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Extract from the Register of European Patents

EP About this file: EP3911742

EP3911742 - SORTASE-LABELLED CLOSTRIDIUM NEUROTOXINS [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  22.10.2021
Database last updated on 29.07.2024
FormerThe international publication has been made
Status updated on  25.07.2020
Formerunknown
Status updated on  04.02.2020
Most recent event   Tooltip15.12.2023New entry: Renewal fee paid 
Applicant(s)For all designated states
Ipsen Biopharm Limited
Unit 9, Ash Road
Wrexham Industrial Estate
Wrexham LL13 9UF / GB
[2021/47]
Inventor(s)01 / LOSS, Omar
c/o Ipsen Biopharm Limited
Unit 9 Ash Road
Wrexham Industrial Estate
Wrexham LL13 9UF / GB
02 / ELLIOTT, Mark
c/o Ipsen Biopharm Limited
Unit 9 Ash Road
Wrexham Industrial Estate
Wrexham LL13 9UF / GB
[N/P]
Former [2021/47]01 / LOSS, Omar
Wrexham LL13 9UF / GB
02 / ELLIOTT, Mark
Wrexham LL13 9UF / GB
Representative(s)Hobson, David James, et al
Mathys & Squire The Shard
32 London Bridge Street
London SE1 9SG / GB
[2021/47]
Application number, filing date20701844.116.01.2020
[2021/47]
WO2020GB50089
Priority number, dateGB2019000062116.01.2019         Original published format: GB 201900621
[2021/47]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2020148542
Date:23.07.2020
Language:EN
[2020/30]
Type: A1 Application with search report 
No.:EP3911742
Date:24.11.2021
Language:EN
The application published by WIPO in one of the EPO official languages on 23.07.2020 takes the place of the publication of the European patent application.
[2021/47]
Search report(s)International search report - published on:EP23.07.2020
ClassificationIPC:C12N9/52, A61K49/00
[2021/47]
CPC:
C12N9/52 (EP,US); A61K49/0056 (EP,US); A61K49/0032 (EP);
C12Y304/24068 (EP,US); C12Y304/24069 (EP,US); G01N33/58 (EP);
G01N33/582 (US); C07K2319/50 (EP); C07K2319/55 (EP);
C07K2319/90 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2021/47]
TitleGerman:SORTASE-MARKIERTE CLOSTRIDIUM-NEUROTOXINE[2021/47]
English:SORTASE-LABELLED CLOSTRIDIUM NEUROTOXINS[2021/47]
French:NEUROTOXINES DE CLOSTRIDIUM MARQUÉES PAR SORTASE[2021/47]
Entry into regional phase26.07.2021National basic fee paid 
26.07.2021Designation fee(s) paid 
26.07.2021Examination fee paid 
Examination procedure26.07.2021Examination requested  [2021/47]
26.07.2021Date on which the examining division has become responsible
22.02.2022Amendment by applicant (claims and/or description)
Fees paidRenewal fee
16.12.2021Renewal fee patent year 03
14.12.2022Renewal fee patent year 04
14.12.2023Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[AD]WO2006059093  (HEALTH PROT AGENCY [GB], et al) [AD] 10-13,19-22,39-42,44-55* the whole document *;
 [XI]WO2011091419  (NEW YORK UNIVERSIY [US]) [X] 1-3,6,23,24,26-30,37,38,43,56-61 * paragraphs [0018] , [0023] , [0025] , [0 46]; claims 64,65 * * paragraphs [0023] , [0025]; examples 8-9 * [I] 14,15,65;
 [A]WO2015042393  (HARVARD COLLEGE [US]) [A] 10-13,16-22,39-42,48-55,65 * paragraphs [0083] , [0084] , [0098] , [0099]; figures 3-4; example 2; claims 60-68 *;
 [XAI]  - OMAR LOSS ET AL, "Engineering fluorescent-labeled botulinum neurotoxins and derivatives to image their trafficking in neuronal and non-neuronal cells", TOXICON, US, (20181201), vol. 156, doi:10.1016/j.toxicon.2018.11.167, ISSN 0041-0101, page S70, XP055673184 [X] 1,3,6-9,23-25,27-29,32-34,37,38,43,56-58,61-64 * the whole document * [A] 35,36 [I] 10-22,39-42,44-55,65

DOI:   http://dx.doi.org/10.1016/j.toxicon.2018.11.167
 [X]  - Anonymous, "Team:Tuebingen/Description - 2018.igem.org", (20180101), URL: http://2018.igem.org/Team:Tuebingen/Description, (20200303), XP055672996 [X] 1,3-5,23,24,26-32,38,43,56-58 * page 1 - page 3, line 1 * * page 3, line l - page 4, paragraph 1; figure on page 4 *
 [AD]  - FONFRIA ELENA ET AL, "Botulinum neurotoxin A and an engineered derivate targeted secretion inhibitor (TSI) A enter cells via different vesicular compartments", JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH, MARCEL DEKKER, NEW YORK, NY, US, (20160101), vol. 36, no. 1, ISSN 1079-9893, pages 79 - 88, XP009193560 [AD] 10-13,19-22,39-42,44-55 * the whole document *
 [A]  - JOHN M. ANTOS ET AL, "Site-Specific N- and C-Terminal Labeling of a Single Polypeptide Using Sortases of Different Specificity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (20090812), vol. 131, no. 31, doi:10.1021/ja902681k, ISSN 0002-7863, pages 10800 - 10801, XP055070582 [A] 14,15 * the whole document *

