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Extract from the Register of European Patents

EP About this file: EP0489836

EP0489836 - LIGHT ACTIVATED ACYL-ENZYMES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.10.1995
Database last updated on 14.09.2024
Most recent event   Tooltip26.10.1995No opposition filed within time limitpublished on 13.12.1995 [1995/50]
Applicant(s)For all designated states
Duke University
Erwin Road, Raleigh Durham
North Carolina 27706 / US
[N/P]
Former [1992/25]For all designated states
DUKE UNIVERSITY
Erwin Road, Raleigh
Durham, North Carolina 27706 / US
Inventor(s)01 / PORTER, Ned, A.
3301 West Cornwallis Road
Durham, NC 27705 / US
02 / BRUHNKE, John, D.
931 Lambeth Circle
Durham, NC 27705 / US
[1992/25]
Representative(s)Horner, Martin Grenville
Marks & Clerk LLP
Aurora
120 Bothwell Street
Glasgow
G2 7JS / GB
[N/P]
Former [1992/25]Horner, Martin Grenville
Cruikshank & Fairweather 19 Royal Exchange Square
Glasgow G1 3AE Scotland / GB
Application number, filing date90913585.727.08.1990
[1992/25]
WO1990US04872
Priority number, dateUS1989040050729.08.1989         Original published format: US 400507
[1992/25]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9103549
Date:21.03.1991
Language:EN
[1991/07]
Type: A1 Application with search report 
No.:EP0489836
Date:17.06.1992
Language:EN
The application published by WIPO in one of the EPO official languages on 21.03.1991 takes the place of the publication of the European patent application.
[1992/25]
Type: B1 Patent specification 
No.:EP0489836
Date:21.12.1994
Language:EN
[1994/51]
Search report(s)International search report - published on:US21.03.1991
(Supplementary) European search report - dispatched on:EP06.04.1993
ClassificationIPC:C12N13/00, C12N9/68, C12N9/70, C12N9/74, C12N9/76, C07C205/43, C07C205/56, C07C229/44, C07C257/18
[1994/51]
CPC:
C12N9/6429 (EP,US); C07C205/43 (EP,US); C07C205/56 (EP,US);
C07C229/44 (EP,US); C07C257/18 (EP,US); C12N13/00 (EP,US);
C12N9/00 (EP,US); C12N9/50 (EP,US); C12Y304/21005 (EP,US);
C12N9/52 (EP,US) (-)
Former IPC [1992/25]C12N13/00, C12N9/68, C12N9/70, C12N9/74, C12N9/76, C07D211/56, C07D211/26, C07D211/98, C07D211/30
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   IT,   LI,   LU,   NL,   SE [1992/25]
TitleGerman:LICHTAKTIVIERTE ACYLENZYME[1992/25]
English:LIGHT ACTIVATED ACYL-ENZYMES[1992/25]
French:ENZYMES-ACYLS ACTIVES PAR LA LUMIERE[1992/25]
Entry into regional phase21.02.1992National basic fee paid 
21.02.1992Search fee paid 
21.02.1992Designation fee(s) paid 
21.02.1992Examination fee paid 
Examination procedure14.03.1991Request for preliminary examination filed
International Preliminary Examining Authority: DE
24.02.1992Examination requested  [1992/25]
31.03.1994Despatch of communication of intention to grant (Approval: Yes)
20.05.1994Communication of intention to grant the patent
16.08.1994Fee for grant paid
16.08.1994Fee for publishing/printing paid
Opposition(s)22.09.1995No opposition filed within time limit [1995/50]
Fees paidRenewal fee
10.08.1992Renewal fee patent year 03
11.08.1993Renewal fee patent year 04
09.08.1994Renewal fee patent year 05
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Documents cited:Search[Y]  - JOURNAL OF ANTIBIOTICS vol. 40, no. 8, August 1987, TOKYO JP pages 1209 - 1210 ISSHIKI,KUNIO ET AL 'Inhibition of Tyrosine protein kinase by synthetic erbstatin analogs.'
 [Y]  - CHEMICAL ABSTRACTS, vol. 108, no. 13, 28 March 1988, Columbus, Ohio, US; abstract no. 108716a, AISINA, R.B. ET AL. 'Synthesis and kinetics of deacylation of some human acylplasmins.' page 288 ;
 [XP]  - JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. vol. 111, no. 19, 13 September 1989, GASTON, PA US pages 7616 - 7618 NED A. PORTER ET AL. 'Acyl Thrombin Photochemistry:Kinetics for deacylation of enzyme cinnamate geometric isomers.'
 [XP]  - BIOCHEMISTRY. vol. 29, no. 20, 1990, EASTON, PA US pages 4871 - 4879 BARRY L: STODDARD ET AL. 'Structure and activity of two photoreversible cinnamates bound to Chymotrypsin.'
 [XP]  - CHEMICAL ABSTRACTS, vol. 112, no. 15, 9 April 1990, Columbus, Ohio, US; abstract no. 136511f, PORTER NED A. ET AL. 'Photocoagulation of human plasma: Acyl serine proteinase photochemistry.' page 482 ;
International search[Y]  - J. Am. Chem, Soc., Vol. 110, No.1, issued 1988, TURNER et al., "Photoreactivation of Irreversibly Inhibited Serine Proteinases", pages 244-250, see especially pages 244-245.
 [Y]  - J. Am. Chem. Soc., Vol. 109, issued 1987, TURNER et al., "Photochemical Activation of Acylated alpha-Thrombin", pages 1274-1275, see entire document.
 [Y]  - Febs Letters, Vol. 15, No.2, issued June 1971, VARTOLOMEYEV et al., "Light Initiated Enzymic Activity Caused by Photostereo Isomerization of Cis-4-Nitrocinnamoyl-alpha-chymotrypsin", pages 118-120, see entire document.
 [A]  - CHEMICAL ABSTRACTS, Volume 78, No. 19, BHAT et al., "Chemotherapy of Fungus Infections. III. Alkyl or aryl thiosemicarbazones, acid hydrazones, and styrl, aryl ketones of 5-bromo-and 5-nitrosalicyclaldehydes". Column 1, Abstract No. 119650n, Indian J. Chem., 10(7), 694-8.
Examination   - Febs Letters, vol. 15, no. 2, iss. June 1971, Vartolomeyer et al., pp. 118-120
    - Chem. Abstracts, vol. 78, no. 19, Bhat et al., abstract no. 119650n; Indian J. Chem. 10(7), 694-8
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