blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP3764098

EP3764098 - INFLUENZA POTENCY ASSAYS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  22.09.2023
Database last updated on 04.06.2024
FormerThe patent has been granted
Status updated on  14.10.2022
FormerGrant of patent is intended
Status updated on  10.07.2022
FormerExamination is in progress
Status updated on  27.06.2022
FormerGrant of patent is intended
Status updated on  15.02.2022
FormerExamination is in progress
Status updated on  06.08.2021
FormerRequest for examination was made
Status updated on  16.07.2021
FormerThe application has been published
Status updated on  11.12.2020
Most recent event   Tooltip24.05.2024Lapse of the patent in a contracting state
New state(s): CH, IT
published on 26.06.2024 [2024/26]
Applicant(s)For all designated states
Seqirus UK Limited
Point
Level 3, 29 Market Street
Maidenhead, Berkshire SL6 8AA / GB
[2021/02]
Inventor(s)01 / WEN, Yingxia
Waltham, MA 02451 / US
02 / SETTEMBRE, Ethan C.
Waltham, MA 02451 / US
03 / WANG, Zihao
Waltham, MA 02451 / US
 [2022/45]
Former [2021/02]01 / WEN, Yingxia
c/o Seqirus
45 Sidney Street
Cambridge, MA 02139 / US
02 / SETTEMBRE, Ethan C.
c/o Seqirus
45 Sidney Street
Cambridge, MA 02139 / US
03 / WANG, Zihao
c/o Seqirus
45 Sidney Street
Cambridge, MA 02139 / US
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2022/46]
Former [2021/02]Wise, Daniel Joseph
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
Application number, filing date20193293.607.07.2016
[2021/02]
Priority number, dateEP2015017576507.07.2015         Original published format: EP 15175765
EP2016015282926.01.2016         Original published format: EP 16152829
[2021/02]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3764098
Date:13.01.2021
Language:EN
[2021/02]
Type: B1 Patent specification 
No.:EP3764098
Date:16.11.2022
Language:EN
[2022/46]
Search report(s)(Supplementary) European search report - dispatched on:EP07.10.2020
ClassificationIPC:G01N33/569, G01N33/68
[2021/02]
CPC:
G01N33/6848 (EP,CN,KR,US); A61K39/12 (CN); A61K39/145 (KR,US);
A61P31/16 (EP,CN); C12N7/00 (US); G01N27/447 (CN);
G01N27/62 (CN); G01N30/02 (CN); G01N30/7266 (KR);
G01N33/56983 (EP,CN,US); C12N2760/16034 (US); C12N2760/16051 (US);
C12N2760/16134 (CN); G01N2030/8831 (KR); G01N2333/11 (EP,CN,KR,US);
G01N2458/15 (KR) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/33]
Former [2021/02]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:INFLUENZA-STÄRKE-ASSAYS[2021/02]
English:INFLUENZA POTENCY ASSAYS[2021/02]
French:DOSAGE DE LA PUISSANCE DE LA GRIPPE[2022/31]
Former [2021/02]DOSAGE DE LA PUISSANCE DE LA GRIPPE
Examination procedure13.07.2021Amendment by applicant (claims and/or description)
13.07.2021Examination requested  [2021/33]
13.07.2021Date on which the examining division has become responsible
10.08.2021Despatch of a communication from the examining division (Time limit: M04)
20.12.2021Reply to a communication from the examining division
16.02.2022Communication of intention to grant the patent
24.06.2022Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
11.07.2022Communication of intention to grant the patent
23.09.2022Fee for grant paid
23.09.2022Fee for publishing/printing paid
23.09.2022Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP16738395.9  / EP3320343
Opposition(s)17.08.2023No opposition filed within time limit [2023/43]
Fees paidRenewal fee
28.08.2020Renewal fee patent year 03
28.08.2020Renewal fee patent year 04
28.08.2020Renewal fee patent year 05
27.07.2021Renewal fee patent year 06
