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EP About this file: EP3943159

EP3943159 - PRODUCTION METHOD OF QUINOLINECARBOXAMIDE DERIVATIVE OR PRODUCTION INTERMEDIATE THEREOF [Right-click to bookmark this link]
Status	The application has been withdrawn Status updated on 05.01.2024 Database last updated on 26.06.2024
Former	Request for examination was made Status updated on 24.12.2021
Former	The international publication has been made Status updated on 03.10.2020
Most recent event Tooltip	05.01.2024	Withdrawal of application	published on 07.02.2024 [2024/06]
Applicant(s)	For all designated states Kabushiki Kaisha Yakult Honsha 1-10-30, Kaigan Minato-ku Tokyo, 105-8660 / JP
	[2022/04]
Inventor(s)	01 / SHIGEYAMA, Takahide c/o Kabushiki Kaisha Yakult Honsha, 1-10-30, Kaigan, Minato-ku Tokyo 105-8660 / JP
	02 / SUGIMOTO, Takuya c/o Kabushiki Kaisha Yakult Honsha, 1-10-30, Kaigan, Minato-ku Tokyo 105-8660 / JP
	03 / KOMATSU, Hideyuki c/o Kabushiki Kaisha Yakult Honsha, 1-10-30, Kaigan, Minato-ku Tokyo 105-8660 / JP
	04 / NISHIYAMA, Hiroyuki c/o Kabushiki Kaisha Yakult Honsha, 1-10-30, Kaigan, Minato-ku Tokyo 105-8660 / JP
	[N/P]
Former [2022/04]	01 / SHIGEYAMA, Takahide Tokyo 105-8660 / JP
	02 / SUGIMOTO, Takuya Tokyo 105-8660 / JP
	03 / KOMATSU, Hideyuki Tokyo 105-8660 / JP
	04 / NISHIYAMA, Hiroyuki Tokyo 105-8660 / JP
Representative(s)	Hartz, Nikolai Wächtershäuser & Hartz Patentanwaltspartnerschaft mbB Weinstrasse 8 80333 München / DE
	[N/P]
Former [2022/04]	Schiener, Jens Wächtershäuser & Hartz Patentanwaltspartnerschaft mbB Weinstraße 8 80333 München / DE
Application number, filing date	20778570.0	19.03.2020
	[2022/04]
	WO2020JP12477
Priority number, date	JP20190055050	22.03.2019 Original published format: JP 2019055050
	JP20190055051	22.03.2019 Original published format: JP 2019055051
	JP20190055052	22.03.2019 Original published format: JP 2019055052
	[2022/04]
Filing language	JA
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2020196327
	Date:	01.10.2020
	Language:	JA
	[2020/40]
	Type:	A1 Application with search report
	No.:	EP3943159
	Date:	26.01.2022
	Language:	EN
	[2022/04]
Search report(s)	International search report - published on:	JP	01.10.2020
	(Supplementary) European search report - dispatched on:	EP	02.03.2023
Classification	IPC:	C07D405/04, C07D409/04, C07D413/04, C07D413/14, C07D417/04, C07B61/00, C07D209/38, C07D215/52, A61K31/4709, A61P35/00, A61P43/00	[2023/04]
	CPC:	A61P35/00 (EP); C07D413/14 (EP,US); A61P43/00 (EP); C07D209/38 (EP,US); C07D215/52 (EP,US); C07D271/113 (EP); (+) C07D405/04 (EP); C07D409/04 (EP); C07D413/04 (EP); C07D417/04 (EP) (-)
	Former IPC [2022/04]	A61P35/00, A61P43/00, C07D405/04, C07D409/04, C07D413/04, C07D413/14, C07D417/04, C07B61/00, C07D209/38, C07D215/52, A61K31/4709
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2022/04]
Title	German:	VERFAHREN ZUR HERSTELLUNG EINES CHINOLINCARBONSÄUREDERIVATS ODER EINES ZWISCHENPRODUKTS DAVON	[2022/04]
	English:	PRODUCTION METHOD OF QUINOLINECARBOXAMIDE DERIVATIVE OR PRODUCTION INTERMEDIATE THEREOF	[2022/04]
