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Extract from the Register of European Patents

EP About this file: EP4129297

EP4129297 - TREATMENT OF COGNITIVE AND MOOD SYMPTOMS IN NEURODEGENERATIVE AND NEUROPSYCHIATRIC DISORDERS WITH ALPHA5-CONTAINING GABAA RECEPTOR AGONISTS [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  11.08.2023
Database last updated on 28.06.2024
FormerThe application has been published
Status updated on  06.01.2023
Most recent event   Tooltip28.03.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
UWM Research Foundation, Inc.
1440 East North Avenue
Milwaukee, WI 53202 / US
For all designated states
Centre For Addiction And Mental Health
1001 Queen Street West
Toronto, ON M6J 1H4 / CA
For all designated states
University of Belgrade-Faculty of Pharmacy
Vojvode Stepe 450
Belgrade 11221 / RS
[2023/06]
Inventor(s)01 / COOK, James M.
Milwaukee, 53217 / US
02 / LI, Guanguan
Milwaukee, 53211 / US
03 / POE, Michael, Ming-Jin
Kalamazoo, 49008 / US
04 / SAVIC, Miroslav M.
11000 Belgrade / RS
05 / SIBILLE, Etienne
Toronto, M4Y 3G4 / CA
 [2023/06]
Representative(s)Marks & Clerk LLP
15 Fetter Lane
London EC4A 1BW / GB
[2023/06]
Application number, filing date22181243.120.03.2017
[2023/06]
Priority number, dateUS201662310409P18.03.2016         Original published format: US 201662310409 P
[2023/06]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP4129297
Date:08.02.2023
Language:EN
[2023/06]
Search report(s)(Supplementary) European search report - dispatched on:EP16.12.2022
ClassificationIPC:A61K31/5517, A61P25/18, C07F7/08, A61P25/24, A61P25/28, A61P25/00, // C07D487/04
[2023/06]
CPC:
C07D487/04 (EP,US); A61P25/00 (EP); A61P25/18 (EP);
A61P25/22 (US); A61P25/24 (EP); A61P25/28 (EP);
C07F7/0812 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/37]
Former [2023/06]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:BEHANDLUNG VON KOGNITIVEN UND STIMMUNGSSYMPTOMEN BEI NEURODEGENERATIVEN UND NEUROPSYCHIATRISCHEN ERKRANKUNGEN MIT ALPHA5-HALTIGEN GABAA-REZEPTORAGONISTEN[2023/06]
English:TREATMENT OF COGNITIVE AND MOOD SYMPTOMS IN NEURODEGENERATIVE AND NEUROPSYCHIATRIC DISORDERS WITH ALPHA5-CONTAINING GABAA RECEPTOR AGONISTS[2023/06]
French:TRAITEMENT DE TROUBLES COGNITIFS ET DE SYMPTÔMES DE L'HUMEUR DANS DES TROUBLES NEURODÉGÉNÉRATIFS ET NEUROPSYCHIATRIQUES AVEC DES AGONISTES DU RÉCEPTEUR GABAA CONTENANT ALPHA5[2023/06]
Examination procedure07.08.2023Examination requested  [2023/37]
07.08.2023Date on which the examining division has become responsible
01.09.2023Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
09.11.2023Amendment by applicant (claims and/or description)
Parent application(s)   TooltipEP17767701.0  / EP3439665
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
09.11.2023Request for further processing filed
09.11.2023Full payment received (date of receipt of payment)
Request granted
20.11.2023Decision despatched
Fees paidRenewal fee
27.06.2022Renewal fee patent year 03
27.06.2022Renewal fee patent year 04
27.06.2022Renewal fee patent year 05
27.06.2022Renewal fee patent year 06
27.03.2023Renewal fee patent year 07
27.03.2024Renewal fee patent year 08
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Documents cited:Search[I]  - NAMJOSHI OJAS A ET AL, "Search for [alpha]3[beta]2/3[gamma]2 subtype selective ligands that are stable on human liver microsomes", BIOORGANIC & MEDICINAL CHEMISTRY : A TETRAHEDRON PUBLICATION FOR THE RAPID DISSEMINATION OF FULL ORIGINAL RESEARCH PAPERS AND CRITICAL REVIEWS ON BIOMOLECULAR CHEMISTRY, MEDICINAL CHEMISTRY AND RELATED DISCIPLINES, (20121115), vol. 21, no. 1, doi:10.1016/J.BMC.2012.10.057, ISSN 0968-0896, pages 93 - 101, XP028961414 [I] 1-16 * abstract;; compounds 10-13 *

DOI:   http://dx.doi.org/10.1016/j.bmc.2012.10.057
 [A]  - MARTA FILIZOLA ET AL, "Benzodiazepine-Induced Hyperphagia: Development and Assessment of a 3D Pharmacophore By Computational Methods", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, US, (20000401), vol. 17, no. 5, doi:10.1080/07391102.2000.10506566, ISSN 0739-1102, pages 769 - 778, XP055628998 [A] 1-16 * page 5, compound 230384 *

DOI:   http://dx.doi.org/10.1080/07391102.2000.10506566
 [AP]  - STAMENIC TAMARA TIMIC ET AL, "Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAAreceptors containing the [alpha]5 subunit", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, (20160914), vol. 791, doi:10.1016/J.EJPHAR.2016.09.016, ISSN 0014-2999, pages 433 - 443, XP029805232 [AP] 1-16 * abstract, compound 1 *

DOI:   http://dx.doi.org/10.1016/j.ejphar.2016.09.016
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