EP3984546 - GENE THERAPY WITH THE GENES HOKD AND LDRB FOR CANCER TREATMENTS [Right-click to bookmark this link] | Status | Request for examination was made Status updated on 18.03.2022 Database last updated on 20.07.2024 | |
Former | The international publication has been made Status updated on 27.11.2020 | Most recent event Tooltip | 06.07.2024 | New entry: Additional fee for renewal fee: despatch of communication + time limit | Applicant(s) | For all designated states Universidad de Granada Hospital Real Avda. del Hospicio, s/n 18071 Granada / ES | For all designated states Servicio Andaluz de Salud Avda. de la Constitución 18 41071 Sevilla / ES | [2022/16] | Inventor(s) | 01 /
BOULAIZ TASSI, Houria Universidad de Granada Dpto. de Anatomía y Embriología Humana 18071 Granada / ES | 02 /
MARCHAL CORRALES, Juan Antonio Universidad de Granada Dpto. Anatomía y Embriología Humana 18071 Granada / ES | 03 /
GRIÑÁN LISÓN, Carmen Universidad de Granada Centro de Investigación Biomédica 18071 Granada / ES | 04 /
JIMÉNEZ GONZÁLEZ, Gema Universidad de Granada Dpto. Anatomía y Embriología Humana 18071 Granada / ES | 05 /
JIMÉNEZ MARTÍNEZ, Yaiza FIBAO C/ Doctor Azpitarte 4, 4ª Planta 18012 Granada / ES | [2022/16] | Representative(s) | Hoffmann Eitle Hoffmann Eitle S.L.U. Paseo de la Castellana 140, 3a planta Edificio LIMA 28046 Madrid / ES | [2022/16] | Application number, filing date | 20810087.5 | 15.05.2020 | [2022/16] | WO2020ES70315 | Priority number, date | ES20190030428 | 15.05.2019 Original published format: ES 201930428 | ES20190030427 | 15.05.2019 Original published format: ES 201930427 | [2022/16] | Filing language | ES | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2020234498 | Date: | 26.11.2020 | Language: | ES | [2020/48] | Type: | A2 Application without search report | No.: | EP3984546 | Date: | 20.04.2022 | Language: | EN | [2022/16] | Search report(s) | International search report - published on: | ES | 04.02.2021 | (Supplementary) European search report - dispatched on: | EP | 28.08.2023 | Classification | IPC: | A61K38/00, A61K31/713, A61K38/16, C12N15/63, C12N15/85, C07K14/245, A61P35/00 | [2022/16] | CPC: |
A61P35/00 (EP,US);
A61K48/005 (EP,US);
C07K14/245 (EP,US);
C12N15/11 (US);
A01K2207/12 (EP);
A01K2227/105 (EP);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2022/16] | Title | German: | GENTHERAPIE MIT DEN GENEN HOKD UND LDRB FÜR KREBSBEHANDLUNGEN | [2022/16] | English: | GENE THERAPY WITH THE GENES HOKD AND LDRB FOR CANCER TREATMENTS | [2022/16] | French: | THÉRAPIE GÉNIQUE UTILISANT LES GÈNES HOKD ET LDRB POUR LE TRAITEMENT DU CANCER | [2022/16] | Entry into regional phase | 09.12.2021 | Translation filed | 09.12.2021 | National basic fee paid | 09.12.2021 | Search fee paid | 09.12.2021 | Designation fee(s) paid | 09.12.2021 | Examination fee paid | Examination procedure | 09.12.2021 | Examination requested [2022/16] | 13.03.2024 | Amendment by applicant (claims and/or description) | Fees paid | Renewal fee | 18.05.2022 | Renewal fee patent year 03 | 26.05.2023 | Renewal fee patent year 04 | Penalty fee | Additional