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Extract from the Register of European Patents

EP About this file: EP3958865

EP3958865 - 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  22.12.2023
Database last updated on 11.09.2024
FormerRequest for examination was made
Status updated on  28.01.2022
FormerThe international publication has been made
Status updated on  31.10.2020
Formerunknown
Status updated on  06.05.2020
Most recent event   Tooltip20.06.2024New entry: Reply to examination report 
Applicant(s)For all designated states
Bayer Aktiengesellschaft
Kaiser-Wilhelm-Allee 1
51373 Leverkusen / DE
For all designated states
The Broad Institute, Inc.
415 Main Street
Cambridge, MA 02142 / US
For all designated states
Dana-Farber Cancer Institute, Inc.
450 Brookline Avenue
Boston, Massachusetts 02215 / US
[2022/09]
Inventor(s)01 / SIEGEL, Franziska
7 Maple Ave.
Cambridge, MA 02139 / US
02 / KORR, Daniel
An den Eldenaer Höfen 49
10247 Berlin / DE
03 / SCHRÖDER, Jens
Chausseestrasse 50b
10115 Berlin / DE
04 / SIEGEL, Stephan
Aschaffenburger Str. 6
10779 Berlin / DE
05 / GREULICH, Heidi
c/o The Broad Institute Inc 415 Main Street
Cambridge, Massachusetts, MA 02142 / US
06 / KAPLAN, Bethany
c/o The Broad Institute Inc 415 Main Street
Cambridge, Massachusetts, MA 02142 / US
07 / MEYERSON, Matthew
c/o Dana Farber Cancer Institute, Inc. 450
Brookline Avenue
Boston, MA 02215 / US
 [2022/09]
Representative(s)BIP Patents
c/o Bayer Intellectual Property GmbH
Alfred-Nobel-Straße 50
40789 Monheim am Rhein / DE
[N/P]
Former [2022/09]BIP Patents
c/o Bayer Intellectual Property GmbH
Alfred-Nobel-Straße 10
40789 Monheim am Rhein / DE
Application number, filing date20721193.922.04.2020
[2022/09]
WO2020EP61167
Priority number, dateUS201962838104P24.04.2019         Original published format: US 201962838104 P
[2022/09]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2020216774
Date:29.10.2020
Language:EN
[2020/44]
Type: A1 Application with search report 
No.:EP3958865
Date:02.03.2022
Language:EN
The application published by WIPO in one of the EPO official languages on 29.10.2020 takes the place of the publication of the European patent application.
[2022/09]
Search report(s)International search report - published on:EP29.10.2020
ClassificationIPC:A61K31/444, A61K31/4545, A61K31/5377, A61K45/06, A61P35/00, G01N33/50, C07D471/04
[2022/09]
CPC:
A61K31/444 (EP,US); A61K31/4545 (EP,US); A61K31/5377 (EP,US);
A61K38/179 (US); A61K45/06 (EP,US); A61P35/00 (EP,US);
C07D471/04 (EP,US); C12Q1/6886 (EP); C12Q2600/106 (EP);
C12Q2600/156 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/09]
TitleGerman:4H-PYRROLO[3,2-C]PYRIDIN-4-ON-DERIVATE[2022/09]
English:4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES[2022/09]
French:DÉRIVÉS DE 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE[2022/09]
Entry into regional phase24.11.2021National basic fee paid 
24.11.2021Designation fee(s) paid 
24.11.2021Examination fee paid 
Examination procedure24.11.2021Examination requested  [2022/09]
24.11.2021Date on which the examining division has become responsible
03.06.2022Amendment by applicant (claims and/or description)
22.12.2023Despatch of a communication from the examining division (Time limit: M06)
20.06.2024Reply to a communication from the examining division
Fees paidRenewal fee
20.03.2022Renewal fee patent year 03
14.03.2023Renewal fee patent year 04
13.03.2024Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[AD]WO2016120196  (BAYER PHARMA AG [DE]) [AD] 1-27 * the whole document *;
 [A]WO2016185333  (NOVARTIS AG [CH], et al) [A] 1-27 * Summary of the invention; p. 3, 4th par. to p. 4, 3rd par.; claim 2 *;
 [XP]WO2019081486  (BAYER AG [DE], et al) [XP] 5,6,12-17* examples, claims *
by applicantUS3966781
 US5011472
 US2004122237
 US2006122168
 WO2009020990
 US2009253767
 EP2151431
 WO2010042699
 WO2012112363
 WO2015022073
 WO2015193339
 WO2016091845
 WO2016100166
 WO2016120196
    - "Isotopic Compositions of the Elements 1997", Pure Appl. Chem., (19980000), vol. 70, no. 1, pages 217 - 235
    - H. J. LEIS et al., Curr. Org. Chem., (19980000), vol. 2, page 131
    - ESAKI et al., Tetrahedron, (20060000), vol. 62, page 10954
    - ESAKI et al., Chem. Eur. J., (20070000), vol. 13, page 4052
    - J. R. MORANDI et al., J. Org. Chem., (19690000), vol. 34, no. 6, page 1889
    - N. H. KHAN, J. Am. Chem. Soc., (19520000), vol. 74, no. 12, page 3018
    - S. CHANDRASEKHAR et al., Tetrahedron, (20110000), vol. 52, page 3865
    - HANZLIK et al., J. Org. Chem., (19900000), vol. 55, pages 3992 - 3997
    - R. P. HANZLIK et al., Biochem. Biophys. Res. Commun., (19890000), vol. 160, page 844
    - P. J. REIDER et al., J. Org. Chem., (19870000), vol. 52, pages 3326 - 3334
    - M. JARMAN et al., Carcinogenesis, (19930000), vol. 16, no. 4, pages 683 - 688
    - J. ATZRODT et al., Angew. Chem., Int. Ed., (20070000), vol. 46, page 7744
    - K. MATOISHI et al., J. Chem. Soc, Chem. Commun., (20000000), pages 1519 - 1520
    - A. STREITWIESER et al., J. Am. Chem. Soc., (19630000), vol. 85, page 2759
    - C. L. PERRIN et al., J. Am. Chem. Soc., (20070000), vol. 129, page 4490
    - C. L. PERRIN et al., J. Am. Chem. Soc., (20030000), vol. 125, page 15008
    - C. L. PERRIN, Advances in Physical Organic Chemistry, vol. 44, page 144
    - C. L. PERRIN et al., J. Am. Chem. Soc., (20050000), vol. 127, page 9641
    - B. TESTA et al., Int. J. Pharm., (19840000), vol. 19, no. 3, page 271
    - D. J. KUSHNER et al., Can. J. Physiol. Pharmacol., (19990000), vol. 77, page 79
    - A. E. MUTLIB et al., Toxicol. Appl. Pharmacol., (20000000), vol. 169, page 102
    - A. M. SHARMA et al., Chem. Res.Toxicol., (20130000), vol. 26, page 410
    - UETRECHT et al., Chemical Research in Toxicology, (20080000), vol. 21, no. 9, page 1862
    - C. J. WENTHUR et al., J. Med. Chem., (20130000), vol. 56, page 5208
    - F. SCHNEIDER et al., Arzneim. Forsch. Drug. Res., (20060000), vol. 56, page 295
    - F. MALTAIS et al., J. Med. Chem., (20090000), vol. 52, page 7974
    - Pure Appl Chem, (19760000), vol. 45, pages 11 - 30
    - S. M. BERGE et al., "Pharmaceutical Salts", J. Pharm. Sci., (19770000), vol. 66, doi:10.1002/jps.2600660104, pages 1 - 19, XP002675560

