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EP0481791

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Extract from the Register of European Patents

EP About this file: EP0481791

EP0481791 - Culture medium for CHO-cells and adapted CHO-cells [Right-click to bookmark this link]
Status	Patent revoked Status updated on 16.03.2007 Database last updated on 29.03.2025
Most recent event Tooltip	23.11.2007	New entry: Decision (+date) in appeal procedure
Applicant(s)	For all designated states THE WELLCOME FOUNDATION LIMITED Glaxo Wellcome House, Berkeley Avenue Greenford Middlesex UB6 0NN / GB
	[N/P]
Former [1997/42]	For all designated states THE WELLCOME FOUNDATION LIMITED Glaxo Wellcome House, Berkeley Avenue Greenford, Middlesex UB6 0NN / GB
Former [1992/17]	For all designated states THE WELLCOME FOUNDATION LIMITED Unicorn House 160 Euston Road London NW1 2BP / GB
Inventor(s)	01 / Keen, Michael John Langley Court Beckenham, Kent BR3 3BS / GB
	02 / Rapson, Nicholas Timothy Langley Court Beckenham, Kent BR3 3BS / GB
	[1992/17]
Representative(s)	Stott, Michael John, et al GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
	[N/P]
Former [1996/35]	Stott, Michael John, et al Glaxo Wellcome plc, Glaxo Wellcome House, Berkeley Avenue Greenford, Middlesex UB6 0NN / GB
Former [1992/17]	Stott, Michael John, et al The Wellcome Research Laboratories Group Patents & Agreements Langley Court Beckenham Kent BR3 3BS / GB
Application number, filing date	91309596.4	17.10.1991
	[1992/17]
Priority number, date	GB19900022545	17.10.1990 Original published format: GB 9022545
	[1992/17]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	EP0481791
	Date:	22.04.1992
	Language:	EN
	[1992/17]
	Type:	A3 Search report
	No.:	EP0481791
	Date:	08.07.1992
	Language:	EN
	[1992/28]
	Type:	B1 Patent specification
	No.:	EP0481791
	Date:	27.08.2003
	Language:	EN
	[2003/35]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	21.05.1992
Classification	IPC:	C12N5/02, C12N5/10	[1992/17]
	CPC:	C07K16/2893 (EP,US); C12N5/0043 (EP,US); C12N9/6459 (EP,US); C12Y304/21069 (EP,US); C12N2500/20 (EP,US); C12N2500/32 (EP,US); (+) C12N2500/34 (EP,US); C12N2500/36 (EP,US); C12N2500/38 (EP,US); C12N2500/74 (EP,US); C12N2500/76 (EP,US); C12N2501/135 (EP,US); C12N2501/23 (EP,US); C12N2501/33 (EP,US); C12N2501/39 (EP,US); C12N2501/392 (EP,US); C12N2501/395 (EP,US) (-)
Designated contracting states	AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE [1992/17]
Title	German:	Nährmedium für CHO-Zellen und daran angepasste Zellen	[1992/17]
	English:	Culture medium for CHO-cells and adapted CHO-cells	[1992/17]
	French:	Milieu de culture pour les cellules CHO et cellules CHO adaptées	[1992/17]
Examination procedure	deleted	Decision about request for accelerated examination - accepted: No
	29.10.1991	Examination requested [1992/17]
	27.02.1995	Despatch of a communication from the examining division (Time limit: M04)
	16.06.1995	Reply to a communication from the examining division
	15.03.1996	Despatch of a communication from the examining division (Time limit: M06)
	24.07.1996	Reply to a communication from the examining division
	23.12.1996	Despatch of a communication from the examining division (Time limit: M06)
	01.07.1997	Reply to a communication from the examining division
	15.09.1998	Despatch of a communication from the examining division (Time limit: M04)
	15.01.1999	Reply to a communication from the examining division
	28.04.2000	Request for accelerated examination filed
	04.08.2000	Despatch of a communication from the examining division (Time limit: M06)
