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Extract from the Register of European Patents

EP About this file: EP4267574

EP4267574 - 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  24.05.2024
Database last updated on 05.07.2024
FormerRequest for examination was made
Status updated on  29.09.2023
FormerThe international publication has been made
Status updated on  02.07.2022
Formerunknown
Status updated on  31.01.2022
Most recent event   Tooltip29.05.2024New entry: Despatch of examination report + time limit 
Applicant(s)For all designated states
AJAX THERAPEUTICS, INC.
275 Madison Avenue, 39th Floor
New York, NY 10016 / US
[2023/44]
Inventor(s)01 / MASSE, Craig E.
New York, New York 10016 / US
02 / GREENWOOD, Jeremy R.
New York, New York 10036 / US
03 / MONDAL, Sayan
New York, New York 10036 / US
04 / XU, Jiayi
New York, New York 10036 / US
05 / GHANAKOTA, Phani
New York, New York 10036 / US
06 / MCROBB, Fiona Michelle
New York, New York 10036 / US
07 / BOYLES, Nicholas
New York, New York 10036 / US
 [2023/44]
Representative(s)J A Kemp LLP
80 Turnmill Street
London EC1M 5QU / GB
[2023/44]
Application number, filing date21847625.722.12.2021
[2023/44]
WO2021US64830
Priority number, dateUS202063130251P23.12.2020         Original published format: US 202063130251 P
US202163218097P02.07.2021         Original published format: US 202163218097 P
US202163277337P09.11.2021         Original published format: US 202163277337 P
[2023/44]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2022140527
Date:30.06.2022
Language:EN
[2022/26]
Type: A1 Application with search report 
No.:EP4267574
Date:01.11.2023
Language:EN
The application published by WIPO in one of the EPO official languages on 30.06.2022 takes the place of the publication of the European patent application.
[2023/44]
Search report(s)International search report - published on:EP30.06.2022
ClassificationIPC:C07D471/04, C07D487/04, C07D495/04, C07D513/04, A61P35/00, A61K31/437
[2023/44]
CPC:
C07D471/04 (EP); C07D519/00 (US); A61P35/00 (EP);
C07D487/04 (EP); C07D495/04 (EP); C07D513/04 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/44]
TitleGerman:6-HETEROARYLOXYBENZIMIDAZOLE UND AZABENZIMIDAZOLE ALS JAK2-INHIBITOREN[2023/44]
English:6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS[2023/44]
French:6-HÉTÉROARYLOXY BENZIMIDAZOLES ET AZABENZIMIDAZOLES UTILISÉS EN TANT QU'INHIBITEURS DE JAK2[2023/44]
Entry into regional phase01.06.2023National basic fee paid 
01.06.2023Designation fee(s) paid 
01.06.2023Examination fee paid 
Examination procedure01.06.2023Examination requested  [2023/44]
01.06.2023Date on which the examining division has become responsible
30.01.2024Amendment by applicant (claims and/or description)
28.05.2024Despatch of a communication from the examining division (Time limit: M04)
Fees paidRenewal fee
27.12.2023Renewal fee patent year 03
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[A]WO2004085425  (AMGEN INC [US]) [A] 1-50* page 203; table 8; compound 229 *;
 [X]CN107383014  (UNIV SOUTHERN MEDICAL) [X] 1-50 * pages 18-26; example - *;
 [A]EP3279187  (SHIONOGI & CO [JP]) [A] 1-50 * compounds I-216 *;
 [A]EP3450435  (SHIONOGI & CO [JP]) [A] 1-50 * examples 35-36,38-40 *;
 [I]WO2020097398  (DANA FARBER CANCER INST INC [US], et al) [I] 1-50 * pages 1-2; claim 23; compounds I-24,I-25 *;
 [X]  - WANG YUANYUAN ET AL, "Design, synthesis, biological evaluation and molecular modeling of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRAFV600Eand VEGFR-2 dual inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, (20180602), vol. 155, doi:10.1016/J.EJMECH.2018.05.054, ISSN 0223-5234, pages 210 - 228, XP085431284 [X] 1-50 * table 1 *

DOI:   http://dx.doi.org/10.1016/j.ejmech.2018.05.054
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    - VAINCHENKER, W. et al., FlOOOResearch, (20180000), vol. 7, page 82
    - O'SHEA, J. J. et al., Ann. Rheum. Dis., (20130400), vol. 72, pages 111 - 115
    - RODRIGUES, M. A.TORRES, T. J., Derm. Treat., (20190000), vol. 31, no. 1, pages 33 - 40
    - MEYER S.C., LEVINE, R. L., Clin. Cancer Res., (20140000), vol. 20, no. 8, pages 2051 - 9
    - WU, S. C. et al., Cancer Cell, (20150713), vol. 28, no. 1, pages 29 - 41
    - S. M. BERGE et al., J. Pharmaceutical Sciences, (19770000), vol. 66, pages 1 - 19
    - The Lancet. doi:10.1016/S0140-6736(20)30628-0
    - YUMEEN, S. et al., Blood Adv., (20200000), vol. 4, no. 10, pages 2213 - 2226
    - JUTZI, J.S. et al., HemaSphere, vol. 2, no. 3, (20180000), URL: http://dx.doi.org/10.1097/HS9.0000000000000054
    - JAFFER, T.MA, D, Transl. Cancer Res., (20160000), vol. 5, pages S616 - S628
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.