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EP About this file: EP0324007

EP0324007 - A PHARMACEUTICAL COMPOSITION CONTAINING S(+) IBUPROFEN SUBSTANTIALLY FREE OF ITS R(-) ANTIPODE [Right-click to bookmark this link]
Status	Patent revoked Status updated on 22.10.1999 Database last updated on 03.04.2025
Most recent event Tooltip	17.04.2015	Change - lapse in a contracting state State(s) deleted from list of lapses: CH, LI	published on 20.05.2015 [2015/21]
Applicant(s)	For all designated states STERLING WINTHROP INC. 90 Park Avenue New York, NY 10016 / US
	[1994/25]
Former [1989/39]	For all designated states Analgesic Associates 34 Dante Street Larchmont, New York 10538 / US
Former [1989/29]	For all designated states SUNSHINE, Abraham 254 East 68 Street Apt. 12D New York, NY 10021 / US
	For all designated states LASKA, Eugene M. 34 Dante Street Larchmont, NY 10538 / US
Inventor(s)	01 / Sunshine, Abraham 254 East 68 Street Apt. 120 New York, NY 10538 / US
	02 / Laska, Eugene M. 34 Dante Street Larchmont, NY 10538 / US
	[1989/39]
Former [1989/29]	01 / see applicant ...
Representative(s)	Vossius, Volker, et al ZSP Patentanwälte PartG mbB Radlkoferstrasse 2 81373 München / DE
	[N/P]
Former [1998/21]	Vossius, Volker, Dr., et al Dr. Volker Vossius, Patentanwaltskanzlei - Rechtsanwaltskanzlei, Holbeinstrasse 5 81679 München / DE
Former [1989/29]	Pendlebury, Anthony, et al PAGE, WHITE & FARRER 54 Doughty Street London WC1N 2LS / GB
Application number, filing date	88906506.6	08.07.1988
	[1989/29]
	WO1988US02253
Priority number, date	US19870071914	10.07.1987 Original published format: US 71914
	[1989/29]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO8900421
	Date:	26.01.1989
	Language:	EN
	[1989/03]
	Type:	A1 Application with search report
	No.:	EP0324007
	Date:	19.07.1989
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 26.01.1989 takes the place of the publication of the European patent application.
	[1989/29]
	Type:	B1 Patent specification
	No.:	EP0324007
	Date:	14.12.1994
	Language:	EN
	[1994/50]
Search report(s)	International search report - published on:	EP	26.01.1989
Classification	IPC:	A61K31/19, C07C57/30	[1989/29]
	CPC:	A61K31/19 (EP,US); A61P25/04 (EP); C07C57/30 (EP,US)
Designated contracting states	AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE [1989/29]
Title	German:	PHARMAZEUTISCHE ZUSAMMENSETZUNGEN, ENTHALTEND S(+)IBUPROFEN, DAS IN DER HAUPTSACHE FREI VON SEINEM R(-)ANTIPODEN IST	[1989/29]
	English:	A PHARMACEUTICAL COMPOSITION CONTAINING S(+) IBUPROFEN SUBSTANTIALLY FREE OF ITS R(-) ANTIPODE	[1989/29]
	French:	COMPOSITION PHARMACEUTIQUE CONTENANT DE L'IBUPROFEN S(+) SENSIBLEMENT EXEMPT DE SON ANTIPODE R(-)	[1989/29]
Entry into regional phase	11.03.1989	National basic fee paid
	11.03.1989	Designation fee(s) paid
	11.03.1989	Examination fee paid
Examination procedure	11.03.1989	Examination requested [1989/29]
	28.05.1990	Despatch of a communication from the examining division (Time limit: M08)
	06.02.1991	Reply to a communication from the examining division