27.07.2022Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL16.11.2022
AT16.11.2022
CZ16.11.2022
DK16.11.2022
EE16.11.2022
ES16.11.2022
FI16.11.2022
HR16.11.2022
IT16.11.2022
LT16.11.2022
LV16.11.2022
MC16.11.2022
PL16.11.2022
RO16.11.2022
RS16.11.2022
SE16.11.2022
SI16.11.2022
SK16.11.2022
SM16.11.2022
NO16.02.2023
GR17.02.2023
IS16.03.2023
PT16.03.2023
LU07.07.2023
CH31.07.2023
[2024/26]
Former [2024/18]AL16.11.2022
AT16.11.2022
CZ16.11.2022
DK16.11.2022
EE16.11.2022
ES16.11.2022
FI16.11.2022
HR16.11.2022
LT16.11.2022
LV16.11.2022
MC16.11.2022
PL16.11.2022
RO16.11.2022
RS16.11.2022
SE16.11.2022
SI16.11.2022
SK16.11.2022
SM16.11.2022
NO16.02.2023
GR17.02.2023
IS16.03.2023
PT16.03.2023
LU07.07.2023
Former [2024/14]AL16.11.2022
AT16.11.2022
CZ16.11.2022
DK16.11.2022
EE16.11.2022
ES16.11.2022
FI16.11.2022
HR16.11.2022
LT16.11.2022
LV16.11.2022
MC16.11.2022
PL16.11.2022
RO16.11.2022
RS16.11.2022
SE16.11.2022
SI16.11.2022
SK16.11.2022
SM16.11.2022
NO16.02.2023
GR17.02.2023
IS16.03.2023
PT16.03.2023
Former [2023/51]AL16.11.2022
AT16.11.2022
CZ16.11.2022
DK16.11.2022
EE16.11.2022
ES16.11.2022
FI16.11.2022
HR16.11.2022
LT16.11.2022
LV16.11.2022
PL16.11.2022
RO16.11.2022
RS16.11.2022
SE16.11.2022
SI16.11.2022
SK16.11.2022
SM16.11.2022
NO16.02.2023
GR17.02.2023
IS16.03.2023
PT16.03.2023
Former [2023/38]AL16.11.2022
AT16.11.2022
CZ16.11.2022
DK16.11.2022
EE16.11.2022
ES16.11.2022
FI16.11.2022
HR16.11.2022
LT16.11.2022
LV16.11.2022
PL16.11.2022
RO16.11.2022
RS16.11.2022
SE16.11.2022
SK16.11.2022
SM16.11.2022
NO16.02.2023
GR17.02.2023
IS16.03.2023
PT16.03.2023
Former [2023/37]AL16.11.2022
AT16.11.2022
CZ16.11.2022
DK16.11.2022
EE16.11.2022
ES16.11.2022
FI16.11.2022
HR16.11.2022
LT16.11.2022
LV16.11.2022
PL16.11.2022
RO16.11.2022
RS16.11.2022
SE16.11.2022
SM16.11.2022
NO16.02.2023
GR17.02.2023
IS16.03.2023
PT16.03.2023
Former [2023/35]AT16.11.2022
CZ16.11.2022
DK16.11.2022
EE16.11.2022
ES16.11.2022
FI16.11.2022
HR16.11.2022
LT16.11.2022
LV16.11.2022
PL16.11.2022
RO16.11.2022
RS16.11.2022
SE16.11.2022
SM16.11.2022
NO16.02.2023
GR17.02.2023
IS16.03.2023
PT16.03.2023
Former [2023/34]AT16.11.2022
DK16.11.2022
EE16.11.2022
ES16.11.2022
FI16.11.2022
HR16.11.2022
LT16.11.2022
LV16.11.2022
PL16.11.2022
RS16.11.2022
SE16.11.2022
SM16.11.2022
NO16.02.2023
GR17.02.2023
IS16.03.2023
PT16.03.2023
Former [2023/33]AT16.11.2022
DK16.11.2022
ES16.11.2022
FI16.11.2022
HR16.11.2022
LT16.11.2022
LV16.11.2022
PL16.11.2022
RS16.11.2022
SE16.11.2022
SM16.11.2022
NO16.02.2023
GR17.02.2023
IS16.03.2023
PT16.03.2023
Former [2023/25]AT16.11.2022
ES16.11.2022
FI16.11.2022
HR16.11.2022
LT16.11.2022
LV16.11.2022
PL16.11.2022
RS16.11.2022
SE16.11.2022
NO16.02.2023
GR17.02.2023
IS16.03.2023
PT16.03.2023
Former [2023/23]AT16.11.2022
ES16.11.2022
FI16.11.2022
LT16.11.2022
LV16.11.2022
SE16.11.2022
NO16.02.2023
GR17.02.2023
PT16.03.2023
Former [2023/22]AT16.11.2022
ES16.11.2022
FI16.11.2022
LT16.11.2022
SE16.11.2022
NO16.02.2023
PT16.03.2023
Former [2023/20]LT16.11.2022
NO16.02.2023
Documents cited:Search[I]US5858368  (SMITH GALE E [US], et al) [I] 1-15 * the whole document * * examples 6, 7 *;
 [XA]  - H KANG, "Development of LC-MS method for quantification of haemagglutinin in influenza vaccine", FEBS JOURNAL, (20140901), vol. 281, no. Suppl. 1, page 113, XP055233341 [X] 1-6,9-15 * abstract * [A] 7,8
 [IA]  - WEI CHIH-JEN ET AL, "Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, (20080701), vol. 82, no. 13, doi:10.1128/JVI.00187-08, ISSN 0022-538X, pages 6200 - 6208, XP009138042 [I] 1-6,9-15 * the whole document * * abstract * [A] 7,8

