Deutsch English Français

Contact

EP4232578

European procedure

Quick help

Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...

News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...

Extract from the Register of European Patents

EP About this file: EP4232578

EP4232578 - SELF-PURIFIED NUCLEIC ACID ENCODED LIBRARIES [Right-click to bookmark this link]
Status	Request for examination was made Status updated on 28.07.2023 Database last updated on 19.10.2024
Former	The international publication has been made Status updated on 30.04.2022
Former	unknown Status updated on 02.11.2021
Most recent event Tooltip	18.10.2024	New entry: Renewal fee paid
Applicant(s)	For all designated states Scheuermann, Jörg Quellenweg 5 5436 Würenlos / CH
	For all designated states Keller, Michelle Josiane Gässli 12 8049 Zürich / CH
	For all designated states Petrov, Dimitar Wieslergasse 2 8049 Zürich / CH
	For all designated states Gloger, Andreas Sihlfeldstrasse 55 8003 Zürich / CH
	[N/P]
Former [2024/35]	For all designated states Scheuermann, Jörg Quellenweg 5 5436 Würenlos / CH
	For all designated states Keller, Michelle Josiane Gässli 12 8049 Zürich / CH
	For all designated states Petrov, Dimitar Wieslergasse 2 8049 Zürich / CH
	For all designated states Gloger, Andreas Sihfeldstrasse 55 8003 Zürich / CH
Former [2023/35]	For all designated states ETH Zurich Rämistrasse 101 8092 Zürich / CH
Inventor(s)	01 / NERI, Dario 8092 Zurich / CH
	02 / SCHEUERMANN, Jörg 8092 Zurich / CH
	03 / KELLER, Michelle 8092 Zurich / CH
	04 / PETROV, Dimitar 8092 Zurich / CH
	05 / ONDA, Yuichi Osaka-shi, Osaka 541-8505 / JP
	06 / BASSI, Gabriele 8112 Otelfingen / CH
	[2023/35]
Representative(s)	Mewburn Ellis LLP Aurora Building Counterslip Bristol BS1 6BX / GB
	[2023/35]
Application number, filing date	21793959.4	21.10.2021
	[2023/35]
	WO2021EP79294
Priority number, date	EP20200203475	23.10.2020 Original published format: EP 20203475
	[2023/35]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2022084486
	Date:	28.04.2022
	Language:	EN
	[2022/17]
	Type:	A1 Application with search report
	No.:	EP4232578
	Date:	30.08.2023
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 28.04.2022 takes the place of the publication of the European patent application.
	[2023/35]
Search report(s)	International search report - published on:	EP	28.04.2022
Classification	IPC:	C12N15/10, C40B40/00	[2023/35]
	CPC:	C12N15/1068 (EP,US)
	C-Set:	C12N15/1068, C12Q2523/109, C12Q2523/319, C12Q2525/149, C12Q2525/186, C12Q2525/197 (EP)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2023/35]
Title	German:	SELBSTGEREINIGTE NUKLEINSÄURECODIERTE BIBLIOTHEKEN	[2023/35]
	English:	SELF-PURIFIED NUCLEIC ACID ENCODED LIBRARIES	[2023/35]
	French:	BIBLIOTHÈQUES CODÉES PAR L'ACIDE NUCLÉIQUE AUTO-PURIFIÉ	[2023/35]
Entry into regional phase	11.05.2023	National basic fee paid
	11.05.2023	Designation fee(s) paid
	11.05.2023	Examination fee paid
Examination procedure	11.05.2023	Examination requested [2023/35]
	11.05.2023	Date on which the examining division has become responsible
	15.12.2023	Amendment by applicant (claims and/or description)
Fees paid	Renewal fee
	31.10.2023	Renewal fee patent year 03
	17.10.2024	Renewal fee patent year 04
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[A]WO2004087933 (UNIV CALIFORNIA [US], et al) [A] 1-53 * claims 1-28 *;
		[A]WO2020212439 (HOFFMANN LA ROCHE [CH], et al) [A] 1-53 * paragraphs [0052] , [0067] *;
		[I] - USANOV DMITRY L ET AL, "Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules", NATURE CHEMISTRY, NATURE PUBLISHING GROUP UK, LONDON, vol. 10, no. 7, doi:10.1038/S41557-018-0033-8, ISSN 1755-4330, (20180402), pages 704 - 714, (20180402), XP036895342 [I] 1,2,4,5,7,9,10,14-16,19-42,44,45,47-51,53 * page 710, column 1, paragraph l - page 712, column 1, paragraph 1; figures 1,2,3 * DOI: http://dx.doi.org/10.1038/s41557-018-0033-8