	25.03.1992	Despatch of a communication from the examining division (Time limit: M07)
	15.10.1992	Reply to a communication from the examining division
	22.10.1992	Despatch of a communication from the examining division (Time limit: M04)
	17.02.1993	Reply to a communication from the examining division
	29.09.1993	Despatch of communication of intention to grant (Approval: No)
	01.06.1994	Despatch of communication of intention to grant (Approval: later approval)
	16.06.1994	Communication of intention to grant the patent
	30.08.1994	Fee for grant paid
	30.08.1994	Fee for publishing/printing paid
Opposition(s)	Opponent(s)	01 08.09.1995 20.09.1995 ADMISSIBLE Spirig AG Postfach 4622 Egerkingen / CH Opponent's representative Zimmermann, Hans c/o A. Braun Braun Héritier Eschmann AG Patentanwälte VSP Holbeinstrasse 36-38 Postfach 160 4003 Basel / CH
		02 11.09.1995 20.09.1995 ADMISSIBLE The Boots Company PLC Patent Dept.R4 Pennyfoot St Nottingham NG2 3AA / GB Opponent's representative Thacker, Michael Anthony The Boots Company plc Group Intellectual Property D31, 1 Thane Road West Nottingham NG90 4GR / GB
		03 12.09.1995 28.09.1995 ADMISSIBLE ZAMBON GROUP S.p.A. Via Lillo del Duca, 10 I-20091 Bresso (Milano) / IT
		04 13.09.1995 25.09.1995 ADMISSIBLE Gebro Broschek Gesellschaft m.b.H. Bahnhofscbichl 13 A-6391 Fieberbrunn / AT Opponent's representative Wildhack, Helmut Wildhack & Jellinek Patentanwälte OG Landstrasser Hauptstrasse 50 1030 Wien / AT
		05 13.09.1995 25.09.1995 ADMISSIBLE KNOLL AG Knoll Strasse D-67008 Ludwigshafen / DE Opponent's representative Miller, Thomas Kerr Knoll Pharmaceuticals Patents Department R4 Pennyfoot Street Nottingham NG2 3AA / GB
		06 14.09.1995 26.09.1995 ADMISSIBLE Nycomed DAK A/S Langebjerg 1, P.O.BOX 88 DK-4000 Roskilde / DK Opponent's representative Plougmann Vingtoft a/s Strandvejen 70 2900 Hellerup / DK
		07 14.09.1995 25.10.1995 ADMISSIBLE PAZ Arzneimittelentwicklungsgesellschaft GmbH In der Schildwacht 13 D-65933 Frankfurt / DE Opponent's representative Grussdorf, Jürgen Patentanwälte Zellentin & Partner Rubensstrasse 30 67061 Ludwigshafen / DE
		[N/P]
	Former [2009/31]
	Opponent(s)	01 08.09.1995 20.09.1995 ADMISSIBLE Spirig AG Postfach 4622 Egerkingen / CH Opponent's representative Zimmermann, Hans, Dr. c/o A. Braun Braun Héritier Eschmann AG Patentanwälte VSP Holbeinstrasse 36-38 Postfach 160 CH-4003 Basel / CH
		02 11.09.1995 20.09.1995 ADMISSIBLE The Boots Company PLC Patent Dept.R4 Pennyfoot St Nottingham NG2 3AA / GB Opponent's representative Thacker, Michael Anthony The Boots Company plc Group Patents Department, D31, 1 Thane Road West Nottingham NG2 3AA / GB
		03 12.09.1995 28.09.1995 ADMISSIBLE ZAMBON GROUP S.p.A. Via Lillo del Duca, 10 I-20091 Bresso (Milano) / IT
		04 13.09.1995 25.09.1995 ADMISSIBLE Gebro Broschek Gesellschaft m.b.H. Bahnhofscbichl 13 A-6391 Fieberbrunn / AT Opponent's representative Wildhack, Helmut Wildhack & Jellinek Patentanwälte OG Landstrasser Hauptstrasse 50 1030 Wien / AT