fee for renewal fee | 31.05.2024 | 05   M06   Not yet paid |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [X]US2016244489 (MASIGNANI VEGA [IT], et al) [X] 1-5* paragraphs [0018] , [0023] , [0024]; table 1; sequence 2377 * | International search | [A]WO02092825 (UNIV AARHUS [DK], et al) [A] 1-18 * , todo el documento. *; | [A]WO2013080147 (ADAMED SP ZOO [PL]) [A] 1-18 * , todo el documento. *; | [X]WO2016185471 (MEDICAL RES INFRASTRUCTURE & HEALTH SERVICES FUND TEL AVIV MEDICAL CT [IL]) [X] 1-18 * , todo el documento. En particular pags. 21, 38-39; ejemplos4-5; figs. 5 y 8 *; | [PX]US2019153409 (ARBER NADIR [IL], et al) [PX] 1-18 * , todo el documento. *; | [A] - KAWANO MITSUOKI, "Divergently overlapping cis-encoded antisense RNA regulating toxin-antitoxin systems from E-coli hok/sok, ldr/rdl, symE/symR", Rna Biology, (20120000), vol. 9, no. 12, doi:10.4161/rna.22757, ISSN 1547-6286, pages 1520 - 1527, XP055785539 [A] 1-18 * todo el documento. Citado en la solicitud * DOI: http://dx.doi.org/10.4161/rna.22757 | [A] - YAMAGUCHI YOSHIHIRO et al., "Regulation of growth and death in Escherichia coli by toxin-antitoxin systems.", Nature Reviews Microbiology, (20110000), vol. 9, no. 11, doi:10.1038/nrmicro2651, ISSN 1740-1526, pages 779 - 790, XP055785540 [A] 1-18 * todo el documento. Citado en solicitud * DOI: http://dx.doi.org/10.1038/nrmicro2651 | [A] - ALIX ERIC et al., "Hydrophobic peptides: novel regulators within bacterial membrane.", Molecular Microbiology, (20090331), vol. 72, no. 1, doi:10.1111/j.1365-2958.2009.06626.x pubmed: 19210615, ISSN 1365-2958, pages 5 - 11, XP055785543 [A] 1-18 * todo el documento. * DOI: http://dx.doi.org/10.1111/j.1365-2958.2009.06626.x | [A] - Yamaguchi Yoshihiro, Tokunaga Narumi, Inouye Masayori, Phadtare Sangita, "Characterization of LdrA (long direct repeat A) protein of Escherichia coli.", Journal Of Molecular Microbiology And Biotechnology, (20140000), vol. 24, no. 2, doi:10.1159/000357949, ISSN 1660-2412, pages 91 - 97, XP009526316 [A] 1-18 * todo el documento. * DOI: http://dx.doi.org/10.1159/000357949 | [A] - KAWANO MITSUOKI et al., "Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35- amino-acid cell -killing peptide and a cis-encoded small antisense RNA in Escherichia coli.", Molecular Microbiology, (20020700), vol. 45, no. 2, ISSN 0950-382X, pages 333 - 349, XP055785547 [A] 1-18 * todo el documento. * DOI: http://dx.doi.org/10.1046/j.1365-2958.2002.03042.x | [A] - Anonymous, "Coding: ATG06226.1: Escherichia coli protein HokD", ENA, (20171002), pages 1 - 2, URL: https://www.ebi.ac.uk/ena/browser/view/ATG06226, (20201126), XP009526312 [A] 1-18 * . todo el documento. * | [A] - Anonymous, "Coding: ASE51079.1 Escherichia coli O157 small toxic polypeptide LdrB", European Nucleotide Archive , (20170629), pages 1 - 2, URL: https://www.ebi.ac.uk/ena/browser/view/ASE51079, (20201126), XP009526309 [A] 1-18 * . todo el documento. * | by applicant | US1685210 | - SIEGEL, R. L.MILLER, K. D.JEMAL, A, Cancer statistics, (20160000), vol. 66, pages 7 - 30 | - VANNUCCI, L.LAI, M.CHIUPPESI, F.CECCHERINI-NELLI, L.PISTELLO, M, "Viral