blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP4176044

EP4176044 - METHODS AND COMPOSITIONS FOR THE PRODUCTION OF ACETYL-COA DERIVED PRODUCTS [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  02.02.2024
Database last updated on 14.09.2024
FormerRequest for examination was made
Status updated on  07.04.2023
FormerThe international publication has been made
Status updated on  28.01.2022
Most recent event   Tooltip06.08.2024New entry: Reply to examination report 
Applicant(s)For all designated states
Duke University
2812 Erwin Road, Suite 406
Durham, NC 27705 / US
[2023/19]
Inventor(s)01 / LYNCH, Michael, David
Durham, North Carolina 27701 / US
02 / LI, Shaui
Durham, North Carolina 27705 / US
 [2023/19]
Representative(s)Dehns
St. Bride's House
10 Salisbury Square
London EC4Y 8JD / GB
[2023/19]
Application number, filing date21845860.223.07.2021
[2023/19]
WO2021US43023
Priority number, dateUS202063056031P24.07.2020         Original published format: US 202063056031 P
[2023/19]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2022020748
Date:27.01.2022
Language:EN
[2022/04]
Type: A1 Application with search report 
No.:EP4176044
Date:10.05.2023
Language:EN
The application published by WIPO in one of the EPO official languages on 27.01.2022 takes the place of the publication of the European patent application.
[2023/19]
Search report(s)International search report - published on:US27.01.2022
(Supplementary) European search report - dispatched on:EP24.01.2024
ClassificationIPC:C12N1/19, C12N1/21, C12N15/09, C12N15/52, C12N5/10
[2023/19]
CPC:
C12N15/70 (EP,IL,US); C12P7/44 (US); C12N15/11 (US);
C12N15/635 (US); C12N9/0006 (EP,IL,US); C12N9/0008 (EP,IL,US);
C12N9/0067 (US); C12N9/1025 (EP,IL,US); C12N9/1029 (EP,IL);
C12Y101/01049 (US); C12Y102/04001 (US); C12Y112/07002 (US);
C12Y203/03001 (US); C12N2310/20 (EP,IL,US); C12N2800/101 (US);
C12N2830/001 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/19]
TitleGerman:VERFAHREN UND ZUSAMMENSETZUNGEN ZUR HERSTELLUNG VON ACETYL-COA-ABGELEITETEN PRODUKTEN[2023/19]
English:METHODS AND COMPOSITIONS FOR THE PRODUCTION OF ACETYL-COA DERIVED PRODUCTS[2023/19]
French:PROCÉDÉS ET COMPOSITIONS POUR LA PRODUCTION DE PRODUITS DÉRIVÉS D'ACÉTYL-COA[2023/19]
Entry into regional phase31.01.2023National basic fee paid 
31.01.2023Search fee paid 
31.01.2023Designation fee(s) paid 
31.01.2023Examination fee paid 
Examination procedure24.05.2022Request for preliminary examination filed
International Preliminary Examining Authority: US
31.01.2023Amendment by applicant (claims and/or description)
31.01.2023Examination requested  [2023/19]
24.01.2024Date on which the examining division has become responsible
05.02.2024Despatch of a communication from the examining division (Time limit: M06)
05.08.2024Reply to a communication from the examining division
Fees paidRenewal fee
27.07.2023Renewal fee patent year 03
29.07.2024Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]WO2017165397  (UNIV GEORGIA [US], et al) [Y] 1-15 * the whole document *;
 [Y]  - WEBB JOSEPH P. ET AL, "Efficient bio-production of citramalate using an engineered Escherichia coli strain", MICROBIOLOGY, Reading, (20180201), vol. 164, no. 2, doi:10.1099/mic.0.000581, ISSN 1350-0872, pages 133 - 141, XP093026261 [Y] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1099/mic.0.000581
