EP4252750 - PHARMACEUTICAL PRESERVATION OF CREB ACTIVATION IN THE TREATMENT OF ALZHEIMER'S DISEASE [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 26.07.2024 Database last updated on 19.10.2024 | |
Former | The application has been published Status updated on 01.09.2023 | Most recent event Tooltip | 26.07.2024 | Application deemed to be withdrawn | published on 28.08.2024 [2024/35] | Applicant(s) | For all designated states Leibniz-Institut für Neurobiologie Brenneckestraße 6 39118 Magdeburg / DE | For all designated states Westfälische Wilhelms-Universität Münster Schlossplatz 2 48149 Münster / DE | [2023/40] | Inventor(s) | 01 /
Kreutz, Michael 39112 Magdeburg / DE | 02 /
Reissner, Carsten 48161 Münster / DE | 03 /
Grochowska, Katarzyna 22085 Hamburg / DE | 04 /
Oelschlegel, Anja 39122 Magdeburg / DE | 05 /
Karpova, Anna 39104 Magdeburg / DE | 06 /
Gomes, Guilherme 39116 Magdeburg / DE | [2023/40] | Representative(s) | Hertin und Partner Rechts- und Patentanwälte PartG mbB Kurfürstendamm 54/55 10707 Berlin / DE | [2023/40] | Application number, filing date | 22166017.8 | 31.03.2022 | [2023/40] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP4252750 | Date: | 04.10.2023 | Language: | EN | [2023/40] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 02.09.2022 | Classification | IPC: | A61K31/285, A61K31/29, A61K31/137, A61K9/00, A61K31/145, A61K31/197, A61P25/28 | [2023/40] | CPC: |
A61K31/137 (EP);
A61K31/145 (EP);
A61K31/197 (EP);
A61K31/285 (EP);
A61K31/29 (EP);
A61K31/662 (EP);
A61P25/28 (EP)
(-)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2023/40] | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | KH | Not yet paid | MA | Not yet paid | MD | Not yet paid | TN | Not yet paid | Title | German: | PHARMAZEUTISCHE KONSERVIERUNG DER CREB-AKTIVIERUNG BEI DER BEHANDLUNG VON MORBUS ALZHEIMER | [2023/40] | English: | PHARMACEUTICAL PRESERVATION OF CREB ACTIVATION IN THE TREATMENT OF ALZHEIMER'S DISEASE | [2023/40] | French: | CONSERVATION PHARMACEUTIQUE DE L'ACTIVATION DE CREB DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER | [2023/40] | Examination procedure | 05.04.2024 | Application deemed to be withdrawn, date of legal effect [2024/35] | 25.04.2024 | Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time [2024/35] | Fees paid | Penalty fee | Additional fee for renewal fee | 31.03.2024 | 03   M06   Not yet paid |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [A]WO0213867 (COLD SPRING HARBOR LAB [US]) [A] 1-15 * page 4, lines 21-28 * * page 7, lines 29-31 * * page 15, line 27 - page 16, line 3 * * page 18, lines 16-20 * * claims 7, 8 *; | [A]WO2012051251 (US HEALTH [US], et al) [A] 1-15 * page 3, lines 25-26 * * page 6, lines 20-25 ** claims 1, 3, 9 *; | [AD] - Grochowska Katarzyna M. ET AL, "A molecular mechanism by which amyloid-[beta] induces inactivation of CREB in Alzheimer's Disease", bioRxiv, doi:10.1101/2020.01.08.898304, (20201014), pages 1 - 69, URL: chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.biorxiv.org/content/10.1101/2020.01.08.898304v2.full.pdf, (20220822), XP055953301 [AD] 1-15 * abstract * * page 8, paragraph 2 - page 10, paragraph 2 * * page 14, paragraph 2 * * page 48; figure 8 * * page 54; figure S4 * * page 60; figure S8 * DOI: