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EP About this file: EP4227952

EP4227952 - SYSTEM COORDINATOR AND MODULAR ARCHITECTURE FOR OPEN-LOOP AND CLOSED-LOOP CONTROL OF DIABETES [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  09.02.2024
Database last updated on 20.05.2024
FormerThe application has been published
Status updated on  14.07.2023
Most recent event   Tooltip09.02.2024The date on which the examining division becomes responsible, has been established 
09.02.2024Request for examination filedpublished on 13.03.2024  [2024/11]
09.02.2024Change - designated statespublished on 13.03.2024  [2024/11]
Applicant(s)For all designated states
University Of Virginia Patent Foundation
722 Preston Avenue, Suite 107
Charlottesville, VA 22903 / US
[2023/33]
Inventor(s)01 / KOVATCHEV, Boris P.
Charlottesville, Virginia, 22901 / US
02 / PATEK, Stephen D.
Charlottesville, Virginia, 22901 / US
03 / BRETON, Marc D.
Charlottesville, Virginia, 22901 / US
 [2023/33]
Representative(s)Appelt, Christian W.
Boehmert & Boehmert
Anwaltspartnerschaft mbB
Pettenkoferstrasse 22
80336 München / DE
[2023/33]
Application number, filing date23179066.828.05.2010
[2023/33]
Priority number, dateUS200918245409P29.05.2009         Original published format: US 18245409 P
[2023/33]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP4227952
Date:16.08.2023
Language:EN
[2023/33]
Search report(s)(Supplementary) European search report - dispatched on:EP18.07.2023
ClassificationIPC:G16H20/17, G16H50/20, G16H50/50, // G16H20/30, G16H20/60
[2023/33]
CPC:
G16H20/17 (EP,US); A61B5/14532 (US); A61B5/7275 (US);
G16H50/20 (EP,US); G16H50/50 (EP,US); G16H20/30 (EP,US);
G16H20/60 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2024/11]
Former [2023/33]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  SM,  TR 
TitleGerman:SYSTEMKOORDINATOR UND MODULARE ARCHITEKTUR ZUR OPEN-LOOP- UND CLOSED-LOOP-STEUERUNG VON DIABETES[2023/33]
English:SYSTEM COORDINATOR AND MODULAR ARCHITECTURE FOR OPEN-LOOP AND CLOSED-LOOP CONTROL OF DIABETES[2023/33]
French:COORDINATEUR DE SYSTÈME ET ARCHITECTURE MODULAIRE POUR LA RÉGULATION ET LA RÉGULATION DU DIABÈTE[2023/33]
Examination procedure05.02.2024Amendment by applicant (claims and/or description)
05.02.2024Examination requested  [2024/11]
05.02.2024Date on which the examining division has become responsible
Parent application(s)   TooltipEP10781299.2  / EP2435962
EP23160318.4  / EP4224483
Fees paidRenewal fee
15.06.2023Renewal fee patent year 03
15.06.2023Renewal fee patent year 04
15.06.2023Renewal fee patent year 05
15.06.2023Renewal fee patent year 06
15.06.2023Renewal fee patent year 07
15.06.2023Renewal fee patent year 08
15.06.2023Renewal fee patent year 09
15.06.2023Renewal fee patent year 10
15.06.2023Renewal fee patent year 11
15.06.2023Renewal fee patent year 12
15.06.2023Renewal fee patent year 13
15.06.2023Renewal fee patent year 14
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Documents cited:Search[XI]US2008183060  (STEIL GARRY M [US], et al) [X] 1,6,11 * paragraphs [0089] , [0090] , [0129] * [I] 2-5,7-10,12-15;
 [XI]US2009006133  (WEINERT STEFAN [US], et al) [X] 1,6,11 * figure 17 * [I] 2-5,7-10,12-15;
 [XI]US2009006061  (THUKRAL AJAY [US], et al) [X] 1,6,11 * figure 8 *[I] 2-5,7-10,12-15
by applicantUS2009697456
 US2004254434
 US6923763
 US7025425
 US10069674
    - BELLAZZI RNUCCI GCOBELLI C, "The subcutaneous route to insulin-dependent diabetes therapy: closed-loop and partially closed-loop control strategies for insulin delivery and measuring glucose concentration", IEEE Eng MedBiol, (20010000), vol. 20, doi:10.1109/51.897828, pages 54 - 64, XP011085089