		[AP] - ONDA YUICHI ET AL, "A DNA-Encoded Chemical Library Based on Peptide Macrocycles", CHEMISTRY - A EUROPEAN JOURNAL, DE, vol. 27, no. 24, doi:10.1002/chem.202005423, ISSN 0947-6539, (20210318), pages 7160 - 7167, URL: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/chem.202005423, XP055878523 [AP] 1-53 * the whole document * DOI: http://dx.doi.org/10.1002/chem.202005423
		[A] - FAVALLI NICHOLAS ET AL, "A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition", CHEMMEDCHEM COMMUNICATIONS, DE, vol. 13, no. 13, doi:10.1002/cmdc.201800193, ISSN 1860-7179, (20180601), pages 1303 - 1307, URL: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcmdc.201800193, XP055784037 [A] 1-53 * the whole document * DOI: http://dx.doi.org/10.1002/cmdc.201800193
	by applicant	WO9320242
		US5573905
		WO03076943
		WO2009077173
		EP3184674
		EP3284851
		- BRENNER, S.LERNER, R.A., PNAS USA, (19920000), vol. 89, pages 5381 - 5383
		- MANNOCCI, L et al., PNAS USA, (19930000), vol. 105, no. 46, pages 10700 - 10704
		- NIELSEN, J. et al., J. Am. Chem. Soc., (19930000), vol. 115
		- GARTNER, Z.J. et al., Science, (20040000), vol. 305, pages 1601 - 1605
		- MELKKO, S. et al., Nat. Biotechnol., (20040000), vol. 22, pages 568 - 574
		- SPRINZ, K.I. et al., Bioorg. Med. Chem. Lett., (20050000), vol. 15, pages 3908 - 3911
		- LEIMBACHER et al., Chemistry, (20120618), vol. 18, no. 25, pages 7729 - 37
		- CLARK et al., Nat Chem Biol., (20090900), vol. 5, no. 9, pages 647 - 54
		- USANOV, D. L. et al., Nat. Chem., (20180000), vol. 10, pages 704 - 714
		- CHAUDHURI, R. G.PARIA, S., "Core/Shell Nanoparticles: Classes, Properties, Synthesis Mechanisms, Characterization, and Applications", Chem. Rev., vol. 112, doi:10.1021/cr100449n, (20110000), pages 2373 - 2433, URL: https://doi.org/10.1021/cr100449n, XP055055307 DOI: http://dx.doi.org/10.1021/cr100449n
		- POMPLUN et al., Angew. Chemie - Int. Ed., (20200000), vol. 59, pages 11566 - 11572
		- MENDE, F.BEISSWENGER, M.SEITZ, O., "Automated Fmoc-Based Solid Phase Synthesis of Peptide Thioesters with Self-Purification Effect and Application in the Construction of Immobilized SH3 Domains.", J. Am. Chem. Soc., vol. 132, no. 32, doi:10.1021/ja101732a, (20100000), pages 11110 - 11118, URL: https://doi.org/10.1021/ja101732a, XP055514066 DOI: http://dx.doi.org/10.1021/ja101732a
		- HERMANSON, G. T., Bioconjugate Techniques: Third Edition, (20130000), pages 1 - 1146
		- PA TEK, M.LEBL, M., "Safety-Catch and Multiply Cleavable Linkers in Solid-Phase Synthesis", Biopoly, (19980000), vol. 47
		- KOCIS, P.KRCHNAK, V.LEBL, Tetrahedron Lett., (19930000), vol. 34, pages 7251 - 7252
		- MENDE, F.SEITZ, 0, "Solid-Phase Synthesis of Peptide Thioesters with Self-Purification", Angew. Chemie Int. Ed., vol. 46, no. 24, doi:10.1002/anie.200700356, (20070000), pages 4577 - 4580, URL: https://doi.org/10.1002/anie.200700356, XP055514067 DOI: http://dx.doi.org/10.1002/anie.200700356
		- MALONE, M. LPAEGEL, B. M., "What is a ''DNA-Compatible'' Reaction?", ACS Comb. Sci., vol. 18, no. 4, (20160000), pages 182 - 187, URL: https://doi.org/10.1021/acscombsci.5b00198
		- WANG, W., KHOJASTEH, S. C.SU, D., "Biosynthetic Strategies for Macrocyclic Peptides", Mol, vol. 26, (20210000), page 3338, URL: https://doi.org/10.3390/molecules26113338
		- ZHANG, R. Y.THAPA, P.ESPIRITU, M. J.MENON, V.BINGHAM, J. P., "From nature to creation: Going around in circles, the art of peptide cyclization", Bioorg. Med. Chem., vol. 26, (20180000), pages 1135 - 1150, URL: https://doi.org/10.1016/j.bmc.2017.11.017
