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Extract from the Register of European Patents

EP About this file: EP0262344

EP0262344 - N-alkylated quaternary nitrogen-containing heterocycles, process for their preparation and their use in pharmaceutical compositions [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  31.01.1997
Database last updated on 28.05.2024
Most recent event   Tooltip23.11.2007Lapse of the patent in a contracting state
Updated state(s): FR		published on 26.12.2007  [2007/52]
Applicant(s)For all designated states
MEDICE Chem.-Pharm. Fabrik Pütter GmbH & Co. KG
Kuhloweg 37-39
58638 Iserlohn / DE
[N/P]
Former [1988/14]For all designated states
MEDICE Chem.-Pharm. Fabrik Pütter GmbH & Co. KG
Kuhloweg 37-39
D-58638 Iserlohn / DE
Inventor(s)01 / Paradies, Henrich Hasko, Prof.Dr.med.Dr.rer.nat.
Kuhloweg 38
D-5860 Iserlohn / DE
[1988/14]
Representative(s)Isarpatent
Patent- und Rechtsanwälte Barth
Charles Hassa Peckmann & Partner mbB
Postfach 44 01 51
80750 München / DE
[N/P]
Former [1988/14]Reinhard - Skuhra - Weise & Partner
Postfach 44 01 51
D-80750 München / DE
Application number, filing date87111387.406.08.1987
[1988/14]
Priority number, dateDE1986362670007.08.1986         Original published format: DE 3626700
[1988/14]
Filing languageDE
Procedural languageDE
PublicationType: A2 Application without search report 
No.:EP0262344
Date:06.04.1988
Language:DE
[1988/14]
Type: A3 Search report 
No.:EP0262344
Date:17.04.1991
Language:DE
[1991/16]
Type: B1 Patent specification 
No.:EP0262344
Date:27.03.1996
Language:DE
[1996/13]
Search report(s)(Supplementary) European search report - dispatched on:EP01.03.1991
ClassificationIPC:A61K47/00, A61K9/10, C07D213/00, C07D239/00, C07D241/00, C07D473/00, C07D209/00, C07D231/00, C07D233/00, C07D235/00
[1989/06]
CPC:
C07D213/20 (EP,US); A61K47/186 (EP,US); A61K9/0014 (EP,US);
A61K9/1075 (EP,US); A61P17/00 (EP); A61P17/16 (EP);
A61P31/04 (EP); A61P31/12 (EP); A61P35/00 (EP);
A61P43/00 (EP); C07D213/30 (EP,US); C07D213/63 (EP,US);
C07D213/65 (EP,US); C07D213/68 (EP,US); C07D213/69 (EP,US);
C07D213/73 (EP,US); C07D213/80 (EP,US); C07D213/81 (EP,US);
C07D213/82 (EP,US); C07D231/12 (EP,US); C07D233/56 (EP,US);
C07D235/06 (EP,US); C07D239/26 (EP,US); C07D239/30 (EP,US);
C07D239/36 (EP,US); C07D239/47 (EP,US); C07D239/54 (EP,US);
C07D239/553 (EP,US); C07D241/24 (EP,US); C07D249/08 (EP,US);
C07D277/22 (EP,US); C07D277/62 (EP,US); C07D473/00 (EP,US);
C07D473/04 (EP,US); C07D473/06 (EP,US); C07D473/16 (EP,US);
C07D473/34 (EP,US); C07D473/40 (EP,US); C07D487/04 (EP,US) (-)
Former IPC [1988/14]A61K9/10, A61K9/10, C07D213/00, C07D239/00, C07D241/00, C07D473/00, C07D209/00, C07D231/00, C07D233/00, C07D235/00
Designated contracting statesBE,   CH,   DE,   FR,   GB,   IT,   LI,   LU,   NL,   SE [1996/02]
Former [1988/14]AT,  BE,  CH,  DE,  ES,  FR,  GB,  GR,  IT,  LI,  LU,  NL,  SE 
TitleGerman:N-alkylierte quartäre stickstoffhaltige Heterozyklen, Verfahren zu deren Herstellung und deren Verwendung in Arzneimitteln[1988/14]
English:N-alkylated quaternary nitrogen-containing heterocycles, process for their preparation and their use in pharmaceutical compositions[1988/14]
French:Hétérocycles azotés N-alkylés quaternaires, procédé pour leur préparation et leur utilisation en compositions pharmaceutiques[1988/14]
Examination procedure22.08.1991Examination requested  [1991/42]
27.07.1992Despatch of a communication from the examining division (Time limit: M06)
05.02.1993Reply to a communication from the examining division
05.03.1993Despatch of a communication from the examining division (Time limit: M06)
18.08.1993Reply to a communication from the examining division
