blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP3978526

EP3978526 - IL-18 BINDING PROTEIN (IL-18BP) IN INFLAMMATORY DISEASES [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  13.01.2023
Database last updated on 03.09.2024
FormerThe application has been published
Status updated on  04.03.2022
Most recent event   Tooltip22.09.2023New entry: Renewal fee paid 
Applicant(s)For all designated states
AB2 Bio SA
EPFL Innovation Park Building B, 4th Floor
1015 Lausanne / CH
[2022/14]
Inventor(s)01 / Pfeifer, Andrea
1806 St-Légier-La Chiésaz / CH
02 / Del Val, Greg
1180 Rolle / CH
 [2022/14]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstraße 3
81675 München / DE
[2022/14]
Application number, filing date21181013.005.09.2014
[2022/14]
Priority number, dateEP2013018319305.09.2013         Original published format: EP 13183193
[2022/14]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3978526
Date:06.04.2022
Language:EN
[2022/14]
Search report(s)(Supplementary) European search report - dispatched on:EP28.02.2022
ClassificationIPC:C07K16/24
[2022/14]
CPC:
C07K16/244 (EP,KR,US); C07K16/24 (RU); A61K38/00 (US);
A61P1/04 (EP); A61P1/16 (EP); A61P11/00 (EP);
A61P11/06 (EP); A61P17/00 (EP); A61P19/06 (EP);
A61P21/02 (EP); A61P25/00 (EP); A61P27/02 (EP);
A61P27/06 (EP); A61P27/14 (EP); A61P29/00 (EP);
A61P3/10 (EP); A61P31/12 (EP); A61P35/00 (EP);
A61P37/06 (EP); A61P9/04 (EP); A61P9/10 (EP);
C07K14/54 (US); C07K14/7155 (US); G01N33/564 (US);
G01N33/6869 (US); G01N33/6893 (KR); A61K2039/505 (KR,US);
C07K14/705 (US); C07K2317/14 (KR); C07K2317/24 (KR);
C07K2317/565 (KR); C07K2317/76 (US); C07K2317/92 (US);
G01N2333/54 (KR,US); G01N2800/105 (US); G01N2800/205 (US);
G01N2800/50 (US); G01N2800/52 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/07]
Former [2022/14]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
Extension statesBANot yet paid
MENot yet paid
TitleGerman:IL-18-BINDENDES PROTEIN (IL-18BP) BEI ENTZÜNDUNGSKRANKHEITEN[2022/14]
English:IL-18 BINDING PROTEIN (IL-18BP) IN INFLAMMATORY DISEASES[2022/14]
French:PROTÉINE DE LIAISON À L'IL-18 (IL-18 BP) DANS DES MALADIES INFLAMMATOIRES[2022/14]
Examination procedure27.10.2022Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time
09.01.2023Amendment by applicant (claims and/or description)
09.01.2023Examination requested  [2023/07]
09.01.2023Date on which the examining division has become responsible
Parent application(s)   TooltipEP14759210.9  / EP3041864
Request for further processing for:The application is deemed to be withdrawn due to non-payment of designation fees
SE, RS, RO, PT, PL, NO, NL, MT, MK, MC, LV, LU, LT, IT, TR, SM, SK, SI, IS, IE, HU, HR, GR, GB, FR, FI, ES, EE, DK, DE, CZ, CY, CH, BG, BE, AT, AL
09.01.2023Request for further processing filed
09.01.2023Full payment received (date of receipt of payment)
Request granted
25.01.2023Decision despatched
The application is deemed to be withdrawn due to non-payment of the examination fee
09.01.2023Request for further processing filed
09.01.2023Full payment received (date of receipt of payment)
Request granted
25.01.2023Decision despatched
The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
09.01.2023Request for further processing filed
09.01.2023Full payment received (date of receipt of payment)
Request granted
25.01.2023Decision despatched
Fees paidRenewal fee
22.06.2021Renewal fee patent year 03
22.06.2021Renewal fee patent year 04
22.06.2021Renewal fee patent year 05
22.06.2021Renewal fee patent year 06
22.06.2021Renewal fee patent year 07
22.06.2021Renewal fee patent year 08
20.09.2022Renewal fee patent year 09
21.09.2023Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]WO0162285  (APPLIED RESEARCH SYSTEMS [NL], et al) [X] 1,2,4-11 * the whole document * * in particular, pages 21, 24-26, 33 and 36-37 *;
 [X]WO02060479  (APPLIED RESEARCH SYSTEMS [NL], et al) [X] 1,2,4,6-9,11 * the whole document * * in particular, pages 7, 12-13, 22-23 and 32-33 *;
 [X]WO02096456  (ARES TRADING SA [CH], et al) [X] 1-3,7-11 * in particular, pages 7-9, 19, 21, 28 and 31-32 *;
 [X]WO2004101617  (APPLIED RESEARCH SYSTEMS [NL], et al) [X] 1,2,4,6-11 * in particular, pages 4, 13, 15 and 16. *;
 [A]  - LOCHNER M ET AL, "Generation of neutralizing mouse anti-mouse IL-18 antibodies for inhibition of inflammatory responses in vivo", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, (20020101), vol. 259, no. 1-2, doi:10.1016/S0022-1759(01)00505-1, ISSN 0022-1759, pages 149 - 157, XP004324209 [A] 1-11 * page 150, column r, paragraph 1 - page 156, column l, paragraph 2 *