		05 13.09.1995 25.09.1995 ADMISSIBLE KNOLL AG Knoll Strasse D-67008 Ludwigshafen / DE Opponent's representative Miller, T K Dr. Knoll Pharmaceuticals Patents Department, R4 Pennyfoot Street Nottingham NG2 3AA / GB
		06 14.09.1995 26.09.1995 ADMISSIBLE Nycomed DAK A/S Langebjerg 1, P.O.BOX 88 DK-4000 Roskilde / DK Opponent's representative Plougmann & Vingtoft A/S Sankt Annae Plads 11, P.O. Box 3007 DK-1021 Copenhagen K / DK
		07 14.09.1995 25.10.1995 ADMISSIBLE PAZ Arzneimittelentwicklungsgesellschaft GmbH In der Schildwacht 13 D-65933 Frankfurt / DE Opponent's representative Grussdorf, Jürgen, Dr. Patentanwälte Zellentin & Partner Rubensstrasse 30 D-67061 Ludwigshafen / DE
	Former [1996/41]
	Opponent(s)	01 08.09.1995 20.09.1995 ADMISSIBLE Spirig AG Postfach 4622 Egerkingen / CH Opponent's representative Zimmermann, Hans, Dr. c/o A. Braun Braun Héritier Eschmann AG Patentanwälte VSP Holbeinstrasse 36-38 Postfach 160 CH-4003 Basel / CH
		02 11.09.1995 20.09.1995 ADMISSIBLE The Boots Company PLC Patent Dept.R4 Pennyfoot St Nottingham NG2 3AA / GB Opponent's representative Thacker, Michael Anthony The Boots Company plc Group Patents Department, D31, 1 Thane Road West Nottingham NG2 3AA / GB
		03 12.09.1995 28.09.1995 ADMISSIBLE ZAMBON GROUP S.p.A. Via Lillo del Duca, 10 I-20091 Bresso (Milano) / IT
		04 13.09.1995 25.09.1995 ADMISSIBLE Gebro Broschek Gesellschaft m.b.H. Bahnhofscbichl 13 A-6391 Fieberbrunn / AT Opponent's representative Wildhack, Helmut, Dipl.-Ing. Dr. Patentanwälte Dipl.-Ing. Leo Brauneiss, Dipl.-Ing. Dr. Helmut Wildhack, Dipl.-Ing. Dr. Gerhard Jellinek, Landstrasser Hauptstrasse 50 A-1031 Wien / AT
		05 13.09.1995 25.09.1995 ADMISSIBLE KNOLL AG Knoll Strasse D-67008 Ludwigshafen / DE Opponent's representative Miller, T K Dr. Knoll Pharmaceuticals Patents Department, R4 Pennyfoot Street Nottingham NG2 3AA / GB
		06 14.09.1995 26.09.1995 ADMISSIBLE Nycomed DAK A/S Langebjerg 1, P.O.BOX 88 DK-4000 Roskilde / DK Opponent's representative Plougmann & Vingtoft A/S Sankt Annae Plads 11, P.O. Box 3007 DK-1021 Copenhagen K / DK
		07 14.09.1995 25.10.1995 ADMISSIBLE PAZ Arzneimittelentwicklungsgesellschaft GmbH In der Schildwacht 13 D-65933 Frankfurt / DE Opponent's representative Grussdorf, Jürgen, Dr. Patentanwälte Zellentin & Partner Rubensstrasse 30 D-67061 Ludwigshafen / DE
	Former [1995/45]
	Opponent(s)	01 08.09.1995 20.09.1995 ADMISSIBLE Spirig AG Postfach 4622 Egerkingen / CH Opponent's representative Zimmermann, Hans, Dr. c/o A. Braun Braun Héritier Eschmann AG Patentanwälte VSP Holbeinstrasse 36-38 Postfach 160 CH-4003 Basel / CH
		02 11.09.1995 20.09.1995 ADMISSIBLE The Boots Company PLC Patent Dept.R4 Pennyfoot St Nottingham NG2 3AA / GB Opponent's representative Thacker, Michael Anthony THE BOOTS COMPANY PLC Group Patents Department 10th Floor, Newland House 49 Mount Street Nottingham NG2 3AA / GB
		03 12.09.1995 28.09.1995 ADMISSIBLE ZAMBON GROUP S.p.A. Via Lillo del Duca, 10 I-20091 Bresso (Milano) / IT
