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Extract from the Register of European Patents

EP About this file: EP4043553

EP4043553 - METHOD FOR ISOLATING URETERIC BUD TIP CELLS [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  15.07.2022
Database last updated on 05.08.2024
FormerThe international publication has been made
Status updated on  10.04.2021
Most recent event   Tooltip13.05.2024The date on which the examining division becomes responsible, has been established 
13.05.2024Amendment by applicant 
Applicant(s)For all designated states
Kyoto University
36-1, Yoshida-honmachi
Sakyo-ku
Kyoto-shi, Kyoto 606-8501 / JP
[2022/33]
Inventor(s)01 / OSAFUNE, Kenji
c/o Kyoto University, 36-1, Yoshida-honmachi,
Sakyo-ku
Kyoto-shi, Kyoto 606-8501 / JP
02 / MAE, Shinichi
c/o Kyoto University, 36-1, Yoshida-honmachi,
Sakyo-ku
Kyoto-shi, Kyoto 606-8501 / JP
03 / RYOSAKA, Makoto
c/o Kyoto University, 36-1, Yoshida-honmachi,
Sakyo-ku
Kyoto-shi, Kyoto 606-8501 / JP
 [2022/33]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2022/33]
Application number, filing date20872677.830.09.2020
[2022/33]
WO2020JP37329
Priority number, dateJP2019018159301.10.2019         Original published format: JP 2019181593
[2022/33]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021066076
Date:08.04.2021
Language:JA
[2021/14]
Type: A1 Application with search report 
No.:EP4043553
Date:17.08.2022
Language:EN
[2022/33]
Search report(s)International search report - published on:JP08.04.2021
(Supplementary) European search report - dispatched on:EP23.10.2023
ClassificationIPC:C12N5/071, C12Q1/02
[2022/33]
CPC:
G01N33/92 (EP); C12N5/0684 (EP,CN,KR,US); C12N5/0697 (EP,KR);
C12Q1/02 (KR); G01N33/5005 (CN); G01N33/56966 (CN,US);
C12N2501/11 (CN,US); C12N2501/113 (CN,KR,US); C12N2501/119 (EP,CN,US);
C12N2501/13 (EP,CN,KR,US); C12N2501/15 (EP,CN); C12N2501/155 (EP,CN,US);
C12N2501/16 (US); C12N2501/415 (EP,CN,US); C12N2501/727 (CN,KR);
C12N2501/998 (CN); C12N2501/999 (US); C12N2506/45 (EP,CN,KR,US);
G01N2333/47 (CN) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/33]
TitleGerman:VERFAHREN ZUM ISOLIEREN VON URETERKNOTENZELLEN[2022/33]
English:METHOD FOR ISOLATING URETERIC BUD TIP CELLS[2022/33]
French:PROCÉDÉ POUR ISOLER DES CELLULES D'EXTRÉMITÉ DE BOURGEON URÉTÉRIQUE[2022/33]
Entry into regional phase25.04.2022Translation filed 
25.04.2022National basic fee paid 
25.04.2022Search fee paid 
25.04.2022Designation fee(s) paid 
25.04.2022Examination fee paid 
Examination procedure25.04.2022Examination requested  [2022/33]
08.05.2024Amendment by applicant (claims and/or description)
08.05.2024Date on which the examining division has become responsible
Fees paidRenewal fee
19.09.2022Renewal fee patent year 03
20.09.2023Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]WO2014066649  (UNIV CALIFORNIA [US]) [Y] 1-15 * claims 1-19 *;
 [XY]WO2019098349  (UNIV KYOTO [JP]) [X] 15 * paragraphs [0014] - [0022] - [0031] - [0051]; claims 1-22 * [Y] 1-14;
 [Y]  - RUTLEDGE ELISABETH A ET AL, "Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.", DEVELOPMENT (CAMBRIDGE, ENGLAND) 01 09 2017, (20170901), vol. 144, no. 17, ISSN 1477-9129, pages 3177 - 3188, XP055811444 [Y] 1-15 * page 3178, column 1, paragraph last; figures 1-3 *

DOI:   http://dx.doi.org/10.1242/dev.149112
 [Y]  - TAGUCHI ATSUHIRO ET AL, "Higher-Order Kidney Organogenesis from Pluripotent Stem Cells", CELL STEM CELL, ELSEVIER, CELL PRESS, AMSTERDAM, NL, (20171109), vol. 21, no. 6, doi:10.1016/J.STEM.2017.10.011, ISSN 1934-5909, page 730, XP085301486 [Y] 1-15 * page 732, column 2, paragraph 2 *

DOI:   http://dx.doi.org/10.1016/j.stem.2017.10.011
 [Y]  - YUN XIA ET AL, "Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells", NATURE CELL BIOLOGY, London, (20131117), vol. 15, no. 12, doi:10.1038/ncb2872, ISSN 1465-7392, pages 1507 - 1515, XP055461411 [Y] 1-15 * page 1508, column 1, paragraph 2 *