DOI:   http://dx.doi.org/10.1016/S0022-1759(01)00505-1
 [A]  - CHARLES A. DINARELLO ET AL, "Interleukin-18 and IL-18 Binding Protein", FRONTIERS IN IMMUNOLOGY, (20130101), vol. 4, doi:10.3389/fimmu.2013.00289, ISSN 1664-3224, XP055154394 [A] 1-11 * the whole document *

DOI:   http://dx.doi.org/10.3389/fimmu.2013.00289
 [A]  - NOVICK D ET AL, "High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein", JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 34, no. 2, doi:10.1016/J.JAUT.2009.08.002, ISSN 0896-8411, (20100301), pages 121 - 126, (20090822), XP026886091 [A] 1-11 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.jaut.2009.08.002
 [A]  - MATTHIAS LOCHNER ET AL, "Anti-Interleukin-18 Therapy in Murine Models of Inflammatory Bowel Disease", PATHOBIOLOGY., CH, (20020101), vol. 70, no. 3, doi:10.1159/000068149, ISSN 1015-2008, pages 164 - 169, XP055155439 [A] 1-11 * the whole document *

DOI:   http://dx.doi.org/10.1159/000068149
 [A]  - S. R. THOMPSON ET AL, "Free Interleukin (IL)-18 Levels, and the Impact of IL18 and IL18BP Genetic Variation, in CHD Patients and Healthy Men", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, (20071201), vol. 27, no. 12, doi:10.1161/ATVBAHA.107.149245, ISSN 1079-5642, pages 2743 - 2749, XP055154486 [A] 1-11 * abstract *

DOI:   http://dx.doi.org/10.1161/ATVBAHA.107.149245
by applicantWO9213095
 WO9527732
 WO9613590
 WO9629605
 US5877293
 US5886152
 US6054297
 EP1635783
 EP1648406
 WO2006085983
 US7129084
 WO2008150431
 EP2112923
    - RIECHMANN LCLARK MWALDMANN HWINTER G, "Reshaping human antibodies for therapy", Nature, (19880000), vol. 332, no. 6162, doi:10.1038/332323a0, pages 332 - 323, XP002007067

DOI:   http://dx.doi.org/10.1038/332323a0
    - KENNEDY, J. H. et al., Clin. Chim. Acta, (19760000), vol. 70, pages 1 - 31
    - SCHURS, A. H. W. M. et al., Clin. Chim Acta, (19770000), vol. 81, pages 1 - 40
    - CHOTHIALESK, J. Mol. Biol, (19870000), vol. 196, pages 901 - 917
    - CHOTHIA et al., Nature, (19890000), vol. 342, pages 878 - 883
    - KHAW, B. A., J. Nucl. Med., (19820000), vol. 23, pages 1011 - 1019
    - QUEEN et al., Proc. Natl Acad Sci USA, (19890000), vol. 121, pages 10029 - 10032
    - HODGSON et al., Bio/Technology, (19910000), vol. 9, page 421
    - CHOTHIALESK J., Mol. Biol., (19870000), vol. 196, pages 901 - 917
    - BOWIE et al., Science, (19910000), vol. 253, no. 164
    - QUEEN CSCHNEIDER WPSELICK HEPAYNE PWLANDOLFI NFDUNCAN JFAVDALOVIC NMLEVITT MJUNGHANS RPWALDMANN TA., "A humanized antibody that binds to the interleukin 2 receptor", Proc Natl Acad Sci U S A., (19891200), vol. 86, no. 24, doi:10.1073/pnas.86.24.10029, pages 10029 - 33, XP000310534