19.10.1993Despatch of a communication from the examining division (Time limit: M03)
05.01.1994Reply to a communication from the examining division
04.03.1994Despatch of a communication from the examining division (Time limit: M04)
29.06.1994Reply to a communication from the examining division
28.04.1995Despatch of communication of intention to grant (Approval: Yes)
31.08.1995Communication of intention to grant the patent
16.11.1995Fee for grant paid
16.11.1995Fee for publishing/printing paid
Opposition(s)28.12.1996No opposition filed within time limit [1997/12]
Fees paidRenewal fee
07.08.1989Renewal fee patent year 03
13.08.1990Renewal fee patent year 04
24.05.1991Renewal fee patent year 05
10.08.1992Renewal fee patent year 06
16.08.1993Renewal fee patent year 07
16.08.1994Renewal fee patent year 08
24.08.1995Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipBE27.03.1996
FR27.03.1996
GB27.03.1996
IT27.03.1996
NL27.03.1996
SE27.06.1996
CH31.08.1996
LI31.08.1996
LU31.08.1996
[2006/14]
Former [2003/07]BE27.03.1996
GB27.03.1996
IT27.03.1996
NL27.03.1996
SE27.06.1996
FR23.08.1996
CH31.08.1996
LI31.08.1996
LU31.08.1996
Former [2000/06]BE27.03.1996
GB27.03.1996
IT27.03.1996
SE27.06.1996
FR23.08.1996
CH31.08.1996
LI31.08.1996
LU31.08.1996
Former [1999/42]BE27.03.1996
GB27.03.1996
IT27.03.1996
SE27.06.1996
FR23.08.1996
CH31.08.1996
LI31.08.1996
Former [1998/04]BE27.03.1996
GB27.03.1996
SE27.06.1996
FR23.08.1996
CH31.08.1996
LI31.08.1996
Former [1997/14]BE27.03.1996
GB27.03.1996
SE27.06.1996
FR23.08.1996
Former [1997/12]BE27.03.1996
SE27.06.1996
FR23.08.1996
Former [1996/52]BE27.03.1996
SE27.06.1996
Former [1996/44]SE27.06.1996
Documents cited:Search[A]DE820949  (LUNDBECK & CO AS H);
 [X]US2643967  (JULIUS PFANNMULLER);
 [A]GB870415  (ICI LTD);
 [X]US3235358  (SOBOCZENSKI EDWARD J);
 [A]FR1544777  ;
 [A]US3635977  (LUTZ ALBERT WILLIAM);
 [A]DE2401619  (ROBUGEN GMBH);
 [A]DE2814202  (TAIHO PHARMACEUTICAL CO LTD)
 [X]  - Journal of Pharmaceutical Sciences, Band 71, Nr. 12, Dezember 1982, Seiten 1313-1318; Am. Pharm. Ass., Washington, US, A. TSUJI et al.: "Effects of surfactants on the aqueous stability and solubility of beta-lactam antibiotics", Seite 1313, Zusammenfassung; Seite 1315, rechte Spalte, Tabelle 1; Seiten 1316-1318, "Discussion".
 [AD]  - Accounts of Chemical Research, Band 12, Nr. 4, April 1979, Seiten 111-118; Am. Chem. Soc., Washington, US, F.M. MENGER: "On the structure of micelles", Insgesamt.
 [A]  - Journal of the American Chemical Society, Band 108, Nr. 11, Mai 1986, Seiten 2980-2984; Am. Chem. Soc., Washington, US, F.M. MENGER et al.: "A microscopic hydrophobicity parameter", Seite 2980, Zusammenfassung; Seite 2981, Tabelle 1.
 [X]  - Proceedings Int. Congres on Surface Active Substances, 7th, Band 2, 1976, Seiten 1048-1057; Natsional'nyi Komitet SSSR po Poverkhnosto-Aktivnym Veshestvam, Moscow, SU, M. MARINESCU et al.: "An H NMR study of some ionic surfactants micellization", Seiten 1048, 1049, Zusammenfassung.
 [X]  - CHEMICAL ABSTRACTS, Band 74, Nr. 18, 3. Mai 1971, Seite 256, Ref. Nr. 91574g; Columbus, Ohio, US, C. BEJAN et al.: "Adsorption of capillary-active substances on ion-exchange resins", & Rev. Chim. /Bucharest) 1970, 21 (7), 397-9, Zusammenfassung.
 [X]  - CHEMICAL ABSTRACTS, Band 95, Nr. 7, 17. August 1971, Seite 260, Ref. Nr. 57049p; Columbus, Ohio, US, S. NICULESCU et al.: "The effect of surfactants upon horseradish peroxidase", & Rev. Roum. Biochim. 1980, 17(1), 51-6, Zusammenfassung.
 [A]  - Journal of the American Chemical Society, Band 77, Nr. 22, 20. November 1955, Seiten 5867-5872; Am. Chem. Soc., Washington, US, C.W. WHITEHEAD et al.: "Synthesis of Cytosines", Seiten 5867, 5868; Seite 5872, rechte Spalte.