vectors: a look back and ahead on gene transfer technology", New Microbiol, (20130000), vol. 36, pages 1 - 22 | - AMER, M. H., "Gene therapy for cancer: present status and future perspective", Mol. Cell. Ther., (20140000), vol. 2, doi:10.1186/2052-8426-2-27, page 27, XP021198259 DOI: http://dx.doi.org/10.1186/2052-8426-2-27 | - KARJOO, Z.CHEN, X.HATEFI, A, "Progress and problems with the use of suicide genes for targeted cancer therapy", Adv. Drug Deliv. Rev., (20160000), vol. 99, doi:10.1016/j.addr.2015.05.009, pages 113 - 128, XP029445824 DOI: http://dx.doi.org/10.1016/j.addr.2015.05.009 | - ORTIZ, R.MELGUIZO, C.PRADOS, J.ALVAREZ, P. J.CABA, O.HITA, F.ARANEGA, A., New Gene Therapy Strategies for Cancer Treatment: A Review of Recent Patents, (20120000), pages 297 - 312 | - GRECO, O.DACHS, G. U., "Gene directed enzyme/prodrug therapy of cancer: Historical appraisal and future prospectives", J. Cell. Physiol., (20010000), vol. 187, doi:10.1002/1097-4652(2001)9999:9999<::AID-JCP1060>3.0.CO;2-H, pages 22 - 36, XP008022473 DOI: http://dx.doi.org/10.1002/1097-4652(2001)9999:9999<::AID-JCP1060>3.0.CO;2-H | - WANG, J.LU, X.-X.CHEN, D.-Z.LI, S.-F.ZHANG, L.-S, "Herpes simplex virus thymidine kinase and ganciclovir suicide gene therapy for human pancreatic cancer", World J. Gastroenterol., (20040000), no. 10, pages 400 - 3 | - KURIYAMA, S.KIKUKAWA, M.MASUI, K.OKUDA, H.NAKATANI, T.AKAHANE, T.MITORO, A.TOMINAGA, K.TSUJINOUE, H.YOSHIJI, H., "Cancer gene therapy with HSV-tk/GCV system depends on T-cell-mediated immune responses and causes apoptotic death of tumor cells in vivo", Int. J. Cancer, (19990000), vol. 83, doi:10.1002/(SICI)1097-0215(19991029)83:3<374::AID-IJC13>3.0.CO;2-#, pages 374 - 380, XP055683373 DOI: http://dx.doi.org/10.1002/(SICI)1097-0215(19991029)83:3<374::AID-IJC13>3.0.CO;2-# | - PORTSMOUTH, D.HLAVATY, J.RENNER, M, "Suicide genes for cancer therapy", Mol. Aspects Med., (20070000), vol. 28, doi:10.1016/j.mam.2006.12.001, pages 4 - 41, XP005909041 DOI: http://dx.doi.org/10.1016/j.mam.2006.12.001 | - BENTIRES-ALJ, M.HELLIN, A. C.LECHANTEUR, C.PRINCEN, F.LOPEZ, M.FILLET, G.GIELEN, J.MERVILLE, M. P.BOURS, V, "Cytosine deaminase suicide gene therapy for peritoneal carcinomatosis", Cancer Gene Ther, (20000000), vol. 7, pages 20 - 6 | - DACHS, G. U.TUPPER, J.TOZER, G. M, "From bench to bedside for gene-directed enzyme prodrug therapy of cancer", Anticancer. Drugs, (20050000), vol. 16, pages 349 - 359 | - LIN, B.GAO, A.ZHANG, R.MA, H.SHEN, H.HU, Q.ZHANG, H.ZHAO, M.LAN, X.LIU, K, "Use of a Novel Integrase-Deficient Lentivirus for Targeted Anti-Cancer Therapy With Survivin Promoter-Driven Diphtheria Toxin A", Medicine (Baltimore, (20150000), vol. 94, page e1301 | - KIM, H. P.FRANKEL, A. E.HOGGE, D. E, "A diphtheria toxin interleukin-3 fusion protein synergizes with tyrosine kinase inhibitors in killing leukemic progenitors from BCR/ABL positive acute leukemia", Leuk. Res., (20100000), vol. 34, doi:10.1016/j.leukres.2009.12.008, pages 1035 - 1042, XP027080531 DOI: http://dx.doi.org/10.1016/j.leukres.2009.12.008 | - HAYES, F, "Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest", Science, (20030000), vol. 301, doi:10.1126/science.1088157, pages 1496 - 1499, XP002389061 DOI: http://dx.doi.org/10.1126/science.1088157 | - SEVIN, E. W.BARLOY-HUBLER, F, "RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes", Genome Biol, (20070000), vol. 8, doi:10.1186/gb-2007-8-8-r155, page R155, XP021031286 DOI: http://dx.doi.org/10.1186/gb-2007-8-8-r155 | - YAMAGUCHI, Y.INOUYE, M, "Regulation of growth and death in Escherichia coli by toxin-antitoxin systems", Nat Rev Microbiol, (20110000), vol. 9, doi:10.1038/nrmicro2651, pages 779 - 790, XP055785540 DOI: http://dx.doi.org/10.1038/nrmicro2651 | - UNTERHOLZNER, S. J.POPPENBERGER, B.ROZHON, W, "Toxin-antitoxin systems", Bioengineered, (20140000), vol. 5, pages 1 - 13 | - BRANTL, S, "Bacterial type I toxin-antitoxin systems", RNA Biol, (20120000), vol. 9, pages 1488 - 90 | - FOZO, E. M.HEMM, M. R.STORZ, G, "Small toxic proteins and the antisense RNAs that repress them", Microbiol Mol Biol Rev, (20080000), vol. 72, doi:10.1128/MMBR.00025-08, pages 579 - 89, XP002667800 DOI: http://dx.doi.org/10.1128/MMBR.00025-08 | - PEDERSEN, K.GERDES, K., "Multiple hok genes on the chromosome of Escherichia coli", Mol. Microbiol., (19990000), vol. 32, pages 1090 - 1102 | - GERDES, K.BECH, F. W.JORGENSEN, S. T.LØBNER-OLESEN, A.RASMUSSEN, P. B.ATLUNG, T.BOE, L.KARLSTROM, O.MOLIN, S.VON MEYENBURG, K, "Mechanism of postsegregational killing by the hok gene product of the parB system of plasmid R1 and its homology with the relF gene product of the E. coli relB operon", EMBO J., (19860000), vol. 5, pages 2023 - 9 | - GERDES, K.RASMUSSEN, P. B.MOLIN, S, "Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells", Proc. Natl. Acad. Sci. U. S. A., (19860000), vol. 83, doi:10.1073/pnas.83.10.3116, pages 3116 - 3120, XP000578399 DOI: http://dx.doi.org/10.1073/pnas.83.10.3116 | - KAWANO, M.OSHIMA, T.KASAI, H.MORI, H, "Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli", Mol. Microbiol., (20020000), vol. 45, doi:10.1046/j.1365-2958.2002.03042.x, pages 333 - 349, XP055785547 DOI: http://dx.doi.org/10.1046/j.1365-2958.2002.03042.x | - KAWANO, M, "Divergently overlapping cis-encoded antisense RNA regulating toxin-antitoxin systems from E. coli: hok/sok, Idr/rdl, symE/symR", RNA Biol, (20120000), vol. 9, doi:10.4161/rna.22757, pages 1520 - 7, XP055785539 DOI: http://dx.doi.org/10.4161/rna.22757 | - WIEWRODT, R.AMIN, K.KIEFER, M.JOVANOVIC, V. P.KAPOOR, V.FORCE, S.CHANG, M.LANUTI, M.BLACK, M. E.KAISER, L. R., "Adenovirus-mediated gene transfer of enhanced Herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing", Cancer Gene Ther, (20030000), vol. 10, pages 353 - 364 | - YANG, W. S.PARK, S.-O.YOON, A.-R.YOO, J. Y.KIM, M. K.YUN, C.-O.KIM, C.