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Extract from the Register of European Patents

EP About this file: EP4076493

EP4076493 - MACROCYCLIC PEPTIDES AS POTENT INHIBITORS OF K-RAS G12D MUTANT [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  23.09.2022
Database last updated on 05.07.2024
FormerThe international publication has been made
Status updated on  25.06.2021
Most recent event   Tooltip12.06.2024The date on which the examining division becomes responsible, has been established 
12.06.2024Amendment by applicant 
Applicant(s)For all designated states
Merck Sharp & Dohme LLC
126 East Lincoln Avenue
Rahway, New Jersey 07065 / US
For all designated states
MSD International GmbH (Singapore Branch)
50 Tuas West Drive
Singapore 638408 / SG
For all designated states
Agency for Science, Technology and Research
1 Fusionopolis Way
21-10 Connexis North Star Tower
Singapore 138632 / SG
[2022/43]
Inventor(s)01 / BOYER, Nicolas, C.
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
02 / GARRIGOU, Michael, B.
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
03 / HA, Sookhee Nicole
2432 Damsel Eve Drive
Lewisville, Texas 75056 / US
04 / HUANG, Chunhui
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
05 / PARTRIDGE, Anthony, W.
8 Biomedical Grove Block A, Neuros Bldg 04-01/05-
01
Singapore 138665 / SG
06 / SAWYER, Tomi, K.
8 Nathan Stone Lane
Southborough, Massachusetts 01772 / US
07 / ARONICA, Pietro
1 Fusionopolis Way 21-10 Connexis North Star
Tower
Singapore 138632 / SG
08 / JOHANNES, Charles, W.
1 Fusionopolis Way 21-10 Connexis North Star
Tower
Singapore 138632 / SG
09 / KANNAN, Srinivasaraghavan
1 Fusionopolis Way 21-10 Connexis North Star
Tower
Singapore 138632 / SG
10 / VERMA, Chandra, S.
1 Fusionopolis Way 21-10 Connexis North Star
Tower
Singapore 138632 / SG
11 / YUEN, Tsz Ying
1 Fusionopolis Way 21-10 Connexis North Star
Tower
Singapore 138632 / SG
 [2022/43]
Representative(s)Merck Sharp & Dohme LLC
120 Moorgate
London EC2M 6UR / GB
[2022/43]
Application number, filing date20902853.915.12.2020
[2022/43]
WO2020US65009
Priority number, dateUS201962949705P18.12.2019         Original published format: US 201962949705 P
[2022/43]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021126799
Date:24.06.2021
Language:EN
[2021/25]
Type: A1 Application with search report 
No.:EP4076493
Date:26.10.2022
Language:EN
The application published by WIPO in one of the EPO official languages on 24.06.2021 takes the place of the publication of the European patent application.
[2022/43]
Search report(s)International search report - published on:US24.06.2021
(Supplementary) European search report - dispatched on:EP06.12.2023
ClassificationIPC:A61K38/00, A61K38/10, A61K38/12, C07K7/00, C07K7/50, C07K7/52, C07K7/08
[2024/01]
CPC:
A61P35/00 (EP,US); A61K38/12 (US); C07K7/08 (EP);
C07K7/52 (US); A61K38/00 (EP); C07K2319/10 (EP)
Former IPC [2022/43]A61K38/00, A61K38/10, A61K38/12, C07K7/00, C07K7/50, C07K7/52
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2022/43]
TitleGerman:MAKROCYCLISCHE PEPTIDE ALS POTENTE INHIBITOREN DER K-RAS-G12D-MUTANTE[2022/43]
English:MACROCYCLIC PEPTIDES AS POTENT INHIBITORS OF K-RAS G12D MUTANT[2022/43]
French:PEPTIDES MACROCYCLIQUES EN TANT QU'INHIBITEURS PUISSANTS DU MUTANT G12D DE LA K-RAS[2022/43]
Entry into regional phase18.07.2022National basic fee paid 
18.07.2022Search fee paid 
18.07.2022Designation fee(s) paid 
18.07.2022Examination fee paid 
Examination procedure18.07.2022Examination requested  [2022/43]
12.06.2024Amendment by applicant (claims and/or description)
12.06.2024Date on which the examining division has become responsible
Fees paidRenewal fee
09.12.2022Renewal fee patent year 03
12.12.2023Renewal fee patent year 04
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Documents cited:Search[ID]  - SAKAMOTO KOTARO ET AL, "K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, (20170130), vol. 484, no. 3, doi:10.1016/J.BBRC.2017.01.147, ISSN 0006-291X, pages 605 - 611, XP029924461 [ID] 1-20 * Title; Abstract; Table 2 *

DOI:   http://dx.doi.org/10.1016/j.bbrc.2017.01.147
International search[A]WO2004037169  (MERCK & CO INC [US], et al) [A] 1* entire document *;
 [A]US2019309020  (PEI DEHUA [US], et al) [A] 1 * entire document *;
 [A]  - Sakamoto Kotaro; Kamada Yusuke; Sameshima Tomoya; Yaguchi Masahiro; Niida Ayumu; Sasaki Shigekazu; Miwa Masanori; Ohkubo Shoichi; Sakamoto Jun-ichi; Kamaura Masahiro; Cho Nobuo; Tani Akiyoshi, "K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology", Biochemical and Biophysical Research Communications, Amsterdam NL, (20170130), vol. 484, no. 3, doi:10.1016/j.bbrc.2017.01.147, ISSN 0006-291X, pages 605 - 611, XP029924461 [A] 1 * . Abstract *

DOI:   http://dx.doi.org/10.1016/j.bbrc.2017.01.147
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.