	09.04.2001	Reply to a communication from the examining division
	13.11.2001	Observations by third parties
	06.12.2001	Despatch of a communication from the examining division (Time limit: M02)
	07.12.2001	Reply to a communication from the examining division
	09.01.2002	Despatch of communication of intention to grant (Approval: Yes)
	21.02.2002	Communication of intention to grant the patent
	10.07.2002	Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time
	12.07.2002	Fee for grant paid
	12.07.2002	Fee for publishing/printing paid
	21.10.2005	Observations by third parties
Divisional application(s)	EP02003143.1 / EP1221476
	EP07114585.8 / EP1849862
Opposition(s)	Opponent(s)	01 27.05.2004 11.06.2004 ADMISSIBLE Amgen Inc. One Amgen Center Drive Thousand Oaks, CA93120-1789 / US Opponent's representative von Menges, Albrecht Uexküll & Stolberg Partnerschaft von Patent- und Rechtsanwälten mbB Beselerstrasse 4 22607 Hamburg / DE
		02 27.05.2004 11.06.2004 ADMISSIBLE F. Hoffmann-La Roche Ltd - 4070 Basel / CH Opponent's representative White, Martin Paul Whites IP Ltd 24A Carnatic Road Liverpool L18 8BZ / GB
		03 27.05.2004 26.11.2004 ADMISSIBLE Dr. Andre Kasche Cremerstr. 7 55595 Wallhausen / DE Opponent's representative Grünecker Patent- und Rechtsanwälte PartG mbB Leopoldstraße 4 80802 München / DE
		[N/P]
	Former [2007/16]
	Opponent(s)	01 27.05.2004 11.06.2004 ADMISSIBLE Amgen Inc. One Amgen Center Drive Thousand Oaks, CA93120-1789 / US Opponent's representative von Menges, Albrecht Uexküll & Stolberg Patentanwälte Beselerstrasse 4 22607 Hamburg / DE
		02 27.05.2004 11.06.2004 ADMISSIBLE F. Hoffmann-La Roche Ltd - 4070 Basel / CH Opponent's representative White, Martin Paul Patents Designs & Brands Ltd. Suit 46 Oriel Chambers 14 Water St Liverpool L2 8TD / GB
		03 27.05.2004 26.11.2004 ADMISSIBLE Dr. Andre Kasche Cremerstr. 7 55595 Wallhausen / DE Opponent's representative Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät Maximilianstrasse 58 80538 München / DE
	Former [2005/03]
	Opponent(s)	01 27.05.2004 11.06.2004 ADMISSIBLE Amgen Inc. One Amgen Center Drive Thousand Oaks, CA93120-1789 / US Opponent's representative von Menges, Albrecht Uexküll & Stolberg Patentanwälte Beselerstrasse 4 22607 Hamburg / DE
		02 27.05.2004 11.06.2004 ADMISSIBLE F. Hoffmann-La Roche Ltd - 4070 Basel / CH Opponent's representative White, Martin Paul White & Co 60 Beach Priory Gardens Southport PR8 1RT / GB
		03 27.05.2004 26.11.2004 ADMISSIBLE Dr. Andre Kasche Cremerstr. 7 55595 Wallhausen / DE Opponent's representative Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät Maximilianstrasse 58 80538 München / DE
	Former [2004/30]
	Opponent(s)	01 27.05.2004 11.06.2004 ADMISSIBLE Amgen Inc. One Amgen Center Drive Thousand Oaks, CA93120-1789 / US Opponent's representative von Menges, Albrecht Uexküll & Stolberg Patentanwälte Beselerstrasse 4 22607 Hamburg / DE
		02 27.05.2004 11.06.2004 ADMISSIBLE F. Hoffmann-La Roche Ltd - 4070 Basel / CH Opponent's representative White, Martin Paul White & Co 60 Beach Priory Gardens Southport PR8 1RT / GB
		03 27.05.2004 26.11.2004 ADMISSIBLE Dr. Andre Kasche Cremerstr. 7 55595 Wallhausen / DE Opponent's representative Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät Maximilianstrasse 58 D-80538 München / DE
	08.07.2004	Invitation to proprietor to file observations on the notice of opposition
	18.03.2005	Reply of patent proprietor to notice(s) of opposition
	10.05.2006	Date of oral proceedings
	19.10.2006	Despatch of minutes of oral proceedings
	19.10.2006	Despatch of communication that the patent will be revoked