DOI:   http://dx.doi.org/10.1128/JVI.00187-08
 [X]  - A. CERIOTTI ET AL, "Trimer formation determines the rate of influenza virus haemagglutinin transport in the early stages of secretion in Xenopus oocytes", THE JOURNAL OF CELL BIOLOGY : JCB, US, (19900801), vol. 111, no. 2, doi:10.1083/jcb.111.2.409, ISSN 0021-9525, pages 409 - 420, XP055233340 [X] 1-15 * the whole document * * page 414; table 1 *

DOI:   http://dx.doi.org/10.1083/jcb.111.2.409
 [XP]  - WEN YINGXIA ET AL, "Conformationally selective biophysical assay for influenza vaccine potency determination", VACCINE, (20150906), vol. 33, no. 41, doi:10.1016/J.VACCINE.2015.08.077, ISSN 0264-410X, pages 5342 - 5349, XP029277477 [XP] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.vaccine.2015.08.077
 [IP]  - WEN YINGXIA ET AL, "Trypsin pre-treatment corrects SRID over-estimation of immunologically active, pre-fusion HA caused by mixed immunoprecipitin rings", VACCINE, ELSEVIER, AMSTERDAM, NL, (20160504), vol. 34, no. 29, doi:10.1016/J.VACCINE.2016.04.091, ISSN 0264-410X, pages 3388 - 3395, XP029596068 [IP] 1-15 * the whole document * * abstract *

