 30 | - LE et al., Nature, (20050000), vol. 437, no. 7062, page 1108 | - KISTNER et al., Dev Biol Stand, (19990000), vol. 98, pages 101 - 110 | - HOFFMANN et al., Vaccine, (20020000), vol. 20, pages 3165 - 3170 | - POLAND, G. A.S. T. ROTTINGHAUSR. M. JACOBSON, "Influenza vaccines: a review and rationale for use in developed and underdeveloped countries", Vaccine, (20010000), vol. 19, no. 17-19, doi:10.1016/S0264-410X(00)00448-5, pages 2216 - 2220, XP004231024 DOI: http://dx.doi.org/10.1016/S0264-410X(00)00448-5 | - KISTNER et al., Vaccine, (19980000), vol. 16, pages 960 - 8 | - BRUHL et al., Vaccine, (20000000), vol. 19, pages 1149 - 58 | - LUNDBLAD, Biotechnology and Applied Biochemistry, (20010000), vol. 34, pages 195 - 197 | - JI et al., Biotechniques, (20020000), vol. 32, pages 1162 - 7 | - BRIGGS, J Parenter Sci Technol, (19910000), vol. 45, pages 7 - 12 | - LAHIJANI et al., Hum Gene Ther, (19980000), vol. 9, pages 1173 - 80 | - LOKTEFF et al., Biologicals, (20010000), vol. 29, pages 123 - 32 | - SUBBARAO et al., Virology, (20030000), vol. 314, pages 580 - 590 | - OZAKI et al., J. Virol., (20040000), vol. 78, pages 1851 - 1857 | - WEBBY et al., Lancet, (20040000), vol. 363, pages 1099 - 1103 | - NEUMANN et al., Proc Natl Acad Sci USA, (20050000), vol. 102, pages 16825 - 9 | - HOFFMANN et al., Virology, (20000000), vol. 267, no. 2, pages 310 - 7 | - HEHME et al., Virus Res, (20040000), vol. 103, no. 1-2, pages 163 - 71 | - TREANOR et al., J Infect Dis, (19960000), vol. 173, pages 1467 - 70 | - KEITEL et al., Clin Diagn Lab Immunol, (19960000), vol. 3, pages 507 - 10 | - BANZHOFF, Immunology Letters, (20000000), vol. 71, pages 91 - 96 | - PODDADEL GIUDICE, Expert Rev Vaccines, (20030000), vol. 2, pages 197 - 203 | - HARIHARAN et al., Cancer Res, (19950000), vol. 55, pages 3486 - 9 | - "Vaccine Adjuvants: Preparation Methods and Research Protocols", Methods in Molecular Medicine series, vol. 42 | - FOX et al., Vaccine, (20130000), vol. 31, pages 1633 - 1640 | - ALLISONBYARS, Res Immunol, (19920000), vol. 143, pages 519 - 25 | - SULI et al., Vaccine, (20040000), vol. 22, no. 25-26, pages 3464 - 9 | - SETTEMBRE et al., Hum Vaccin Immunother, (20140000), vol. 10, pages 600 - 4 | - BRAND, C. M.J. J. SKEHEL, "Crystalline antigen from the influenza virus envelope", Nat New Biol, (19720000), vol. 238, no. 83, doi:10.1038/238145a0, pages 145 - 147, XP009057291 DOI: http://dx.doi.org/10.1038/238145a0 | - BULLOUGH, P. A.F. M. HUGHSONJ. J. SKEHELD. C. WILEY, "Structure of influenza haemagglutinin at the pH of membrane fusion", Nature, (19940000), vol. 371, no. 6492, doi:10.1038/371037a0, pages 37 - 43, XP037115416 DOI: http://dx.doi.org/10.1038/371037a0 | - ENNIS, F. A.R. E. MAYNERD. W. BARRYJ. E. MANISCHEWITZR. C. DUNLAPM. W. VERBONITZR. M. BOZEMANG. C. SCHILD, "Correlation of laboratory studies with clinical responses to A/New Jersey influenza vaccines", J Infect Dis, (19770000), vol. 136, pages S397 - 406 | - KNOSSOW, M.M. GAUDIERA. DOUGLASB. BARRERET. BIZEBARDC. BARBEYB. GIGANTJ. J. SKEHEL, "Mechanism of neutralization of influenza virus infectivity by antibodies", Virology, (20020000), vol. 302, no. 2, doi:10.1006/viro.2002.1625, pages 294 - 298, XP002683777 DOI: http://dx.doi.org/10.1006/viro.2002.1625 | - LA MONTAGNE, J. R.G. R. NOBLEG. V. QUINNANG. T. CURLINW. C. BLACKWELDERJ. I. SMITHF. A. ENNISF. M. BOZEMAN, "Summary of clinical trials of inactivated influenza vaccine - 1978", Rev Infect Dis, (19830000), vol. 5, no. 4, pages 723 - 736 | - MINOR, P. D., "Assaying the Potency of Influenza Vaccines", Vaccines, (20150000), vol. 3, pages 90 - 104 | - QUAN, F. S.Z. N. LIM. C. KIMD. YANGR. W. COMPANSD. A. STEINHAUERS. M. KANG, "Immunogenicity of low-pH treated whole viral influenza vaccine", Virology, (20110000), vol. 417, no. 1, doi:10.1016/j.virol.2011.05.014, pages 196 - 202, XP028252094 DOI: http://dx.doi.org/10.1016/j.virol.2011.05.014 | - RUIGROK, R. W.A. AITKENL. J. CALDERS. R. MARTINJ. J. SKEHELS. A. WHARTONW. WEISD. C. WILEY, "Studies on the structure of the influenza virus haemagglutinin at the pH of membrane fusion", J Gen Virol, (19880000), vol. 69, no. 11, pages 2785 - 2795 | - RUIGROK, R. W.S. R. MARTINS. A. WHARTONJ. J. SKEHELP. M. BAYLEYD. C. WILEY, "Conformational changes in the hemagglutinin of influenza virus which accompany heat-induced fusion of virus with liposomes", Virology, (19860000), vol. 155, no. 2, doi:10.1016/0042-6822(86)90210-2, pages 484 - 497, XP023050114 DOI: http://dx.doi.org/10.1016/0042-6822(86)90210-2 | - SCHILD, G. C.J. M. WOODR. W. NEWMAN, "A single-radial-immunodiffusion technique for the assay of influenza haemagglutinin antigen. Proposals for an assay method for the haemagglutinin content of influenza vaccines", Bull World Health Organ, (19750000), vol. 52, no. 2, pages 223 - 231 | - SKEHEL, J. J.P. M. BAYLEYE. B. BROWNS. R. MARTINM. D. WATERFIELDJ. M. WHITEI. A. WILSOND. C. WILEY, "Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion", Proc Natl Acad Sci U S A, (19820000), vol. 79, no. 4, pages 968 - 972 | - SKEHEL, J. J.D. C. WILEY, "Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin", Annu Rev Biochem, (20000000), vol. 69, pages 531 - 569 | - TAY, T.C. AGIUSR. HAMILTONJ. BODLES. ROCKMAN, "Investigation into alternative testing methodologies for characterization of influenza virus vaccine", Hum Vaccin Immunother, (20150000), vol. 11, no. 7, pages 1673 - 1684 | - WEN, Y.L. HANG. PALLADINOA. FERRARIY. XIEA. CARFIP. R. DORMITZERE. C. SETTEMBRE, "Conformationally selective biophysical assay for influenza vaccine potency determination", Vaccine, (20150000), vol. 33, no. 41, doi:10.1016/j.vaccine.2015.08.077, pages 5342 - 5349, XP029277477 DOI: http://dx.doi.org/10.1016/j.vaccine.2015.08.077 | - WHARTON, S. A.J. J. SKEHELD. C. WILEY, "Studies of influenza haemagglutinin-mediated membrane fusion", Virology, (19860000), vol. 149, no. 1, doi:10.1016/0042-6822(86)90083-8, pages 27 - 35, XP023048687 DOI: http://dx.doi.org/10.1016/0042-6822(86)90083-8 | - WILEY, D. C.J. J. SKEHEL, "Crystallization and x-ray diffraction studies on the haemagglutinin glycoprotein from the membrane of influenza virus", J Mol Biol, (19770000), vol. 112, no. 2, pages 343 - 347 | - WILEY, D. C.I. A. WILSONJ. J. SKEHEL, "Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation", Nature, (19810000), vol. 289, no. 5796, doi:10.1038/289373a0, pages 373 - 378, XP037135084 DOI: http://dx.doi.org/10.1038/289373a0 | - WILSON, I. A.J. J. SKEHELD. C. WILEY, "Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution", Nature, (19810000), vol. 289, no. 5796, doi:10.1038/289366a0, pages 366 - 373, XP002689324 DOI: http://dx.doi.org/10.1038/289366a0 | - WOOD, J. M.G. C. SCHILDR. W. NEWMANV. SEAGROATT, "An improved single-radial-immunodiffusion technique for the assay of influenza haemagglutinin antigen: application for potency determinations of inactivated whole virus and subunit vaccines", J Biol Stand, (19770000), vol. 5, no. 3, pages 237 - 247 | - ZAMBON, M. C., "Epidemiology and pathogenesis of influenza", J Antimicrob Chemother, (19990000), vol. 44, no. B, pages 3 - 9 | - MINOR, PHILIP D., "Assaying the potency of influenza vaccines", Vaccines, (20150000), vol. 3, pages 90 - 104 | EP20150175765 | EP20160152829 |