EP4103588 - HEPADNAVIRUS CAPSID PROTEIN HETERODIMERS AND VIRUS-LIKE PARTICLES [Right-click to bookmark this link] | Status | Request for examination was made Status updated on 18.11.2022 Database last updated on 24.08.2024 | |
Former | The international publication has been made Status updated on 20.08.2021 | ||
Former | unknown Status updated on 17.03.2021 | Most recent event Tooltip | 27.02.2024 | New entry: Renewal fee paid | Applicant(s) | For all designated states The Trustees of Indiana University 107 S. Indiana Avenue Bloomington, IN 47405 / US | For all designated states Zhao, Zhongchao 107 S. Indiana Avenue Bloomington, IN 47405 / US | [2022/51] | Inventor(s) | 01 /
ZLOTNICK, Adam 615 S. Clifton Ave. Bloomington, Indiana 47401 / US | 02 /
ZHAO, Zhongchao c/o 107 S. Indiana Avenue Bloomington, Indiana 47405 / US | [2022/51] | Representative(s) | Barker Brettell LLP 100 Hagley Road Edgbaston Birmingham B16 8QQ / GB | [2022/51] | Application number, filing date | 21710754.9 | 12.02.2021 | [2022/51] | WO2021US17923 | Priority number, date | US202062975916P | 13.02.2020 Original published format: US 202062975916 P | [2022/51] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2021163538 | Date: | 19.08.2021 | Language: | EN | [2021/33] | Type: | A1 Application with search report | No.: | EP4103588 | Date: | 21.12.2022 | Language: | EN | The application published by WIPO in one of the EPO official languages on 19.08.2021 takes the place of the publication of the European patent application. | [2022/51] | Search report(s) | International search report - published on: | EP | 19.08.2021 | Classification | IPC: | C07K14/005 | [2022/51] | CPC: |
C07K14/005 (EP);
C07K14/02 (US);
C12N15/63 (US);
C12N2730/10122 (EP,US);
C12N2730/10123 (EP,US);
C12N2730/10142 (EP)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2022/51] | Title | German: | HEPADNAVIRUS-KAPSIDPROTEIN-HETERODIMERE UND VIRUSÄHNLICHE PARTIKEL | [2022/51] | English: | HEPADNAVIRUS CAPSID PROTEIN HETERODIMERS AND VIRUS-LIKE PARTICLES | [2022/51] | French: | HÉTÉRODIMÈRES DE PROTÉINE DE CAPSIDE D'HÉPADNAVIRUS, ET PARTICULES PSEUDO-VIRALES | [2022/51] | Entry into regional phase | 25.08.2022 | National basic fee paid | 25.08.2022 | Designation fee(s) paid | 25.08.2022 | Examination fee paid | Examination procedure | 25.08.2022 | Examination requested [2022/51] | 25.08.2022 | Date on which the examining division has become responsible | 30.03.2023 | Amendment by applicant (claims and/or description) | Fees paid | Renewal fee | 27.02.2023 | Renewal fee patent year 03 | 27.02.2024 | Renewal fee patent year 04 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [A]WO2013010069 (UNIV INDIANA RES & TECH CORP [US], et al) [A] 1-47 * abstract * * page 37, paragraph 1; figure 7 *; | [A]WO2013036973 (BIOMED REALTY L P [US], et al) [A] 1-47 * page 18, line 13 - page 19, line 10 *; | [Y]WO2016004255 (UNIV INDIANA RES & TECH CORP [US]) [Y] 1-10,12-47 * paragraph [0007] - paragraph [0012] * * paragraph [0018]; figures 5,7 *; | [X] - KAZAKS A ET AL, "Mosaic particles formed by wild-type hepatitis B virus core protein and its deletion variants consist of both homo- and heterodimers", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, (20030814), vol. 549, no. 1-3, doi:10.1016/S0014-5793(03)00805-6, ISSN 0014-5793, pages 157 - 162, XP004446882 [X] 1-4,8,29 * abstract * DOI: http://dx.doi.org/10.1016/S0014-5793(03)00805-6 | [A] - KRIS HOLMES ET AL, "Assembly Pathway