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Extract from the Register of European Patents

EP About this file: EP0042064

EP0042064 - Modulators of the immune system [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  15.07.1988
Database last updated on 09.04.2026
Most recent event   Tooltip15.07.1988No opposition filed within time limitpublished on 31.08.1988 [1988/35]
Applicant(s)For all designated states
Gottlieb, Arthur A.
5915 Pitt Street New Orleans
Louisiana 70115 / US
[N/P]
Former [1981/51]For all designated states
Gottlieb, Arthur A.
5915 Pitt Street
New Orleans Louisiana 70115 / US
Inventor(s)01 / see applicant
...
[1981/51]
Representative(s)Popp, Eugen, et al
Meissner Bolte Patentanwälte
Rechtsanwälte Partnerschaft mbB
Widenmayerstrasse 47
80538 München / DE
[N/P]
Former [1987/13]Popp, Eugen, Dr., et al
MEISSNER, BOLTE & PARTNER Widenmayerstrasse 48
D-80538 München / DE
Former [1985/13]Popp, Eugen, Dr.
MEISSNER, BOLTE & PARTNER Postfach 86 06 24
D-81633 München / DE
Former [1984/31]Popp, Eugen, Dr.
MEISSNER, BOLTE & PARTNER Widenmayerstrasse 48
D-80538 München / DE
Former [1983/52]Popp, Eugen, Dr.
Patentanwälte Popp, Sajda, v. Bülow, Hrabal & Partner Widenmayerstrasse 48 Postfach 86 06 24
D-8000 München 86 / DE
Former [1981/51]DELETED Beil, Walter (deceased 22.07.83)
BEIL, WOLFF & BEIL Rechtsanwälte Adelonstrasse 58
D-6230 Frankfurt am Main 80 / DE
Application number, filing date81103702.714.05.1981
[1981/51]
Priority number, dateUS1980014973714.05.1980         Original published format: US 149737
US1981025688606.05.1981         Original published format: US 256886
[1981/51]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP0042064
Date:23.12.1981
Language:EN
[1981/51]
Type: A3 Search report 
No.:EP0042064
Date:19.01.1983
Language:EN
[1983/03]
Type: B1 Patent specification 
No.:EP0042064
Date:16.09.1987
Language:EN
[1987/38]
Search report(s)(Supplementary) European search report - dispatched on:EP18.11.1982
ClassificationIPC:A61K39/00, A61K49/00, A61K35/14
[1981/51]
CPC:
A61K45/05 (EP); A61K35/15 (EP,US); A61P37/00 (EP);
B01D15/325 (EP); B01D15/34 (EP); B01D15/3847 (EP);
B01D15/426 (EP) (-)
C-Set:
B01D15/34, B01D15/325 (EP)
Designated contracting statesAT,   BE,   CH,   DE,   FR,   GB,   IT,   LI,   LU,   NL,   SE [1981/51]
TitleGerman:Immunsystemmodulatoren[1981/51]
English:Modulators of the immune system[1981/51]
French:Modulateurs du système immun[1981/51]
Examination procedure27.06.1983Examination requested  [1983/36]
24.08.1984Despatch of a communication from the examining division (Time limit: M08)
03.04.1985Reply to a communication from the examining division
28.06.1985Despatch of a communication from the examining division (Time limit: M04)
14.10.1985Reply to a communication from the examining division
04.12.1985Despatch of a communication from the examining division (Time limit: M06)
24.04.1986Reply to a communication from the examining division
26.09.1986Despatch of communication of intention to grant (Approval: )
16.02.1987Communication of intention to grant the patent
19.02.1987Fee for grant paid
19.02.1987Fee for publishing/printing paid
Opposition(s)17.06.1988No opposition filed within time limit [1988/35]
Fees paidRenewal fee
05.05.1983Renewal fee patent year 03
18.04.1984Renewal fee patent year 04
17.05.1985Renewal fee patent year 05
20.05.1986Renewal fee patent year 06
26.05.1987Renewal fee patent year 07
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]   JOURNAL OF CLINICAL HEMATOLOGY AND ONCOLOGY, vol. 8, no. 4, 1978 G. PADDOCK et al.: "Purification and structural analyses of the transfer factor (TF)-like activity detected in vitro by leukocyte migration inhibition LMI" page 122 [X]
