Extract from the Register of European Patents

EP About this file: EP4562011

EP4562011 - IMMUNOMODULATOR PURINE-DERIVED COMPOUNDS, CONJUGATES THEREOF, AND METHODS OF USE THEREOF [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  14.05.2025
Database last updated on 21.03.2026
FormerThe international publication has been made
Status updated on  02.02.2024
Most recent event   Tooltip03.10.2025Change: Validation statespublished on 05.11.2025  [2025/45]
03.10.2025Change - extension statespublished on 05.11.2025  [2025/45]
Applicant(s)For all designated states
Zymeworks BC Inc.
Suite 800 - 114 East 4th Avenue
Vancouver, BC V5T 1G4 / CA
[2025/23]
Inventor(s)01 / GARNETT, Graham Albert Edwin
Vancouver, British Columbia V5T 1G4 / CA
02 / HIRKALA-SCHAEFER, Truman
Vancouver, British Columbia V5T 1G4 / CA
03 / BRANT, Michael G.
Vancouver, British Columbia V5T 1G4 / CA
04 / COLOMBO, Raffaele
Vancouver, British Columbia V5T 1G4 / CA
05 / DUAN, Zhuang
Vancouver, British Columbia V5T 1G4 / CA
06 / BARNSCHER, Stuart Daniel
Vancouver, British Columbia V5T 1G4 / CA
 [2025/23]
Representative(s)Grund, Martin, et al
Grund Intellectual Property Group
Patentanwälte und Solicitor PartG mbB
Steinsdorfstraße 2
80538 München / DE
[2025/23]
Application number, filing date23844724.726.07.2023
[2025/23]
WO2023CA51006
Priority number, dateUS202263392329P26.07.2022         Original published format: US 202263392329 P
[2025/23]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2024020684
Date:01.02.2024
Language:EN
[2024/05]
Type: A1 Application with search report 
No.:EP4562011
Date:04.06.2025
Language:EN
The application published by WIPO in one of the EPO official languages on 01.02.2024 takes the place of the publication of the European patent application.
[2025/23]
Search report(s)International search report - published on:CA01.02.2024
ClassificationIPC:C07D473/18, A61K31/52, A61K31/522, A61K47/50, A61K47/60, A61K47/65, A61K47/68, A61P35/00, C07D473/16, C07K5/00, C07K16/18, C07K16/30
[2025/23]
CPC:
C07D473/16 (EP,IL,KR); C07D473/18 (EP,IL,KR); A61K47/6879 (KR,US);
A61K31/52 (KR); A61K47/65 (KR); A61K47/6803 (EP,IL,US);
A61K47/6807 (KR); A61K47/6851 (EP,IL,KR); A61K47/6889 (US);
A61P35/00 (EP,IL,KR,US); C07D487/04 (US); C07D519/00 (EP,IL,US);
C07K16/32 (EP,IL); C07K5/06034 (EP,IL); C07K5/0806 (EP,IL) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   ME,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2025/23]
TitleGerman:IMMUNMODULATORISCHE VERBINDUNGEN AUS PURIN, KONJUGATE DAVON UND VERFAHREN ZUR VERWENDUNG DAVON[2025/23]
English:IMMUNOMODULATOR PURINE-DERIVED COMPOUNDS, CONJUGATES THEREOF, AND METHODS OF USE THEREOF[2025/23]
French:COMPOSÉS DÉRIVÉS DE PURINE IMMUNOMODULATEURS, LEURS CONJUGUÉS ET LEURS PROCÉDÉS D'UTILISATION[2025/23]
Entry into regional phase25.02.2025National basic fee paid 
25.02.2025Search fee paid 
25.02.2025Designation fee(s) paid 
25.02.2025Examination fee paid 
Examination procedure25.02.2025Examination requested  [2025/23]
26.08.2025Amendment by applicant (claims and/or description)
Fees paidRenewal fee
28.07.2025Renewal fee patent year 03
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Cited inInternational search[X] US2009105212  (ISOBE YOSHIAKI et al.) [X] 1-60 * (entire document, abstract; examples 16, 17 and 23; para. [0217]; other examples; and claims) *
 [X] CA2680397  (ASTRAZENECA AB et al.) [X] 1-60 * (entire document, abstract; example 48; paragraph[0067f; also examples 3, 9, 11, 12, 24, 32, 40-46, 48, 56-62, 70, 77, 86-3, 86-7, 87-2, 94, 95, 102 and 105; and claims) *
 [X] WO2022040596  (AMBRX INC et al.) [X] 1-60 * (entire document, compounds 129, 130, 134; examples; claims) *
 [X] WO2020168017  (AMBRX INC et al.) [X] 1-60 * (entire document, compounds 119, 120, 127, 129-130; examples; claims) *
 [X] WO2017056494  (SUMITOMO DAINIPPON PHARMA CO LTD et al.) [X] 1-60 * (entire document, examples 1, 2, 3, 4 and 5 [Chem. 35, 40, 43, 50 and 54]; claims) *
 [A] WO2017072662  (NOVARTIS AG et al.) [A] 1-60 * - cited in the application - (entire document) *
 [X]   NAKAMURA, T. ET AL.: "Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll- like receptor 7 agonists with high water solubility", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 3, 2013, pages 669 - 672, XP028962582, DOI: 10.1016/j.bmcl.2012.11.114 [X] 1, 7, 8, 11-12, 15, 34-38 * (entire document, incl. Table 2, compound 29) *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2012.11.114
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