		04 13.09.1995 25.09.1995 ADMISSIBLE Gebro Broschek Gesellschaft m.b.H. Bahnhofscbichl 13 A-6391 Fieberbrunn / AT Opponent's representative Wildhack, Helmut, Dipl.-Ing. Dr. Patentanwälte Dipl.-Ing. Leo Brauneiss, Dipl.-Ing. Dr. Helmut Wildhack, Dipl.-Ing. Dr. Gerhard Jellinek, Landstrasser Hauptstrasse 50 A-1031 Wien / AT
		05 13.09.1995 25.09.1995 ADMISSIBLE KNOLL AG Knoll Strasse D-67008 Ludwigshafen / DE Opponent's representative Miller, T K Dr. Knoll Pharmaceuticals Patents Department, R4 Pennyfoot Street Nottingham NG2 3AA / GB
		06 14.09.1995 26.09.1995 ADMISSIBLE Nycomed DAK A/S Langebjerg 1, P.O.BOX 88 DK-4000 Roskilde / DK Opponent's representative Plougmann & Vingtoft A/S Sankt Annae Plads 11, P.O. Box 3007 DK-1021 Copenhagen K / DK
		07 14.09.1995 25.10.1995 ADMISSIBLE PAZ Arzneimittelentwicklungsgesellschaft GmbH In der Schildwacht 13 D-65933 Frankfurt / DE Opponent's representative Grussdorf, Jürgen, Dr. Patentanwälte Zellentin & Partner Rubensstrasse 30 D-67061 Ludwigshafen / DE
	Former [1995/45]
	Opponent(s)	01 08.09.1995 Spirig AG Postfach 4622 Egerkingen / CH Opponent's representative Zimmermann, Hans, Dr. c/o A. Braun Braun Héritier Eschmann AG Patentanwälte VSP Holbeinstrasse 36-38 Postfach 160 CH-4003 Basel / CH
		02 11.09.1995 The Boots Company PLC Patent Dept.R4 Pennyfoot St Nottingham NG2 3AA / GB Opponent's representative Thacker, Michael Anthony THE BOOTS COMPANY PLC Group Patents Department 10th Floor, Newland House 49 Mount Street Nottingham NG2 3AA / GB
		03 12.09.1995 28.09.1995 ADMISSIBLE ZAMBON GROUP S.p.A. Via Lillo del Duca, 10 I-20091 Bresso (Milano) / IT
		04 13.09.1995 25.09.1995 ADMISSIBLE Gebro Broschek Gesellschaft m.b.H. Bahnhofscbichl 13 A-6391 Fieberbrunn / AT Opponent's representative Wildhack, Helmut, Dipl.-Ing. Dr. Patentanwälte Dipl.-Ing. Leo Brauneiss, Dipl.-Ing. Dr. Helmut Wildhack, Dipl.-Ing. Dr. Gerhard Jellinek, Landstrasser Hauptstrasse 50 A-1031 Wien / AT
		05 13.09.1995 KNOLL AG Knoll Strasse D-67008 Ludwigshafen / DE Opponent's representative Miller, Thomas Kerr The Boots Company plc, Patents Department, R4 Pennyfoot Street Nottingham NG2 3AA / GB
		06 14.09.1995 26.09.1995 ADMISSIBLE Nycomed DAK A/S Langebjerg 1, P.O.BOX 88 DK-4000 Roskilde / DK Opponent's representative Plougmann & Vingtoft A/S Sankt Annae Plads 11, P.O. Box 3007 DK-1021 Copenhagen K / DK
		07 14.09.1995 25.10.1995 ADMISSIBLE PAZ Arzneimittelentwicklungsgesellschaft GmbH In der Schildwacht 13 D-65933 Frankfurt / DE Opponent's representative Grussdorf, Jürgen, Dr. Patentanwälte Zellentin & Partner Rubensstrasse 30 D-67061 Ludwigshafen / DE
	Former [1995/44]
	Opponent(s)	01 08.09.1995 ADMISSIBLE Spirig AG Postfach 4622 Egerkingen / CH Opponent's representative Zimmermann, Hans, Dr. c/o A. Braun Braun Héritier Eschmann AG Patentanwälte VSP Holbeinstrasse 36-38 Postfach 160 CH-4003 Basel / CH
		02 11.09.1995 The Boots Company PLC Patent Dept.R4 Pennyfoot St Nottingham NG2 3AA / GB Opponent's representative Thacker, Michael Anthony THE BOOTS COMPANY PLC Group Patents Department 10th Floor, Newland House 49 Mount Street Nottingham NG2 3AA / GB