		- PON, R. T., "Solid-Phase Supports for Oligonucleotide Synthesis", Curr. Protoc. Nucleic Acid Chem., vol. 00, (20000000), URL: https://doi.org/10.1002/0471142700.nc0301s00
		- WU, W.HE, Q.JIANG, C., "Magnetic Iron Oxide Nanoparticles: Synthesis and Surface Functionalization Strategies", Nanoscale Res. Lett., vol. 311, no. 3, (20080000), pages 397 - 415, URL: https://doi.org/10.1007/s11671-008-9174-9
		- SELVARAJ, A.CHEN, H.-T.YA, A.HUANG, T.KAO, C.-L., "Expedient On-Resin Modification of a Peptide C-Terminus through a Benzotriazole Linker", Chem. Sci., vol. 9, (20180000), pages 345 - 349, URL: https://doi.org/10.1039/C7SC03229C
		- LI, Y et al., "Bioorthogonal Ligation and Cleavage by Reactions of Chloroquinoxalines with Ortho - Dithiophenols", Angew. Chemie Int. Ed., vol. 59, no. 9, (20200000), pages 3671 - 3677, URL: https://doi.org/10.1002/anie.201913620
		- GLESS B. H. et al., "Direct Peptide Cyclization and One-Pot Modification Using the MeDbz Linker", J. Org. Chem., vol. 83, no. 17, (20180000), pages 10525 - 10534, URL: https://doi.org/10.1021/acs.joc.8b01237
		- FAN, L.DAVIE, C. P., "Zirconium(IV)-Catalyzed Ring Opening of on-DNA Epoxides in Water", ChemBioChem, vol. 18, no. 9, (20170000), pages 843 - 847, URL: https://doi.org/10.1002/cbic.201600563
		- SERRA, G. et al., "On-Resin Synthesis of Cyclic Peptides: Via Tandem N -to- S Acyl Migration and Intramolecular Thiol Additive-Free Native Chemical Ligation", Chem. Commun., vol. 56, no. 6, (20200000), pages 956 - 959, URL: https://doi.org/10.1039/c9cc07783a
		- KONDASINGHE, T. D. et al., "Direct Palladium-Mediated on-Resin Disulfide Formation from Allocam Protected Peptides", Org. Biomol. Chem., vol. 15, no. 14, (20170000), pages 2914 - 2918, URL: https://doi.org/10.1039/c7ob00536a
		- LIU, H.LI, X, "Serine/Threonine Ligation: Origin, Mechanistic Aspects, and Applications", Acc. Chem. Res., vol. 51, no. 7, (20180000), pages 1643 - 1655, URL: https://doi.org/10.1021/acs.accounts.8b00151
		- CLARK, M. A. et al., "A. Design, Synthesis and Selection of DNA-Encoded Small-Molecule Libraries", Nat. Chem. Biol., vol. 5, no. 9, doi:10.1038/nchembio.211, (20090000), pages 647 - 654, URL: https://doi.org/10.1038/nchembio.211, XP055618604 DOI: http://dx.doi.org/10.1038/nchembio.211
		- RHODES, C. A.PEI, D., "Bicyclic Peptides as Next-Generation Therapeutics", Chem. A Eur. J., vol. 23, no. 52, doi:10.1002/chem.201702117, (20170000), pages 12690 - 12703, URL: https://doi.org/10.1002/chem.201702117, XP055479791 DOI: http://dx.doi.org/10.1002/chem.201702117
		- DECURTINS, W.WICHERT, M.FRANZINI, R. et al., "Automated screening for small organic ligands using DNA-encoded chemical libraries", Nat Protoc, vol. 11, doi:10.1038/nprot.2016.039, (20160000), pages 764 - 780, URL: https://doi.org/10.1038/nprot.2016.039, XP055643002 DOI: http://dx.doi.org/10.1038/nprot.2016.039
		- ANDREW B. MACCONNELLPATRICK J. MCENANEYVALERIE J. CAVETTBRIAN M. PAEGEL, ACS Combinatorial Science, (20150000), vol. 17, no. 9, pages 518 - 534
		- PENGPUMKIAT SKOESDJOJO MROWLEY ERMOCKLER TCREMCHO VT, PLOS ONE, vol. 11, no. 3, (20160000), page e0149774, URL: https://doi.org/10.1371/journal.pone.0149774
		- SCOTT, P. J. H., "Linker Strategies in Solid-Phase Organic Synthesis", Link. Strateg. Solid-Phase Org. Synth., (20090000), pages 1 - 677, URL: https://doi/10.1002/9780470749043
		- LERICHE, G.CHISHOLM, L.WAGNER, A., "Cleavable linkers in chemical biology", Bioorg. Med. Chem., vol. 20, doi:10.1016/j.bmc.2011.07.048, (20120000), pages 571 - 582, URL: https://doi.org/10.1016/j.bmc.2011.07.048, XP028442289 DOI: http://dx.doi.org/10.1016/j.bmc.2011.07.048
		EP20200203475

The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.

Legal notice
Terms of use
24.2.25; 35p