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Extract from the Register of European Patents

EP About this file: EP4121512

EP4121512 - HEART TISSUE MODEL [Right-click to bookmark this link]
StatusThe patent has been granted
Status updated on  19.07.2024
Database last updated on 24.03.2026
FormerGrant of patent is intended
Status updated on  06.06.2024
FormerExamination is in progress
Status updated on  21.07.2023
FormerRequest for examination was made
Status updated on  23.12.2022
FormerThe international publication has been made
Status updated on  24.09.2021
Formerunknown
Status updated on  24.03.2021
Most recent event   Tooltip08.01.2026New entry: Date of oral proceedings 
Applicant(s)For all designated states
IMBA-Institut für Molekulare Biotechnologie GmbH
Dr. Bohrgasse 3
1030 Wien / AT
[2023/04]
Inventor(s)01 / MENDJAN, Sasha
Adamsgasse 28, 7-8
1030 Wien / AT
02 / JAHNEL, Stefan
Bruno Marek-Allee 11/2/7
1020 Wien / AT
03 / HOFBAUER, Pablo
1190 Wien / AT
04 / PAPAI, Nora
Taborstraße 87/17
1020 Wien / AT
 [2024/34]
Former [2023/04]01 / MENDJAN, Sasha
Adamsgasse 28, 7-8
1030 Wien / AT
02 / JAHNEL, Stefan
Bruno Marek-Allee 11/2/7
1020 Wien / AT
03 / HOFBAUER, Pablo
Lainzerstraße 88/11
1130 Wien / AT
04 / PAPAI, Nora
Taborstraße 87/17
1020 Wien / AT
Representative(s)SONN Patentanwälte GmbH & Co KG
Riemergasse 14
1010 Wien / AT
[2024/34]
Former [2023/04]SONN Patentanwälte OG
Riemergasse 14
1010 Wien / AT
Application number, filing date21712188.819.03.2021
[2023/04]
WO2021EP57110
Priority number, dateEP2020016463720.03.2020         Original published format: EP 20164637
[2023/04]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2021186044
Date:23.09.2021
Language:EN
[2021/38]
Type: A1 Application with search report 
No.:EP4121512
Date:25.01.2023
Language:EN
The application published by WIPO in one of the EPO official languages on 23.09.2021 takes the place of the publication of the European patent application.
[2023/04]
Type: B1 Patent specification 
No.:EP4121512
Date:21.08.2024
Language:EN
[2024/34]
Search report(s)International search report - published on:EP23.09.2021
ClassificationIPC:C12N5/077, C12N5/071, A61K35/34
[2023/04]
CPC:
C12N5/0657 (EP,KR,US); C12N5/0697 (EP,KR,US); G01N33/5082 (US);
A61K35/34 (EP); C12N5/0656 (US); C12N5/0691 (US);
G01N33/5023 (US); G01N33/5088 (KR); A61K35/545 (EP);
C12N2501/115 (EP,KR,US); C12N2501/15 (US); C12N2501/155 (EP,KR,US);
C12N2501/16 (EP,KR,US); C12N2501/165 (US); C12N2501/415 (EP,KR,US);
C12N2501/727 (EP,KR); C12N2506/02 (EP,KR); C12N2506/45 (US);
C12N2513/00 (EP,KR,US); C12N2533/52 (US); G01N2800/52 (KR) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/04]
Extension statesBANot yet paid
MENot yet paid
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:HERZGEWEBEMODELL[2023/04]
English:HEART TISSUE MODEL[2023/04]
French:MODÈLE DE TISSU CARDIAQUE[2023/04]
Entry into regional phase13.10.2022National basic fee paid 
13.10.2022Designation fee(s) paid 
13.10.2022Examination fee paid 
Examination procedure04.08.2021Request for preliminary examination filed
International Preliminary Examining Authority: EP
13.10.2022Amendment by applicant (claims and/or description)
13.10.2022Examination requested  [2023/04]
13.10.2022Date on which the examining division has become responsible
24.07.2023Despatch of a communication from the examining division (Time limit: M04)
16.10.2023Reply to a communication from the examining division
19.01.2024Despatch of a communication from the examining division (Time limit: M04)
04.03.2024Reply to a communication from the examining division
07.06.2024Communication of intention to grant the patent
12.07.2024Fee for grant paid
12.07.2024Fee for publishing/printing paid
12.07.2024Receipt of the translation of the claim(s)
Divisional application(s)EP24188062.4  / EP4483888
Opposition(s)Opponent(s)01  25.11.2024  27.11.2024  ADMISSIBLE
Genome Biologics GmbH
Danziger Weg 17
61476 Kronberg im Taunus / DE
 [2025/46]
Former [2025/01]
Opponent(s)01  25.11.2024  27.11.2024  ADMISSIBLE
Genome Biologics GmbH
Danziger Weg 17
61476 Kronberg im Taunus / DE
Opponent's representative
Willnegger, Eva, et al, et al
Montgomery IP
Boulevard Saint Michel 10/4
1150 Bruxelles / BE
03.06.2025Invitation to proprietor to file observations on the notice of opposition
25.09.2025Reply of patent proprietor to notice(s) of opposition
08.10.2026Date of oral proceedings
Fees paidRenewal fee
09.03.2023Renewal fee patent year 03
09.02.2024Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipBG21.08.2024
EE21.08.2024
HR21.08.2024
LV21.08.2024
MC21.08.2024
PL21.08.2024
RO21.08.2024
SK21.08.2024
SM21.08.2024
RS21.11.2024
GR22.11.2024
IS21.12.2024
[2025/47]
Former [2025/23]BG21.08.2024
EE21.08.2024
HR21.08.2024
LV21.08.2024
PL21.08.2024
RO21.08.2024
SK21.08.2024
SM21.08.2024
RS21.11.2024
GR22.11.2024
IS21.12.2024
Former [2025/22]BG21.08.2024
EE21.08.2024
HR21.08.2024
LV21.08.2024
PL21.08.2024
RO21.08.2024
SM21.08.2024
RS21.11.2024
GR22.11.2024
IS21.12.2024
Former [2025/21]BG21.08.2024
HR21.08.2024
LV21.08.2024
PL21.08.2024
RO21.08.2024
SM21.08.2024
RS21.11.2024
GR22.11.2024
IS21.12.2024
Former [2025/11]BG21.08.2024
HR21.08.2024
LV21.08.2024
PL21.08.2024
RS21.11.2024
GR22.11.2024
IS21.12.2024
Former [2025/09]BG21.08.2024
LV21.08.2024
PL21.08.2024
GR22.11.2024
IS21.12.2024
Former [2025/08]PL21.08.2024
GR22.11.2024
Cited inInternational search[XDY] WO2019174879  (MEDIZINISCHE HOCHSCHULE HANNOVER et al.)
 [Y] WO2018170280  (UNIV WASHINGTON et al.)
 [Y] WO2016009196  (CAMBRIDGE ENTPR LTD et al.)
 [XDY]   ZHEN MA ET AL: "Self-organizing human cardiac microchambers mediated by geometric confinement", NATURE COMMUNICATIONS, vol. 6, no. 1, 14 July 2015 (2015-07-14), XP055729124, DOI: 10.1038/ncomms8413

