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Extract from the Register of European Patents

EP About this file: EP0204549

EP0204549 - Method of isolating antibiotic biosynthetic genes [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.11.1994
Database last updated on 26.06.2024
Most recent event   Tooltip13.06.1995Lapse of the patent in a contracting state
New state(s): CH, LI
published on 02.08.1995 [1995/31]
Applicant(s)For all designated states
ELI LILLY AND COMPANY
Lilly Corporate Center
Indianapolis, IN 46285 / US
[N/P]
Former [1986/50]For all designated states
ELI LILLY AND COMPANY
Lilly Corporate Center
Indianapolis, Indiana 46285 / US
Inventor(s)01 / Rao, Ramachandra Nagaraja
6818 Hoover Road
Indianapolis Indiana 46260 / US
02 / Baltz, Richard Henry
7446 Sunset Lane
Indianapolis Indiana 46260 / US
03 / Stanzak, Richard Kale
Route 2 Box 286-c
Poland Indiana 47868 / US
04 / Treadway, Patti Jean
2273 Horizon Boulevard
Greenwood Indiana 46142 / US
[1986/50]
Representative(s)Hudson, Christopher Mark, et al
Lilly Industries Limited European Patent Operations Erl Wood Manor Windlesham
Surrey GU20 6PH / GB
[N/P]
Former [1986/50]Hudson, Christopher Mark, et al
Lilly Industries Limited European Patent Operations Erl Wood Manor
Windlesham Surrey GU20 6PH / GB
Application number, filing date86304239.604.06.1986
[1986/50]
Priority number, dateUS1985074234907.06.1985         Original published format: US 742349
[1986/50]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP0204549
Date:10.12.1986
Language:EN
[1986/50]
Type: A3 Search report 
No.:EP0204549
Date:02.12.1987
Language:EN
[1987/49]
Type: B1 Patent specification 
No.:EP0204549
Date:26.01.1994
Language:EN
[1994/04]
Search report(s)(Supplementary) European search report - dispatched on:EP12.10.1987
ClassificationIPC:C12N15/52, C12P19/62, C12N15/76, C12R1/465
[1994/04]
CPC:
C12N15/76 (EP,US); C12N15/52 (EP,US)
Former IPC [1986/50]C12N15/00, C12P19/62, C12N1/20, // (C12N1/20, C12R1:465)
Designated contracting statesBE,   CH,   DE,   FR,   GB,   IT,   LI,   NL,   SE [1986/50]
TitleGerman:Verfahren zur Isolierung von Genen zur Biosynthese von Antibiotika[1986/50]
English:Method of isolating antibiotic biosynthetic genes[1986/50]
French:Procédé d'isolement des gènes de biosynthèse d'antibiotiques[1986/50]
Examination procedure09.06.1986Examination requested  [1986/50]
12.03.1990Despatch of a communication from the examining division (Time limit: M06)
11.09.1990Reply to a communication from the examining division
13.05.1991Despatch of a communication from the examining division (Time limit: M06)
14.11.1991Reply to a communication from the examining division
24.04.1992Despatch of a communication from the examining division (Time limit: M06)
28.10.1992Reply to a communication from the examining division
17.11.1992Despatch of a communication from the examining division (Time limit: M04)
25.03.1993Reply to a communication from the examining division
23.04.1993Despatch of communication of intention to grant (Approval: Yes)
22.07.1993Communication of intention to grant the patent
07.10.1993Fee for grant paid
07.10.1993Fee for publishing/printing paid
Opposition(s)27.10.1994No opposition filed within time limit [1995/03]
Fees paidRenewal fee
13.04.1988Renewal fee patent year 03
30.04.1989Renewal fee patent year 04
