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Extract from the Register of European Patents

EP About this file: EP0576792

EP0576792 - Plasmids and processes for producing recombinant desulphatohirudin HV-1 peptides in Saccharomyces [Right-click to bookmark this link]
Former [1994/01]Plasmids and process for producing recombinant desulphatohirudin HV-1 peptide
[2002/40]
StatusThe application has been withdrawn
Status updated on  21.03.2003
Database last updated on 05.10.2024
Most recent event   Tooltip21.03.2003Withdrawal of applicationpublished on 07.05.2003  [2003/19]
Applicant(s)For all designated states
BIOGAL GYOGYSZERGYAR RT.
Pallagi ut 13
4042 Debrecen / HU
[N/P]
Former [1994/01]For all designated states
BIOGAL GYOGYSZERGYAR RT.
Pallagi ut 13
H-4042 Debrecen / HU
Inventor(s)01 / Ott, István, Dr.
Benczur u. 2
H-1068 Budapest / HU
02 / Klupp, Tibor, Dr.
Zöldlomb t 19
H-1025 Budapest / HU
03 / Molnár, István
Kossuth L. u. 32
H-1121 Budapest / HU
04 / Patthy, András, Dr.
Fenyö u. 10
H-1016 Budapest / HU
05 / Barta, István
Kassai u. 10
H-1142 Budapest / HU
06 / Berk -T th, Zsuzsa, Ir.-Chem.
Oceánárok u. 11
H-1046 Budapest / HU
07 / Ambrus, Gábor, Dr. Ir.-Chem.
Csalán 45/B
H-1025 Budapest / HU
08 / Salát, János
Veresegyházi u. 21
H-1151 Budapest / HU
09 / Tegdes, Anik
Vizimolnár u. 6
H-1031 Budapest / HU
10 / Moravcsik, Imre, Ir.-Chem.
Mester u. 38
H-1095 Budapest / HU
11 / Együd, Cecilia
Rákoczi t 32
H-1072 Budapest / HU
12 / Albrecht, Károly
Mexik i t 44
H-1145 Budapest / HU
13 / Könczöl, Kálmán, Dr. Ir.-Chem.
Dunyov I. u. 16
H-1134 Budapest / HU
14 / Vincze, Attila
Csáktornya park 4
H-1142 Budapest / HU
15 / Barabás, Eva, Dr.
Pusztaszeri t 6
H-1025 Budapest / HU
16 / Máté, György, Ir.-Chem.
Eötvös J. u. 15
H-1046 Budapest / HU
17 / Botond Kiss, György Dr.
Dugonics tér 11
H-6722 Szeged / HU
18 / Kiss, Péter
Epitö u. 13/a
H-6723 Szeged / HU
19 / Pölya, Kálmán, Dr.
Péchy u. 9
H-4028 Debrecen / HU
20 / Erdei, Janos Dr.
Andahazi u. 8
H-4032 Debrecen / HU
21 / Erdei, Jan s Dr.
Hámán K. u. 32
H-4027 Debrecen / HU
22 / Zilahi, Erika
Urrétje u. 1
H-4032 Debrecen / HU
[1994/01]
Representative(s)Beszédes, Stephan G.
Patentanwalt
Postfach 11 68
85201 Dachau / DE
[N/P]
Former [1994/01]Beszédes, Stephan G., Dr.
Patentanwalt Postfach 11 68
D-85201 Dachau / DE
Application number, filing date93105848.113.04.1993
[1994/01]
Priority number, dateHU1912000009209.04.1992         Original published format: HU 120092
[1994/01]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP0576792
Date:05.01.1994
Language:EN
[1994/01]
Type: A3 Search report 
No.:EP0576792
Date:24.08.1994
Language:EN
[1994/34]
Search report(s)(Supplementary) European search report - dispatched on:EP08.07.1994
ClassificationIPC:C12N15/15, C07K14/815
[2002/40]
CPC:
C07K14/815 (EP,US); C12N15/76 (EP,US); A61K38/00 (EP,US);
C07K2319/00 (EP,US)
Former IPC [2000/44]C12N15/15, // C07K14/815
Former IPC [1994/01]C12N15/15, // C07K7/10
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1994/01]
TitleGerman:Plasmide und Verfahren zur Herstellung von rekombinanten Desulphatohirudin HV-1 Peptiden in Saccharomyces[2002/40]
English:Plasmids and processes for producing recombinant desulphatohirudin HV-1 peptides in Saccharomyces[2002/40]
French:Plasmides et procédés pour la production de peptides desulphatohirudin HV-1 recombinants dans Saccharomyces[2002/40]
Former [1994/01]Plasmide und Verfahren zur Herstellung von rekombinante Desulphatohirudin HV-1 Peptide
Former [1994/01]Plasmids and process for producing recombinant desulphatohirudin HV-1 peptide
Former [1994/01]Plasmides et procédés pour la production des peptides HV-1 de sulphatohirudin recombinants