of Hepatitis B Core Virus-like Particles from Genetically Fused Dimers", JOURNAL OF BIOLOGICAL CHEMISTRY, US, (20150626), vol. 290, no. 26, doi:10.1074/jbc.M114.622035, ISSN 0021-9258, pages 16238 - 16245, XP055448599 [A] 1-47 * abstract * * page 16240, column 1, paragraph 6 - column 2, paragraph 1 * * page 16243, column 2, paragraph 2; figure 7 * DOI: http://dx.doi.org/10.1074/jbc.M114.622035 | [Y] - HADRIEN PEYRET ET AL, "Tandem Fusion of Hepatitis B Core Antigen Allows Assembly of Virus-Like Particles in Bacteria and Plants with Enhanced Capacity to Accommodate Foreign Proteins", PLOS ONE, (20150401), vol. 10, no. 4, doi:10.1371/journal.pone.0120751, page e0120751, XP055251306 [Y] 1-10,12-47 * abstract * DOI: http://dx.doi.org/10.1371/journal.pone.0120751 | [Y] - LEE LYE SIANG ET AL, "A molecular breadboard: Removal and replacement of subunits in a hepatitis B virus capsid : A Molecular Breadboard", PROTEIN SCIENCE, US, vol. 26, no. 11, doi:10.1002/pro.3265, ISSN 0961-8368, (20170916), pages 2170 - 2180, URL: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpro.3265, XP055805934 [Y] 1-10,12-47 * abstract * * figure 1 * DOI: http://dx.doi.org/10.1002/pro.3265 | [A] - ZHAO ZHONGCHAO ET AL, "Structural Differences between the Woodchuck Hepatitis Virus Core Protein in the Dimer and Capsid States Are Consistent with Entropic and Conformational Regulation of Assembly", JOURNAL OF VIROLOGY, US, vol. 93, no. 14, doi:10.1128/JVI, ISSN 0022-538X, (20190628), pages 1 - 16, URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600186/pdf/JVI.00141-19.pdf, XP055805783 [A] 1-47 * abstract * * page 12, paragraph 2 - paragraph 5 * DOI: http://dx.doi.org/10.1128/JVI.00141-19 | [XP] - ZHAO ZHONGCHAO ET AL, "Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry", NATURE COMMUNICATIONS, vol. 12, no. 1, doi:10.1038/s41467-020-20862-1, (20210126), URL: https://www.nature.com/articles/s41467-020-20862-1.pdf, XP055804991 [XP] 1-47 * the whole document * DOI: http://dx.doi.org/10.1038/s41467-020-20862-1 | by applicant | US9950050 | - VAN ELDIJK, M. B. et al., "Designing two self-assembly mechanisms into one viral capsid protein", J Am Chem Soc, (20120000), vol. 134, doi:10.1021/ja308132z, pages 18506 - 18509, XP055051864 DOI: http://dx.doi.org/10.1021/ja308132z | - CONTINO, N. C.JARROLD, M. F., "Charge detection mass spectrometry for single ions with a limit of detection of 30 charges", Int. J. Mass Spect., (20130000), vol. 345-347, doi:10.1016/j.ijms.2012.07.010, pages 153 - 159, XP055546596 DOI: http://dx.doi.org/10.1016/j.ijms.2012.07.010 | - SCHLICKSUP, C. et al., "Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids", Elife, vol. 7, (20180000), URL: doi:10.7554/eLife.31473 | - WALKER, A.SKAMEL, C.NASSAL, M., "SplitCore: an exceptionally versatile viral nanoparticle for native whole protein display regardless of 3D structure", Sci Rep, (20110000), vol. 1, page 5 | - PEYRET, H. et al., "Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins", PLoS One, (20150000), vol. 10, page e0120751 | - HOLMES, K. et al., "Assembly Pathway of Hepatitis B Core Virus-like Particles from Genetically Fused Dimers", J Biol Chem, (20150000), vol. 290, doi:10.1074/jbc.M114.622035, pages 16238 - 16245, XP055448599 DOI: http://dx.doi.org/10.1074/jbc.M114.622035 | - LEE, L. S. et al., "A Molecular Breadboard: Removal and Replacement of Subunits in a Hepatitis B Virus Capsid", Protein Sci, (20170916), vol. 26, no. 11, pages 2170 - 2180 |