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Extract from the Register of European Patents

EP About this file: EP4192819

EP4192819 - HETEROBIARYL COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  12.05.2023
Database last updated on 15.06.2024
FormerThe international publication has been made
Status updated on  11.02.2022
Formerunknown
Status updated on  22.09.2021
Most recent event   Tooltip13.10.2023Change: Validation statespublished on 15.11.2023  [2023/46]
13.10.2023Change - extension statespublished on 15.11.2023  [2023/46]
Applicant(s)For all designated states
CHDI Foundation, Inc.
c/o CHDI Management, Inc.
350 Seventh Avenue
Suite 200
New York, NY 10001 / US
[2023/24]
Inventor(s)01 / LIU, Longbin
New York, New York 10001 / US
02 / DOMINGUEZ, Celia
New York, New York 10001 / US
03 / CHEN, Xuemei
New York, New York 10001 / US
04 / MANGETTE, John, E.
New York, New York 10001 / US
 [2023/24]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2023/24]
Application number, filing date21769835.605.08.2021
[2023/24]
WO2021US44702
Priority number, dateUS202063062310P06.08.2020         Original published format: US 202063062310 P
[2023/24]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2022031946
Date:10.02.2022
Language:EN
[2022/06]
Type: A1 Application with search report 
No.:EP4192819
Date:14.06.2023
Language:EN
The application published by WIPO in one of the EPO official languages on 10.02.2022 takes the place of the publication of the European patent application.
[2023/24]
Search report(s)International search report - published on:EP10.02.2022
ClassificationIPC:C07D239/28, C07D401/06, C07D401/12, C07D401/14, C07D239/34, C07D239/36, C07D403/06, C07D403/12, C07D471/04, A61P25/28, C07B59/00
[2023/24]
CPC:
A61P25/28 (EP,IL); C07D239/28 (EP,IL,KR,US); A61K51/0459 (IL,KR,US);
C07B59/002 (EP,IL,KR); C07D239/34 (EP,IL); C07D239/36 (EP,IL);
C07D401/12 (EP,IL,KR,US); C07D401/14 (EP,IL,KR,US); C07D403/06 (EP,IL,KR,US);
C07D403/12 (EP,IL,KR); C07D471/04 (EP,IL,KR,US); C07B2200/05 (IL,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/24]
TitleGerman:HETEROBIARYLVERBINDUNGEN UND ABBILDUNGSMITTEL ZUR ABBILDUNG VON HUNTINGTINPROTEIN[2023/24]
English:HETEROBIARYL COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN[2023/24]
French:COMPOSÉS HÉTÉROBIARYLES ET AGENTS D'IMAGERIE POUR L'IMAGERIE DE LA PROTÉINE HUNTINGTINE[2023/24]
Entry into regional phase03.03.2023National basic fee paid 
03.03.2023Designation fee(s) paid 
03.03.2023Examination fee paid 
Examination procedure03.03.2023Examination requested  [2023/24]
03.03.2023Date on which the examining division has become responsible
20.09.2023Amendment by applicant (claims and/or description)
Fees paidRenewal fee
28.08.2023Renewal fee patent year 03
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[I]WO2010137351  (RAQUALIA PHARMA INC [JP], et al) [I] 1,3,4,13-21,25,28-31,40,41,45 * compound of Example 118 on page 93; paragraph [0090]; claim 1 *;
 [XI]WO2013033068  (COURTNEY STEPHEN MARTIN [GB], et al) [X] 2-4,15,19-22,24,27 * 1st and last but one compound on page 78, 1st on page 79; last but one compound on page 107, last compound on page 107 (5-oxo-pyrrolidin-3-yl), last compound on page 109; paragraphs [0114] , [0116] , [0165]; claims 1,31-35 * [I] 1-4,13-31;
 [XI]WO2014049488  (PFIZER [US]) [X] 2,3,8,13,17,21-23,25,26 * generic formula (I) on page 2; compounds 100 and 102 on page 155, 108 on page 157, 110 and 111 on page 158, 115 on page 160, 124 on page 163; page 61, lines 12-32 * [I] 28,29;
 [A]WO2016033445  (CHDI FOUNDATION INC [US], et al) [A] 1-45* compounds of examples;; claims 1,49-60 *
by applicant   - FOSTER, "Deuterium Isotope Effects in Studies of Drug Metabolism", Trends Pharmacol. Sci., (19840000), vol. 5, no. 12, doi:10.1016/0165-6147(84)90534-0, pages 524 - 527, XP025943358

DOI:   http://dx.doi.org/10.1016/0165-6147(84)90534-0
    - T. HIGUCHIV. STELLA, "Pro-drugs as Novel Delivery Systems", A.C.S. Symposium Series, vol. 14
    - MILLER et al., Angewandte Chemie International Edition, (20080000), vol. 47, pages 8998 - 9033
    - JACOBSON, O. et al., Bioconjugate Chem., (20150000), vol. 26, pages 1 - 18
    - DENG, X. et al., Angewandte Chemie International Edition, (20190000), vol. 58, no. 9, pages 2580 - 2605
    - FIESERFIESER, Reagents for Organic Synthesis, John Wiley, and Sons, (19910000), vol. 1-40
    - Larock's Comprehensive Organic Transformations, Elsevier Science Publishers, (19890000), vol. 1-5
    - SCHERZINGER et al., Cell, (19970808), vol. 90, pages 549 - 558
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.