Extract from the Register of European Patents

EP About this file: EP0137542

EP0137542 - Use of Defibrotide in the treatment of states of acute renal insufficiency [Right-click to bookmark this link]
Former [1985/16]Pharmaceutical composition for the treatment of states of acute renal insufficiency
[1991/31]
StatusNo opposition filed within time limit
Status updated on  04.06.1992
Database last updated on 11.04.2026
Most recent event   Tooltip04.06.1992No opposition filed within time limitpublished on 22.07.1992 [1992/30]
Applicant(s)For all designated states
Crinos Industria Farmacobiologica S.p.A.
Piazza XX Settembre, n. 2 I-22079 Villa Guardia
Como / IT
[N/P]
Former [1985/16]For all designated states
Crinos Industria Farmacobiologica S.p.A.
Piazza XX Settembre, n. 2
I-22079 Villa Guardia Como / IT
Inventor(s)01 / Bonomini, Vittorio
Via Molinelli 45
I-40100 Bologna / IT
[1985/16]
Representative(s)Dragotti, Gianfranco
Dragotti & Associati srl
Via Paris Bordone 9
31100 Treviso / IT
[N/P]
Former [1985/16]Dragotti, Gianfranco
SAIC BREVETTI s.r.l. Galleria San Babila, 4/D
I-20122 Milano / IT
Application number, filing date84201286.607.09.1984
[1985/16]
Priority number, dateIT1983002285612.09.1983         Original published format: IT 2285683
[1985/16]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP0137542
Date:17.04.1985
Language:EN
[1985/16]
Type: A3 Search report 
No.:EP0137542
Date:02.09.1987
Language:EN
[1987/36]
Type: B1 Patent specification 
No.:EP0137542
Date:31.07.1991
Language:EN
[1991/31]
Search report(s)(Supplementary) European search report - dispatched on:EP16.07.1987
ClassificationIPC:A61K35/12, A61K31/70
[1985/16]
CPC:
A61K31/70 (EP,US); A61P13/02 (EP); A61P15/00 (EP);
A61P7/10 (EP); C07H21/00 (EP,US)
Designated contracting statesAT,   FR,   GB,   IT,   NL,   SE [1985/16]
TitleGerman:Verwendung von Defibrotid bei der Behandlung von Zuständen akuter Nierenschwäche[1991/31]
English:Use of Defibrotide in the treatment of states of acute renal insufficiency[1991/31]
French:Utilisation de Défibrotide dans le traitement d'états d'insuffisance rénale aigue[1991/31]
Former [1985/25]Pharmazeutische Zusammensetzung zur Behandlung von Zuständen akuter Nierenschwäche
Former [1985/16]Pharmaceutical composition for the treatment of states of acute renal insufficiency
Former [1985/25]Compostion pharmaceutique pour le traitement d'états d'insuffisance rénale aigue
Examination procedure23.02.1988Examination requested  [1988/18]
25.07.1988Despatch of a communication from the examining division (Time limit: M04)
02.12.1988Reply to a communication from the examining division
21.04.1989Despatch of a communication from the examining division (Time limit: M04)
07.08.1989Reply to a communication from the examining division
19.02.1990Despatch of a communication from the examining division (Time limit: M02)
24.04.1990Reply to a communication from the examining division
20.09.1990Despatch of communication of intention to grant (Approval: Yes)
28.01.1991Communication of intention to grant the patent
13.03.1991Fee for grant paid
13.03.1991Fee for publishing/printing paid
Opposition(s)05.05.1992No opposition filed within time limit [1992/30]
Fees paidRenewal fee
18.09.1986Renewal fee patent year 03
19.09.1987Renewal fee patent year 04
22.09.1988Renewal fee patent year 05
20.09.1989Renewal fee patent year 06
14.09.1990Renewal fee patent year 07
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Lapses during opposition  TooltipAT31.07.1991
[1992/15]
Documents cited:Search[A]   W. PSCHYREMBEL: "Klinisches Wrterbuch", 253rd edition, 1977, Walter de Gruyter, Berlin [A]
 [X]   PHARMACOLOGICAL RESEARCH COMMUNICATIONS, vol. 14, no. 10, November 1982, pages 949-957, The Italian Pharmacological Society; R. NIADA et al.: "PGI2-Generation and antithrombotic activity of orally administered defibrotide" [X]
 [XD]   THROMBOSIS RESEARCH, vol. 30, no. 1, 1st April 1983, pages 1-11, Pergamon Press Ltd, US; R. PESCADOR et al.: "Pharmacokinetics of defibrotide and of its profibrinolytic activity in the rabbit" [XD]
 [XD]   THROMBOSIS AND HAEMOSTASIS, vol. 42, 1979, page 474, abstract no. 1162; R. NIADA et al.: "Antithrombotic activity of polydeoxyribonucleotides of mammalian origin (laboratory code: fraction P) in experimental animals" [XD]
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