	29.10.2006	Legal effect of revocation of patent [2007/16]
Appeal following opposition	02.02.2007	Appeal received No. T0261/07
	31.05.2007	Statement of grounds filed
	27.09.2007	Result of appeal procedure: appeal of the proprietor deemed not to be filed
	27.09.2007	Date of oral proceedings
	08.10.2007	Minutes of the oral proceedings despatched
Request for further processing for:	12.07.2002	Request for further processing filed
	12.07.2002	Full payment received (date of receipt of payment) Request granted
	01.08.2002	Decision despatched
	09.04.2001	Request for further processing filed
	09.04.2001	Full payment received (date of receipt of payment) Request granted
	24.04.2001	Decision despatched
Fees paid	Renewal fee
	05.08.1993	Renewal fee patent year 03
	03.08.1994	Renewal fee patent year 04
	04.08.1995	Renewal fee patent year 05
	09.10.1996	Renewal fee patent year 06
	10.10.1997	Renewal fee patent year 07
	12.10.1998	Renewal fee patent year 08
	14.10.1999	Renewal fee patent year 09
	11.10.2000	Renewal fee patent year 10
	11.10.2001	Renewal fee patent year 11
	15.10.2002	Renewal fee patent year 12
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[X]WO8800967 (UNIV NEW SOUTH WALES [AU], et al);
		JPS63196268 [ ] (KANEGAFUCHI CHEMICAL IND);
		[X]US4767704 (CLEVELAND WILLIAM L [US], et al);
		[A]EP0307247 (GENENTECH INC [US]);
		[A]EP0316068 (COLLABORATIVE RES INC [US]);
		[X]EP0325190 (BOEHRINGER MANNHEIM GMBH [DE]);
		[YD]EP0328404 (MEDICAL RES COUNCIL [GB], et al);
		[X]EP0390327 (LILLY CO ELI [US]);
		[X]EP0389786 (GRACE W R & CO [US]);
		[X] - CHEMICAL ABSTRACTS, (19890508), vol. 110, no. 19, Database accession no. 171821N, page 652
		[X] - FEYS V. ET AL., "Expression of functional mouse antibodies directed against the tumor marker human placental alkaline phosphatase in non-lymphoid cells", CHEMICAL ABSTRACTS, (19880606), vol. 108, no. 23, Database accession no. 202886C, page 514
		[ ] - INT. J. CANCER, (1988), no. SUPPL2, pages 26 - 27
		[X] - TSUJIMOTO M. ET AL., "Purification and characterization of recombinant human interleukin 5 expressed in Chinese Hamster ovary cells", JOURNAL OF BIOCHEMISTRY, TOKYO, JP, (1989), vol. 106, pages 23 - 28, XP000028774
		[X] - ZETTWEISSL G. ET AL., "Expression of biologically active human antithrombin III in Chinese Hamster ovary cells", BIOTECHNOLOGY, NEW YORK, US, (198707), vol. 5, pages 720 - 725
		[XP] - PAGE M.J. ET AL., "High level expression of the humanized monoclonal antibody compath-1H in Chinese Hamster Ovary cells", BIOTECHNOLOGY, NEW YORK, US, (199101), vol. 9, doi:doi:10.1038/nbt0191-64, pages 64 - 68, XP001204851 DOI: http://dx.doi.org/10.1038/nbt0191-64
		[A] - FRESHNEY R.I., "CULTURE OF ANIMAL CELLS", ALAN R. LISS, NEW YORK, US, (1988), pages 71 - 84
	other	WO0151615
		- MERTEN O.W. ET AL, "Development of a Protein-free Medium for Bioreactor Cultures of Hybridoma Cell Lines", THE 10TH MEETING - PRODUCTION OF BIOLOGICALS FROM ANIMAL CELLS IN CULTURE RESEARCH, DEVELOPMENT AND ACHIEVEMENTS, AVIGNON, FRANCE, (19900507), page 151, XP001052757
		- BIOTECHABS, Database accession no. 1986-01469, XP001052758
		- GASSER F. ET AL, "Long-term multiplication of the Chinese hamster ovary (CHO) cell line in a serum-free medium; composition of a new synthetic culture medium GC3", IN VITRO, TOULOUSE, (198510), vol. 21, no. 10, pages 588 - 592
		- LITWIN J., "A survey of various media and growth factors used in cell cultivation", PROCEEDINGS OF THE 2ND GENERAL MEETING OF ESACT, BASEL, (1979), vol. 42, pages 37 - 45, XP002991480

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