DOI:   http://dx.doi.org/10.1021/ja902681k
by applicantEP0257742
 WO9206204
 US5223409
 WO9315766
 WO9421300
 WO9633273
 WO9807864
 WO9917806
 WO9958571
 US5989545
 WO0004926
 WO0010598
 WO0061192
 WO0062814
 WO0121213
 WO0208268
 US6395513
 US6461617
 EP0689459
 EP0996468
 US6632440
 EP0826051
 EP0939818
 US6962703
 WO2006027207
 US7052702
 EP1107794
 WO2006059093
 WO2006114308
 US7192596
 US2007166332
 WO2007104567
 WO2008008803
 WO2008008805
 WO2009150469
 WO2009150470
 WO2010120766
 US8071110
 US2011318385
 WO2018009903
 WO2019145577
    - DONALD et al., Pharmacol Res Perspect, (20180000), pages e00446,1 - 14
    - FONFRIA, E.S. DONALDV. A. CADD, "Botulinum neurotoxin A and an engineered derivate targeted secretion inhibitor (TSI) A enter cells via different vesicular compartments", J Recept Signal Transduct Res, (20160000), vol. 36, no. 1, pages 79 - 88, XP009193560
    - MAZMANIAN, S. K.G. LIUH. TON-THATO. SCHNEEWIND, "Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wa!!", Science, (19990000), vol. 285, no. 5428, doi:10.1126/science.285.5428.760, pages 760 - 763, XP002288783

DOI:   http://dx.doi.org/10.1126/science.285.5428.760
    - PATERSON, G. K.T. J. MITCHELL, "The biology of Gram-positive sortase enzymes", Trends Microbiol, (20040000), vol. 12, no. 2, pages 89 - 95
    - DORR, B. M.H. O. HAMC. ANE. L. CHAIKOFD. R. LIU, "Reprogramming the specificity of sortase enzymes", Proc Natl Acad Sci U S A, (20140000), vol. 111, no. 37, doi:10.1073/pnas.1411179111, pages 13343 - 13348, XP055340492

DOI:   http://dx.doi.org/10.1073/pnas.1411179111
    - CHEN, I.B. M. DORRD. R. LIU, "A general strategy for the evolution of bond-forming enzymes using yeast display", Proc Natl Acad Sci U S A, (20110000), vol. 108, no. 28, doi:10.1073/pnas.1101046108, pages 11399 - 11404, XP055299966

DOI:   http://dx.doi.org/10.1073/pnas.1101046108
    - CHEN, L.J. COHENX. SONGA. ZHAOZ. YEC. J. FEULNERP. DOONANW. SOMERSL. LINP. R. CHEN, "Improved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiency", Sci Rep, (20160000), vol. 6, page 31899
    - ANTOS et al., J Am Chem Soc, (20090000), vol. 131, pages 10800 - 10801
    - NGUYEN, G. K.Y. CAOW. WANGC. F. LIUJ. P. TAM, "Site-Specific N-Termina! Labeling of Peptides and Proteins using Butelase 1 and Thiodepsipeptide", Angew Chem Int Ed Engl, (20150000), vol. 54, no. 52, doi:10.1002/anie.201506810, pages 15694 - 15698, XP055385936

DOI:   http://dx.doi.org/10.1002/anie.201506810
    - NGUYEN et al., Nature Protocols, (20160000), vol. 11, page 10
    - HARRIS et al., Nat Commun, (20150000), vol. 6, page 10199
    - LUO H, Chemistry and Biology, (20140000), vol. 21, pages 1610 - 1617
    - "GenBank", Database accession no. OT022244.1
    - BLANKE et al., Proc. Natl. Acad. Sci. USA, (19960000), vol. 93, pages 8437 - 8442
    - ROBERTSON, J. Am. Chem. Soc., (19910000), vol. 113, page 2722
    - NAGY, PNAS, (19980000), vol. 95, pages 1794 - 99
    - "Receptor-binding studies, a brief outline", HULME, E.C., Receptor biochemistry, A Practical Approach, Oxford University Press, (19900000), pages 303 - 311
    - SHONE et al., Eur. J. Biochem., (19850000), vol. 151, pages 75 - 82
    - RUMMEL et al., Molecular Microbiol., (20040000), vol. 51, pages 631 - 634
    - UMLAND TC, Nat. Struct. Biol., (19970000), vol. 4, pages 788 - 792
    - HERREROS J, Biochem. J., (20000000), vol. 347, pages 199 - 204
    - SILVERMAN et al., J. Biol. Chem., (19930000), vol. 269, no. 15, pages 22524 - 22532
    - RUMMEL A, PNAS, (20070000), vol. 104, pages 359 - 364
    - LACEY DB, Nat. Struct. BioI., (19980000), vol. 5, pages 898 - 902
    - KNAPP, Am. Cryst. Assoc. Abstract Papers, (19980000), vol. 25, page 90
    - SWAMINATHANESWARAMOORTHY, Nat. Struct. Biol., (20000000), vol. 7, pages 1751 - 1759
    - RUMMEL A, Mol. Microbiol., (20040000), vol. 51, no. 3, pages 631 - 643
    - POHLNER, J. et al., Nature, (19870000), vol. 325, pages 458 - 462
    - SHONE C., Eur. J. Biochem, (19870000), vol. 167, no. 1, pages 175 - 180
    - BLAUSTEIN, FEBS Letts, (19870000), vol. 226, no. 1, pages 115 - 120
    - C. E. LAWRENCE et al., "Detecting Subtle Sequence Signals: A Gibbs Sampling Strategy for Multiple Alignment", Science, (19930000), vol. 220, 221, no. 5131, doi:10.1126/science.8211139, pages 208 - 214, XP001152872