DOI:   http://dx.doi.org/10.1109/51.897828
    - BERGMAN RNIDER YZBOWDEN CRCOBELLI C, "Quantitative estimation of insulin sensitivity", Am J Physiol., (19790000), vol. 236, pages E667 - E677, XP055126324
    - BRETON MKOVATCHEV BP, "Analysis, modeling, and simulation of the accuracy of continuous glucose sensors", J Diabetes Sci Technol, (20080000), vol. 2, pages 853 - 862
    - BRETON MDSHIELDS DPKOVATCHEV BP, "Optimum Subcutaneous Glucose Sampling and FourierAnalysis of Continuous Glucose Monitors", J Diabetes Sci, (20080000), vol. 2, pages 495 - 300
    - BUCKINGHAM BCORBY ECLINTON P et al., "Preventing Hypoglycemia Using Predictive Alarm Algorithms and Insulin Pump Suspension", Diabetes Technol Ther, (20090000), vol. 11, doi:10.1089/dia.2008.0032, pages 93 - 97, XP055078304

DOI:   http://dx.doi.org/10.1089/dia.2008.0032
    - CHAN ABRETON MDKOVATCHEV BP, "Effects of pulsatile subcutaneous injections of insulin lispro on plasma insulin concentration levels", J Diabetes Sci Technol, (20080000), vol. 2, pages 844 - 852
    - CLARKE WLKOVATCHEV BP, "The Artificial Pancreas: How Close We Are to Closing the Loop?", PedEndocrinol Rev, (20070000), vol. 1, pages 314 - 316
    - CLARKE WL, KOVATCHEV BP, "Statistical Tools to Analyze Continuous Glucose Monitoring Data", Diabetes Technol Ther
    - CLEMENS AHCHANG PHMYERS RW, "The development of Biostator, a glucose-controlled insulin infusion system", Horm Metab Res Supplement, (19770000), vol. 7, pages 23 - 33
    - COBELLI C, RUGGERI A, "Evaluation of portal/peripheral route and of algorithms for insulin delivery in the closed-loop control of glucose in diabetes. A modeling study", Trans Biomed Eng, (19830000), vol. 30, pages 93 - 103
    - CRYER PE, "Hypoglycaemia: The limiting factor in the glycaemic management of type I and type II diabetes", Diabetologia, (20020000), vol. 45, pages 937 - 948
    - DALLA MAN C, BRETON MD, COBELLI C, "Model of Type 1 Diabetes: In Silico Studies", J Diabetes Sci Technol, (20090000), vol. 3, pages 56 - 67, XP055137742
    - DALLA MAN CRAIMONDO DMRIZZA RACOBELLI C, "GIM, Simulation Software of Meal Glucose-Insulin Model", J Diabetes Science and Technology, (20070000), vol. 1, doi:10.1177/193229680700100303, pages 323 - 330, XP055570592

DOI:   http://dx.doi.org/10.1177/193229680700100303
    - DALLA MAN CRIZZA RACOBELLI C, "Meal simulation model of the glucose-insulin system", IEEE Trans Biomed Eng, (20070000), vol. 54, pages 1740 - 1749
    - DASSAU EPALERM CCZISSER HBUCKINGHAM BAJOVANOVIC LFJ DOYLE III, "In silico benchmark platform for artificial pancreatic b-cell development - a dynamic simulator for closed-loop control with hardware-in-the-loop", Diabetes Technol Ther, (20090000), vol. 11
    - DASSAU EZISSER HPALERM CCBUCKINGHAM BAJOVANOVIC LDOYE III FJ, "Modular Artificial β-Cell System: A Prototype for Clinical Research", J Diabetes Sci Technol, (20080000), vol. 2, pages 863 - 872
    - DASSAU E.CAMERON F.LEE H.BEQUETTE B. W.DOYLE III F. J.GUNTER N.CHASE H. P.BUCKINGHAM B. A., "Real-time Hypoglycemia Prediction Using Continuous Glucose Monitoring (CGM), A Safety Net to the Artificial Pancreas", Diabetes, (20080000), vol. 57, page A13
    - DUA PDOYLE FJ 3RDPISTIKOPOULOS EN, "Model-Based Blood Glucose Control for Type 1 Diabetes via Parametric Programming", IEEE Trans Biomed Eng., (20060000), vol. 53, doi:10.1109/TBME.2006.878075, pages 1478 - 1491, XP055220345