02.04.1990Renewal fee patent year 05
10.04.1991Renewal fee patent year 06
22.04.1992Renewal fee patent year 07
25.03.1993Renewal fee patent year 08
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipSE05.06.1994
BE30.06.1994
CH30.06.1994
LI30.06.1994
[1995/31]
Former [1995/29]SE05.06.1994
BE30.06.1994
Former [1995/27]BE30.06.1994
Documents cited:Search[XP]EP0173327  (MEIJI SEIKA KAISHA [JP]);
 [E]WO8703907  (LUBRIZOL GENETICS INC [US])
 [XP]  - BIOTECHNOLOGY, vol. 4, no. 3, March 1986, pages 229-232, New York, US; R. STANZAK et al.: "Cloning and expression in Streptomyces lividans of clustered erythromycin biosynthesis genes from streptomyces erythreus"
 [A]  - NATURE, vol. 309, no. 5967, May/June 1984, pages 462-464, London, GB; F. MALPARTIDA et al.: "Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host"
 [AP]  - GENE, vol. 38, no. 1/3, 1985, pages 215-26, Elsevier Science Publishers, Amsterdam, NL; M.J. BIBB et al.: "Cloning and analysis of the promoter region of the erythromycin resistance gene (ermE) of Streptomyces erythraeus"
 [A]  - BIOTECHNOLOGY, vol. 2, no. 1, January 1984, pages 63-72; J.F. MARTIN et al.: "Cloning and expression of antibiotic production genes"
 [AD]  - CHEMICAL ABSTRACTS, vol. 104, 1986, page 155, abstract no. 29785m, Columbus, Ohio, US; D.A. HOPWOOD et al.: "Cloning of antibiotic biosynthesis genes in Streptomyces", & GENET.: NEW FRONT., PROC. INT. CONGR., 15th 1983 (PUB. 1984). 2, 3-16
 [A]  - GENE, vol. 20, 1982, pages 51-62, Elsevier Biomedical Press, ; C.J. THOMPSON et al.: "Physical analysis of antibiotic-resistance genes from Streptomyces and their use in vector construction"
 [AD]  - CHEMICAL ABSTRACTS, vol. 105, 1986, page 169, abstract no. 184895m, Columbus, Ohio, US; D.A. HOPWOOD et al.: "Gene cloning to analyse the organization and expression of antibiotic biosynthesis genes in Streptomyces", & REGUL. SECOND. METAB. FORM., PROC. WORKSHOP CONF. HOECHST, 16TH 1985 (PUB. 1986), 23-33
 [A]  - TRENDS IN BIOTECHNOLOGY, vol. 1, no. 2, 1983, pages 42-48, Elsevier Science Publishers B.V., Amsterdam, NL; D.A. HOPWOOD et al.: "Cloning Streptomyces genes for antibiotic production"
Examination   - GENE, vol. 20, 1982, pages 51-62, Elsevier Biomedical Press, ; C.J. THOMPSON et al.: "Physical analysis of antibiotic-resistance genes from Streptomyces and their use in vector construction"
    - Mol. Gen. Genet 204 (1986) 532-539
    - Chater in: Microbiol Development, Cold Spring Harbor 1984, p.89-115
    - Hopwood and Chater in : Regulation of Secondary Metabolite formation, Proceedings of the Workshop May 12-16 (1985), 23-33
by applicantUS4340674
 US4343906
 US4362816
 US4416994
 US4477571
 EP0176321
    - ISRAELI-RECHES ET AL., MOL. GEN. GENET., (1984), vol. 194, page 362
    - JONES ET AL., J. BIOL. CHEM., (1984), vol. 259, page 14158
    - THOMPSON ET AL., NATURE, (1980), vol. 286, page 525
    - SENO; BALTZ, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (1981), vol. 20, no. 3, page 370
    - TUDZYNSKI; ESSER, CURRENT GENETICS, (1982), vol. 5, page 227
    - DENTE ET AL., NUCLEIC ACIDS RESEARCH, (1983), vol. 11, page 1645
    - BALTZ; MATSUSHIMA, J. GEN. MICROBIOL., (1981), vol. 127, page 137
    - BALTZ; MATSUSHIMA, J. GEN. MICROBIOLOGY, (1981), vol. 127, page 137
 US19840655178
 US19850742172
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.