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Extract from the Register of European Patents

EP About this file: EP0451836

EP0451836 - Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.11.1996
Database last updated on 03.08.2024
Most recent event   Tooltip03.10.2003Lapse of the patent in a contracting state
New state(s): DK		published on 19.11.2003  [2003/47]
Applicant(s)For all designated states
HEALTH RESEARCH, INC.
Roswell Park Division, 666 Elm Street Buffalo
NY 14263 / US
For all designated states
MERRELL PHARMACEUTICALS INC.
2110 East Galbraith Road, P.O. Box 156300 Cincinnati
Ohio 45215-6300 / US
For all designated states
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
3003 S. State Street Wolverine Tower, Room 2071
Ann Arbor, Michigan 48109-1280 / US
[N/P]
Former [1996/32]For all designated states
HEALTH RESEARCH, INC.
Roswell Park Division, 666 Elm Street
Buffalo, NY 14263 / US
For all designated states
MERRELL PHARMACEUTICALS INC.
2110 East Galbraith Road, P.O. Box 156300
Cincinnati, Ohio 45215-6300 / US
For all designated states
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
3003 S. State Street Wolverine Tower, Room 2071
Ann Arbor Michigan 48109-1280 / US
Former [1996/21]For all designated states
HEALTH RESEARCH INCORPORATED
66 Hackett Boulevard, 3rd Floor
Albany NY 12209 / US
For all designated states
MERRELL PHARMACEUTICALS INC.
2110 East Galbraith Road, P.O. Box 156300
Cincinnati, Ohio 45215-6300 / US
For all designated states
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Technology Management Office, Wolverline Towers, Room 2071, 3003 South State Street
Ann Arbor, Michigan 48109-1280 / US
Former [1996/20]For all designated states
HEALTH RESEARCH INCORPORATED
66 Hackett Boulevard, 3rd Floor
Albany NY 12209 / US
For all designated states
MERRELL PHARMACEUTICALS INC.
2110 East Galbraith Road, P.O. Box 156300
Cincinnati, Ohio 45215-6300 / US
For all designated states
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
3003 S. State Street Wolverine Tower, Room 2071
Ann Arbor Michigan 48109-1280 / US
Former [1996/16]For all designated states
HEALTH RESEARCH INCORPORATED
66 Hackett Boulevard, 3rd Floor
Albany NY 12209 / US
For all designated states
MERRELL DOW PHARMACEUTICALS INC.
P.O. Box 156300 2110 East Galbraith Road
Cincinnati Ohio 45215-6300 / US
For all designated states
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
3003 S. State Street Wolverine Tower, Room 2071
Ann Arbor Michigan 48109-1280 / US
Former [1995/24]For all designated states
HEALTH RESEARCH, INC.
Roswell Park Division, 666 Elm Street
Buffalo, NY 14263 / US
For all designated states
MERRELL DOW PHARMACEUTICALS INC.
P.O. Box 156300 2110 East Galbraith Road
Cincinnati Ohio 45215-6300 / US
For all designated states
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
3003 S. State Street Wolverine Tower, Room 2071
Ann Arbor Michigan 48109-1280 / US
Former [1991/42]For all designated states
HEALTH RESEARCH, INC.
Roswell Park Division, 666 Elm Street
Buffalo, NY 14263 / US
For all designated states
MERRELL DOW PHARMACEUTICALS INC.
P.O. Box 156300 2110 East Galbraith Road
Cincinnati Ohio 45215-6300 / US
For all designated states
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
475 East Jefferson, Room 2354
Ann Arbor, Michigan 48109-1248 / US
Inventor(s)01 / Bey, Philippe
7875 Ivygate Lane
Cincinnati, Ohio 45242 / US
02 / Coward, James K.
6 Haverhill Court
Ann Arbor, Michigan 48105 / US
03 / McGuire, John J.
250 Knowlton Avenue
Kenmore, New York 14217 / US
[1991/42]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[N/P]
Former [1991/42]VOSSIUS & PARTNER
Postfach 86 07 67
D-81634 München / DE
Application number, filing date91105768.511.04.1991
[1991/42]
Priority number, dateUS1990050887312.04.1990         Original published format: US 508873
[1991/42]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP0451836
Date:16.10.1991
Language:EN
[1991/42]
Type: A3 Search report 
No.:EP0451836
Date:01.07.1992
Language:EN
[1992/27]
Type: B1 Patent specification 
No.:EP0451836
Date:27.12.1995
Language:EN
[1995/52]
Search report(s)(Supplementary) European search report - dispatched on:EP08.05.1992
ClassificationIPC:C07D475/08, A61K31/52
[1991/42]
CPC:
C07D475/08 (EP,US); C07D475/00 (KR); A61P35/00 (EP);
A61P35/02 (EP)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IT,   LI,   LU,   NL,   SE [1991/42]
TitleGerman:Konjugate von Difluoroglutaminsäure mit Fölaten und Antifölaten für die Behandlung von neoplastischen Krankheiten[1991/42]
English:Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases[1991/42]
French:Conjugats de l'acide difluoroglutamique avec des folats et des antifolats pour le traitement de maladies néoplastiques[1991/42]
Examination procedure23.12.1992Examination requested  [1993/08]
13.05.1994Despatch of a communication from the examining division (Time limit: M04)
23.09.1994Reply to a communication from the examining division
09.12.1994Despatch of communication of intention to grant (Approval: No)
11.05.1995Despatch of communication of intention to grant (Approval: later approval)
18.05.1995Communication of intention to grant the patent
06.07.1995Fee for grant paid
06.07.1995Fee for publishing/printing paid
Opposition(s)28.09.1996No opposition filed within time limit [1996/51]
Fees paidRenewal fee
26.02.1993Renewal fee patent year 03
25.02.1994Renewal fee patent year 04
28.04.1995Renewal fee patent year 05
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competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipGR27.12.1995
NL27.12.1995
DK27.03.1996
SE27.03.1996
LU30.04.1996
[2003/47]
Former [2003/07]GR27.12.1995
NL27.12.1995
SE27.03.1996
LU30.04.1996
Former [2000/05]GR27.12.1995
SE27.03.1996
LU30.04.1996
Former [1996/32]SE27.03.1996
Documents cited:Search[A]US4584375  (COWARD JAMES K [US])
 [AP]  - JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 24, 25 August 1990, BALTIMORE, US; JOHN J. MC GUIRE: 'DL-3,3-Difluoroglutamate: An Enhancer of Folylpolyglutamate Elongation.'
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.