DOI:   http://dx.doi.org/10.1126/science.8211139
    - HENIKOFFHENIKOFF, Proc. Natl. Acad. Sci. USA, (19920000), vol. 89, pages 10915 - 6206
    - LONDON, E., Biochem. Biophys. Acta., (19920000), vol. 1112, pages 25 - 51
    - PRIOR, Biochemistry, (19920000), vol. 31, pages 3555 - 3559
    - PLANK et al., J. BioI. Chem., (19940000), vol. 269, pages 12918 - 12924
    - WAGNER et al., PNAS, (19920000), vol. 89, pages 7934 - 7938
    - MURATA et al., Biochem., (19920000), vol. 31, pages 1986 - 1992
    - ULIE D. THOMPSON et al., "CLUSTAL W: Improving the Sensitivity of Progressive Multiple Sequence Alignment Through Sequence Weighting, Position- Specific Gap Penalties and Weight Matrix Choice", Nucleic Acids Research, (19940000), vol. 22, no. 22, pages 4673 - 4680, XP002956304
    - OSAMU GOTOH, "Significant Improvement in Accuracy of Multiple Protein. Sequence Alignments by Iterative Refinement as Assessed by Reference to Structural Alignments", J. Mol. Biol., (19960000), vol. 264, no. 4, pages 823 - 838
    - ERIC DEPIEREUXERNEST FEYTMANS, "Match-Box: A Fundamentally New Algorithm for the Simultaneous Alignment of Several Protein Sequences", CABIOS, (19920000), vol. 8, no. 5, pages 501 - 509
    - IVO VAN WALLE et al., "Align-M - A New Algorithm for Multiple Alignment of Highly Divergent Sequences", Bioinformatics, (20040000), vol. 20, no. 9, pages 1428 - 1435
    - ALTSCHUL et al., Bull. Math. Bio., (19860000), vol. 48, pages 603 - 16
    - ELLMAN et al., Methods Enzymol., (19910000), vol. 202, page 301
    - CHUNG et al., Science, (19930000), vol. 259, pages 806 - 9
    - CHUNG et al., Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 10145 - 9
    - TURCATTI et al., J. Biol. Chem., (19960000), vol. 271, pages 19991 - 8
    - KOIDE et al., Biochem., (19940000), vol. 33, pages 7470 - 6
    - WYNNRICHARDS, Protein Sci., (19930000), vol. 2, pages 395 - 403
    - CUNNINGHAMWELLS, Science, (19890000), vol. 244, pages 1081 - 5
    - DE VOS, Science, (19920000), vol. 255, pages 306 - 12
    - SMITH et al., J. Mol. Biol., (19920000), vol. 224, pages 899 - 904
    - WLODAVER, FEBS Lett., (19920000), vol. 309, pages 59 - 64
    - REIDHAAR-OLSONSAUER, Science, (19880000), vol. 241, pages 53 - 7
    - BOWIESAUER, Proc. Natl. Acad. Sci. USA, (19890000), vol. 86, pages 2152 - 6
    - LOWMAN et al., Biochem., (19910000), vol. 30, pages 10832 - 7
    - DERBYSHIRE et al., Gene, (19860000), vol. 46, page 145
    - NER et al., DNA, (19880000), vol. 7, page 127
    - "UniProt", Database accession no. P04958
    - MASUYER, G.M. BEARDV. A. CADDJ. A. CHADDOCKK. R. ACHARYA, "Structure and activity of a functional derivative of Clostridium botulinum neurotoxin B", J Struct Biol, (20110000), vol. 174, no. 1, pages 52 - 57
    - SOMM, E.N. BONNETA. MARTINEZP. M. MARKSV. A. CADDM. ELLIOTTA. TOULOTTES. L. FERRARIR. RIZZOLIP. S. HUPPI, "A botulinum toxin-derived targeted secretion inhibitor downregulates the GH/IGF1 axis", J Clin Invest, (20120000), vol. 122, no. 9, doi:10.1172/JCI63232, pages 3295 - 3306, XP002768080

DOI:   http://dx.doi.org/10.1172/JCI63232
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.