DOI:   http://dx.doi.org/10.1038/ncomms8413
 [XY]   PLANSKY HOANG ET AL: "Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells", NATURE PROTOCOLS, vol. 13, no. 4, 15 March 2018 (2018-03-15), GB, pages 723 - 737, XP055488131, ISSN: 1754-2189, DOI: 10.1038/nprot.2018.006

DOI:   http://dx.doi.org/10.1038/nprot.2018.006
 [Y]   YUANWEI YAN ET AL: "Cell population balance of cardiovascular spheroids derived from human induced pluripotent stem cells", SCIENTIFIC REPORTS, vol. 9, no. 1, 1 December 2019 (2019-12-01), pages 1295, XP055728357, DOI: 10.1038/s41598-018-37686-1

DOI:   http://dx.doi.org/10.1038/s41598-018-37686-1
 [T]   YONATAN ISRAELI ET AL: "GENERATION OF HEART ORGANOIDS MODELING EARLY HUMAN CARDIACDEVELOPMENT UNDER DEFINED CONDITIONS", BIORXIV, 26 June 2020 (2020-06-26), XP055728358, Retrieved from the Internet DOI: 10.1101/2020.06.25.171611

DOI:   http://dx.doi.org/10.1101/2020.06.25.171611
ExaminationWO2006020919
 WO2018119155
   HOFBAUER PABLO ET AL: "Cardioids reveal self-organizing principles of human cardiogenesis", CELL, ELSEVIER, AMSTERDAM NL, vol. 184, no. 12, 20 May 2021 (2021-05-20), pages 3299 - 3317, XP086614595, ISSN: 0092-8674, [retrieved on 20210520], DOI: 10.1016/J.CELL.2021.04.034

DOI:   http://dx.doi.org/10.1016/j.cell.2021.04.034
   DRAKHLIS LIKA ET AL: "Human heart-forming organoids recapitulate early heart and foregut development", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 39, no. 6, 8 February 2021 (2021-02-08), pages 737 - 746, XP037524008, ISSN: 1087-0156, [retrieved on 20210208], DOI: 10.1038/S41587-021-00815-9

DOI:   http://dx.doi.org/10.1038/s41587-021-00815-9
   LI RONALD A ET AL: ""Human heart-in-a-Jar": An electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells", JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, ELSEVIER, NEW YORK, NY, US, vol. 99, 1 September 2018 (2018-09-01), XP085864085, ISSN: 1056-8719, [retrieved on 20191017], DOI: 10.1016/J.VASCN.2019.05.178

DOI:   http://dx.doi.org/10.1016/j.vascn.2019.05.178
   LI RONALD A. ET AL: "Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells", BIOMATERIALS, vol. 163, 1 May 2018 (2018-05-01), AMSTERDAM, NL, pages 116 - 127, XP055841118, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.02.024

DOI:   http://dx.doi.org/10.1016/j.biomaterials.2018.02.024
   SASANO YUMI ET AL: "Construction of 3D cardiac tissue with synchronous powerful beating using human cardiomyocytes from human iPS cells prepared by a convenient differentiation method", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, ELSEVIER, AMSTERDAM, NL, vol. 129, no. 6, 6 March 2020 (2020-03-06), pages 749 - 755, XP086144887, ISSN: 1389-1723, [retrieved on 20200306], DOI: 10.1016/J.JBIOSC.2020.01.001

DOI:   http://dx.doi.org/10.1016/j.jbiosc.2020.01.001
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.