	French:	PROCÉDÉ DE PRODUCTION D'UN DÉRIVÉ QUINOLINECARBOXAMIDE OU D'UN INTERMÉDIAIRE DE PRODUCTION DE CELUI-CI	[2022/04]
Entry into regional phase	06.10.2021	Translation filed
	06.10.2021	National basic fee paid
	06.10.2021	Search fee paid
	06.10.2021	Designation fee(s) paid
	06.10.2021	Examination fee paid
Examination procedure	06.10.2021	Examination requested [2022/04]
	29.09.2023	Amendment by applicant (claims and/or description)
	28.12.2023	Application withdrawn by applicant [2024/06]
Fees paid	Renewal fee
	31.03.2022	Renewal fee patent year 03
	31.03.2023	Renewal fee patent year 04
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[Y]EP2325181 (PHARMA IP GENERAL INC ASS [JP], et al) [Y] 3,6-9 * page 38; example Production Example 1 *;
		[Y] - ISLAM RAFIQUL ET AL, "Facile Synthesis of 2- Phenylquinoline-4-Carboxamide Derivatives with Variant Structural Features", HETEROCYCLES, JAPAN INSTITUTE OF HETEROCYCLIC CHEMISTRY, JP, (20140206), vol. 89, no. 3, doi:10.3987/COM-14-12939, ISSN 0385-5414, pages 693 - 708, XP009526849 [Y] 3,6-9 * Scheme 3; page 696 * * Process for the preparation of compound 13; page 703 * * Scheme I; page 695 * DOI: http://dx.doi.org/10.3987/COM-14-12939
		[Y] - KENJI MATSUNO ET AL, "Identification of a New Series of STAT3 Inhibitors by Virtual Screening", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, (20100101), vol. 1, no. 8, doi:10.1021/ML1000273, ISSN 1948-5875, pages 371 - 375, XP009173598 [Y] 3 * Scheme 1, method B; page 373 * DOI: http://dx.doi.org/10.1021/ml1000273
		[Y] - HARDIK G BHATT ET AL, "Microwave-irradiated synthesis and antimicrobial activity of 2-phenyl-7-substitutedalkyl/arylaminoquinoline-4-carboxylic acid derivatives", MEDICINAL CHEMISTRY RESEARCH, BIRKHÄUSER-VERLAG, BOSTON, (20090429), vol. 19, no. 4, ISSN 1554-8120, pages 392 - 402, XP019803498 [Y] 1-3 * abstract * * Scheme I; page 394 * * page 394; table 1 *
		[Y] - ABOUL-ENEIN H Y ET AL, "SYNTHESIS AND ANALGESIC-ANTI-INFLAMMATORY ACTIVITY OF CERTAIN FLUORINATED CINCHOPHEN ANALOGUES", JOURNAL OF FLUORINE CHEMISTRY, ELSEVIER, NL, (19920101), vol. 59, doi:10.1016/S0022-1139(00)82415-X, ISSN 0022-1139, pages 233 - 237, XP002945158 [Y] 1-3 * Passages headed "Chemistry" and "Preparation ..."; page 234 * * page 235; table 1; compounds 1-11 * DOI: http://dx.doi.org/10.1016/S0022-1139(00)82415-X
		[Y] - WANG L M ET AL, "One-pot synthesis of quinoline-4-carboxylic acid derivatives in water: Ytterbium perfluorooctanoate catalyzed Doebner reaction", JOURNAL OF FLUORINE CHEMISTRY, ELSEVIER, NL, vol. 130, no. 4, doi:10.1016/J.JFLUCHEM.2009.01.002, ISSN 0022-1139, (20090401), pages 406 - 409, (20090130), XP026032433 [Y] 1-3 * Schemes 1 and 2; page 407 * * page 407; table 1 and 2 * DOI: http://dx.doi.org/10.1016/j.jfluchem.2009.01.002
		[XYI] - LARRY L. KLEIN ET AL, "Synthesis of substituted isatins", TETRAHEDRON LETTERS, Amsterdam , NL, (20130201), vol. 54, no. 8, doi:10.1016/j.tetlet.2012.12.035, ISSN 0040-4039, pages 1008 - 1011, XP055743672 [X] 4 * page 1009; figure 2 * * page 1010; figure 3 * [Y] 6-9 [I] 5 DOI: http://dx.doi.org/10.1016/j.tetlet.2012.12.035