DOI:   http://dx.doi.org/10.1016/j.vaccine.2016.04.091
by applicantWO9014837
 WO9511700
 WO9637624
 WO9737000
 WO9737001
 WO9846262
 US5948410
 US6080725
 WO0060050
 EP0870508
 WO0104333
 WO0121151
 WO0122992
 WO0164846
 WO0183794
 WO0185938
 WO0228422
 WO02067983
 WO02074336
 EP1260581
 WO02097072
 WO03023021
 WO03023025
 WO03043415
 WO03076601
 US6630161
 US6635452
 US6649354
 US6649372
 WO2005042728
 WO2005097181
 WO2005113756
 WO2005113758
 WO2006027698
 WO2006067211
 WO2006071563
 WO2006108846
 WO2006113373
 US7132519
 US2007014805
 WO2007052163
 US2007191314
 WO2008043774
 WO2009000891
 WO2009110873
 WO2010052214
 WO2010136896
 WO2013087945
 WO2014141125
    - WILLIAMS, M. S., "Single-radial-immunodiffusion as an in vitro potency assay for human inactivated viral vaccines", Vet Microbiol, (19930000), vol. 37, no. 3-4, doi:10.1016/0378-1135(93)90027-5, pages 253 - 262, XP023914316

DOI:   http://dx.doi.org/10.1016/0378-1135(93)90027-5
    - FITZGERALDNEEDY, Dev Biol Stand, (19860000), vol. 64, pages 73 - 79
    - KAPTEYN et al., Vaccine, (20090000), vol. 27, pages 1468 - 77
    - LORBETSKIE et al., Vaccine, (20110000), vol. 29, pages 3377 - 89
    - WILLIAMSA et al., Vaccine, (20080000), vol. 26, pages 2510 - 20
    - SANTANA et al., Anal Chem, (20140000), vol. 86, pages 4088 - 95
    - BODLE et al., Influenza Other Respir Viruses, (20130000), vol. 7, pages 191 - 200
    - SKEHEL et al., Proc Natl Acad Sci USA, (19820000), vol. 79, pages 968 - 72
    - BOTTCHER et al., J Virol, (20061000), vol. 80, no. 19, pages 9896 - 9898
    - KAPTEYN et al., Vaccine, (20060000), vol. 24, pages 3137 - 44
    - PICOTTIAEBERSOLD, Nat Methods, (20120000), vol. 9, pages 555 - 66
    - HUCKRIEDE et al., Methods Enzymol, (20030000), vol. 373, pages 74 - 91
    - HERLOCHER et al., J Infect Dis, (20040000), vol. 190, no. 9, pages 1627 - 30
    - LE et al., Nature, (20050000), vol. 437, no. 7062, page 1108
    - KISTNER et al., Dev Biol Stand, (19990000), vol. 98, pages 101 - 110
    - HOFFMANN et al., Vaccine, (20020000), vol. 20, pages 3165 - 3170
    - POLAND, G. A.S. T. ROTTINGHAUSR. M. JACOBSON, "Influenza vaccines: a review and rationale for use in developed and underdeveloped countries", Vaccine, (20010000), vol. 19, no. 17-19, doi:10.1016/S0264-410X(00)00448-5, pages 2216 - 2220, XP004231024

