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Extract from the Register of European Patents

EP About this file: EP0616640

EP0616640 - PRODUCTION OF ANTI-SELF ANTIBODIES FROM ANTIBODY SEGMENT REPERTOIRES AND DISPLAYED ON PHAGE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  08.07.2005
Database last updated on 05.10.2024
Most recent event   Tooltip28.12.2007Lapse of the patent in a contracting state
New state(s): PT
published on 30.01.2008  [2008/05]
Applicant(s)For all designated states
MEDICAL RESEARCH COUNCIL
20 Park Crescent
London W1N 4AL / GB
For all designated states
CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED
Milstein Building Granta Park
Cambridge CB4 6GH / GB
[N/P]
Former [2004/28]For all designated states
MEDICAL RESEARCH COUNCIL
20 Park Crescent
London W1N 4AL / GB
For all designated states
Cambridge Antibody Technology Limited
Milstein Building Granta Park
Cambridge CB4 6GH / GB
Former [1994/39]For all designated states
MEDICAL RESEARCH COUNCIL
20 Park Crescent
London W1N 4AL / GB
For all designated states
CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED
The Science Park
Melbourn, Cambridgeshire SG8 6EJ / GB
Inventor(s)01 / GRIFFITHS, Andrew, David 28 Lilac Court
Cherry Hinton Road
Cambridge CB1 4AY / GB
02 / HOOGENBOOM, Hendricus, Renerus, Jacobus, Mattheus
1 Hauxton Road Little Shelford
Cambridge CB2 5JH / GB
03 / MARKS, James, David
971 Page Street
San Francisco, CA 94117 / US
04 / McCAFFERTY, John
32 Wakelin Avenue Sawston
Cambridgeshire CB2 4DA / GB
05 / WINTER, Gregory, Paul
64 Cavendish Avenue
Cambridge CB1 4UT / GB
06 / GRIGG, Geoffrey, Walter 352 Burns Bay Road
Lane Cove
Linley Point, NSW 2066 / AU
[1994/39]
Representative(s)Armitage, Ian Michael, et al
Mewburn Ellis LLP
York House
23 Kingsway
London WC2B 6HP / GB
[N/P]
Former [1994/39]Armitage, Ian Michael, et al
MEWBURN ELLIS York House 23 Kingsway
London WC2B 6HP / GB
Application number, filing date92924775.702.12.1992
[1994/39]
WO1992GB02240
Priority number, dateGB1991002557902.12.1991         Original published format: GB 9125579
GB1991002558202.12.1991         Original published format: GB 9125582
GB1992000631824.03.1992         Original published format: GB 9206318
GB1992000637224.03.1992         Original published format: GB 9206372
WO1992GB0175523.09.1992         Original published format: PCT/GB92/01755
[1994/39]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9311236
Date:10.06.1993
Language:EN
[1993/14]
Type: A1 Application with search report 
No.:EP0616640
Date:28.09.1994
Language:EN
The application published by WIPO in one of the EPO official languages on 10.06.1993 takes the place of the publication of the European patent application.
[1994/39]
Type: B1 Patent specification 
No.:EP0616640
Date:01.09.2004
Language:EN
[2004/36]
Search report(s)International search report - published on:EP10.06.1993
ClassificationIPC:C12N15/13, C12N15/62, C07K14/00, C12P21/08, G01N33/531, G01N33/68
[2004/13]
CPC:
C07K16/005 (EP); C07K16/18 (EP); C07K16/241 (EP);
C07K16/26 (EP); C07K16/28 (EP); C07K16/2812 (EP);
C07K16/2863 (EP); C07K16/2866 (EP); C07K16/3007 (EP);
C07K16/3092 (EP); C07K16/34 (EP); C07K16/4241 (EP);
B01J2219/00718 (EP); C07K2317/24 (EP); C07K2317/55 (EP);
C07K2317/622 (EP); C07K2319/41 (EP); C07K2319/735 (EP) (-)
Former IPC [1994/39]C12N15/13, C12N15/62, C07K13/00, C12P21/08, G01N33/531, G01N33/68
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1994/39]
TitleGerman:Herstellung von Antikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken.[1994/39]
English:PRODUCTION OF ANTI-SELF ANTIBODIES FROM ANTIBODY SEGMENT REPERTOIRES AND DISPLAYED ON PHAGE[1994/39]
French:PRODUCTION D'ANTICORPS ANTI-AUTO-ANTIGENES A PARTIR DE REPERTOIRES DE SEGMENTS D'ANTICORPS AFFICHES SUR PHAGE[1994/39]
Entry into regional phase21.06.1994National basic fee paid 
21.06.1994Designation fee(s) paid 
21.06.1994Examination fee paid 
Examination procedure16.04.1993Request for preliminary examination filed