DOI:   http://dx.doi.org/10.1002/jps.2600660104
    - "UniProt", Database accession no. P00533-1
    - D. E. WORRALL, J. Am. Chem. Soc., (19400000), vol. 62, page 675
    - VANOTTI et al., J. Med. Chem., (20080000), vol. 51, pages 6631 - 6634
    - GUO, Tetrahedron Letts., (20130000), vol. 54, pages 3233 - 3237
    - WATTERSON et al., J. Med. Chem., (20070000), vol. 50, pages 2647 - 3742
    - BELLALE et al., J. Med. Chem., (20140000), vol. 57, pages 6572 - 6582
    - KLIMESOVA et al., Eur. J. Med. Chem., (19960000), vol. 31, pages 389 - 395
    - LEROY et al., Synth. Commun., (19970000), vol. 27, pages 2905 - 2916
    - LAMATTINA et al., J. Org. Chem., (19810000), vol. 46, pages 4179 - 4182
    - BEUGELMANS et al., Tetrahedron, (19830000), vol. 39, pages 4153 - 4162
    - BULLOCK et al., J. Am. Chem. Soc., (19560000), vol. 78, page 490
    - WANG et al., J. Org. Chem., (20060000), vol. 71, pages 4021 - 3160
    - RABE, Chem. Ber., (19130000), vol. 46, page 1024
    - DE MUNNO et al., Heterocycles, (19960000), vol. 43, pages 1893 - 1900
    - STOKKER et al., J. Med. Chem., (19810000), vol. 24, pages 115 - 117
    - BERTINI et al., J. Med. Chem., (20050000), vol. 48, pages 1610 - 670
    - WALPOLE et al., J. Med. Chem., (19930000), vol. 36, pages 2362 - 2372
    - KURAMOCHI et al., Bioorg. Med. Chem., (20050000), vol. 13, pages 4022 - 4036
    - MACIAS et al., J. Agric. Food Chem., (20060000), vol. 54, page 9843
    - CHAN et al., J. Am. Chem. Soc., (20110000), vol. 133, page 2989
    - NIEMANN et al., J. Am. Chem Soc., (19410000), vol. 63, page 2204
    - SWEENEY et al., Bioorg. Med. Chem. Lett., (20080000), vol. 18, page 4348
    - CHONG et al., J. Med. Chem., (20120000), vol. 55, page 10601
    - DEGORCE, Tetrahedron Lett., (20110000), vol. 52, page 6719
    - FAIRHURST et al., Org. Lett., (20050000), vol. 7, page 4697
    - CHASKAR et al., Synth. Commun., (20080000), vol. 38, page 16940
    - AIELLO et al., New Engl. J. Med., (19940000), vol. 331, page 1480
    - PEER et al., Lab. Invest., (19950000), vol. 72, page 638
    - LOPEZ et al., Invest. Opththalmol. Vis. Sci., (19960000), vol. 37, page 855
    - POWELL, M.F., "Compendium of Excipients for Parenteral Formulations", PDA Journal of Pharmaceutical Science & Technology, (19980000), vol. 52, no. 5, pages 238 - 311, XP009119027
    - STRICKLEY, R.G, "Parenteral Formulations of Small Molecule Therapeutics Marketed in the United States (1999)-Part-1", PDA Journal of Pharmaceutical Science & Technology, (19990000), vol. 53, no. 6, pages 324 - 349
    - NEMA, S. et al., "Excipients and Their Use in Injectable Products", PDA Journal of Pharmaceutical Science & Technology, (19970000), vol. 51, no. 4, pages 166 - 171
    - GOODMANGILMAN et al., The Pharmacological Basis of Therapeutics, McGraw-Hill, (19960000), pages 1225 - 1287
    - CHEMICAL ABSTRACTS, Database accession no. 1539076-88-4
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.