DOI:   http://dx.doi.org/10.1073/pnas.86.24.10029
    - KASHMIRI SVDE PASCALIS RGONZALES NRSCHLOM J., "SDR grafting-a new approach to antibody humanization", Methods, (20050500), vol. 36, no. 1, doi:10.1016/j.ymeth.2005.01.003, pages 25 - 34, XP004852550

DOI:   http://dx.doi.org/10.1016/j.ymeth.2005.01.003
    - HOU SLI BWANG LQIAN WZHANG DHONG XWANG HGUO Y, "Humanization of an anti-CD34 monoclonal antibody by complementarity-determining region grafting based on computer-assisted molecular modeling", J Biochem, (20080700), vol. 144, no. 1, pages 115 - 20, XP002605633
    - LEFRANC, M.-P. et al., Nucleic Acids Research, (19990000), vol. 27, pages 209 - 212
    - J Biol Chem, (20090000), vol. 284, no. 36, pages 24478 - 24489
    - AZOULAY EEDDAHIBI SMARCOS ELEVAME MHARF ASCHLEMMER BADNOT SDELCLAUX C, "Granulocyte colony-stimulating factor enhances alpha-naphthylthiourea-induced pulmonary hypertension", J Appl Physiol, (20030000), vol. 94, pages 2027 - 2033
    - BARON R MCHOI AJSOWEN CACHOI AMK, "Genetically manipulated mouse models of lung disease: potential and pitfalls", Am J Physiol Lung Cell Mol Physiol, (20120000), pages L485 - L497
    - CHEN DYLAN JLLIN FJHSIEH TY, "Proinflammatory cytokine profiles in sera and pathological tissues of patients with active untreated adult onset Still's disease", J Rheumatol, (20040000), vol. 31, pages 2189 - 2198
    - CHEN DYLAN JLLIN FJHSIEH TYWEN MC, "Predominance of Th1 cytokine in peripheral blood and pathological tissues of patients with active untreated adult onset Still's disease", Ann Rheum Dis, (20040000), vol. 63, no. 10, pages 1300 - 1306
    - CUNNINGHAM RE, "Tissue disaggregation", Methods Mol Biol, (19940000), vol. 34, pages 225 - 228, XP008141500
    - DALEY EEMSON CGUIGNABERT CDE WAAL MALEFYT RLOUTEN JKURUP VPHOGABOAM CARASEVICIENE-STEWART LVOELKEL NFRABINOVITCH M et al., "Pulmonary arterial remodeling induced by a Th2 immune response", J Exp Med, (20080000), vol. 205, pages 361 - 372
    - ELIAS JAKANG MJCROTHERS K et al., "Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice", Proc Am Thorac Soc, (20060000), pages 494 - 498
    - ELTOM SSTEVENSON CSRASTRICK J, "P2X7 Receptor and Caspase - 1 Activation Are Central to Airway Inflammation Observed after Exposure to Tobacco Smoke", PLoS ONE, (20110000), vol. 6, no. 9, page e24097
    - HACKETT BPSHIMIZU NGITLIN JD, "Clara cell secretory protein gene expression in bronchiolar epithelium", Am J Physiol, (19920000), vol. 262, pages L399 - L404
    - HALBOWER ACMASON RJABMAN SHTUDER RM, "Agarose infiltration improves morphology of cryostat sections of lung", Lab Invest, (19940000), vol. 71, pages 149 - 153
    - HAUTAMAKI RDKOBAYASHI DKSENIOR RMSHAPIRO SD, "Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice", Science, (19970000), vol. 277, doi:10.1126/science.277.5334.2002, pages 2002 - 2004, XP002258397

