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Extract from the Register of European Patents

EP About this file: EP3986397

EP3986397 - HCK DEGRADERS AND USES THEREOF [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  25.03.2022
Database last updated on 15.06.2024
FormerThe international publication has been made
Status updated on  15.01.2021
Most recent event   Tooltip23.10.2023Amendment by applicant 
Applicant(s)For all designated states
Dana-Farber Cancer Institute, Inc.
450 Brookline Avenue
Boston, MA 02215 / US
[2022/17]
Inventor(s)01 / TREON, Steven, P.
180 Pond Street
Jamaica Plain, MA 02130 / US
02 / WANG, Jinhua
103 Loring Avenue
Winchester, MA 01890 / US
03 / YANG, Guang
3 Jennifer Circle
Natick, MA 01760 / US
04 / GRAY, Nathanael, S.
26 Greenview Avenue
Boston, MA 02130 / US
05 / BUHRLAGE, Sara, Jean
28 Josephine Avenue
Somerville, MA 02144 / US
06 / TAN, Li
573 Bibo Road, Building 8, Room 301 Pudong
Shanghai, 201203 / CN
 [2022/17]
Representative(s)Haseltine Lake Kempner LLP
Cheapside House
138 Cheapside
London EC2V 6BJ / GB
[2022/17]
Application number, filing date20833532.324.06.2020
[2022/17]
WO2020US39304
Priority number, dateUS201962865780P24.06.2019         Original published format: US 201962865780 P
[2022/17]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2020263935
Date:30.12.2020
Language:EN
[2020/53]
Type: A1 Application with search report 
No.:EP3986397
Date:27.04.2022
Language:EN
The application published by WIPO in one of the EPO official languages on 30.12.2020 takes the place of the publication of the European patent application.
[2022/17]
Search report(s)International search report - published on:US30.12.2020
(Supplementary) European search report - dispatched on:EP06.04.2023
ClassificationIPC:A61K47/55, A61K31/381, A61K31/397, A61K31/4025, C07D401/14, C07D471/04, C07D487/04, A61P35/00, A61P35/02
[2023/19]
CPC:
A61K45/06 (EP); C07D401/14 (EP,US); A61K47/55 (EP);
A61P35/00 (EP); A61P35/02 (EP); C07D471/04 (EP);
C07D487/04 (EP,US) (-)
Former IPC [2022/17]A61K31/381, A61K31/397, A61K31/4025
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/17]
TitleGerman:HCK-DEGRADER UND VERWENDUNGEN DAVON[2022/17]
English:HCK DEGRADERS AND USES THEREOF[2022/17]
French:AGENTS DE DÉGRADATION DE HCK ET LEURS UTILISATIONS[2022/17]
Entry into regional phase17.01.2022National basic fee paid 
17.01.2022Search fee paid 
17.01.2022Designation fee(s) paid 
17.01.2022Examination fee paid 
Examination procedure17.01.2022Examination requested  [2022/17]
20.10.2023Amendment by applicant (claims and/or description)
Fees paidRenewal fee
27.06.2022Renewal fee patent year 03
27.06.2023Renewal fee patent year 04
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]WO2014063061  (DANA FARBER CANCER INST INC [US], et al) [X] 1,2,4,14,15 * p. 87, Table 1; p. 134; claim 39 *;
 [A]WO2017189999  (DANA FARBER CANCER INST INC [US]) [A] 1-16* claims 1, 15, 30 *;
 [A]WO2018085247  (UNIV CORNELL [US], et al) [A] 1-16 * claims 44, 49 *;
 [XP]WO2019177902  (UNIV YALE [US]) [XP] 1,2,4,7,10,14-16 * p. 4, l. 30-34; p. 151, l. 14, 15; p. 268; claim 43 *
International search[A]WO0119829  (BASF AG [DE], et al) [A] 1-2 * , entire document. *;
 [A]US9604988  (ISHIKAWA FUMIHIKO [JP], et al) [A] 1-2 * , entire document, especially: col 21, In 20-50, Example 1. *;
 [A]WO2018052120  (RIKEN [JP]) [A] 1-2* , entire document, especially: (para [0121], RK-20620: 1-((1R,4R)-4-(4-methylpiperazin-1-yl)cyclohexyl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine). *;
 [A]  - ohn M Hatcher; Eric S Wang; Liv Johannessen; Nicholas Kwiatkowski; Taebo Sim; Nathanael S Gray, "Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8", ACS Medicinal chemistry letters, (20180000), vol. 9, no. 6, doi:10.1021/acsmedchemlett.8b00011, ISSN 1948-5875, pages 540 - 545, XP055631975 [A] 1-2 * , entire document, especially: abstract; pg 543, col 1, para 3; pg 544, col 1, para 3; Figure 4. *

DOI:   http://dx.doi.org/10.1021/acsmedchemlett.8b00011
 [A]  - Anonymous, "1-[4-[3-(4-Phenoxyphenyl)pyrazol-1-yl]cyclohexyl]piperazine", PubChem, (20150317), Database accession no. 90969978, URL: NCBI, XP055780254 [A] 1-2 * , pg 2, Fig. *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.