blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP3994254

EP3994254 - COMPOSITIONS AND METHODS FOR GENE REPLACEMENT [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  08.04.2022
Database last updated on 05.10.2024
FormerThe international publication has been made
Status updated on  15.01.2021
Most recent event   Tooltip29.07.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
CHILDREN'S MEDICAL CENTER CORPORATION
55 Shattuck Street
Boston, Massachusetts 02115 / US
[2022/19]
Inventor(s)01 / HOLT, Jeffrey R.
c/o Children's Medical Center Corporation 55
Shattuck Street
Boston, Massachusetts 02115 / US
 [2022/19]
Representative(s)Impact Intellectual Property LLP
1 Sans Walk
London EC1R 0LT / GB
[2022/19]
Application number, filing date20834446.502.07.2020
[2022/19]
WO2020US40608
Priority number, dateUS201962870488P03.07.2019         Original published format: US 201962870488 P
[2022/19]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021003337
Date:07.01.2021
Language:EN
[2021/01]
Type: A1 Application with search report 
No.:EP3994254
Date:11.05.2022
Language:EN
The application published by WIPO in one of the EPO official languages on 07.01.2021 takes the place of the publication of the European patent application.
[2022/19]
Search report(s)International search report - published on:US07.01.2021
(Supplementary) European search report - dispatched on:EP30.06.2023
ClassificationIPC:C12N9/16, C12N9/22, C12N9/78, C12N9/99
[2022/19]
CPC:
C07K14/705 (EP,US); A61K48/005 (EP,US); A01K67/0276 (EP);
A61K48/0075 (EP,US); C12N15/102 (EP,US); C12N15/86 (EP,US);
C12N9/22 (EP,US); A01K2217/075 (EP,US); A01K2227/105 (EP,US);
A01K2267/0306 (EP,US); C12N2310/20 (EP,US); C12N2750/14143 (EP,US);
C12N2800/40 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/19]
TitleGerman:ZUSAMMENSETZUNGEN UND VERFAHREN ZUM GENAUSTAUSCH[2022/19]
English:COMPOSITIONS AND METHODS FOR GENE REPLACEMENT[2022/19]
French:COMPOSITIONS ET PROCÉDÉS DE REMPLACEMENT DE GÈNE[2022/19]
Entry into regional phase10.01.2022National basic fee paid 
10.01.2022Search fee paid 
10.01.2022Designation fee(s) paid 
10.01.2022Examination fee paid 
Examination procedure10.01.2022Examination requested  [2022/19]
17.01.2024Amendment by applicant (claims and/or description)
17.01.2024Date on which the examining division has become responsible
Fees paidRenewal fee
27.07.2022Renewal fee patent year 03
27.07.2023Renewal fee patent year 04
29.07.2024Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]WO2017053879  (EDITAS MEDICINE INC [US]) [X] 1-15 * page 43, line 2, paragraph l * * page 44, line 3 ** page 139, lines 1-2, paragraph 4 *;
 [X]  - ROBERTSON LOUISE ET AL, "Expanding the RNA-Guided Endonuclease Toolkit for Mouse Genome Editing", THE CRISPR JOURNAL, (20181201), vol. 1, no. 6, doi:10.1089/crispr.2018.0050, ISSN 2573-1599, pages 431 - 439, XP093053593 [X] 1-15 * abstract * * page 432, column l * * page 432, column l, paragraph l - column r, paragraph 1 *

DOI:   http://dx.doi.org/10.1089/crispr.2018.0050
International search[Y]US2017073674  (MAEDER MORGAN L [US], et al) [Y] 1-20 * entire document *;
 [Y]US9758781  (SMITH RICHARD J H [US], et al) [Y] 7,10,11,18 * entire document *;
 [Y]US2017321214  (ZHANG FENG [US], et al) [Y] 9, 11 * entire document *;
 [Y]US2018282714  (JOUNG J KEITH [US], et al) [Y] 1-20 * entire document *;
 [Y]  - GAO Xue; Gao Xue; Tao Yong; Lamas Veronica; Huang Mingqian; Yeh Wei-Hsi; Pan Bifeng; Hu Yu-Juan; Hu Johnny; Thompson David; Shu Yilai; Li Yamin; Wang Hongyang; Yang Shiming; Xu Qiaobing; Polley Daniel; Liberman; Kong Wei-Jia; Holt Jeffrey; Chen Zheng-Yi; Liu David, "Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents", Nature, (20171220), vol. 553, no. Iss. 7687, doi:10.1038/nature25164, pages 217 - 221, XP055776079 [Y] 5, 10, 11, 16, 17 * . entire document *

DOI:   http://dx.doi.org/10.1038/nature25164
 [Y]  - GYORGY et al., "Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate", Molecular Therapy Methods & Clinical Development, (20181119), vol. 13, pages 1 - 13, XP055637659 [Y] 10, 11 * . entire document *
 [PX]  - GYORGY et al., "Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss", Nature Medicine, (20190703), vol. 25, no. Iss. 7, doi:10.1038/s41591-019-0500-9, pages 1123 - 1130, XP036901105 [PX] 1-20 * . entire document *

DOI:   http://dx.doi.org/10.1038/s41591-019-0500-9
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.