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Extract from the Register of European Patents

EP About this file: EP4320146

EP4320146 - MATERIALS AND METHODS FOR ENHANCED STEM-CELL LIKE MEMORY T CELL ENGINEERING [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  12.01.2024
Database last updated on 17.05.2024
FormerThe international publication has been made
Status updated on  14.10.2022
Formerunknown
Status updated on  09.05.2022
Most recent event   Tooltip13.03.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
Janssen Biotech, Inc.
800/850 Ridgeview Drive
Horsham, PA 19044 / US
[2024/07]
Inventor(s)01 / SUKUMAR, Madhusudhanan
Springhouse, PA 19477 / US
02 / GANESAN, Rajkumar
Springhouse, PA 19477 / US
03 / SINGH, Sanjaya
Springhouse, PA 19477 / US
04 / ORAVECZ, Tamas
Springhouse, PA 19477 / US
 [2024/07]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2024/07]
Application number, filing date22719716.707.04.2022
[2024/07]
WO2022US23883
Priority number, dateUS202163172601P08.04.2021         Original published format: US 202163172601 P
US202163172605P08.04.2021         Original published format: US 202163172605 P
US202163172595P08.04.2021         Original published format: US 202163172595 P
US202163172610P08.04.2021         Original published format: US 202163172610 P
[2024/07]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2022216963
Date:13.10.2022
Language:EN
[2022/41]
Type: A1 Application with search report 
No.:EP4320146
Date:14.02.2024
Language:EN
The application published by WIPO in one of the EPO official languages on 13.10.2022 takes the place of the publication of the European patent application.
[2024/07]
Search report(s)International search report - published on:EP13.10.2022
ClassificationIPC:C07K14/725, A61K35/17, A61K39/00, C12N5/0783
[2024/07]
CPC:
C12N5/0636 (EP,IL,KR); A61K39/4611 (EP,IL,KR); A61K39/4631 (EP,IL,KR);
A61K39/4632 (KR); A61K39/464417 (EP,IL,KR); A61P35/00 (KR);
C07K14/7051 (EP,IL,KR); C07K16/30 (KR); C07K2317/622 (KR);
C07K2319/03 (EP,IL,KR); C12N2501/2307 (EP,IL,KR); C12N2501/2315 (EP,IL,KR);
C12N2501/2321 (EP,IL,KR); C12N2501/51 (EP,IL,KR); C12N2501/515 (EP,IL,KR);
C12N2510/00 (EP,IL,KR) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2024/07]
Extension statesBANot yet paid
MENot yet paid
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:MATERIALIEN UND VERFAHREN FÜR VERBESSERTE STAMMZELLEN-ÄHNLICHE SPEICHER-T-ZELLEN-KONSTRUKTION[2024/07]
English:MATERIALS AND METHODS FOR ENHANCED STEM-CELL LIKE MEMORY T CELL ENGINEERING[2024/07]
French:MATÉRIAUX ET MÉTHODES POUR INGÉNIERIE DE CELLULE T MÉMOIRE DE TYPE CELLULE SOUCHE AMÉLIORÉE[2024/07]
Entry into regional phase08.11.2023National basic fee paid 
08.11.2023Designation fee(s) paid 
08.11.2023Examination fee paid 
Examination procedure08.11.2023Amendment by applicant (claims and/or description)
08.11.2023Examination requested  [2024/07]
08.11.2023Date on which the examining division has become responsible
Fees paidRenewal fee
13.03.2024Renewal fee patent year 03
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[XI]CN109913412  (SHANGHAI SINOBAY BIO TECH CO LTD) [X] 1-18,20,21,24-26,28-30,55-57,62,66-70,72-78 * abstract; claim 1, 3-6, 8; figures 1 and 4A * [I] 19,22,27,31-54,65,71;
 [XI]WO2020177071  (SHANGHAI SINOBAY BIOTECHNOLOGY CO LTD [CN]) [X] 1-18,20,21,24-26,28-30,55-57,62,66-70,72-78 * abstract; claim 1, 3-6, 8, 12; [0078] * [I] 19,22,27,31-54,65,71;
 [XI]CN111893094  (LU CHUNGUANG) [X] 1-16,18,20,21,24-26,28-30,55-57,59-62,66-70,72-78 * abstract; claims 1, 2, 4, 10; Example 3; Table 1; [0005], [0026], [0028] * [I] 19,22,27,31-54,65,71;
 [XI]  - CIERI NICOLETTA ET AL, "IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 121, no. 4, doi:10.1182/BLOOD-2012-05-431718, ISSN 0006-4971, (20130124), pages 573 - 584, (20201119), XP086511136 [X] 1,2,5-16,18,20,24-26,28-30,55,56,66-70,72-78 * abstract; Method section paragraphs 1, 2, 4 and 5; figure 4 * [I] 19,22,27,31-54,71