Biological materialThis application mentions deposited biological material, check the file for details
Examination procedure07.09.1994Examination requested  [1994/44]
04.10.1995Despatch of a communication from the examining division (Time limit: M04)
05.02.1996Reply to a communication from the examining division
06.11.1996Despatch of a communication from the examining division (Time limit: M06)
16.05.1997Reply to a communication from the examining division
09.03.1998Despatch of a communication from the examining division (Time limit: M06)
21.09.1998Reply to a communication from the examining division
08.11.1999Despatch of a communication from the examining division (Time limit: M06)
08.05.2000Reply to a communication from the examining division
12.01.2001Despatch of a communication from the examining division (Time limit: M04)
23.04.2001Reply to a communication from the examining division
24.07.2001Despatch of a communication from the examining division (Time limit: M04)
19.11.2001Reply to a communication from the examining division
13.09.2002Communication of intention to grant the patent
13.01.2003Fee for grant paid
13.01.2003Fee for publishing/printing paid
10.03.2003Application withdrawn by applicant  [2003/19]
Fees paidRenewal fee
27.04.1995Renewal fee patent year 03
26.04.1996Renewal fee patent year 04
14.04.1997Renewal fee patent year 05
15.04.1998Renewal fee patent year 06
15.04.1999Renewal fee patent year 07
10.04.2000Renewal fee patent year 08
17.04.2001Renewal fee patent year 09
16.04.2002Renewal fee patent year 10
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Documents cited:Search[Y]WO9117250  (ERBA CARLO SPA [IT]) [Y] 1 * examples 1,2 *;
 [Y]EP0364942  (HOECHST AG [DE]) [Y] 1 * claim - *;
 [YD]EP0168342  (CIBA GEIGY AG [CH]) [YD] 1,2,4,11,12 * page 75 - page 77 *;
 [Y]EP0190686  (GREEN CROSS CORP [JP]) [Y] 1,2,4,11,12 * page 10; table 4 *;
 [X]WO9109946  (BASF AG [DE]) [X] 1,2,5,6,13-15 * figure 2 *;
 [X]WO8504418  (TRANSGENE SA [FR]) [X] 1 * page 15; claim - *;
 [DY]EP0340170  (CIBA GEIGY AG [CH], et al) [DY] 1,2,7-10 * claim - *;
 [YD]EP0341215  (CIBA GEIGY AG [CH], et al) [YD] 1,2,7-10 * claim - *;
 [AD]WO8603517  (GEN BIO TEC GES [DE], et al) [AD] * figure 1; examples 2,3 *;
 [X]  - FURUSAKI, S. ET AL. (EDS.), Biochemical Engineering for 2001, TOKYO, JAPAN, SPRINGER, (19920318) [X] 1 * SATORU MISAWA ET AL.: High level expression and secretion of biologically active leech hirudin variant 1 (HV1) by Escherichia coli, pages 62-64 *
 [Y]  - DODT, J. ET AL., "Expression, secretion and processing of hirudin in E. coli using the alkaline phosphatase signal sequence", FEBS LETTERS, AMSTERDAM NL, (198606), vol. 202, no. 2, pages 373 - 377, XP001316574 [Y] 1 * figures 2,5 * * page 376 *
 [Y]  - JOHNSON, P.H. ET AL., "Biochemistry and genetic engineering of hirudin", SEMINARS IN THROMBOSIS AND HEMOSTASIS, (1989), vol. 15, no. 3, pages 302 - 315 [Y] 1,2,4,11,12 * page 304 - page 305 * * table 1 *
 [X]  - BERGMANN C. ET AL., "Chemical synthesis and expression of a gene coding for hirudin, the thrombin-specific inhibitor from the leech hirudo medicinalis", BIOL. CHEM. HOPPE-SEYLER, (198608), vol. 367, pages 731 - 740 [X] 1,2,5,6,13-16 * see abstract *
 [DX]  - BENDER, E. ET AL., "Synthesis and secretion of hirudin by Streptomyces lividans", APPLI. MICROBIOL. BIOTECHNOL., (199011), vol. 34, pages 203 - 207 [DX] 1 * the whole document *
 [A]  - DODT, J. ET AL., "The complete amino acid sequence of hirudin, a thrombin specific inhibitor", FEBS LETTERS, AMSTERDAM NL, (198401), vol. 165, no. 2, doi:doi:10.1016/0014-5793(84)80165-9, pages 180 - 184, XP025592630

DOI:   http://dx.doi.org/10.1016/0014-5793(84)80165-9
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