DOI:   http://dx.doi.org/10.1109/TBME.2006.878075
    - HOVORKA RCANONICO VCHASSIN LJ et al., "Nonlinear model predictive control of glucose concentration in subjects with type 1 diabetes", Physiol Meas, (20040000), vol. 25, doi:10.1088/0967-3334/25/4/010, pages 905 - 920, XP055420209

DOI:   http://dx.doi.org/10.1088/0967-3334/25/4/010
    - HOVORKA R, "The future of continuous glucose monitoring: closed loop", Diabetes Rev, (20080000), vol. 4, pages 269 - 79
    - HOVORKA R, "Continuous glucose monitoring and closed-loop systems", Diabet Med, (20060000), vol. 23, doi:10.1111/j.1464-5491.2005.01672.x, pages 1 - 12, XP007900887

DOI:   http://dx.doi.org/10.1111/j.1464-5491.2005.01672.x
    - KING CR, ANDERSON SM, BRETON MD, CLARKE WL, KOVATCHEV BP, "Modeling of calibration effectiveness and blood-to-interstitial glucose dynamics as potentialconfounders of the accuracy of continuous glucose sensors during hyperinsulinemic clamp", J Diabetes Sci Technol, (20070000), vol. 1, doi:10.1177/193229680700100302, pages 317 - 322, XP055530555

DOI:   http://dx.doi.org/10.1177/193229680700100302
    - KLONOFF DC, "The Artificial Pancreas: How Sweet Engineering Will Solve Bitter Problems", J Diabetes Sci Technol, (20070000), vol. 1, pages 72 - 81
    - KOVATCHEV BP, CLARKE WL, "Peculiarities of the Continuous Glucose Monitoring Data Stream and Their Impact on Developing Closed-Loop Control Technology", Diabetes Sci Technol, (20080000), vol. 2, pages 158 - 163
    - KOVATCHEV BP et al., "Personalized subcutaneous model-predictive closed-loop control of T1DM: Pilot studies in the USA and Italy", Proc 69th ADA Scientific Session, page 228
    - KOVATCHEV BPANDERSON SMHEINEMANN LCLARKE WL, "Comparison of the numerical and clinical accuracy of four continuous glucose monitors", Diabetes Care, (20080000), vol. 31, doi:10.2337/dc07-2401, pages 1160 - 1164, XP055624899

DOI:   http://dx.doi.org/10.2337/dc07-2401
    - KOVATCHEV BP, ANDERSON SM, OTTO E, "Field Glucose Variability Index is Related to Laboratory Measures of Insulin Sensitivity and Hypoglycemia Counterregulation", Diabetologia, (20050000), vol. 49, page A855
    - KOVATCHEV BPBRETON MDDALLA MAN CCOBELLI C, "In Silico Preclinical Trials: A Proof of Concept in Closed-Loop Control of Type 1 Diabetes", J Diabetes Sci Technol, (20090000), vol. 3, doi:10.1177/193229680900300106, pages 44 - 55, XP055078894

DOI:   http://dx.doi.org/10.1177/193229680900300106
    - KOVATCHEV BP, CLARKE WL, BRETON M, BRAYMAN K, MCCALL A, "Methods and Clinical Application", Diabetes Tech Ther, (20050000), vol. 7, doi:10.1089/dia.2005.7.849, pages 849 - 862, XP055135886