DOI:   http://dx.doi.org/10.1182/blood-2012-05-431718
 [XI]  - M. SABATINO ET AL, "Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies", BLOOD, US, (20160728), vol. 128, no. 4, doi:10.1182/blood-2015-11-683847, ISSN 0006-4971, pages 519 - 528, XP055340306 [X] 1-3,5-18,24-26,28-30,55-58,60,61,63,66-70,72-78 * abstract; Materials section paragraph 1; p 525, RHC, 1st paragraph; figure 1 * [I] 19,22,27,31-54,65,71

DOI:   http://dx.doi.org/10.1182/blood-2015-11-683847
 [XI]  - YANG XU ET AL, "Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15", BLOOD, US, (20140612), vol. 123, no. 24, doi:10.1182/blood-2014-01-552174, ISSN 0006-4971, pages 3750 - 3759, XP055662271 [X] 1,2,5-18,20,21,23-26,28,55-58,60,61,63,64,66-70,72-78 * abstract; Materials and Methods section paragraphs 2 and 7; p 3755, paragraph bridging LHC and RHC * [I] 19,22,27,31-54,65,71

DOI:   http://dx.doi.org/10.1182/blood-2014-01-552174
 [XI]  - C. ALVAREZ?FERNáNDEZ ET AL, "A short CD3/CD28 costimulation combined withIL?21 enhance the generation ofhuman memory stem T cells foradoptive immunotherapy", JOURNAL OF TRANSLATIONAL MEDICINE, (20160719), vol. 14, doi:10.1186/s12967-016-0973-y, pages 1 - 10, XP055503489 [X] 1-12,20,24-26,28,29,55,56,66-68,70,72-78 * abstract; Methods section pargraphs 1 and 2 * [I] 19,22,27,31-54,71

DOI:   http://dx.doi.org/10.1186/s12967-016-0973-y
 [A]  - TIAN YONGGUI ET AL, "Gene modification strategies for next-generation CAR T cells against solid cancers", JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 13, no. 1, doi:10.1186/s13045-020-00890-6, (20200518), URL: https://link.springer.com/article/10.1186/s13045-020-00890-6/fulltext.html, XP055888282 [A] 1-78 * the whole document *