 [X]   THE JOURNAL IMMUNOLOGY, vol. 122, no. 3, March 1979 (US) D.R. BURGER et al. "Human transfer factor: structural properties suggested by HPRP chromatography and enzymatic sensitivities" pages 1091-1098 [X]
 [X]   CHEMICAL ABSTRACTS, vol. 92, no. 23, 9th June 1980 abstract no. 196150r, page 499 COLUMBUS, OHIO (US) & ANN. N.Y. ACAD. SCI. 1979, 332, 236-40 D.R. BURGER et al.: "A structural model for human transfer factor" [X]
 [Y]   SCANDINAVIAN JOURNAL OF IMMUNOLOGY vol. 2, no. 4, 1973 K. KROHN et al.: "Fractions of human leukocyte dialysates and their transfer factor activity" page 450 [Y]
 [Y]   FEDERATION PROCEEDINGS, vol. 35, no. 3, 1976 A.A. GOTTLIEB et al.: "Biochemical analysis of "transfer factor" page 337 [Y]
 [Y]   FEDERATION PROCEEDINGS , vol. 35, no. 3, 1976 L.A. ANDRON et al. "Transfer factor in vitro: chromatography of components that enhance antigen induced lymphocyte transformation" page 337 [Y]
 [Y]   JOURNAL OF CLINICAL INVESTIGATION, vol. 53, no. 6, 1974 J. NEIDHART et al.: "Preparative chromatographic technique for the active component of transfer factor" pages 55a and 56a [Y]
 [Y]   BIOLOGICAL ABSTRACTS, vol. 61, no. 10, 1976 abstract no. 55347, page 5738 PHILA. PA. (US) & Z. IMMUNITAETSFORSCH. EXP. KLIN. IMMUNOL. 149(5): 365-371 J. SCHROEDER et al.: "The preparation and characterization of transfer factor" [Y]
 [Y]   BIOLOGICAL ABSTRACTS, vol. 61, no. 3, 1976 abstract no. 14396, page 1494 PHILA. PA. (US) & VOX. SANG 29(5): 338-351 J.F. REYMOND et al.: "Transfer factor preparations: some physicochemical and biological properties" [Y]
 [Y]   BIOLOGICAL ABSTRACTS, vol. 64, 1st November 1977 abstract no. 50550, page 4957 PHILA. PA. (US) & J. IMMUNOL. METHODS 16(2): 119-129, 1977 J.W.M. LAWTON et al.: "Human transfer factor prepared by dialysis, ultrafiltration and gel chromatography: Biological activity in local transfer of skin sensitivity" [Y]
 [Y]   BIOLOGICAL ABSTRACTS, vol. 67, no. 3, 1979 abstract no. 15703, page 1542 PHILA. PA. (US) & MED. BIOL. (HELSINKI) 54(5): 334-340, 1976 K. KROHN et al.: "Fractionation studies on human leucocyte dialyzates: Demonstration of three components with transfer factor activity" [Y]
 [Y]   CHEMICAL ABSTRACTS, vol. 80, no. 21, 27th May 1974 abstract no. 119055p, page 293 COLUMBUS, OHIO (US) & INT. ARCH. ALLERGY APPL. IMMUNOL. 1974, 46(4), 612-18 M. ARALA-CHAVES et al.: "Transfer factor in vitro. Additional data concerning a new method" [Y]
 [Y]   CHEMICAL ABSTRACTS, vol. 85, no. 5, 2nd August 1976 abstract no. 31473r, page 279 COLUMBUS, OHIO (US) & CELL. IMMUNOL. 1976, 23(2), 191-202 M.S. O'DORISIO et al.: "Identification of hypoxanthine as the major component of a chromatographic fraction of transfer factor" [Y]
 [Y]   CHEMICAL ABSTRACTS, vol. 85, no. 9, 30th August 1976 abstract no. 92022q, page 453 COLUMBUS, OHIO (US) & J. ALLERGY CLIN. IMMUNOL. 1976, 58(1, Pt. 2), 190-7 R.H. TOMAR et al.: "Transfer factor Hypoxanthine with in vivo activity" [Y]
 [Y]   CHEMICAL ABSTRACTS, vol. 91, no. 11, 10th September 1979 abstract no. 89355u, page 593 COLUMBUS, OHIO (US) & CLIN. IMMUNOL. IMMUNOPATHOL. 1979, 13(3), 287-95 C.C. WHITACRE et al.: "Guinea pig transfer factor: restriction of macrophage migration inhibitory activity to extraordinary dilution confirmed with demonstration of diminished potency of stored preparations" [Y]
 [Y]   CHEMICAL ABSTRACTS, vol. 81, no. 19, 11th November 1974 abstract no. 118427v, page 367 COLUMBUS, OHIO (US) & PROC. NAT. ACAD. SCI. U.S.A. 1974, 71(6), 2473-7 S. ROSENFELD et al.: "Transfer factor. Subcellular component that transmits information for specific immune responses" [Y]
 [Y]   CHEMICAL ABSTRACTS, vol. 87, no. 9, 29th August 1977 abstract no. 66487s, page 392 COLUMBUS, OHIO (US) & CELL. IMMUNOL. 1977, 31(2), 311-20 K. SAITO et al.: "Inhibition of DNA synthesis in lymphocytes by dialyzable components of human leukocyte extracts" [Y]