DOI:   http://dx.doi.org/10.1089/dia.2005.7.849
    - KOVATCHEV BPCOX DJFARHY LSSTRAUME MGONDER-FREDERICK LACLARKE, WL, "Episodes of Severe Hypoglycemia in Type 1 Diabetes are Preceded, and Followed, within 48 Hours by Measurable Disturbances in Blood Glucose", J of Clinical, (20000000), vol. 85, doi:10.1210/jc.85.11.4287, pages 4287 - 4292, XP002256624

DOI:   http://dx.doi.org/10.1210/jc.85.11.4287
    - KOVATCHEV BPCOX DJGONDER-FREDERICK LAWL CLARKE, "Symmetrization of the blood glucose measurement scale and its applications", Diabetes Care, (19970000), vol. 20, doi:10.2337/diacare.20.11.1655, pages 1655 - 1658, XP008128145

DOI:   http://dx.doi.org/10.2337/diacare.20.11.1655
    - KOVATCHEV BP, COX DJ, GONDER-FREDERICK LA YOUNG-HYMAN D, SCHLUNDT D, CLARKE WL, "of the Low Blood Glucose Index", Diabetes Care, (19980000), vol. 21, pages 1870 - 1875
    - KOVATCHEV BPCOX DJKUMAR AGONDER-FREDERICK LAWL CLARKE, "Algorithmic Evaluation of Metabolic Control and Risk of Severe Hypoglycemia in Type 1 and Type 2 Diabetes Using Self-Monitoring Blood Glucose (SMBG) Data", Diabetes Technol Ther, (20030000), vol. 2, pages 817 - 828
    - "Association of Self-monitoring Blood Glucose Profiles with Glycosylated Hemoglobin", KOVATCHEV BPCOX DJSTRAUME MFARHY LS, Methods in Enzymology, vol. 321: Numerical Computer Methods, Academic Press, (20000000), vol. 321, pages 410 - 417
    - KOVATCHEV BPGONDER-FREDERICK LACOX DJCLARKE WL, "Evaluating the accuracy of continuous glucose monitoring sensors: Continuous Glucose Error-Grid Analysis (CG-EGA) illustrated by Therasense Freestyle NavigatorTM data", Diabetes Care, (20040000), vol. 27, pages 1922 - 1928
    - KOVATCHEV BPHOVORKA RWEINZIMER S, "JDRF Artificial Pancreas Consortium. Outcome measures: Judging the effectiveness of closed-loop control", JDRF AP
    - KOVATCHEV BP, OTTO E, COX DJ, GONDER-FREDERICK LA, CLARKE WL, "Evaluation of a New Measure of Blood Glucose Variability in Diabetes", Diabetes Care, (20060000), vol. 29, doi:10.2337/dc06-1085, pages 2433 - 2438, XP008128830

DOI:   http://dx.doi.org/10.2337/dc06-1085
    - KOVATCHEV BPSTRAUME MCOX DJFARHY LS, "Risk analysis of blood glucose data: A quantitative approach to optimizing the control of insulin dependent diabetes", J of, (20010000), vol. 3, pages 1 - 10, XP009136223
    - MAGNI LRAIMONDO FBOSSI LDALLA MAN CDE NICOLAO GKOVATCHEV BPCOBELLI C, "Model Predictive Control of Type 1 Diabetes: An In Silico Trial", J Diabetes Sci Technol, (20070000), vol. 1, doi:10.1177/193229680700100603, pages 804 - 812, XP055166918

DOI:   http://dx.doi.org/10.1177/193229680700100603
    - MAGNI LRAIMONDO FDALLA MAN CBRETON MDPATEK SDE NICOLAO GCOBELLI CKOVATCHEV BP, "Evaluating the Efficacy of Closed-Loop Glucose Regulation via Control-Variability Grid Analysis", J Diabetes Sci Technol, (20080000), vol. 2, pages 630 - 635, XP055166405
    - MCCALL ACOX DJCREAN JGLOSTER MKOVATCHEV BP, "A Novel Analytical Method for Assessing Glucose Variability: Using CGMS in Type 1 Diabetes Mellitus", Diabetes Technology and Therapeutics, (20060000), vol. 8, pages 644 - 653, XP008128838
    - NUCCI G., COBELLI C., "Models of subcutaneous insulin kinetics. A critical review", Comput Methods Programs Biomed., (20000000), vol. 62, doi:10.1016/S0169-2607(00)00071-7, pages 249 - 57, XP055570595

