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Extract from the Register of European Patents

EP About this file: EP4168409

EP4168409 - VMAT2 INHIBITORS AND METHODS OF USE [Right-click to bookmark this link]
StatusGrant of patent is intended
Status updated on  31.01.2024
Database last updated on 20.05.2024
FormerRequest for examination was made
Status updated on  10.01.2024
FormerGrant of patent is intended
Status updated on  12.06.2023
FormerRequest for examination was made
Status updated on  24.03.2023
FormerThe international publication has been made
Status updated on  30.09.2022
Formerunknown
Status updated on  19.04.2022
Most recent event   Tooltip28.03.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
Neurocrine Biosciences, Inc.
12780 El Camino Real
San Diego, California 92130 / US
[2023/17]
Inventor(s)01 / HARRIOTT, Nicole
San Diego, California 92130 / US
02 / PAGANO, Nicholas
San Diego, California 92130 / US
03 / BOON, Byron A.
San Diego, California 92130 / US
 [2023/17]
Representative(s)Mewburn Ellis LLP
Aurora Building
Counterslip
Bristol BS1 6BX / GB
[2023/17]
Application number, filing date22715479.621.03.2022
[2023/17]
WO2022US21080
Priority number, dateUS202163164135P22.03.2021         Original published format: US 202163164135 P
[2023/17]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2022203984
Date:29.09.2022
Language:EN
[2022/39]
Type: A1 Application with search report 
No.:EP4168409
Date:26.04.2023
Language:EN
The application published by WIPO in one of the EPO official languages on 29.09.2022 takes the place of the publication of the European patent application.
[2023/17]
Search report(s)International search report - published on:EP29.09.2022
ClassificationIPC:C07D471/04, A61K31/4745, A61P25/00
[2023/17]
CPC:
C07D471/04 (EP,IL,KR,US); A61K31/4745 (KR); A61P25/00 (EP,IL,KR);
A61P25/18 (IL,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2023/17]
Extension statesBA19.01.2023
ME19.01.2023
Validation statesMA19.01.2023
MD19.01.2023
TN19.01.2023
TitleGerman:VMAT2-INHIBITOREN UND VERFAHREN ZUR VERWENDUNG[2023/17]
English:VMAT2 INHIBITORS AND METHODS OF USE[2023/17]
French:INHIBITEURS DE VMAT2 ET PROCÉDÉS D'UTILISATION[2023/17]
Entry into regional phase19.01.2023National basic fee paid 
19.01.2023Designation fee(s) paid 
19.01.2023Examination fee paid 
Examination procedure22.09.2022Request for preliminary examination filed
International Preliminary Examining Authority: EP
19.01.2023Amendment by applicant (claims and/or description)
19.01.2023Examination requested  [2023/17]
19.01.2023Date on which the examining division has become responsible
13.06.2023Communication of intention to grant the patent
14.11.2023Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time
10.01.2024Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
01.02.2024Communication of intention to grant the patent
Request for further processing for:The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent
10.01.2024Request for further processing filed
10.01.2024Full payment received (date of receipt of payment)
Request granted
17.01.2024Decision despatched
Fees paidRenewal fee
27.03.2024Renewal fee patent year 03
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[Y]WO2009070552  (GEN ELECTRIC [US], et al) [Y] 1-138 * claim 2 *;
 [Y]WO2021027792  (SHANDONG LUYE PHARMACEUTICAL CO LTD [CN]) [Y] 1-138 * claim 1 *;
 [A]  - DIMITRI E. GRIGORIADIS ET AL, "Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, (20170412), vol. 361, no. 3, doi:10.1124/jpet.116.239160, ISSN 0022-3565, pages 454 - 461, XP055486504 [A] 1-138 * figure 1 *

DOI:   http://dx.doi.org/10.1124/jpet.116.239160
 [A]  - ZHANGYU YAO ET AL, "Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 46, no. 5, doi:10.1016/J.EJMECH.2011.02.046, ISSN 0223-5234, (20110217), pages 1841 - 1848, (20110223), XP028370954 [A] 1-138 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.ejmech.2011.02.046
by applicantWO2008058261
 WO2018195121
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    - BAS, M.-D, "J. Labelled Compd", Radiopharm, (20010000), vol. 44, pages S280 - S282
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    - WADENBERGHICKS, Neuroscience and Biobehavioral Reviews, (19990000), vol. 23, pages 851 - 862
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.