DOI:   http://dx.doi.org/10.1038/ncb2872
International search[YA]JP2006312638  (MASSACHUSETTS INST TECHNOLOGY, et al) [Y] 1-17, 26-28 * paragraph [0089] paragraph [0089] * [A] 18-25;
 [Y]US2011008892  (NIGAM SANJAY KUMAR [US], et al) [Y] 1-17, 26-28 * paragraphs [0046], [0048] *;
 [YA]US2015284689  (NIGAM SANJAY K [US]) [Y] 1-17, 26-28 * paragraphs [0008]-[0009] paragraphs [0008]-[0009] * [A] 18-25;
 [A]JP2017537655  (THE UNIVERSITY OF QUEENSLAND) [A] 1-28 * claims, examples *;
 [A]JP2018183137  (UNIV KUMAMOTO) [A] 1-28 * claims, examples *;
 [XYA]  - RUTLEDGE, Elisabeth A. et al., "Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development", Development, (20170000), vol. 144, doi:10.1242/dev.149112, pages 3177 - 3188, XP055811444 [X] 27-28 * fig. 3 fig. 3 fig. 3 * [Y] 1-17, 26-28 [A] 18-25

DOI:   http://dx.doi.org/10.1242/dev.149112
 [YA]  - MAE, SHINICHI et al., "Generation of branching ureteric bud tissues from human pluripotent stem cells", Biochem. Biophys. Res. Commun., (20180000), vol. 495, doi:10.1016/j.bbrc.2017.11.105, pages 954 - 961, XP055609767 [Y] 1-17, 26-28 * abstract, page 958, right column, "3.4. Generation of branching UB tissue", fig. 3, 4 abstract, page 958, right column, "3.4. Generation of branching UB tissue", fig. 3, 4 * [A] 18-25

DOI:   http://dx.doi.org/10.1016/j.bbrc.2017.11.105
 [YA]  - YURI, Shunsuke et al., "In vitro propagation and branching morphogenesis from single ureteric bud cells", Stem Cell Reports, (20170000), vol. 8, no. 2, doi:10.1016/j.stemcr.2016.12.011, pages 401 - 416, XP055609758 [Y] 1-17, 26-28 * page 403, left column, "R-Spondin Mediates the Effect of WNT-beta-Catenin Signaling in UB Cells", page 406, right column, "Propagation and Reconstruction of UB-like Structure from Single UB Cells" page 403, left column, "R-Spondin Mediates the Effect of WNT-beta-Catenin Signaling in UB Cells", page 406, right column, "Propagation and Reconstruction of UB-like Structure from Single UB Cells" * [A] 18-25

DOI:   http://dx.doi.org/10.1016/j.stemcr.2016.12.011
 [YA]  - BUSH, Kevin T, Sakurai Hiroyuki, Steer Dylan L, Leonard Martin O, Sampogna Rosemary V, Meyer Tobias N, Schwesinger Catherine, Qiao Jizeng, Nigam Sanjay K, "TGF- beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud", Dev. Biol., (20040000), vol. 266, no. 2, doi:10.1016/j.ydbio.2003.10.023, pages 285 - 298, XP055811456 [Y] 1-17, 26-28 * page 290, left column, line 1 to right column, line 9 page 290, left column, line 1 to right column, line 9 * [A] 18-25

DOI:   http://dx.doi.org/10.1016/j.ydbio.2003.10.023
 [YA]  - GUI, Ting; Sun Yujing; Gai Zhibo; Shimokado Aiko; Muragaki Yasuteru; Zhou Gengyin, "The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-beta signaling", Dev. Biol., (20130000), vol. 377, no. 2, doi:10.1016/j.ydbio.2013.03.014, pages 415 - 427, XP028590005 [Y] 1-17, 26-28 * fig. 8 fig. 8 * [A] 18-25

DOI:   http://dx.doi.org/10.1016/j.ydbio.2013.03.014
 [YA]  - CHI, Lijun, Saarela Ulla, Railo Antti, Prunskaite-Hyyryläinen Renata, Skovorodkin Ilya, Anthony Shelagh, Katsu Kenjiro, Liu Yu, Shan Jingdong, Salgueiro Ana Marisa, Belo José António, Davies Jamie, Yokouchi Yuji, Vainio Seppo J., "A secreted EMP antagonist, Cer1, fine tunes the spatial organization of the ureteric bud tree during mouse kidney development", PLOS ONE, (20110000), vol. 6, no. issue 11, doi:10.1371/journal.pone.0027676, pages 1 - 16, XP055811462 [Y] 1-17, 26-28 * fig. 2 fig. 2 * [A] 18-25

DOI:   http://dx.doi.org/10.1371/journal.pone.0027676
 [PX]  - MAE, Shin-Ichi, Ryosaka Makoto, Sakamoto Satoko, Matsuse Kyoko, Nozaki Aya, Igami Maiko, Kabai Ryotaro, Watanabe Akira, Osafune Kenji, "Expansion of human iPSC-derived ureteric bud organoid, with repeated branching potential", Cell Reports, (20200728), vol. 32, no. 4, doi:10.1016/j.celrep.2020.107963, pages 1 - 16, XP055811473 [PX] 1-28 * abstract, fig. 1-4 *

DOI:   http://dx.doi.org/10.1016/j.celrep.2020.107963
by applicantUS4326055
 US5234926
 WO2007069666
 WO2009146408
 WO2011007900
 WO2019098349
 JP2019181593
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