International Preliminary Examining Authority: DE
21.06.1994Examination requested  [1994/47]
11.08.1997Despatch of a communication from the examining division (Time limit: M06)
09.02.1998Reply to a communication from the examining division
23.06.1999Despatch of a communication from the examining division (Time limit: M06)
10.04.2000Reply to a communication from the examining division
07.05.2001Despatch of a communication from the examining division (Time limit: M08)
21.02.2002Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
02.05.2002Reply to a communication from the examining division
09.05.2003Despatch of a communication from the examining division (Time limit: M08)
19.01.2004Reply to a communication from the examining division
05.03.2004Communication of intention to grant the patent
03.05.2004Fee for grant paid
03.05.2004Fee for publishing/printing paid
Divisional application(s)EP00107845.0  / EP1024191
EP06001908.0  / EP1696031
EP10002988.3  / EP2224006
Opposition(s)02.06.2005No opposition filed within time limit [2005/34]
Request for further processing for:02.05.2002Request for further processing filed
02.05.2002Full payment received (date of receipt of payment)
Request granted
24.05.2002Decision despatched
10.04.2000Request for further processing filed
10.04.2000Full payment received (date of receipt of payment)
Request granted
27.04.2000Decision despatched
Fees paidRenewal fee
16.12.1994Renewal fee patent year 03
21.12.1995Renewal fee patent year 04
23.12.1996Renewal fee patent year 05
23.12.1997Renewal fee patent year 06
23.12.1998Renewal fee patent year 07
27.12.1999Renewal fee patent year 08
22.12.2000Renewal fee patent year 09
27.12.2001Renewal fee patent year 10
27.12.2002Renewal fee patent year 11
23.12.2003Renewal fee patent year 12
Penalty fee
Penalty fee Rule 85b EPC 1973
16.08.1994M01   Fee paid on   25.08.1994
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipGR01.12.2004
LU02.12.2004
MC31.12.2004
PT01.02.2005
[2008/05]
Former [2007/16]GR01.12.2004
LU02.12.2004
MC31.12.2004
Former [2005/45]GR01.12.2004
MC31.12.2004
Former [2005/18]GR01.12.2004
Cited inInternational search[X]WO8806630  (GENEX CORP [US]);
 [X]WO9014443  (HUSE WILLIAM D [US]);
 [X]WO9014430  (SCRIPPS CLINIC RES [US], et al);
 [X]WO9014424  (SCRIPPS CLINIC RES [US]);
 [XP]WO9201047  (CAMBRIDGE ANTIBODY TECH [GB], et al);
 [XP]WO9220791  (CMABRIDGE ANTIBODY TECH [GB], et al)
 [X]  - SCIENCE vol. 246, 8 December 1989, LANCASTER, PA pages 1275 - 1281 Huse, W.D. et al.; 'Generation of a large combinatorial library of the Immunoglobulin repertoire in Phage lambda.'
 [X]  - NATURE. vol. 349, 24 January 1991, LONDON GB pages 293 - 299 Winter, Greg; Milstein, Cesar; 'Man-made antibodies' cited in the application
 [X]  - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 88, May 1991, WASHINGTON US pages 4363 - 4366 Kang, A.S. et al.; 'Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surface.'
 [XP]  - BIOTECHNOLOGY vol. 10, no. 7, July 1992, NEW YORK US pages 779 - 783 Marks, James D.; Griffiths, Andrew D.; Malmqvist, Magnus; Clackson, Tim P.; Bye, Jacqueline M.; Winter, Greg; 'By-passing immunization: building high affinity human antibodies by chain shuffling'
ExaminationEP0368684
    - PORTOLANO S. ET AL, "A human Fab Fragment Specific for Thyroid peroxidase generated by cloning thyroid lymphocyte-derived immunoglobulin genes in a bacteriophage lambda library", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (19910830), vol. 179, no. 1, doi:doi:10.1016/0006-291X(91)91380-U, pages 372 - 377, XP024836340

DOI:   http://dx.doi.org/10.1016/0006-291X(91)91380-U
    - GARRARD L.J. ET AL, "Fab assembly and enrichment in a monovalent phage display system", BIOTECHNOLOGY, (199112), vol. 9, doi:doi:10.1038/nbt1291-1373, pages 1373 - 1377, XP001084206

DOI:   http://dx.doi.org/10.1038/nbt1291-1373
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.