DOI:   http://dx.doi.org/10.1186/s13045-020-00890-6
by applicantUS4650764
 EP0273085
 US4980289
 US5124263
 WO9409699
 US5384253
 WO9507358
 US5399346
 US5538880
 US5550318
 US5610042
 US5858358
 US5883223
 US6352694
 US6534055
 US6692964
 US6797514
 US6867041
 US6887466
 US6905680
 US6905681
 US6905874
 US7067318
 US7144575
 US7172869
 US7175843
 US7232566
 WO2017093326
    - GATTINONI et al., Nat. Med., (20110000), vol. 17, pages 1290 - 7
    - FLYNN et al., Clin. Translat. Immunol., (20140000), vol. 3, page e20
    - MANN et al., Cell, (19830000), vol. 33, page 153
    - POTTER et al., Proc. Nat'l Acad. Sci. USA, (19840000), vol. 81, pages 7161 - 7165
    - TUR-KASPA et al., Mol. Cell Biol., (19860000), vol. 6, pages 716 - 718
    - SARDESAI, N. Y.WEINER, D. B., Current Opinion in Immunotherapy, (20110000), vol. 23, pages 421 - 9
    - FERRARO, B. et al., Human Vaccines, (20110000), vol. 7, pages 120 - 127
    - MARKOWITZ et al., J. Virol., (19880000), page 1120
    - KUO et al., Blood, (19930000), vol. 82, page 845
    - GHOSHBACHHAWAT, Liver Diseases, Targeted Diagnosis and Therapy Using Specific Receptors and Ligands, (19910000), pages 87 - 104
    - GOPAL, T. V., Mol Cell Biol., (19850500), vol. 5, no. 5, pages 1188 - 90
    - GRAHAMVAN DER EB, Virology, (19730000), vol. 52, pages 456 - 467
    - CHENOKAYAMA, Mol. Cell Biol., (19870000), vol. 7, no. 8, pages 2745 - 2752
    - RIPPE et al., Mol. Cell Biol., (19900000), vol. 10, pages 689 - 695
    - FECHHEIMER et al., Proc. Nat'l Acad. Sci. USA, (19870000), vol. 84, pages 8463 - 8467
    - KLEIN et al., Nature, (19870000), vol. 327, pages 70 - 73
    - YANG et al., Proc. Nat'l Acad. Sci. USA, (19900000), vol. 87, pages 9568 - 9572
    - WUWU, J. Biol. Chem., (19870000), vol. 262, pages 4429 - 4432
    - WAGNER et al., Proc. Natl. Acad. Sci. USA, (19900000), vol. 87, no. 9, pages 3410 - 3414
    - PERALES et al., Proc. Natl. Acad. Sci. USA, (19940000), vol. 91, pages 4086 - 4090
    - WUWU, Adv. Drug Delivery Rev., (19930000), vol. 12, pages 159 - 167
    - NICOLAU et al., Methods Enzymol., (19870000), vol. 149, pages 157 - 176
    - MEUER, S. C. et al., Cell, (19840000), vol. 36, pages 897 - 906
    - YANG, S. Y. et al., J. Immunol., (19860000), vol. 137, pages 1097 - 1100
    - ILIADES, P. et al., FEBS Lett, (19970000), vol. 409, pages 437 - 441
    - STONE, E. et al., Journal of Immunological Methods, (20070000), vol. 318, pages 88 - 94
    - HOLT, L. J. et al., Trends Biotechnol., (20030000), vol. 21, no. 11, pages 484 - 490
    - BRUDNO JNKOCHENDERFER JN, "Toxicities of chimeric antigen receptor T cells: recognition and management", Blood, (20160000), vol. 127, no. 26, doi:10.1182/blood-2016-04-703751, pages 3321 - 30, XP055547499

DOI:   http://dx.doi.org/10.1182/blood-2016-04-703751
    - JUNE CHO'CONNOR RSKAWALEKAR OUGHASSEMI SMILONE MC, "CAR T cell immunotherapy for human cancer", Science (New York, NY, (20180000), vol. 359, no. 6382, pages 1361 - 5
    - MIRZAEI HRRODRIGUEZ ASHEPPHIRD JBROWN CEBADIE B, "Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications", Front Immunol, (20170000), vol. 8, page 1850
    - ANDERSON JK, MEHTA A, "A review of chimeric antigen receptor T-cells in lymphoma", Expert Rev Hematol, (20190000), vol. 12, no. 7, pages 551 - 61
    - MINUTOLO NGHOLLANDER EEPOWELL DJ, JR, "The Emergence of Universal Immune Receptor T Cell Therapy for Cancer", Front Oncol, (20190000), vol. 9, page 176
    - KLOSS CCCONDOMINES MCARTELLIERI MBACHMANN MSADELAIN M, "Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells", Nat Biotechnol, (20130000), vol. 31, no. 1, doi:10.1038/nbt.2459, pages 71 - 5, XP055130697

DOI:   http://dx.doi.org/10.1038/nbt.2459
    - PORTER DLHWANG WTFREY NVLACEY SFSHAW PALOREN AW et al., "Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia", Sci Transl Med, (20150000), vol. 7, no. 303, doi:10.1126/scitranslmed.aac5415, pages 303 - 139, XP055411906

DOI:   http://dx.doi.org/10.1126/scitranslmed.aac5415
    - ESHHAR ZWAKS TGROSS GSCHINDLER DG, "Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors", Proceedings of the National Academy of Sciences of the United States of America, (19930000), vol. 90, no. 2, doi:10.1073/pnas.90.2.720, pages 720 - 4, XP002009770

DOI:   http://dx.doi.org/10.1073/pnas.90.2.720
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