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Extract from the Register of European Patents

EP About this file: EP0489771

EP0489771 - MODIFIED HUMAN ANTI-Rh(D) ANTIBODIES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  16.03.1995
Database last updated on 25.09.2024
Most recent event   Tooltip16.03.1995No opposition filed within time limitpublished on 03.05.1995 [1995/18]
Applicant(s)For all designated states
National Blood Authority
Oak House, Reeds Crescent
Watford, Herts. WD1 1QH / GB
[1993/47]
Former [1992/25]For all designated states
Central Blood Laboratories Authority
"The Crest", Dagger Lane, Elstree
Boreham Wood, Hertfordshire, WD6 3AU / GB
Inventor(s)01 / SCOTT, Marion, Lesley
Flat 16 5 Royal York Crescent Clifton
Bristol BS8 4JW / GB
02 / GUEST, Alan, Robert
5 Chequers Court Palmers Leaze
Bradley Stoke South Bristol BS12 0HD / GB
03 / ANSTEE, David, John
1 Cavendish Road Henleaze
Bristol BS9 4DZ / GB
[1992/25]
Representative(s)Holmes, Michael John, et al
Frank B. Dehn & Co. St Bride's House 10 Salisbury Square
London EC4Y 8JD / GB
[N/P]
Former [1992/25]Holmes, Michael John, et al
Frank B. Dehn & Co. European Patent Attorneys Imperial House 15-19 Kingsway
London, WC2B 6UZ / GB
Application number, filing date90912594.031.08.1990
[1992/25]
WO1990EP01463
Priority number, dateGB1989001976101.09.1989         Original published format: GB 8919761
[1992/25]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9103492
Date:21.03.1991
Language:EN
[1991/07]
Type: A1 Application with search report 
No.:EP0489771
Date:17.06.1992
Language:EN
The application published by WIPO in one of the EPO official languages on 21.03.1991 takes the place of the publication of the European patent application.
[1992/25]
Type: B1 Patent specification 
No.:EP0489771
Date:11.05.1994
Language:EN
[1994/19]
Search report(s)International search report - published on:EP21.03.1991
ClassificationIPC:C07K15/28, G01N33/80, A61K39/395
[1992/25]
CPC:
C07K16/34 (EP); G01N33/80 (EP); A61K38/00 (EP)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   IT,   LI,   LU,   NL,   SE [1992/25]
TitleGerman:MODIFIZIERTE MENSCHLICHE ANTI-RH(D)-ANTIKÖRPER[1992/25]
English:MODIFIED HUMAN ANTI-Rh(D) ANTIBODIES[1992/25]
French:ANTICORPS ANTI-Rh(D) HUMAINS MODIFIES[1992/25]
Biological materialThis application mentions deposited biological material, check the file for details
Entry into regional phase20.02.1992National basic fee paid 
20.02.1992Designation fee(s) paid 
20.02.1992Examination fee paid 
Examination procedure28.03.1991Request for preliminary examination filed
International Preliminary Examining Authority: DE
20.02.1992Examination requested  [1992/25]
05.05.1993Despatch of communication of intention to grant (Approval: No)
11.10.1993Despatch of communication of intention to grant (Approval: later approval)
27.10.1993Communication of intention to grant the patent
01.02.1994Fee for grant paid
01.02.1994Fee for publishing/printing paid
Opposition(s)14.02.1995No opposition filed within time limit [1995/18]
Fees paidRenewal fee
24.08.1992Renewal fee patent year 03
24.08.1993Renewal fee patent year 04
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Cited inInternational search[Y]EP0022669  (ORTHO DIAGNOSTIC SYSTEMS INC [US]);
 [Y]GB2066259  (GAMMA BIOLOGICALS INC);
 [Y]WO8902600  (CENTRAL BLOOD LAB AUTHORITY [GB]);
 [A]WO8902443  (CENTRAL BLOOD LAB AUTHORITY [GB])
 [Y]  - Proc. Natl. Acad. Sci., Vol. 74, No. 6, June 1977 D G Romans et al.: "Conversion of incomplete antibodies to direct agglutinins by mild reduction: Evidence for segmental flexibility within the Fc fragment of immunoglobulin G ",
 [A]  - TRANSFUSION, Vol. 27, 1987 E C Jones et al.: "False-positive results with chemically modified anti-D ",
 [Y]  - Immunology, Vol. 67, August 1989 A G Hadley et al.: "Synergistic effect of blending IgG1 and IgG3 monoclonal anti-D in promoting the metabolic response of monocytes to sensitized red cells ",
 [A]  - Immunology, Vol. 62, November 1987 E. Wiener et al.: "Differences between the activities of human monoclonal IgG1 and IgG3 subclasses of anti-D(Rh) antibody in their ability to mediate red cell-binding to macrophages ",
 [A]  - Proc. Natl. Acad. Sci. USA, Vol. 81, May 1984 Dominique Bron et al.: "Production of human monoclonal IgG antibodies against Rhesus (D) antigen ",
 [A]  - Immunology, Vol. 58, 1986 K M Thompson et al.: "Production of human monoclonal IgG and IgM antibodies with anti-D (rhesus) specificity using heterohybridomas ",
Examination   - Proc. Natl. Acad. Sci., vol. 74, no. 6, June 1977, D.G. Romans et al., pp.2531-2535
    - Transfusion, vol. 27, 1987, E.C. Jones et al., pp. 142-144
    - Immunology, vol. 67, August 1989, A.G. Hadley et al., pp. 550-552
    - Immunology, vol. 62, Nov. 1987, E. Wiener et al., pp. 401-404
    - Proc. Natl. Acad. Sci. USA, vol. 81, May 1984, D. Bron et al., pp. 3214-3217
    - Immunology, vol. 58, 1986, K.M. Thompson et al., pp. 157-160
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.