DOI:   http://dx.doi.org/10.1126/science.277.5334.2002
    - HOSHINO TKAWASE YOKAMOTO M et al., "IL-18-transgenic mice: in vivo evidence of a broad role for IL-18 in modulating immune function", J Immuno, (20010000), pages 7014 - 7018, XP002956672
    - HOSHINO TKATO SOKA N et al., "Pulmonary inflammation and emphysema: role of the cytokines I L-18 and I L-13", Am J Respir Crit Care Med, (20070000), pages 49 - 62
    - HELMUT FENNER, "Targeting IL-18 in Chronic Obstructive Pulmonary Disease: Background and rationale", CONFIDENTIAL, (20130322), page 19
    - IMAOKA HHOSHINO TTAKEI SKINOSHITA T et al., "Interleukin-18 production and pulmonary function in COPD", Eur Respir J, (20080000), pages 287 - 97
    - KANG MJLEE CGLEE JYDELA CRUZ CSCHEN ZJENELOW RELIAS JA, "Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice", J Clin Invest, (20080000), vol. 118, pages 2771 - 2784
    - KANG MJHOMER RJGALLO A et al., "IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation", J Immunol, (20070000), page 1948, XP008130670
    - KANG MJCHOI JMKIM BH et al., "IL-18 induces emphysema and airway and vascular remodeling via IFNy, IL-17A, and IL-13", Am J Respir Crit Care Med, (20120000), pages 1205 - 1217
    - KAWASHIMA, M. et al., "Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease", Arthritis Rheum, (20010000), vol. 44, no. 3, pages 550 - 560
    - KIM, S. H. et al., "Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18", Proc Natl Acad Sci USA, (20000000), vol. 97, no. 3, doi:10.1073/pnas.97.3.1190, pages 1190 - 1195, XP002275382

DOI:   http://dx.doi.org/10.1073/pnas.97.3.1190
    - KRATZER ASALYS JNOLD-PETRY EL, "Role of IL-18 in second hand smoke-induced emphysema", Am J Respir Cell Mol Biol, (20130000), vol. 48, no. 6, pages 725 - 32
    - LEE CGLINK HBALUK PHOMER RJCHAPOVAL SBHANDARI VKANG MJCOHN LKIM YKMCDONALD DM et al., "Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2- mediated sensitization and inflammation in the lung", Nat Med, (20040000), vol. 10, doi:10.1038/nm1105, pages 1095 - 1103, XP055033561

DOI:   http://dx.doi.org/10.1038/nm1105
    - LEE CGHARTL DLEE GRKOLLER BMATSUURA HDA SILVA CASOHN MHCOHN LHOMER RJKOZHICH AA et al., "Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis", J Exp Med, (20090000), vol. 206, pages 1149 - 1166
    - LIU J et al., "Requirement for tumor necrosis factor-receptor 2 in alveolar chemokine expression depends upon the form of the ligand", Am J Respir Cell Mol Biol, (20050000), vol. 33, pages 463 - 469
    - LONDHE VAMAISONET TMLOPEZ BJENG JMLI CMINOO P. A, "subset of epithelial cells with CCSP promoter activity participates in alveolar development", Am J Respir Cell Mol Biol, (20110000), vol. 44, pages 804 - 812
    - LOZA MJWATT RBARIBAUD FBARNATHAN ESRENNARD SI, "Systemic inflammatory profile and response to anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease", Respir Res, (20120000), vol. 13, no. 12
    - MA BKANG MJLEE CGCHAPOVAL SLIU WCHEN QCOYLE AJLORA JMPICARELLA DHOMER RJ, "Role of CCR5 in IFN-y-induced and cigarette smoke-induced emphysema", J Clin Invest, (20050000), vol. 115, pages 3460 - 3472
    - NAKAJIMA TOWEN C, "Interleukin-18: The Master Regulator Driving Destructive and Remodeling Processes in the Lungs of Patients with Chronic Obstructive Pulmonary Disease", Am J Respir Crit Care Med, (20120000), pages 1137 - 1138
    - NOVICK D et al., "A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18", Cytokine, (20010000), vol. 14, pages 334 - 342, XP002310408
    - NOVICK D et al., "High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein", J Autoimmun, (20100000), vol. 34, doi:10.1016/j.jaut.2009.08.002, pages 121 - 126, XP026886091