		03 12.09.1995 28.09.1995 ADMISSIBLE ZAMBON GROUP S.p.A. Via Lillo del Duca, 10 I-20091 Bresso (Milano) / IT
		04 13.09.1995 25.09.1995 ADMISSIBLE Gebro Broschek Gesellschaft m.b.H. Bahnhofscbichl 13 A-6391 Fieberbrunn / AT Opponent's representative Wildhack, Helmut, Dipl.-Ing. Dr. Patentanwälte Dipl.-Ing. Leo Brauneiss, Dipl.-Ing. Dr. Helmut Wildhack, Dipl.-Ing. Dr. Gerhard Jellinek, Landstrasser Hauptstrasse 50 A-1031 Wien / AT
		05 13.09.1995 KNOLL AG Knoll Strasse D-67008 Ludwigshafen / DE Opponent's representative Miller, Thomas Kerr The Boots Company plc, Patents Department, R4 Pennyfoot Street Nottingham NG2 3AA / GB
		06 14.09.1995 26.09.1995 ADMISSIBLE Nycomed DAK A/S Langebjerg 1, P.O.BOX 88 DK-4000 Roskilde / DK Opponent's representative Plougmann & Vingtoft A/S Sankt Annae Plads 11, P.O. Box 3007 DK-1021 Copenhagen K / DK
	30.10.1995	Invitation to proprietor to file observations on the notice of opposition
	04.11.1997	Date of oral proceedings
	09.02.1998	Despatch of minutes of oral proceedings
	11.02.1998	Despatch of communication that the patent will be revoked
	07.07.1999	Legal effect of revocation of patent [1999/49]
Appeal following opposition	25.03.1998	Appeal received No. T0315/98
	12.06.1998	Statement of grounds filed
	07.07.1999	Result of appeal procedure: appeal of the proprietor was rejected
	07.07.1999	Date of oral proceedings
	19.07.1999	Minutes of the oral proceedings despatched
Fees paid	Renewal fee
	27.07.1990	Renewal fee patent year 03
	30.07.1991	Renewal fee patent year 04
	27.07.1992	Renewal fee patent year 05
	12.07.1993	Renewal fee patent year 06
	07.07.1994	Renewal fee patent year 07
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	deleted
	[2015/21]
Former [2000/52]	CH	14.12.1994
	LI	14.12.1994
Cited in	International search	[X]JP61210049 ;
		[P]EP0267321 (PUETTER MEDICE CHEM PHARM [DE])
		[X] - BIOCHEMICAL PHARMACOLOGY, Vol. 35, No. 19, Publ. October 1986, PERGAMON JOURNALS LTD., K. WILLIAMS et al., "The Stereoselective Uptake of Ibuprofen Enantiomers Into Adipose Tissue", pages 3403-3405.
		[X] - CURRENT MEDICAL RESEARCH AND OPINION, Vol. 3, No. 8, 1975, S.S. ADAMS et al., "The Optical Isomers of Ibuprofen", page 552.
		[X] - J. PHARM. PHARMACOL., Vol. 28, 1976, S.S. ADAMS et al., "Pharmacological Difference Between the Optical Isomers of Ibuprofen: Evidence for Metabolic Inversion of the (-)-Isomer", pages 256-257.
		[X] - JOURNAL OF PHARMACEUTICAL SCIENCES, Vol. 56, 1967, S.S. ADAMS et al., "Some Biological Properties of 2-(4-Isobutylphenyl)-Propionic Acid", page 1686.
		[X] - BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol. 61, No. 3, 1974, W.J. WECHTER et al., "Enzymatic Inversion at Saturated Carbon: Nature and Mechanism of the Inversion of R(-) p-iso-Butyl Hydratropic Acid", pages 833-837.
		[X] - J. PHARM. PHARMACOL., Vol. 35, 1983, ANDREW J. HUTT et al., "The Metabolic Chiral Inversion of 2-Arylpropionic Acids - a Novel Route With Pharmacological Consequences", pages 693-704.
