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Extract from the Register of European Patents

EP About this file: EP4288780

EP4288780 - METHODS FOR CANCER DETECTION [Right-click to bookmark this link]
StatusThe patent has been granted
Status updated on  02.05.2025
Database last updated on 07.03.2026
FormerGrant of patent is intended
Status updated on  26.01.2025
FormerRequest for examination was made
Status updated on  10.11.2023
FormerThe international publication has been made
Status updated on  12.08.2022
Formerunknown
Status updated on  11.02.2022
Most recent event   Tooltip30.01.2026Lapse of the patent in a contracting state
New state(s): SK		published on 04.03.2026  [2026/10]
Applicant(s)For all designated states
Disruptive Technological Advances In Life Science S.r.l.- Società Benefit, In forma abbreviata, D-TAILS S.r.l. SB
Via Agrigento 4a-4b
00161 Roma / IT
For all designated states
Fondazione Istituto Italiano di Tecnologia
Via Morego, 30
16163 Genova / IT
[2025/12]
Former [2024/15]For all designated states
Disruptive Technological Advances In Life Sciences S.r.l.- Società Benefit, In forma abbreviata, D-TAILS S.r.l. SB
Via Di Torre Rossa 66
00165 Roma / IT
For all designated states
Fondazione Istituto Italiano di Tecnologia
Via Morego, 30
16163 Genova / IT
Former [2023/50]For all designated states
Disruptive Technological Advances in Life Science S.r.l. Societá Benefit In Forma Abbreviata, Dtails S.r.l. SB
Via Di Torre Rossa 66
00165 Roma / IT
For all designated states
Fondazione Istituto Italiano di Tecnologia
Via Morego, 30
16163 Genova / IT
Inventor(s)01 / FOLLI, Viola
00046 Grottaferrata RM / IT
02 / LANZA, Enrico
00184 Roma / IT
03 / RICCO, Vincenzo
70125 Bari / IT
 [2023/50]
Representative(s)Predazzi, Valentina, et al
Società Italiana Brevetti S.p.A.
Piazza di Pietra, 39
00186 Roma / IT
[2023/50]
Application number, filing date22702054.201.02.2022
[2023/50]
WO2022IB50852
Priority number, dateIT2021000229403.02.2021         Original published format: IT202100002294
[2023/50]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2022167924
Date:11.08.2022
Language:EN
[2022/32]
Type: A1 Application with search report 
No.:EP4288780
Date:13.12.2023
Language:EN
The application published by WIPO in one of the EPO official languages on 11.08.2022 takes the place of the publication of the European patent application.
[2023/50]
Type: B1 Patent specification 
No.:EP4288780
Date:04.06.2025
Language:EN
[2025/23]
Search report(s)International search report - published on:EP11.08.2022
ClassificationIPC:G01N33/574, B01L3/00, G16B40/00
[2023/50]
CPC:
G01N33/57585 (EP); G01N33/493 (US); G01N33/0001 (US);
G01N2333/43534 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/50]  
Extension statesBANot yet paid
MENot yet paid
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:VERFAHREN ZUR KREBSERKENNUNG[2023/50]
English:METHODS FOR CANCER DETECTION[2023/50]
French:MÉTHODES DE DÉTECTION DU CANCER[2023/50]
Entry into regional phase25.08.2023National basic fee paid 
25.08.2023Designation fee(s) paid 
25.08.2023Examination fee paid 
Examination procedure25.08.2023Examination requested  [2023/50]
25.08.2023Date on which the examining division has become responsible
18.04.2024Amendment by applicant (claims and/or description)
27.01.2025Communication of intention to grant the patent
23.04.2025Fee for grant paid
23.04.2025Fee for publishing/printing paid
23.04.2025Receipt of the translation of the claim(s)
Divisional application(s)EP24177632.7  / EP4404201
Fees paidRenewal fee
15.02.2024Renewal fee patent year 03
07.02.2025Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCZ04.06.2025
ES04.06.2025
HR04.06.2025
PL04.06.2025
SK04.06.2025
SM04.06.2025
NO04.09.2025
RS04.09.2025
GR05.09.2025
IS04.10.2025
[2026/10]
Former [2026/09]CZ04.06.2025
ES04.06.2025
HR04.06.2025
PL04.06.2025
SM04.06.2025
NO04.09.2025
RS04.09.2025
GR05.09.2025
IS04.10.2025
Former [2026/08]ES04.06.2025
HR04.06.2025
PL04.06.2025
SM04.06.2025
NO04.09.2025
RS04.09.2025
GR05.09.2025
IS04.10.2025
Former [2026/07]ES04.06.2025
HR04.06.2025
PL04.06.2025
NO04.09.2025
RS04.09.2025
GR05.09.2025
IS04.10.2025
Former [2025/48]ES04.06.2025
HR04.06.2025
PL04.06.2025
NO04.09.2025
RS04.09.2025
GR05.09.2025
Former [2025/47]ES04.06.2025
PL04.06.2025
NO04.09.2025
GR05.09.2025
Former [2025/46]ES04.06.2025
Cited inInternational search[AD] EP3081935  (UNIV KYUSHU NAT UNIV CORP et al.)
 [AD]   DRAPER C. F. ET AL: "Menstrual cycle rhythmicity: metabolic patterns in healthy women", vol. 8, no. 1, 1 October 2018 (2018-10-01), XP055845831, Retrieved from the Internet DOI: 10.1038/s41598-018-32647-0