-W, "Suicide cancer gene therapy using pore-forming toxin, streptolysin O", Mol. Cancer Ther., (20060000), vol. 5, doi:10.1158/1535-7163.MCT-05-0515, pages 1610 - 1619, XP003012500 DOI: http://dx.doi.org/10.1158/1535-7163.MCT-05-0515 | - PRADOS, J.MELGUIZO, C.RAMA, A. R.ORTIZ, R.SEGURA, A.BOULAIZ, H.VELEZ, C.CABA, O.RAMOS, J. L.ARANEGA, A, "Gef gene therapy enhances the therapeutic efficacy of doxorubicin to combat growth of MCF-7 breast cancer cells", Cancer Chemother. Pharmacol., (20100000), vol. 66, pages 69 - 78, XP019800797 | - ORTIZ, R.PRADOS, J.MELGUIZO, C.RAMA, A. R.AVAREZ, P. J.RODRIGUEZ-SERRANO, F.CABA, O.BOULAIZ, H.ARANEGA, A, "Gef gene therapy enhances the therapeutic efficacy of cytotoxics in colon cancer cells", Biomed. Pharmacother., (20120000), vol. 66, pages 563 - 567 | - TANG, Y.JACKSON, M.QIAN, K.PHILLIPS, M. I, Ischemia Gene Therapy, (20020000), pages 695 - 699 | - DALLE, B.PAYEN, E.BEUZARD, Y, "Modulation of transduced erythropoietin expression by iron", Exp. Hematol., (20000000), vol. 28, pages 760 - 764 | - COULTER, J. AMCCARTHY, H. O.WORTHINGTON, J.ROBSON, T.SCOTT, S.HIRST, D. G, "The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation", Gene Ther, (20080000), vol. 15, pages 495 - 503 | - GOSSEN, M.BUJARD, H, "Tight control of gene expression in mammalian cells by tetracycline-responsive promoters", Proc. Natl. Acad. Sci. U. S. A., (19920000), vol. 89, doi:10.1073/pnas.89.12.5547, pages 5547 - 51, XP002202393 DOI: http://dx.doi.org/10.1073/pnas.89.12.5547 | - YAO, F.THEOPOLD, C.HOELLER, D.BLEIZIFFER, O.LU, Z, "Highly Efficient Regulation of Gene Expression by Tetracycline in a Replication-Defective Herpes Simplex Viral Vector", Mol. Ther., (20060000), vol. 13, doi:10.1016/j.ymthe.2006.01.009, pages 1133 - 1141, XP005469387 DOI: http://dx.doi.org/10.1016/j.ymthe.2006.01.009 | - LOEW, R.HEINZ, N.HAMPF, M.BUJARD, H.GOSSEN, M, "Improved Tet-responsive promoters with minimized background expression", BMC Biotechnol, (20100000), vol. 10, doi:10.1186/1472-6750-10-81, page 81, XP021087812 DOI: http://dx.doi.org/10.1186/1472-6750-10-81 | - VANDERVEEN, N.PARAN, C.KRASINKIEWICZ, J.ZHAO, L.PALMER, D.HERVEY-JUMPER, S.NG, P.LOWENSTEIN, P.CASTRO, M, "Effectiveness and preclinical safety profile of doxycycline to be used ''off-label'' to induce therapeutic transgene expression in a Phase I clinical trial for glioma", Hum. Gene Ther. Clin. Dev., (20130000), vol. 126, pages 116 - 126 | - GIMENEZ, E.LAVADO, A.GIRALDO, P.COZAR, P.JEFFERY, G.MONTOLIU, L, "A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism", Pigment Cell Res, (20040000), vol. 17, doi:10.1111/j.1600-0749.2004.00158.x, pages 363 - 370, XP055208930 DOI: http://dx.doi.org/10.1111/j.1600-0749.2004.00158.x | - WANG, Z. X.BIAN, H. B.YANG, J. S.DE, W.JI, X. H, "Adenovirus-mediated suicide gene therapy under the control of Cox-2 promoter for colorectal cancer", Cancer Biol. Ther., (20090000), page 8 | - SHIEH, G. S.SHIAU, A. L.YO, Y. TELIN, P. R.CHANG, C. C.TZAI, T. S.WU, C. L., "Low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model", Cancer Res., (20060000), vol. 66, pages 9957 - 9966 | - DEHARVENGT, S.REJIBA, S.WACK, S.APRAHAMIAN, M.HAJRI, A, "Efficient electrogene therapy for pancreatic adeno carcinoma treatment using the bacterial purine nucleoside phosphorylase suicide gene with fludarabine", Int. J. Oncol., (20070000), vol. 30, pages 1397 - 1406 |