		[XI] - HATVATE NAVNATH T. ET AL, "Metal-free synthesis of 2-aminothiadiazoles via TBHP-Mediated oxidative C-S bond formation", SYNTHETIC COMMUNICATIONS, US, (20180103), vol. 48, no. 3, doi:10.1080/00397911.2017.1398330, ISSN 0039-7911, pages 285 - 290, XP093025777 [X] 10 * abstract * * page 287 - page 288; tables 1, 2 * [I] 11 DOI: http://dx.doi.org/10.1080/00397911.2017.1398330
		[XI] - FALLON GARY D. ET AL, "N,N-Dialkyl-N'-Chlorosulfonylchloroformamidines in Heterocyclic Synthesis. II. Thiazolo-, Thiadiazolo-, and Oxadiazolo-Fused [1,2,4,6]Thiatriazine Dioxides", AUSTRALIAN JOURNAL OF CHEMISTRY, AU, (20050101), vol. 58, no. 12, doi:10.1071/CH05070, ISSN 0004-9425, page 891, XP093025748 [X] 10 * page 899; compound 12c * [I] 11 DOI: http://dx.doi.org/10.1071/CH05070
	International search	[YA]WO2010004761 (PHARMA IP GENERAL INC ASS [JP], et al) [Y] 4, 6-9 * claims, production process, examples * [A] 1-3, 5, 10, 11;
		[A]WO2011002067 (TAKEDA PHARMACEUTICAL [JP], et al) [A] 10, 11 * paragraphs [0110], [0115] *;
		[A]CN103351360 (UNIV ZHEJIANG TECHNOLOGY) [A] 10, 11* entire text *;
		[A] - KOST, A. N. , "Reaction of vinyl ethers with amines", Zhurnal Obshchei Khimii, (19950000), vol. 25, ISSN 0514-7492, pages 943 - 947, XP009531076 [A] 1-3 * entire text *
		[Y] - MATSUNO, K. et al., "Identification of a New Series of STAT3 Inhibitors by Virtual Screening", ACS Medicinal Chemistry Letters, (20100000), vol. 1, no. 8, doi:10.1021/ml1000273, pages 371 - 375, XP009173598 [Y] 4, 6-9 * table 1, scheme 1 * DOI: http://dx.doi.org/10.1021/ml1000273
		[Y] - ISLAM, R. et al., "Facile synthesis of 2- phenylquinoline-4-carboxamide derivatives with variant structural features", Heterocycles, (20140000), vol. 89, no. 3, pages 693 - 708, XP009526849 [Y] 4, 6-9 * schemes 1, 3 * DOI: http://dx.doi.org/10.3987/COM-14-12939
		[Y] - OLSON, M. E. et al., "Oxidative reactivities of 2- furylquinolines: ubiquitous scaffolds in common high-throughput screening libraries", Journal of Medicinal Chemistry, (20150924), vol. 58, no. 18, pages 7419 - 7430, XP055743666 [Y] 4, 6-8 * scheme 1 * DOI: http://dx.doi.org/10.1021/acs.jmedchem.5b00930
		[Y] - SENTHIL, S. et al., "N-Substituted-1,2,3-triazoles: Synthesis, characterization and antimicrobial activity studies", Pharma Chemica, (20150000), vol. 7, no. 6, pages 15 - 23, XP055743669 [Y] 4, 6-9 * scheme 1 *
		[Y] - KLEIN, L. L. et al., "Synthesis of substituted isatins", Tetrahedron Letters, (20130200), vol. 54, no. 8, pages 1008 - 1011, XP055743672 [Y] 4, 6-9 * page 1008, left column, paragraph [0003] to right column, paragraph [0001], fig. 2, 3 * DOI: http://dx.doi.org/10.1016/j.tetlet.2012.12.035
	by applicant	JPS5650529B
		- Synthetic comm., (20110000), vol. 41, pages 1435 - 1443
		- Mod. Chem. Appl., (20160000), vol. 4
		- Heterocycles, (20140000), vol. 89, pages 693 - 707
		- Bioorg. Med. Chem., (20100000), vol. 18, pages 1482 - 1496
		- J. Org. Chem., (20150000), vol. 80, pages 1018 - 1024

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