DOI:   http://dx.doi.org/10.1016/j.jaut.2009.08.002
    - PARK MCPARK YBLEE SK, "Elevated interleukin-18 levels correlated with disease activity in systemic lupus erythematosus", Clin Rheumatol, (20040000), vol. 23, pages 225 - 229
    - PETERSEN AMWPENKOWA MIVERSEN M, "Elevated Levels of IL-18 in Plasma and Skeletal Muscle in Chronic Obstructive Pulmonary Disease", Lung, (20070000), doi:10.1007/s00408-007-9000-7, pages 161 - 171, XP019516839

DOI:   http://dx.doi.org/10.1007/s00408-007-9000-7
    - RASTRICK JMDSTEVENSON CSELTOM SGRACE MDAVIES M et al., "Cigarette Smoke Induced Airway Inflammation Is Independent of NF- B Signalling", PLoS ONE, (20130000), vol. 8, no. 1, page e54128
    - RAY PTANG WWANG PHOMER RKUHN C IIIFLAVELL RA AND ELIAS JA, "Regulated overexpression of interleukin 11 in the lung: use to dissociate development-dependent and - independent phenotypes", J Clin Invest, (19970000), vol. 100, pages 2501 - 2511
    - REED LJMUENCH H., "A simple method of estimating 50% endpoints", Am J Hyg, (19380000), vol. 27, pages 493 - 497
    - ROVINA NDIMA EGERASSIMOU C, "Interleukin-18 in induced sputum: Association with lung function in chronic obstructive pulmonary disease", Respiratory Medicine, (20090000), doi:10.1016/j.rmed.2009.01.011, pages 1056 - 1062, XP026168640

DOI:   http://dx.doi.org/10.1016/j.rmed.2009.01.011
    - SHAPIRO DS, "Transgenic and gene-targeted mice as models for chronic obstructive pulmonary disease", Eur J Respir, (20070000), pages 375 - 378
    - TANIGUCHI, M. et al., "Characterization of anti-human interleukin-18 (IL-18)/interferon-gamma-inducing factor (IGIF) monoclonal antibodies and their application in the measurement of human IL-18 by ELISA", J Immunol Methods, (19970000), vol. 206, doi:10.1016/S0022-1759(97)00094-X, pages 107 - 113, XP002929440

DOI:   http://dx.doi.org/10.1016/S0022-1759(97)00094-X
    - WANG ZZHENGZHU TZHOMER RJRIESE RJCHAPMAN HAHAPIRO SDELIAS JA, "Interferon γ induction of pulmonary emphysema in the adult murine lung", J Exp Med, (20000000), vol. 192, pages 1587 - 1600
    - WRIGHT J LCOSIO MCHURG A, "Animal models of chronic obstructive disease", Am J Physiol Lung Cell Mol Physiol, (20080000), pages L1 - L15
    - WONG CKLI EKHO CYLAM CW, "Elevation of plasma interleukin-18 concentration is correlated with disease activity in systemic lupus erythematosus", Rheumatology (Oxford, (20000000), vol. 39, doi:10.1093/rheumatology/39.10.1078, pages 1078 - 1081, XP002236732

DOI:   http://dx.doi.org/10.1093/rheumatology/39.10.1078
    - ZHANG JDONG ZZHOU RLUO DWEI HTIAN Z, "Isolation of lymphocytes and their innate immune characterizations from liver, intestine, lung and uterus", Cell Mol Immunol, (20050000), vol. 2, pages 271 - 280
    - ZHENG TZHU ZWANG ZHOMER RJMA BRIESE RCHAPMAN HSHAPIRO SDELIAS JA, "Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema", J Clin Invest, (20000000), vol. 106, doi:10.1172/JCI10458, pages 1081 - 1093, XP008039111

DOI:   http://dx.doi.org/10.1172/JCI10458
    - ZHENG T et al., "Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema", J Immunol, (20050000), vol. 174, pages 8106 - 8115
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.