 [YD]   CHEMICAL ABSTRACTS, vol. 87, no. 13, 26th September 1977 abstract no. 100421c, page 468 COLUMBUS, OHIO (US) & J. RETICULOENDOTHEL. SOC. 1977, 21(6), 401-14 A.A. GOTTLIEB et al.: "Biochemical analysis of dialyzable leukocyte extracts" [YD]
 [Y]   CHEMICAL ABSTRACTS, vol. 91, no. 7, 13th August 1979 abstract no. 54336m, page 492 COLUMBUS, OHIO (US) & J. LAB. CLIN. MED. 1979, 93(5), 819-37 G.B. WILSON et al.: "Effects of dialyzable leukocyte extracts with transfer factor activity on leukocyte migration in vitro. II. Separation and partial characterization of the components in DLE producing antigen-independent effects" [Y]
 [Y]   CHEMICAL ABSTRACTS, vol. 87, no. 23, 5th December 1977 abstract no. 182419v, page 448 COLUMBUS, OHIO (US) & SHENG WU HUA HSUEH YU SHENG WU WU LI HSUEH PAO 1976, 8(4), 283-92 SANGHAI SECOND MEDICAL COLLEGE: "Preparation and some properties of the human transfer factor" [Y]
 [Y]   CHEMICAL ABSTRACTS, vol. 88, no. 15, 10th April 1978 abstract no. 103120k, page 389 COLUMBUS, OHIO (US) & SHENG WU HUA HSUEH YU SHENG WU WU LI HSUEH PAO 1977, 9(1), 53-62 SANGHAI SECOND MEDICAL COLLEGE et al.: "A method for the simultaneous extraction of transfer factor and "immune" RNA from human leukocytes. I. Transfer factor" [Y]
 [Y]   CHEMICAL ABSTRACTS, vol. 88, no. 25, 19th June 1978 abstract no. 187896d, page 3 COLUMBUS, OHIO (US) & DISS. ABSTR. INT. B 1978, 38(9), 4153 R.P. MISCHAK: "Potentiation of delayed type hypersensitivity by leukocyte extracts" [Y]
 [Y]   CHEMICAL ABSTRACTS, vol. 91, no. 15, 8th October 1979 abstract no. 122024k, page 467 COLUMBUS, OHIO (US) & CLIN. EXP. IMMUNOL. 1979, 37(1), 50-7 R.G.I. ASHORN et al.: "Human transfer factor in vitro. II. Augmentation of the secretion of leukocyte migration inhibitory factor (LIF) by leukocyte dialysate and by its components L-serine and glycine" [Y]
 [Y]   CHEMICAL ABSTRACTS, vol. 91, no. 5, 30th July 1979 abstract no. 37394m, page 471 COLUMBUS, OHIO (US) & CELL. IMMUNOL. 1979, 45(1), 133-41 A. TOGAWA et al.: "Ability of dialysates containing transfer factor to induce lymphocyte activating factor by human mononuclear cells" [Y]
 [YP]   CHEMICAL ABSTRACTS, vol. 94, no. 19, 11th May 1981 abstract no. 154692e, page 473 COLUMBUS, OHIO (US) & THYMUS 1981, 2(4-5), 257-76 G.B. WILSON et al.: "Effects of dialyzable leukocyte extracts with transfer factor activity on leukocyte migration in vitro. V. Antingen specific lymphocyte responsiveness can be initiated by two structurally distinct polyribonucleopeptides" [YP]
 [YP]   CHEMICAL ABSTRACTS, vol. 93, no. 23, 8th December 1980 abstract no. 219228j, page 409 COLUMBUS, OHIO (US) & CELL. IMMUNOL. 1980, 55(2), 420-7 A. KHAN et al.: "Isolation and characterization of immunopeptide from dialyzable leukocyte extract" [YP]
 [A]   CHEMICAL ABSTRACTS, vol. 93, no. 25, 22nd December 1980 abstract no. 236622a, page 625 COLUMBUS, OHIO (US) & MATER. MED. POL. (ENGL. ED.) 1979, 11(4), 317-19 A. KOMOROWSKA-RYCERZ et al.: "Transfer factor (TFd). Part I. Some physicochemical data" [A]
 [A]   CHEMICAL ABSTRACTS, vol. 86, no. 21, 23rd May 1977 abstract no. 153824x, page 326 COLUMBUS, OHIO (US) & CLIN. EXP. IMMUNOL. 1977, 27(3), 416-20 K. NEKAM et al.: "In vitro effect of transfer factor on active rosettes and leukocyte migration of patients with cancer" [A]
Examination  Journal of Immunology, vol. 124 (2), pages 885-892, 1980 [X]
   FEDERATION PROCEEDINGS, vol. 35, no. 3, 1976, L.A. ANDRON et al.: "Transfer factor in vitro: chromatography of components that enhance entigen induced lymphocyte transformation", page 337 [X]
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.