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EP4019515
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EP About this file: EP4019515
| EP4019515 - INHIBITORS OF CYCLIN-DEPENDENT KINASES [Right-click to bookmark this link] | Status | The application has been withdrawn Status updated on 02.12.2022 Database last updated on 11.04.2026 | |
| Former | The application has been published Status updated on 27.05.2022 | Most recent event Tooltip | 02.12.2022 | Withdrawal of application | published on 04.01.2023 [2023/01] | Applicant(s) | For all designated states Dana-Farber Cancer Institute, Inc. 450 Brookline Avenue Boston, MA 02215 / US | [2022/26] | Inventor(s) | 01 /
HAO, Mingfeng Boston, MA 02115 / US | 02 /
GRAY, Nathanael, S Boston, MA 02130 / US | 03 /
ZHANG, Tinghu Boston, MA 02445 / US | 04 /
KWIATKOWSKI, Nicholas, P Aubrun, MA 01501 / US | [2022/26] | Representative(s) | HGF HGF Limited 4th Floor, 1 City Square Leeds LS1 2ES / GB | [N/P] |
| Former [2022/26] | HGF HGF Limited 1 City Walk Leeds LS11 9DX / GB | Application number, filing date | 21193645.5 | 09.09.2016 | [2022/26] | Priority number, date | US201562216271P | 09.09.2015 Original published format: US 201562216271 P | [2022/26] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP4019515 | Date: | 29.06.2022 | Language: | EN | [2022/26] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 11.05.2022 | Classification | IPC: | C07D417/14, A61K31/496, A61K31/501, A61P25/00, A61P35/00 | [2022/26] | CPC: |
C07D277/46 (EP,US);
A61K31/497 (EP,US);
A61P25/00 (EP,US);
A61P35/00 (EP,US);
C07D417/04 (EP,US);
C07D417/12 (EP,US);
C07D417/14 (EP,US)
(-)
| C-Set: |
A61K31/497, A61K2300/00 (EP,US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2022/26] | Title | German: | HEMMER VON CYCLINABHÄNGIGEN KINASEN | [2022/26] | English: | INHIBITORS OF CYCLIN-DEPENDENT KINASES | [2022/26] | French: | INHIBITEURS DE KINASES CYCLINE-DÉPENDANTES | [2022/26] | Examination procedure | 30.11.2022 | Application withdrawn by applicant [2023/01] | Parent application(s) Tooltip | EP16845194.6 / EP3347018 | Fees paid | Renewal fee | 29.12.2021 | Renewal fee patent year 03 | 29.12.2021 | Renewal fee patent year 04 | 29.12.2021 | Renewal fee patent year 05 | 27.09.2021 | Renewal fee patent year 06 | 27.09.2022 | Renewal fee patent year 07 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [A] US6214852 (KIM KYOUNG S et al.) | [A] WO2004074283 (PFIZER et al.) | [Y] WO2015058140 (DANA FARBER CANCER INST INC et al.) | [YA] WO2008049856 (INGENIUM PHARMACEUTICALS AG et al.) | [XPI] WO2015154022 (SYROS PHARMACEUTICALS INC et al.) | [XY] WO2010075542 (CURIS INC et al.) | [X] WO2013049279 (CRYSTAL BIOPHARMACEUTICALS LLC et al.) | [A] CHOONG I C ET AL: "A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 18, no. 21, 1 November 2008 (2008-11-01), pages 5763 - 5765, XP025562040, ISSN: 0960-894X, [retrieved on 20080924], DOI: 10.1016/J.BMCL.2008.09.073 DOI: http://dx.doi.org/10.1016/j.bmcl.2008.09.073 | by applicant | DESAI ET AL.: "Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2", MOL. CELL BIOL., vol. 15, 1995, pages 345 - 350, XP002405789 | KALDIS ET AL.: "Analysis of CAK activities from human cells", EUR. J. BIOCHEM., vol. 267, 2000, pages 4213 - 4221 | LAROCHELLE ET AL.: "Requirements for CDK7 in the assembly of CDKl/cyclin B and activation of CDK2 revealed by chemical genetics in human cells", MOL. CELL, vol. 25, 2007, pages 839 - 850 | SERIZAWA. ET AL.: "Association of CDK-activating kinase subunits with transcription factor TFIIH", NATURE, vol. 374, 1995, pages 280 - 282 | SHIEKHATTAR ET AL.: "CDK-activating kinase complex is a component of human transcription factor TFIIH", NATURE, vol. 374, 1995, pages 283 - 287 | DRAPKIN ET AL.: "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes", PROC. NATL. ACAD. SCI. U.S.A., vol. 93, 1996, pages 6488 - 6493 | LIU. ET AL.: "Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex", MOL. CELL BIOL., vol. 24, 2004, pages 1721 - 1735 | AKHTAR ET AL.: "TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II", MOL. CELL, vol. 34, 2009, pages 387 - 393 | GLOVER-CUTTER ET AL.: "TFIIH-associated CDK7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II", MOL. CELL BIOL., vol. 29, 2009, pages 5455 - 5464 | KO ET AL., J. CELL SCI., vol. 114, 2001, pages 2591 - 2603 | MARQUES ET AL., BIOCHEM BIOPHYS RES COMMUN., vol. 279, no. 3, 2000, pages 832 - 837 | EVEN ET AL., J CELL BIOCHEM., vol. 99, no. 3, 2006, pages 890 - 904 | ERRATUM, NATURE, vol. 474, no. 7353, 2011, pages 609 - 615 | KAURANIEMI ET AL., CANCER RES., vol. 61, no. 22, 2001, pages 8235 - 8240 | ZANG ET AL., CANCER RES., vol. 71, no. 1, 2011, pages 29 - 39 | IORNS ET AL., CARCINOGENESIS, vol. 30, no. 10, 2009, pages 1696 - 1701 | "Thomas Sorrell, Organic Chemistry, University Science Books, Sausalito", 1999, JOHN WILEY & SONS | SMITH AND MARCH: "March's Advanced Organic Chemistry", 2001, JOHN WILEY & SONS | LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS | CARRUTHERS: "Some Modern Methods of Organic Synthesis,", 1987, CAMBRIDGE UNIVERSITY PRESS | JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE | WILEN ET AL., TETRAHEDRON, vol. 33, 1977, pages 2725 | ELIEL: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL | WILEN: "Tables of Resolving Agents and Optical Resolutions", 1972, NOTRE DAME PRESS, pages: 268 | BERGE ET AL., DESCRIBE PHARMACEUTICALLY ACCEPTABLE SALTS IN DETAIL IN J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19 | BUNDGARD, H.: "Design of Prod rugs", vol. 21-24, 1985, ELSEVIER, pages: 7 - 9 | WALKER: "Cambridge Dictionary of Biology", 1990, CAMBRIDGE UNIVERSITY PRESS: CAMBRIDGE | "GenBank", Database accession no. M80629 | CHEN ET AL., EXP. NEUROL.,, vol. 261, 2014, pages 10 - 21 |