http://dx.doi.org/10.1101/2020.01.08.898304 | [A] - PARRA-DAMAS ARNALDO ET AL, "Synapse-to-Nucleus Signaling in Neurodegenerative and Neuropsychiatric Disorders", BIOLOGICAL PSYCHIATRY, ELSEVIER, AMSTERDAM, NL, vol. 86, no. 2, doi:10.1016/J.BIOPSYCH.2019.01.006, ISSN 0006-3223, (20190715), pages 87 - 96, (20190117), XP085727030 [A] 1-15 * abstract * * page 90, column 1, paragraphs 1-2 * * page 92, column 2, paragraph l * * page 93, column 1, paragraph 2 * DOI: http://dx.doi.org/10.1016/j.biopsych.2019.01.006 | by applicant | - CAS , no. 98-72-6 | - BEHNISCH TYUANXIANG P et al., "Nuclear translocation of jacob in hippocampal neurons after stimuli inducing long-term potentiation but not long-term depression", PLoS One, (20110000), vol. 6, page e17276 | - CREIGHTON, S.D.MENDELL, A.L.PALMER, D.KALISCH, B.E.MACLUSKY, N.J. et al., "Dissociable cognitive impairments in two strains of transgenic Alzheimer's disease mice revealed by a battery of object-based tests", Sci. Rep., (20190000), vol. 9, page 57 | - DIETERICH DCKARPOVA AMIKHAYLOVA MZDOBNOVA I et al., "Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus", PLoS Biol, (20080000), vol. 6, page e34 | - GOMES GMDALMOLIN GDBAR J et al., "Inhibition of the polyamine system counteracts β-amytoid peptide-induced memory impairment in mice: involvement of extrasynaptic NMDA receptors", PLoS One, (20140000), vol. 9, page e99184 | - GROCHOWSKA KMYUANXIANG PBAR J et al., "Posttranslational modification impact on the mechanism by which amyloid-p induces synaptic dysfunction", EMBO Rep, (20170000), vol. 18, pages 962 - 981 | - KARPOVA AMIKHAYLOVA MBERA SBAR JREDDY PPBEHNISCH TRANKOVIC VSPILKER CBETHGE PSAHIN J et al., "Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus", Cell, (20130000), vol. 152, doi:10.1016/j.cell.2013.02.002, pages 1119 - 33, XP028987300 DOI: http://dx.doi.org/10.1016/j.cell.2013.02.002 | - KINDLER SDIETERICH DC et al., "Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced nuclear translocation after calpain-mediated proteolysis", J Biol Chem, (20090000), vol. 284, pages 25431 - 40 | - MELGAREJO DA ROSA MYUANXIANG P et al., "Synaptic GluN2B/CaMKII-a Signaling Induces Synapto-Nuclear Transport of ERK and Jacob", Front Mol Neurosci, (20160000), vol. 9, page 66 | - MIKHAYLOVA MKARPOVA ABAR JBETHGE PYUANXIANG PCHEN YZUSCHRATTER WBEHNISCH TKREUTZ MR, "Cellular distribution of the NMDA-receptor activated synapto-nuclear messenger Jacob in the rat brain", Brain Struct Funct, (20140000), vol. 219, pages 843 - 60 | - PANAYOTIS NKARPOVA AKREUTZ MRFAINZILBER M, "Macromolecular transport in synapse to nucleus communication", Trends Neurosci, (20150000), vol. 38, pages 108 - 16 | - RONICKE RMIKHAYLOVA MRONICKE SMEINHARDT JSCHRODER UHFANDRICH M et al., "Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors", Neurobiol Aging, (20110000), vol. 32, doi:10.1016/j.neurobiolaging.2010.01.011, pages 2219 - 28, XP028311638 DOI: http://dx.doi.org/10.1016/j.neurobiolaging.2010.01.011 | - SPILKER CGROCHOWSKA KMKREUTZ MR, "What do we learn from the murine Jacob/Nsmf gene knockout for human disease?", Rare Dis, (20160000), vol. 4, page e1241361 | - SPILKER CNULLMEIER SGROCHOWSKA KM et al., "A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis", PLoS Genet, (20160000), vol. 12, page e1005907 |