DOI:   http://dx.doi.org/10.1016/S0169-2607(00)00071-7
    - OWENS C, ZISSER H, JOVANOVIC L, SRINIVASAN B, BONVIN D, DOYLE FJ 3RD, "Run-to-run control of blood glucose concentrations for people with Type 1 diabetes mellitus", Trans Biomed Eng., (20060000), vol. 53, pages 996 - 1005
    - PALERM CC, ZISSER H, BEVIER WC, JOVANOVIC L, DOYLE FJ 3RD, "suitable performance metric", Diabetes Care, (20070000), vol. 30, pages 1131 - 1136
    - PARKER RSDOYLE FJ 3RDPEPPAS NA, "A model-based algorithm for blood glucose control in Type I diabetic patients", IEEE Trans Biomed Eng, (19990000), vol. 48, pages 148 - 157
    - PATEK SDBRETON MDCHEN YSOLOMON CKOVATCHEV BP, "LQG-Based Closed-Loop Control of Type 1 Diabetes", J Diabetes Sci Technol, (20070000), vol. 1, doi:10.1177/193229680700100606, pages 834 - 841, XP009172134

DOI:   http://dx.doi.org/10.1177/193229680700100606
    - PILLONETTO GCAUMO ASPARACINO GCOBELLI C, "A new dynamic index of insulin sensitivity", IEEE Transactions on Biomedical Engineering, (20060000), vol. 53, pages 369 - 79
    - SPARACINO GZANDERIGO FCORAZZA GMARAN AFACCHINETTI ACOBELLI C, "Glucose concentration can be predicted ahead in time from continuous glucose monitoring sensor time-series", IEEE Trans. Biomed Eng, (20070000), vol. 54, doi:10.1109/TBME.2006.889774, pages 931 - 937, XP011176961

DOI:   http://dx.doi.org/10.1109/TBME.2006.889774
    - STEIL GMREBRIN KDARWIN CHARIRI FSAAD MF, "Feasibility of automating insulin delivery for the treatment of type 1 diabetes", Diabetes, (20060000), vol. 55, doi:10.2337/db06-0419, pages 3344 - 3350, XP002476472

DOI:   http://dx.doi.org/10.2337/db06-0419
    - "The effect of intensive treatment of diabetes on the development and progression of long-term complications of insulin-dependent diabetes mellitus", N Engl JMed, (19930000), vol. 329, pages 978 - 986
    - "Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes", Lancet, (19980000), vol. 352, pages 837 - 853
    - WEINZIMER SASTEIL GMSWAN KLDZIURA JKURTZ NTAMBORLANE WV, "Fully automated closed-loop insulin delivery versus semi-automated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas", Diabetes Care, (20080000), vol. 31, doi:10.2337/dc07-1967, pages 934 - 939, XP007915338

DOI:   http://dx.doi.org/10.2337/dc07-1967
    - ZANDERIGO F, SPARACINO G, KOVATCHEV B, COBELLI C, "Grid Analysis", J Diabetes Sci Technol, (20070000), vol. 1, pages 645 - 651
    - ZISSER HJOVANOVIC LDOYLE FJ 3RDOSPINA POWENS C, "Run-to-Run Control of Meal-Related Insulin Dosing", Diab Technol Ther, (20050000), vol. 7, pages 48 - 57
 US20090516044
 US20060578831
 EP20060094947
 US19940105240
 EP20050214892
 US20080159891
 WO2000US22886
 WO2001US09884
 WO2003US25053
 WO2005US13792
 US20050305946
 WO2006US33724
 WO2007US00370
 US20070925689
 WO2007US82744
 US20070943226
 WO2007US85588
 WO2008US67725
 WO2008US67723
 WO2008US69416
 US20080065257
 WO2008US82063
 WO2009US65725
 WO2010US25405
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