DOI:   http://dx.doi.org/10.1016/S0264-410X(00)00448-5
    - KISTNER et al., Vaccine, (19980000), vol. 16, pages 960 - 8
    - BRUHL et al., Vaccine, (20000000), vol. 19, pages 1149 - 58
    - LUNDBLAD, Biotechnology and Applied Biochemistry, (20010000), vol. 34, pages 195 - 197
    - JI et al., Biotechniques, (20020000), vol. 32, pages 1162 - 7
    - BRIGGS, J Parenter Sci Technol, (19910000), vol. 45, pages 7 - 12
    - LAHIJANI et al., Hum Gene Ther, (19980000), vol. 9, pages 1173 - 80
    - LOKTEFF et al., Biologicals, (20010000), vol. 29, pages 123 - 32
    - SUBBARAO et al., Virology, (20030000), vol. 314, pages 580 - 590
    - OZAKI et al., J. Virol., (20040000), vol. 78, pages 1851 - 1857
    - WEBBY et al., Lancet, (20040000), vol. 363, pages 1099 - 1103
    - NEUMANN et al., Proc Natl Acad Sci USA, (20050000), vol. 102, pages 16825 - 9
    - HOFFMANN et al., Virology, (20000000), vol. 267, no. 2, pages 310 - 7
    - HEHME et al., Virus Res, (20040000), vol. 103, no. 1-2, pages 163 - 71
    - TREANOR et al., J Infect Dis, (19960000), vol. 173, pages 1467 - 70
    - KEITEL et al., Clin Diagn Lab Immunol, (19960000), vol. 3, pages 507 - 10
    - BANZHOFF, Immunology Letters, (20000000), vol. 71, pages 91 - 96
    - PODDADEL GIUDICE, Expert Rev Vaccines, (20030000), vol. 2, pages 197 - 203
    - HARIHARAN et al., Cancer Res, (19950000), vol. 55, pages 3486 - 9
    - "Vaccine Adjuvants: Preparation Methods and Research Protocols", Methods in Molecular Medicine series, vol. 42
    - FOX et al., Vaccine, (20130000), vol. 31, pages 1633 - 1640
    - ALLISONBYARS, Res Immunol, (19920000), vol. 143, pages 519 - 25
    - SULI et al., Vaccine, (20040000), vol. 22, no. 25-26, pages 3464 - 9
    - SETTEMBRE et al., Hum Vaccin Immunother, (20140000), vol. 10, pages 600 - 4
    - BRAND, C. M.J. J. SKEHEL, "Crystalline antigen from the influenza virus envelope", Nat New Biol, (19720000), vol. 238, no. 83, doi:10.1038/238145a0, pages 145 - 147, XP009057291

DOI:   http://dx.doi.org/10.1038/238145a0
    - BULLOUGH, P. A.F. M. HUGHSONJ. J. SKEHELD. C. WILEY, "Structure of influenza haemagglutinin at the pH of membrane fusion", Nature, (19940000), vol. 371, no. 6492, doi:10.1038/371037a0, pages 37 - 43, XP037115416

DOI:   http://dx.doi.org/10.1038/371037a0
    - ENNIS, F. A.R. E. MAYNERD. W. BARRYJ. E. MANISCHEWITZR. C. DUNLAPM. W. VERBONITZR. M. BOZEMANG. C. SCHILD, "Correlation of laboratory studies with clinical responses to A/New Jersey influenza vaccines", J Infect Dis, (19770000), vol. 136, pages S397 - 406
    - KNOSSOW, M.M. GAUDIERA. DOUGLASB. BARRERET. BIZEBARDC. BARBEYB. GIGANTJ. J. SKEHEL, "Mechanism of neutralization of influenza virus infectivity by antibodies", Virology, (20020000), vol. 302, no. 2, doi:10.1006/viro.2002.1625, pages 294 - 298, XP002683777

DOI:   http://dx.doi.org/10.1006/viro.2002.1625
    - LA MONTAGNE, J. R.G. R. NOBLEG. V. QUINNANG. T. CURLINW. C. BLACKWELDERJ. I. SMITHF. A. ENNISF. M. BOZEMAN, "Summary of clinical trials of inactivated influenza vaccine - 1978", Rev Infect Dis, (19830000), vol. 5, no. 4, pages 723 - 736
    - MINOR, P. D., "Assaying the Potency of Influenza Vaccines", Vaccines, (20150000), vol. 3, pages 90 - 104
    - QUAN, F. S.Z. N. LIM. C. KIMD. YANGR. W. COMPANSD. A. STEINHAUERS. M. KANG, "Immunogenicity of low-pH treated whole viral influenza vaccine", Virology, (20110000), vol. 417, no. 1, doi:10.1016/j.virol.2011.05.014, pages 196 - 202, XP028252094