		[X] - CLINICAL PHARMACOKINETICS, Vol. 9, 1984, ANDREW J. HUTT et al., "The Importance of Stereo-Chemistry in the Clinical Pharmacokinetics of the 2-Arylpropionic Acid Non-Steroidal Anti-Inflammatory Drugs", pages 371-373.
		[X] - THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol. 232, No. 3, 1985, J.W. COX et al., "Ibuprofen Stereoisomer Hepatic Clearance and Distribution in Normal and Fatty in Situ Perfused Rat Liver", pages 636-643.
		[X] - CLINICAL PHARMACOLOGY & THERAPEUTICS, Vol. 41, No. 2, February 1987, page 200.
		[X] - CLINICAL PHARMACOLOGY & THERAPEUTICS, Vol. 40, No. 1, 1986, EUGENE M. LASKA et al., "The Correlation Between Blood Levels of Ibuprofen and Clinical Analgesic Response", pages 1-7.
		[X] - CHEMICAL ABSTRACTS, Vol. 106, 1987, Abstract No. 66922r, (Daicel Chemical Industries, Ltd.); & JP,A,61 210 049 (18-09-86)., & JP61210049 A 00000000
		[A] - PHYSICIANS' DESK REFERENCE, 40TH Edition, 1986, EDWARD R. BARNHART, pages 1854-1855.
		[A] - XENOBIOTICA, Vol. 3, No. 9, 1973, R.F.N. MILLS et al., "The Metabolism of Ibuprofen", pages 589-598.
		[A] - JOURNAL OF PHARMACEUTICAL SCIENCES, Vol. 64, No. 5, 1975, GARRETT J. VANGIESSEN et al., "GLC Determination of Ibuprofen [dl-2-(p-Isobutyl-phenyl)Propionic Acid] Enantiomers in Biological Specimens", pages 798-801.
		[A] - JOURNAL OF PHARMACEUTICAL SCIENCE, Vol. 65, No. 2, February 1976, D.G. KAISER et al., "Isomeric Inversion of Ibuprofen (R)-Enantiomer in Humans", pages 269-73.
		[A] - ANTI-INFLAMMATORY AND ANTI-RHEUMATIC DRUGS, eds. RAINSFORD and PATH, CRC PRESS INC., Boca Raton Florida, 1985, ANTHONY C. ALLISON et al., "Naproxen", page 172.
		[A] - ANGEW. CHEM. INTERNAT. EDIT., Vol. 11, No. 6, 1972, T.Y. SHEN, "Perspectives in Nonsteroidal Anti-Inflammatory Agents", pages 460-72.
		[A] - NONSTEROIDAL ANTI-INFLAMMATORY AGENTS, "Chapter 62 in Burger's Medicinal Chemistry", 4th Edition, Part III, WILEY INTERSCIENCE, NEW YORK (1981), T.Y. SHEN, pages 1205-1271.
		[A] - BR. J. CLIN. PHARMAC., Vol. 19, 1985, E.J.D LEE et al., "Stereoselective Disposition of Ibuprofen Enantiomers in Man", pages 669-674.
		[A] - THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol. 148, No. 3, 1965, CHARLES A. WINTER et al., "Nociceptive Thresholds as Affected by Parenteral Administration of Irritants and of Various Antinociceptive Drugs", pages 373-379.
		[A] - PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, Vol. 118, 1965, H. BLUMBERG et al., "Use of Writhing Test for Evaluating Analgesic Activity of Narcotic Antagonists", pages 763-766.
		[A] - JOURNAL OF PHARMACEUTICAL SCIENCES, Vol. 73, No. 11, November 1984, E.J.D. LEE et al., AMERICAN PHARMACEUTICAL ASSOCIATION, "Liquid Chromatographic Dermination and Plasma Concentration Profile of Optical Isomers of Ibuprofen in Humans", pages 1542-1544.
		[A] - REMINGTON'S PHARMACEUTICAL SCIENCES, 15th Ed., 1975, MACK PUBLISHING COMPANY, EASTON, PENNSYLVANIA 18042, JOHN E. HOOVER, Chapter 59, page 1054.

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