 [A]  - Chemische Berichte, Band 99, Nr. 7, Juli 1966, Seiten 2380-2390; Verlag Chemie GmbH, Weinheim, DE, E. WITTENBURG: "Alkyl- und Silyl-Derivate des Thymins", Seiten 2382-2384, "Alkyl-Derivate".
 [A]  - Journal of Organic Chemistry, Band 31, Nr. 12, Dezember 1966, Seiten 3969-3973; Am. Chem. Soc., Easton, US, G.C. HOPKINS et al.: "Alkylations of heterocylic ambident anions. I. 2-Hydroxypyrimidines", Insgesamt.
 [A]  - Journal of Organic Chemistry, Band 35, Nr. 8, August 1970, Seiten 2512-2516; Am. Chem. Soc., Easton, US, J.P. JONAK et al.: "Alkylations of heterocyclic ambident anions. III. 4-Hydroxypyrimidines", Insgesamt.
 [A]  - Journal of Heterocyclic Chemistry, Band 18, Maerz 1981, Seiten 339-342, Hetero Corporation, Provo, US; M. HEDAYATULLAH: "Alkylation des pyrimidines en catalyse par transfert de phase", Insgesamt.
 [A]  - Chemische Berichte, Band 96, 1963, Seiten 534-549, Verlag Chemie GmbH, Weinheim, DE; J. GOERDELER et al.: "Ueber die Alkylierung einiger Aminoheterocyclen und die Umlagerung heterocyclischer Imine in Amine", Seite 537, Absaetze 2,3; Seite 540, letzter Absatz; Seite 542, Absaetze 5,6,; Seite 543, Tabelle.
 [A]  - Journal of the Chemical Society, 1951, Seiten 1565-1570, Chemical Society, Letchworth, GB; N. WHITTAKER: "A new synthesis and the chemical properties of 5-aminopyrimidine", Seite 1566, Zeilen 6-25; Seite 1569, Absaetze 38.
 [A]  - Collection of Czechoslovak Chemical Communications, Band 40, 1975, Seiten 1390-1395, Academica, Prag, CS; V. KRCHNAK et al.: "Diazotisation of the amino group on the pyrimidine nucleus", Seite 1391, Formeln; Seite 1393, Absatz 3 - Seite 1394, Absatz 2; Seite 1395, Absatz 3.
 [A]  - Angewandte Chemie, Band 70, Nr. 17/18, 23. September 1958, Seiten 519, 520, Verlag Chemie GmbH, Weinheim, DE; H. BREDERECK et al.: "Reaktionen des pyrimidins", Insgesamt.
 [A]  - Journal of the Chemical Society, Perkin Transactions 1, 1981, Seiten 489-491, Chemical Society, Letchworth, GB; C. KASHIMA et al.: "Reaction of pyrimidin-2(1H)-ones and -thiones with organometallic compounds. Regioselective preparation of dihydropyrimidin-2(1H)-ones and -thiones", Insgesamt.
 [A]  - Angewandte Chemie, Band 77, Nr. 13, 7. Juli 1965, Seiten 557-571, Verlag Chemie, Weinheim, DE; TH. KAUFFMANN: "Die Hetarine", Insgesamt.
 [A]  - Chemical and Pharmaceutical Bulletin, Band 26, Nr. 7, 1978, Seiten 2160-2166, Pharmaceutical Society of Japan, Tokyo, JP; H. YAMANAKA et al.: "Studies on pyrimidine derivatives. VII. Nickel-phosphine complex-catalyzed grignard coupling of chloropyrimidines", Seiten 2160-2161.
 [A]  - Tetrahedron Letters, Nr. 39, 1969, Seiten 3361-3363, Pergamon Press, Oxford, GB; Y. KANAOKA et al.: "Alkylation of nucleosides in aqueous solution", Insgesamt.
 [A]  - Synthesis, Nr. 12, Dezember 1976, Seiten 824-825, Georg Thieme Verlag, Stuttgart, DE; D.G. McMINN: "Ethylation of hydroxypyrimidines using trethyloxonium tetrafluoroborate (Meerwein's Reagent)", Insgesamt.
 [A]  - Journal of Organic Chemistry, Band 37, Nr. 14, 1972, Seiten 2259-2266, American Chemical Society, Easton, US; T.J. CURPHEY et al.: "Diquaternary salts. I. Preparation and characterization of the diquaternary salts of some diazines and diazoles", Seiten 2260-2261, Abschnitt, "Preparation of diquats", Seite 2264, linke Spalte, Vorschriften 4,5.
 [A]  - Analytica Chimica Acta, Band 169, Maerz 1985, Seiten 1-29, Elseviers Science Publishers, Amsterdam, NL; E. PELIZZETTI et al.: "Analytical applications of organized molecular assemblies", Insgesamt.
Examination   - ACCOUNTS OF CHEMICAL RESEARCH, Band 12, Nr. 4, April 1979, Seiten 111-118; Am.Chem. Soc., Washington, US. F.M.MENGER:
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.