DOI:   http://dx.doi.org/10.1016/j.virol.2011.05.014
    - RUIGROK, R. W.A. AITKENL. J. CALDERS. R. MARTINJ. J. SKEHELS. A. WHARTONW. WEISD. C. WILEY, "Studies on the structure of the influenza virus haemagglutinin at the pH of membrane fusion", J Gen Virol, (19880000), vol. 69, no. 11, pages 2785 - 2795
    - RUIGROK, R. W.S. R. MARTINS. A. WHARTONJ. J. SKEHELP. M. BAYLEYD. C. WILEY, "Conformational changes in the hemagglutinin of influenza virus which accompany heat-induced fusion of virus with liposomes", Virology, (19860000), vol. 155, no. 2, doi:10.1016/0042-6822(86)90210-2, pages 484 - 497, XP023050114

DOI:   http://dx.doi.org/10.1016/0042-6822(86)90210-2
    - SCHILD, G. C.J. M. WOODR. W. NEWMAN, "A single-radial-immunodiffusion technique for the assay of influenza haemagglutinin antigen. Proposals for an assay method for the haemagglutinin content of influenza vaccines", Bull World Health Organ, (19750000), vol. 52, no. 2, pages 223 - 231
    - SKEHEL, J. J.P. M. BAYLEYE. B. BROWNS. R. MARTINM. D. WATERFIELDJ. M. WHITEI. A. WILSOND. C. WILEY, "Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion", Proc Natl Acad Sci U S A, (19820000), vol. 79, no. 4, pages 968 - 972
    - SKEHEL, J. J.D. C. WILEY, "Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin", Annu Rev Biochem, (20000000), vol. 69, pages 531 - 569
    - TAY, T.C. AGIUSR. HAMILTONJ. BODLES. ROCKMAN, "Investigation into alternative testing methodologies for characterization of influenza virus vaccine", Hum Vaccin Immunother, (20150000), vol. 11, no. 7, pages 1673 - 1684
    - WEN, Y.L. HANG. PALLADINOA. FERRARIY. XIEA. CARFIP. R. DORMITZERE. C. SETTEMBRE, "Conformationally selective biophysical assay for influenza vaccine potency determination", Vaccine, (20150000), vol. 33, no. 41, doi:10.1016/j.vaccine.2015.08.077, pages 5342 - 5349, XP029277477

DOI:   http://dx.doi.org/10.1016/j.vaccine.2015.08.077
    - WHARTON, S. A.J. J. SKEHELD. C. WILEY, "Studies of influenza haemagglutinin-mediated membrane fusion", Virology, (19860000), vol. 149, no. 1, doi:10.1016/0042-6822(86)90083-8, pages 27 - 35, XP023048687

DOI:   http://dx.doi.org/10.1016/0042-6822(86)90083-8
    - WILEY, D. C.J. J. SKEHEL, "Crystallization and x-ray diffraction studies on the haemagglutinin glycoprotein from the membrane of influenza virus", J Mol Biol, (19770000), vol. 112, no. 2, pages 343 - 347
    - WILEY, D. C.I. A. WILSONJ. J. SKEHEL, "Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation", Nature, (19810000), vol. 289, no. 5796, doi:10.1038/289373a0, pages 373 - 378, XP037135084

DOI:   http://dx.doi.org/10.1038/289373a0
    - WILSON, I. A.J. J. SKEHELD. C. WILEY, "Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution", Nature, (19810000), vol. 289, no. 5796, doi:10.1038/289366a0, pages 366 - 373, XP002689324

DOI:   http://dx.doi.org/10.1038/289366a0
    - WOOD, J. M.G. C. SCHILDR. W. NEWMANV. SEAGROATT, "An improved single-radial-immunodiffusion technique for the assay of influenza haemagglutinin antigen: application for potency determinations of inactivated whole virus and subunit vaccines", J Biol Stand, (19770000), vol. 5, no. 3, pages 237 - 247
    - ZAMBON, M. C., "Epidemiology and pathogenesis of influenza", J Antimicrob Chemother, (19990000), vol. 44, no. B, pages 3 - 9
    - MINOR, PHILIP D., "Assaying the potency of influenza vaccines", Vaccines, (20150000), vol. 3, pages 90 - 104
 EP20150175765
 EP20160152829
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.