DOI:   http://dx.doi.org/10.1038/s41598-018-32647-0
 [T]   LANZA ENRICO ET AL: "C. elegans-based chemosensation strategy for the early detection of cancer metabolites in urine samples", vol. 11, no. 1, 24 August 2021 (2021-08-24), XP055845840, Retrieved from the Internet DOI: 10.1038/s41598-021-96613-z

DOI:   http://dx.doi.org/10.1038/s41598-021-96613-z
by applicantWO2015088039
 EP3698133
 WO2014169336
   BARGMANN ET AL.: "Odorant-selective genes and neurons mediate olfaction in C. elegans", CELL, vol. 74, 13 August 1993 (1993-08-13), pages 515 - 527, XP023913410, DOI: 10.1016/0092-8674(93)80053-H

DOI:   http://dx.doi.org/10.1016/0092-8674(93)80053-H
   IWANIR, S. ET AL.: "Irrational behavior in c. elegans arises from asymmetric modulatory effects within single sensory neurons", NAT. COMMUNICATIONS, vol. 10, 2019, pages 3202
   COHEN, D. ET AL.: "Bounded rationality in c. elegans is explained by circuit-specific normalization in chemosensory pathways", NAT. COMMUNICATIONS, vol. 10, 2019, pages 1 - 12
   HIROTSU, T. ET AL.: "A highly accurate inclusive cancer screening test using Caenorhabditis elegans scent detection", PLOS ONE, vol. 10, 2015, pages e0118699, XP055311189, DOI: 10.1371/journal.pone.0118699

DOI:   http://dx.doi.org/10.1371/journal.pone.0118699
   UEDA, YUJI ET AL.: "Application of C. elegans cancer screening test for the detection of pancreatic tumour in genetically engineered mice", ONCOTARGET, vol. 10, no. 52, 2019, pages 5412
   DRAPER, C. ET AL.: "Menstrual cycle rhythmicity: metabolic patterns in healthy women", SCI. REPORTS, vol. 8, 2018, pages 14568, XP055845831, DOI: 10.1038/s41598-018-32647-0

DOI:   http://dx.doi.org/10.1038/s41598-018-32647-0
   HIROTSU, T. ET AL., PLOS ONE, vol. 10, 2015, pages e0118699
   ALBRECHTBARGMANN: "High-content behavioral analysis of Caenorabditis elegans in precise spatiotemporal chemical environments", NATURE METHODS, 2011
   ADRIANA SAN-MIGUELHANG LU: "Microfluidics as a tool for C. elegans research", WORMBOOK, 2013, pages 3
   "Molecular Cloning: A Laboratory Manual (4th Edition", 2012, COLD SPRING HARBOR LABORATORY PRESS
   MELLO, C. CKRAMER, J. M.STINCHCOMB, DAMBROS, V.: "EMBO J", vol. 10, 1991, article "Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences", pages: 3959 - 3970
   KAPOLKA ET AL.: "DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery", PNAS, vol. 117, no. 23, 2020, pages 13117 - 13126
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.