 [Y]  - Webb Joseph ET AL, "Systems Analyses Reveal the Resilience of Escherichia coli Physiology during Accumulation and Export of the Nonnative Organic Acid Citramalate", mSystems, United States, doi:10.1128/mSystems.00187-19, (20190611), URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561320/pdf/mSystems.00187-19.pdf, (20240110), XP093117692 [Y] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1128/mSystems.00187-19
 [Y]  - PARIMI NAGA SIRISHA ET AL, "Eliminating acetate formation improves citramalate production by metabolically engineered Escherichia coli", MICROBIAL CELL FACTORIES, vol. 16, no. 1, doi:10.1186/s12934-017-0729-2, (20171201), URL: https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-017-0729-2.pdf, XP055901570 [Y] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1186/s12934-017-0729-2
 [A]  - HOSSAIN ABEER H. ET AL, "Identification of novel citramalate biosynthesis pathways in Aspergillus niger", FUNGAL BIOLOGY AND BIOTECHNOLOGY, London, UK, vol. 6, no. 1, doi:10.1186/s40694-019-0084-7, ISSN 2054-3085, (20191201), URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862759/pdf/40694_2019_Article_84.pdf, XP093117679 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1186/s40694-019-0084-7
 [XP]  - Li Shuai ET AL, "Dynamic control over feedback regulation identifies pyruvate-ferredoxin oxidoreductase as a central metabolic enzyme in stationary phase E. coli", bioRxiv, doi:10.1101/2020.07.26.219949, (20200810), URL: https://www.biorxiv.org/content/10.1101/2020.07.26.219949v2, (20230807), XP093071135 [XP] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1101/2020.07.26.219949
 [XP]  - YE ZHIXIA ET AL, "Two-stage dynamic deregulation of metabolism improves process robustness & scalability in engineered E. coli", METABOLIC ENGINEERING, ACADEMIC PRESS, AMSTERDAM, NL, vol. 68, doi:10.1016/J.YMBEN.2021.09.009, ISSN 1096-7176, (20210930), pages 106 - 118, (20210930), XP086849203 [XP] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.ymben.2021.09.009
International search[Y]WO2013184602  (GENOMATICA INC [US], et al) [Y] 8-11 * ; Especially: para [0007], [0098], [00157] *;
 [Y]US2014004597  (CHANG MICHELLE C Y [US], et al) [Y] 5 * ; Especially: para [0039] *;
 [Y]WO2014057008  (CHALMERS INTELLECTUAL PROPERTY RIGHTS AB [SE]) [Y] 1-5,8-14 * ; Especially: p 9, In 19-25; Claim 1 *;
 [Y]WO2016053397  (UNIV DUKE [US], et al) [Y] 2-3 * ; Especially: Abstract, para [0007], [0085], [0086] *;
 [Y]  - SONDEREGGER et al., "Selection of quiescent Escherichia coli with high metabolic activity", Metabolic Engineering, (20050107), vol. 7, doi:10.1016/j.ymben.2004.05.005, pages 4 - 9, XP004753533 [Y] 1-5, 8-14 * ; Especially: Abstract, pg 8, col 1, para 2 *

DOI:   http://dx.doi.org/10.1016/j.ymben.2004.05.005
 [Y]  - Parimi Naga Sirisha, Durie Ian A., Wu Xianghao, Niyas Afaq M. M., Eiteman Mark A., "Eliminating acetate formation improves citramalate production by metabolically engineered Escherichia coli", Microbial Cell Factories, (20171201), vol. 16, no. 1, doi:10.1186/s12934-017-0729-2, XP055901570 [Y] 14 * ; Especially: Abstract *

DOI:   http://dx.doi.org/10.1186/s12934-017-0729-2
 [Y]  - CHERVAUX et al., "Physiological Study of Lactobacillus delbrueckii subsp. bulgaricus Strains in a Novel Chemically Defined Medium", Applied and Environmental Microbiology, (20001200), vol. 66, no. 12, doi:10.1128/AEM.66.12.5306-5311.2000, pages 5306 - 5311, XP055065341 [Y] 11 * ; Especially: p 5306, col 1, para 2- col 2, para 1 *

DOI:   http://dx.doi.org/10.1128/AEM.66.12.5306-5311.2000
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.